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FIP-fve is a fungal immunomodulatory protein purified from Flammulina velutipes, an edible golden needle mushroom thought to possess potent immunomodulatory properties. When examined for its effects on lymphocytes, FIP-fve exhibited potent mitogenic effects on human peripheral blood lymphocytes, inducing G1/G0 to S phase proliferation.
ICOS ligand variant immunomodulatory proteins and uses thereof
Owner:ALPINE IMMUNE SCIENCES INC
Variant ICOS ligand immunomodulatory protein and related compositions and methods
To provide a variant ICOS ligand (ICOSL) polypeptide.SOLUTION: Provided is a variant ICOSL polypeptide that comprises one or more amino acid modifications in an immunoglobulin superfamily domain of an ICOSL polypeptide, the variant ICOSL polypeptide being a truncated extracellular domain comprising: a contiguous sequence of amino acids comprising amino acids 1 to 112; and a C-terminal truncation of at least 25 amino acids, based on the ICOSL extracellular domain sequence represented by a specific sequence.SELECTED DRAWING: Figure 13A
Owner:ALPINE IMMUNE SCIENCES INC