204results about How to "Efficient targeting" patented technology

The invention relates to a method, system and apparatus for managing a small business' advertising. More specifically, the system creates and administers a virtual online world accessible to users (players) within a virtual environment. A player interacts with various elements of the virtual environment and during those interactions the advertising is displayed to the user. To subscribe to the virtual environment, a player provides user information through a registration process to create a user profile. The system selects and displays advertisements that are correlated to a given user. The correlation between advertisement and user in one embodiment of the invention is based on a user's zip code. Further, in order to facilitate the quick adoption of the system among small business owners, a fundraising paradigm is implemented. More specifically, people volunteer to sell advertising opportunities within a virtual environment in exchange for a share of sales revenues.

Systems and methods are presented for providing dynamic temporally and geographically relevant information or content to mobile communications devices, in which a profile and a current location are obtained for a mobile device, profile specific geographically and temporally relevant content from a data store according to the user profile, the current user location, and the current time, and the content is provided to mobile communications device via a communications network.

The present invention is a method and system for automatically changing the advertisement contents on a means for displaying the contents based on a customer's behavior or a group of customers' behavior in a retail store. The analysis of behavioral pattern is performed automatically and in real-time based on the visual information from the shopping and walkthrough history of a customer or a group of customers, using arrays of sensing devices, such as a plurality of means for capturing images, and a plurality of computer vision technologies on the visual information.

The invention provides pharmaceutical compositions comprising short single stranded oligonucleotides, of length of between 8 and 17 nucleobases which are complementary to human microRNAs. The short oligonucleotides are particularly effective at alleviating miRNA repression in vivo. It is found that the incorporation of high affinity nucleotide analogues into the oligonucleotides results in highly effective anti-microRNA molecules which appear to function via the formation of almost irreversible duplexes with the miRNA target, rather than RNA cleavage based mechanisms, such as mechanisms associated with RNaseH or RISC.

A method of targeting a diagnostic or therapeutic agent to a focus of infection comprises injecting a patient infected with a pathogen parenterally with an antibody conjugate which specifically binds to an accessible epitope of the pathogen or of a pathogen-associated antigen accreted at the focus of infection, the antibody conjugate further comprising a bound diagnostic or therapeutic agent for detecting, imaging or treating the infection. Polyspecific composite conjugates enhance the efficacy of the method, which is especially useful for treating infections that are refractory towards systemic chemotherapy.

The present invention is directed to compositions of matter useful for the diagnosis and treatment of tumor in mammals and to methods of using those compositions of matter for the same.

A computer application is used for the serving and creation of user-annotated web pages, which may include associated advertisements, to client devices. The user is able to submit comments to one or more web servers wherein the web server or servers appends the submitted comment or comments and updates them for use and display on one or more web pages at one or more client devices. The comments are also distributed for viewing or listening, potential annotation, and update by other users viewing the same or related annotations across multiple websites. Annotated advertisements are an embodiment of the invention.

To enable a non-profit to make informed decision about how to spend its limited resources efficiently to maximize its donations, systems and methods to determine prospect propensity and prospect capacity to identify what types of donations, such as annual gifts, major one-time gifts, or planned gifts, the non-profit should solicit from its pool of prospective donors and the likely amount of each such gift. Systems and methods that enable the non-profit further to identify what types of planned gift, such as bequests, charitable remainder trusts, charitable gift annuities, pooled income funds, and life insurance, it should solicit from each of its prospective donors. The systems and methods use models developed using statistical analysis to generate relative scores for all prospective donors in the pool. Such scores and additional wealth information are provided to the non-profit in electronic format for further manipulation and use.

A device, system and method for producing glycosylated proteins in plant culture, particularly proteins having a high mannose glycosylation, while targeting such proteins with an ER signal and/or by-passing the Golgi. The invention further relates to vectors and methods for expression and production of enzymatically active high mannose lysosomal enzymes using transgenic plant root, particularly carrot cells. More particularly, the invention relates to host cells, particularly transgenic suspended carrot cells, vectors and methods for high yield expression and production of biologically active high mannose Glucocerebrosidase (GCD). The invention further provides for compositions and methods for the treatment of lysosomal storage diseases.

A device, system and method for producing glycosylated proteins in plant culture, particularly proteins having a high mannose glycosylation, while targeting such proteins with an ER signal and/or by-passing the Golgi. The invention further relates to vectors and methods for expression and production of enzymatically active high mannose lysosomal enzymes using transgenic plant root, particularly carrot cells. More particularly, the invention relates to host cells, particularly transgenic suspended carrot cells, vectors and methods for high yield expression and production of biologically active high mannose Glucocerebrosidase (GCD). The invention further provides for compositions and methods for the treatment of lysosomal storage diseases.

A computer-based system and method are described to provide advertisers with effective target advertising. More specifically, the system and method enable individuals to explicitly specify which brands they feel an affinity for in order to determine and present advertisements based on the individual's actual self-described affinities.

An entertainment content consumer selects the manner in which advertisements are presented at a client by selecting one of plural available advertisement content layouts. Entertainment content is served to the entertainment content consumer's client with advertisement content by using the advertisement content layout selected by the consumer. For example, a consumer selects whether to have advertisements served within a social media news feed or to have advertisements served by a video shown over the social media news feed according to a predetermined metric, such as an advertisement at regular time intervals or predetermined download metrics. Empowering the consumer to control how advertisements are served improves the consumer's experience by providing fewer higher quality advertisements to the consumer for a given allocation of entertainment content viewing.

Compositions comprising first and second oligomers are provided wherein at least a portion of the first oligomer is capable of hybridizing with at least a portion of the second oligomer, at least a portion of the first oligomer is complementary to and capable of hybridizing to a selected target nucleic acid, and at least one of the first or second oligomers includes a modification comprising a sugar surrogate. Oligomer/protein compositions are also provided comprising an oligomer complementary to and capable of hybridizing to a selected target nucleic acid and at least one protein comprising at least a portion of an RNA-induced silencing complex (RISC), wherein at least one nucleoside of the oligomer has a sugar surrogate modification.

A contrast agent having a contrast protein have contrast properties and at least one targeting moiety, wherein the at least one targeting moiety is operatively linked to or incorporated within the contrast protein. Methods for targeting contrast agents and for preparing such agents are included.

Disclosed are a system and methods for online marketing of goods and services to consumers. More particularly, a method for target marketing to specific consumers on the Internet based upon the profile of the consumer, including geographic location, is disclosed.

An end user earns points by selecting advertisement content and observing the advertisement content at a client at a first time period. The points are stored in memory until the end user desires to view entertainment content. A server streams entertainment content selected by the end user to the client at a second time period if the points stored for the end user are at least equal to a point cost of the entertainment content. For example, entertainment content that is normally streamed with advertisement content for presentation during commercial breaks is streamed at the second time period without advertisement content since the end user has already viewed advertisement content at the first time period.

The present invention relates to compositions and methods, in particular to methods based on systemic administration of scAAV, for delivering genes to cells of the retina of mammals, and in particular to photoreceptor cells, ganglion cells, glial cells, inner nuclear layer cells or cells of the retinal pigmented epithelium.

Methods are provided for producing functional antigen presenting dendritic cells. The dendritic cells are produced by treating an extracorporeal quantity of a subject's blood to induce differentiation of blood monocytes into dendritic cells. The dendritic cells may be exposed to cellular material encapsulated within a biodegradable polymer material to produce the antigen presenting dendritic cells.

The invention relates to a preparation method of a difunctional mesoporous silicon ball composite targeted drug delivery system, and belongs to the field of nanobiomedicine. The method comprises the steps that a coprecipitation method is adopted for preparing superpara magnetism Fe3O4 nanoparticles, then, hexadecyl trimethyl ammonium bromide is used as a template, a photosensitizer is doped, accordingly, the surfaces of the magnetic nanoparticles and the photosensitizer are wrapped by a layer of mesoporous silica, covalent linkage and physical absorption of anti-cancer medicine are achieved, finally, surface modification is carried out through folic acid and hyaluronic acid, and the difunctional mesoporous silicon ball composite targeted drug delivery system is obtained. According to the system, multiple effects of nuclear magnetism radiography, fluorescence imaging, magnetic hyperthermia, photoactive therapy and chemotherapy are integrated, diagnosis and treatment are integrated, magnetic targeting and FA/HA dual receptor-mediated targeting effect can more effectively enhance the targeting combination of the medicine and tumor cells, the effective concentration of the medicine in the tumor parts is improved, effect enhancement and toxicity reduction are achieved, the killability for the cancer cells is enhanced through dual drug loading, and the treatment effect on tumors is remarkably improved. The product obtained through the preparation method has a quite large application prospect in the field of medicine control release.

The present invention relates to chemical modification motifs for oligonucleotides. The oligonucleotides of the present invention, such as chemically modified antisense oligonucleotides, can have increased in vivo efficacy. The chemically modified oligonucleotides provide advantages in one or more of potency, efficiency of delivery, target specificity, toxicity, and/or stability. The chemically modified oligonucleotides have a specific chemical modification motif or pattern of locked nucleic acids (LNAs). The oligonucleotide (e.g. antisense oligonucleotide) can target RNA, such as miRNA or niflNA. Also provided herein are compositions comprising the chemically modified oligonucleotides and methods of using the chemically modified oligonucleotides as therapeutics for various disorders, including cardiovascular disorders.