6results about How to "Long retention time" patented technology

The invention relates to the technical field of biomedical materials and tissue engineering, and discloses sequential slow-release temperature-sensitive hydrogel and a preparation method and application thereof.The preparation method comprises the following steps that a blood sample is subjected to programmed centrifugation, and a gel layer of leukocyte-rich platelet-rich fibrin L-PRF and a gel layer of improved platelet-rich fibrin A-PRF are obtained respectively; and the gel layer is cut into pieces, pre-frozen, freeze-dried, ground and sieved, so that L-PRF freeze-dried powder and A-PRF freeze-dried powder are obtained respectively, and the methacrylic acid gelatin microspheres entrapped with the L-PRF freeze-dried powder are prepared. The microspheres and A-PRF freeze-dried powder are loaded into a temperature-sensitive hydrogel system composed of chitosan, polygalacturonic acid and sodium beta-glycerophosphate, so that the growth factors can be effectively entrapped in the hydrogel structure, and continuous release is realized; the system has good mechanical strength and structural stability, the retention time of the material in vivo is prolonged, and stable three-dimensional network support is provided.

The invention relates to a controlled-release linalool emulsion based on a ternary system as well as a preparation method and application of the controlled-release linalool emulsion. The linalool emulsion is an oil-in-water Pickering emulsion composed of a water phase and an oil phase, the water phase comprises a ternary system composed of soybean protein isolate, pectin and hydroxypropyl methyl cellulose, and the oil phase is linalool essential oil. The preparation method comprises the following steps: respectively preparing soybean protein isolate, pectin and hydroxypropyl methyl cellulose solutions, and mixing to obtain a ternary composite water phase; and mixing the ternary composite water phase with the oil phase, and carrying out high-pressure homogenization treatment and ultrasonic treatment under a low-temperature condition to obtain the controlled-release linalool emulsion based on the ternary system. Compared with the prior art, the linalool essential oil emulsion embedding method solves the problem that linalool is easy to volatilize, and can be used in the fields of fruit and vegetable fresh keeping, tea fragrance maintaining and the like.

The application provides a surface-modified gadolinium-based covalent organic framework magnetic resonance contrast agent and a preparation method and application thereof, characterized in that: tetra-(p-aminophenyl porphyrin) is used as a monomer to prepare Gd(III)-porphyrin, and then the Gd-porphyrin-based covalent organic framework polymer Gd-PCOFs contrast agent is connected by forming an imine bond with a dialsyl compound. Then, the surface of the Gd-PCOFs is modified by a molecule containing a mercapto group, so that a magnetic resonance contrast agent with uniform particle size and good dispersity is obtained, and the longitudinal relaxation rate can reach 126.35 s ‑ 1 mM ‑1 , which can be used for super-sensitive magnetic resonance imaging of solution, cells and living bodies.

A non-volatile memory cell (200) is disclosed comprising a pinch-off ferroelectric memory FET (40) and at least one select device (80), said at least one select device (80) being electrically connected in series to the pinch-off ferroelectric memory FET (40).

The application discloses an InGaN nanocolumn-based optoelectronic memristor and a preparation method and application thereof. The composition of the InGaN nanocolumn-based optoelectronic memristor comprises a substrate, an InGaN functional layer, a first Schottky contact electrode and a second Schottky contact electrode, the InGaN functional layer is arranged on the surface of the substrate, the InGaN functional layer is composed of a plurality of InGaN nanocolumns epitaxially grown on the surface of the substrate, and the first Schottky contact electrode and the second Schottky contact electrode are arranged on the side of the InGaN functional layer away from the substrate. The InGaN nanocolumn-based optoelectronic memristor has the advantages of stable resistance state change, long resistance state retention time and the like, is suitable for neural network algorithm and image recognition application, and has simple structure and simple preparation process, and is suitable for large-scale industrial production and application.

The application provides a drug-loaded nanoparticle Cor@PDA-PEG@CD11b and a preparation method and application thereof, the preparation method comprises the following steps: S1, mixing cordycepin solution and PDA aqueous solution, so that the cordycepin and the PDA form a complex Cor@PDA through π-π stacking effect; S2, the obtained complex Cor@PDA is modified by PEG to prepare a complex Cor@PDA@PEG; S3, the obtained Cor@PDA@PEG is dispersed in a buffer solution, and an anti-CD11b antibody is added; after reacting for 24h, centrifugation, washing, collecting the precipitate, and drying, the Cor@PDA-PEG@CD11b is obtained. The drug-loaded nanoparticle Cor@PDA-PEG@CD11b prepared by the application provides a new idea and direction for the treatment of sepsis-related lung injury; through the characteristics of the PDA nanoparticles, the cordycepin is released in a controlled manner, and the problem that the cordycepin is rapidly oxidized and inactivated after entering the body is avoided, the bioavailability is improved, the specific antibodies on the surface of immune cells and the physiological characteristics are utilized, the immune cells are quickly and chemotactically recruited to the inflammatory injury site in the early stage of acute inflammation, the drug is quickly and accurately targeted, and the sepsis lung injury is reduced.