209results about How to "Efficient targeting" patented technology

The present invention is directed to compositions of matter useful for the diagnosis and treatment of tumor in mammals and to methods of using those compositions of matter for the same.

The invention provides pharmaceutical compositions comprising short single stranded oligonucleotides, of length of between 8 and 26 nucleobases which are complementary to human microRNAs selected from the group consisting of miR19b, miR21, miR122a, miR155 and miR375. The short oligonucleotides are particularly effective at alleviating miRNA repression in vivo. It is found that the incorporation of high affinity nucleotide analogues into the oligonucleotides results in highly effective anti-microRNA molecules which appear to function via the formation of almost irreversible duplexes with the miRNA target, rather than RNA cleavage based mechanisms, such as mechanisms associated with RNaseH or RISC.

A request for information (RFI) system is provided for use in communications networks including broadcast networks and the internet. In one implementation, a viewer of a cable television network enters an RFI input (1) to a digital set top box using a user remote. Based on this RFI input, the digital set top box transmits a data request (2) to an RFI data center. The RFI data center also receives asset data (3) from an asset database so as to associate the RFI input (1) with a particular asset. An RFI request (4) can then be transmitted to the appropriate asset provider. The asset provider can then provide a report such package of assets or follow-on information (5) back to the RFI data center. The RFI data center may then, in turn, provide the package of assets or follow-on information to a user data terminal, for example, of the cable television network viewer, via access through a web-portal or e-mail (6). The digital set top box may also record inputs from the user to verify consumption of assets and track data requests. Using this information, the RFI data center or an RFI platform may credit value to a rewards account established for the network user based on the user's verified consumption of assets and / or data requests. Further, the RFI data center or RFI platform may be used to collect consumer behavior information, including purchasing decisions made by the user after consumption of assets, and correlate the consumer behavior information with the user's verified asset consumption.