85 results about "Ultrasound stimulation" patented technology

Ultrasound stimulation devices and related techniques are disclosed. An ultrasound transducer for generating ultrasound energy is carried by a transducer housing that seals the transducer and may also include a positioning element for positioning the transducer proximate an application area to which generated ultrasound energy is to be applied. The transducer housing may also carry such components as a battery, a wireless receiver, and a controller. The same housing or a separate sensor housing may include an ultrasound sensor that provides feedback to the ultrasound transducer or its controller, illustratively through a wireless transmitter.

Disclosed are methods and systems for non-invasive ultrasound stimulation of neural structures, whether the central nervous systems (such as the brain), nerve roots, or peripheral nerves using macro- and micro-pulse shaping. Which macro-pulse and micro-pulse shapes are most effect depends on the target. This can be assessed either by functional results (e.g., doing motor cortex stimulation and seeing which macro- and micro-pulse shape combination causes the greatest motor response) or by imaging (e.g., PET of fMRI) results.

Systems and methods are disclosed for providing therapeutic treatment using vibrational stimulation, ultrasound stimulation and electro-stimulation. The combined therapeutic treatment allows for more flexible and effective treatment of bone-loss related and other ailments and conditions by providing one or a combination of vibrational, ultrasound and / or electro-stimulation to a patient.

A medical device comprising a medical device body having drug-loaded vesicles thereon. The vesicles are ultrasound sensitive and release the drug upon ultrasound stimulation. Also provided is a method for controlling drug release from a medical device using drug-loaded vesicles that are ultrasound sensitive.

Ultrasound stimulation devices and related techniques are disclosed. An ultrasound transducer for generating ultrasound energy is carried by a transducer housing that seals the transducer and may also include a positioning element for positioning the transducer proximate an application area to which generated ultrasound energy is to be applied. The transducer housing may also carry such components as a battery, a wireless receiver, and a controller. The same housing or a separate sensor housing may include an ultrasound sensor that provides feedback to the ultrasound transducer or its controller, illustratively through a wireless transmitter.

The invention provides an ultrasonic focusing lens based on a planar artificial structure. An acoustic soft material plate is provided with, at upper and lower surfaces, circular portions and a plurality of concentric annular portions continuously arranged around the corresponding circular portions. The adjacent annular portions have different thicknesses. The circular portions at the upper and lower surfaces and the annular portions at the upper and lower surfaces are symmetrical up and down relative to the central horizontal line of the acoustic soft material plate. Silica gel covering layers cover the upper and lower surfaces of the acoustic soft material plate so that the ultrasonic focusing lens has a uniform total thickness. The thickness of each annular portion is related to the focal length of the ultrasonic focusing lens. The planar focusing lens of the invention can regulate the focusing of the acoustic wave. In cooperation with a planar ultrasonic probe, the ultrasonic focusing lens can generate a focusing ultrasonic sound field and can accurately control a focusing depth to realize a single-point and multi-point focusing effect with different depths so as to achieve ultrasound stimulation on areas at different depths of an object, and is easy to operate, low in cost, and flexible to use.

The invention discloses albumen powder richening in antimicrobial peptide fly maggot, a preparation method for the albumen powder and a feed additive of the albumen powder. The albumen powder richening in the antimicrobial peptide fly maggot is prepared by a method comprising the following steps of: (1) feeding flies, luring the flies to lay eggs and feeding larva by using feed after incubation; (2) conducting ultrasound induction on the larva; (3) continuously feeding, collecting the larva, washing, conducting disinfection treatment, and conducting tissue homogenate smashing; and (4) filtering, treating filtrate at 0-5 DEG C, removing surface lipid compositions, drying to obtain the albumen powder; adding auxiliary materials in the albumen powder, pelletizing to obtain the feed additive. A ultrasound stimulation mode under specified conditions is adopted to induce the larva to enable an antimicrobial peptide active ingredient content in a body of a housefly to obviously improve, and the feed additive has certain growth promotion and disease-resistant strengthening effects on litopenaeus vannamei, crucian and the like.

The present invention is suitable for the field of ultrasound neural stimulation research technology, and discloses a head-mounted ultrasound transmission device. The device comprises a pedestal capable of being arranged on a skull of an experimental animal and a top cover connected with the pedestal, the pedestal is internally provided with an inner cavity configured to hold a couplant, and the top cover is connected with an ultrasound transducer having a working surface facing the bottom portion of the inner cavity; and the device also comprises a fixing device configured to fix the pedestalat the skull of the experimental animal, the fixing device comprises a skull connection piece which has a front end capable of being embedded into the skull of the experimental animal, and the pedestal is applied to the skull of the experimental animal and is directly connected with or connected with the fixing device through a binder. The head-mounted ultrasound transmission device can achieve accurate, controllable and repeatable ultrasound stimulation at an implementation position of a brain of an unrestrained experimental animal, is suitable for development of animal experiments related to memory such as feeling, emotion, cognition and the like, and is good in implementation effect.

Provided herein is a stimulation device, system and method for therapeutic treatment of a condition or disease. In various aspects, the device may include one or more modules for low temperature, vibration, pressure, or ultrasound stimulation, operably connected to a contact tip; a data logging module; and a wireless communication module. Also provided is a system including such device and a remote server. Additionally, a method of treatment using such device or system is provided.

Provided is an over-metal sleeve magnetosonic resistivity imaging logging method and device. A magnetic body distributed in a well is used for generating magnetostatic fields on stratums at the periphery of the well, and an ultrasonic probe array launches ultrasonic waves to a certain area of the stratums at the periphery of the well. Ultrasound stimulation and the magnetostatic fields mutually affect to stimulate lorentz force and alternating voltage, an equivalent current source is formed in a target area, and further electromagnetic fields are generated on the stratums at the periphery of the well. Voltage signals and ultrasound echo signals are propagated to the well through the stratums after measurement, obtained information is processed based on an electromagnetism reciprocal theory, the resistivity of the target area is obtained, and resistivity image reconstruction of the periphery of the well is further achieved. By using device in the method, a magnetic body system, the ultrasonic probe array and a measurement coil serve as one portion of underground instruments to be arranged in a well cylinder. Radial movement and longitudinal movement of an ultrasound focal zone are achieved by using whole longitudinal extraction of the ultrasonic probe array, electronic control technology and instruments in the well cylinder, and stratum resistivity imaging of an over-metal sleeve is further achieved.

The present invention discloses an ultrasonic diagnosis and treatment method and system. The system comprises a plurality of biological signal processing devices, an ultrasonic wave transmitting device and a central processing device. The biological signal processing devices calculate the difference between the biological signals of a positioning target before and after the excitation of difference frequency ultrasound, generates a first index change amount, and calculate the difference between the biological signals of a positioning target before the excitation of the difference frequency ultrasound and after ablation of differential frequency ultrasound stimulation, and generates a second index change amount. The central processing apparatus transmits corresponding instructions to the ultrasonic wave transmitting device based on a comparison result of the first index change amount and a first preset index change amount as well as a comparison result of the second index change amount and a second preset index change amount, wherein the instructions include a target positioning instruction and a difference frequency ultrasound stimulation instruction, the same frequency ultrasound ablation instruction or a difference frequency ultrasound ablation instruction to achieve the diagnosis of a positioning target and the evaluation of ablation effect for the integration and automation of diagnosis and treatment.

The invention relates to a wearable transcranial ultrasound nerve stimulation and electrophysiological recording combined system and method. The combined system comprises a computer control and data processing unit, a digital-to-analog / analog-to-digital conversion unit, a power amplifier, a wearable ultrasound transducer and an electrode assembly and a signal amplification unit. A signal instruction is sent out through the computer control and data processing unit; after the digital-to-analog / analog-to-digital conversion unit receives the instruction, a corresponding waveform is generated; the power amplifier amplifies the signal into a high-voltage signal; the ultrasound transducer is driven to emit ultrasound waves; and the goal of nerve stimulation is achieved. The electrophysiological signal recorded by the electrode assembly is amplified by the signal amplifier, and is then transmitted to the digital-to-analog / analog-to-digital conversion unit to be converted into a digital signal; through the control by a computer, the digital signal is received by the data processing unit; and the data processing and the display are performed. The goal of completing complicated ultrasound stimulation and electrophysiological signal synchronous recording by one set of system is well achieved; and the technical support is provided for brain scientific research.

A system for treating at least one sensory capacity of a person with the help of a stimulation device comprises an electronic converter of a sensory signal into an electronic signal for controlling at least one transducer for emitting signals that are images of the sensory signal. The stimulation device for direct ultrasound stimulation of the sensory cortex of a brain comprises at least one support that is implantable in a skull and that includes at least one internal wall and at least one ultrasound transducer carried by the support. Means for emitting focused ultrasound waves through the internal wall of the support towards a determined zone of the sensory cortex of the patient's brain in order to generate modulation of the brain activity in the cortex are provided. The ultrasound transducer is driven by the electronic converter to emit focused ultrasound signals that are images of the sensory signal.

The invention relates to a method for promoting macrophages to polarize to M1 type by utilizing a piezoelectric effect and application. According to the method, a piezoelectric material is combined with ultrasound to trigger non-contact and non-invasive electrical stimulation, and the important role of the electrical stimulation in immune regulation is verified; by taking the piezoelectric material as a cell culture substrate, and combining with ultrasound stimulation, M1 type polarized macrophages are cultured in vitro, and compared with a common biochemical method, the method does not need to introduce external polarized macrophages (PMAPs); and by utilizing the commercialized piezoelectric material, macrophages can be rapidly promoted to polarize to the M1 type by a method for applyingthe ultrasound; The method has a good effect of promoting the macrophages to polarize to the M1 type by utilizing the piezoelectric effect, and has the clinical application potential of tumor immunotherapy and anti-infective therapy. The method disclosed by the invention can be used for producing the M1 type polarized macrophages in batches so as to promote application of the piezoelectric material in immunotherapy.

A pancreatic beta cell stimulation system for stimulating release of insulin from pancreatic beta cells can include an ultrasonic transducer configured to be acoustically coupled to a body of a user; and an ultrasound controller configured to be in communication with the ultrasonic transducer so as to provide control signals to the ultrasonic transducer during operation. The ultrasound controller can be further configured to generate the control signals based on a planned amount of stimulation of pancreatic beta cells within the body of the user such that the control signals instruct the ultrasonic transducer to transmit ultrasound waves having selected intensity and frequency calculated to cause stimulation of the pancreatic beta cells.

The invention relates to the technical field of medical equipment, and provides a wearable ultrasound stimulation apparatus for median nerve. The wearable ultrasound stimulation apparatus for median nerve comprises a wearable sleeve ring and a plurality of ultrasound transducer assemblies, wherein each ultrasound transducer assembly comprises an ultrasound stimulation part, and an ultrasound imaging part arranged at the outer side of the corresponding ultrasound stimulation part in a sleeve manner. The ultrasound transducer assemblies are fixed by the wearable sleeve ring worn on a wrist, andthereby the apparatus is simple and convenient, and realizes the stable output of the ultrasonic energy of the ultrasound transducer assemblies. At the same time, the ultrasound imaging parts in the ultrasound transducer assemblies are used to emit and receive the ultrasonic energy to obtain position images of the median nerve, a position is adjusted by rotating the wearable sleeve ring, and finally the ultrasound stimulation parts in the ultrasound transducer assemblies are used to emit the ultrasonic energy to the median nerve to regulate the median nerve.

An ultrasound stimulation helmet (100) configured to regulate an endogenous neurotrophic factor in a brain or expression of proteins related to a neurodegenerative disease comprises: a main body (1) having a forehead perimeter adjustment knob (12), a back head perimeter adjustment knob (13), a fastening support frame (14), and multiple position adjustment knobs (15); and multiple ultrasound probes (2) detachably mounted on the main body (1), wherein the ultrasound probe (2) has a frequency adjustment button and an intensity adjustment button to respectively control an output frequency and output intensity of the ultrasound probe (2), and other ultrasound parameters and an angle of the ultrasound probe (2) itself are adjustable as well. The fastening support frame (14) can be used to adjust the length of the main body (1) according to the size of a head of a patient, and the ultrasound probes (2) are connected to the position adjustment knobs (15) to enable the ultrasound probes (2) to move upward, downward, or toward the left or right with respect to the head of the patient.

The invention provides a closed-loop transcranial brain stimulation system and method. The system comprises a transcranial ultrasonic signal generation module, a transcranial ultrasonic stimulation module, an electroencephalogram and electromyogram signal acquisition and processing module and an electrode module; the electrode module is used for collecting brain muscle signals of an experimental subject; the electroencephalogram and electromyographic signal collecting and processing module is configured to be used for collecting signals of the electrode module, processing the signals and then sending detection signals to the transcranial ultrasonic signal generating module; the transcranial ultrasonic signal generation module is configured to receive the detection signal, generate a stimulation signal according to the detection signal and an adjustment strategy, and send the stimulation signal to the transcranial ultrasonic stimulation module; the transcranial ultrasonic stimulation module is configured to emit ultrasonic stimulation to the experimental subject according to the stimulation signal. The beneficial effects of the invention are that the transcranial ultrasonic signal generation module adjusts the signal parameters of the transcranial ultrasonic stimulation module to the experimental subject next time according to the brain and muscle signals collected by the electrode module and a system expected value through a configuration strategy, thereby achieving the closed-loop control of the transcranial brain stimulation.

Systems and methods are provided for combined ultrasound and electrical stimulation for treating inflammation, autoimmune disorders, rheumatoid arthritis, and the like. Noninvasive ultrasound stimulation may be applied to the spleen, joints, limbs, or a region experiencing pain that has local swelling, and electrical stimulation may be applied to the face, neck, or other body region to access a peripheral nerve, vagus nerve, trigeminal nerve, or other nerves in appropriately-timed patterns to drive therapeutic effects. Stimulation timings or delay timings may be optimized based upon a desired clinical effect or treatment. Multiple targets may be stimulated in a coordinated fashion to better mimic natural physiology. A wearable ultrasound phased array device may be used to beam form energy to target the spleen while also having imaging capabilities to track the motion of the spleen to maintain localized stimulation of target regions.

Methods for the treatment of stroke, such as stroke of undetermined origin, by administration of xenon (Xe)-loaded liposome compositions are provided. In some aspects, Xe is encapsulated in echogenic liposomes and release of Xe can be enhanced by application of ultrasound stimulation. Compositions for use in treating stroke, such as liposomes loaded with Xe or Xe in combination with H2 or H2S, are also provided.

The invention discloses an ultrasonic transducer coupling device for transcranial ultrasonic stimulation of a human body. The ultrasonic transducer coupling device comprises an automatic pitch adjusting mechanism, an ultrasonic transducer and a water bag structure, wherein the automatic pitch adjusting mechanism is connected with distal and proximal ends of the ultrasonic transducer and is used for adjusting an axial distance between the ultrasonic transducer and scalp of a testee; the ultrasonic transducer is used for generating focused ultrasonic waves required for the transcranial ultrasonic stimulation; the water bag structure is used for storing a liquid couplant and comprises a liquid couplant internal cavity and a liquid couplant external cavity, and a sound-transmitting film in contact with the human body is arranged at the distal end of the liquid couplant internal cavity of the water bag structure; and the liquid couplant internal cavity communicates with the liquid couplantexternal cavity, and the liquid couplant internal cavity and the liquid couplant external cavity store a liquid couplant which is used for conducting ultrasonic waves to the scalp of the testee. The ultrasonic transducer coupling device has the advantages that the depth of stimulation can be adjusted, the use method is simple, accurate positioning can be achieved, the safety is good, and the like.

The invention provides a closed-loop electroencephalogram regulation and control method and system. The method comprises the following steps: receiving an electroencephalogram signal of an experimental subject; preprocessing the electroencephalogram signal to obtain a preprocessed electroencephalogram signal; calculating and processing the preprocessed electroencephalogram signal to obtain a theta rhythm electroencephalogram signal and an electroencephalogram characteristic value; processing the theta rhythm electroencephalogram signal and the electroencephalogram characteristic value to obtain an ultrasonic stimulation parameter and a theta rhythm set stimulation phase; and according to the ultrasonic stimulation parameters and the theta rhythm, setting a stimulation phase, and sending ultrasonic stimulation to the experimental subject to perform electroencephalogram regulation and control. By collecting and analyzing the electroencephalogram signals of the experimental subject in real time and using the closed-loop ultrasonic stimulation technology, electroencephalogram regulation and control on the experimental subject with the electroencephalogram theta rhythm as the marker are achieved.

The invention discloses a focused ultrasound regulation and control device and method for positioning stimulation of the brain function area of a small animal. The focused ultrasound regulation and control device comprises a head fixator connected to the skull plane of the small animal, wherein the head fixator is connected with an ultrasonic collimator and an ultrasonic transducer in sequence; the head fixator, the ultrasonic collimator and the ultrasonic transducer are coaxially arranged; and the ultrasonic collimator is adjustably connected with the ultrasonic transducer. The focused ultrasound regulation and control device also comprises a positioner and a protector which can be connected with the head fixator, wherein the positioner is used for conducting coordinate positioning on the skull plane of the small animal, and the protector is used for preventing the skull plane of the small animal from being in contact with the outside to cause infection under a non-experimental condition. Under the condition that the small animal is conscious and freely moves, ultrasonic stimulation with different parameters can be achieved on different positions and depths of the brain function area of the small animal.

Provided herein are a stimulation device, system and method for therapeutic treatment of a condition or disease. In various aspects, the device may include one or more modules for low temperatures, vibration, pressure, or ultrasound stimulation, operably connected to a contact tip; a data logging module; and a wireless communication module. Also provided is a system including the device and a remote server. Additionally, a method of treatment using such device or system is provided.

A guide framework for positioning an ultrasonic transducer which emits a focused ultrasound to a target point in carrying out surgery to apply ultrasonic stimulation to a subject's brain, includes a body in a shape of a mask that is laid on the subject's face, and a positioning hole formed through an inner surface and an outer surface of the mask body, the positioning hole into which the ultrasonic transducer is inserted, wherein the inner surface of the mask body is formed to conform a facial contour of the subject, and when the guide framework is laid on the subject's face and the ultrasonic transducer is disposed at the positioning hole, the position of the target point is naturally disposed at a preset stimulation site of the brain. An ultrasonic stimulation device includes an ultrasonic transducer and the guide framework for positioning the ultrasonic transducer.

The invention relates to a wearable transcranial ultrasound nerve stimulation and electrophysiological recording combined system and method. The combined system comprises a computer control and data processing unit, a digital-to-analog / analog-to-digital conversion unit, a power amplifier, a wearable ultrasound transducer and an electrode assembly and a signal amplification unit. A signal instruction is sent out through the computer control and data processing unit; after the digital-to-analog / analog-to-digital conversion unit receives the instruction, a corresponding waveform is generated; the power amplifier amplifies the signal into a high-voltage signal; the ultrasound transducer is driven to emit ultrasound waves; and the goal of nerve stimulation is achieved. The electrophysiological signal recorded by the electrode assembly is amplified by the signal amplifier, and is then transmitted to the digital-to-analog / analog-to-digital conversion unit to be converted into a digital signal; through the control by a computer, the digital signal is received by the data processing unit; and the data processing and the display are performed. The goal of completing complicated ultrasound stimulation and electrophysiological signal synchronous recording by one set of system is well achieved; and the technical support is provided for brain scientific research.

The invention is suitable for the technical field of focused ultrasound, and discloses a composite physical focused energy converter and a manufacturing method thereof. The energy converter comprisesa housing and a plurality of composite energy conversion units; a plurality of through holes are formed in the front end of the housing; the composite energy conversion units are arranged in the through holes in an inserting manner; the axes of the multiple composite energy conversion units are directed to the same point; and the composite energy conversion units are connected with electrode leads. The manufacturing method is used for manufacturing the previous composite physical focused energy converter. With the adoption of the composite physical focused energy converter and the manufacturing method thereof, the various composite energy conversion units are not required to be subjected to compression forming, so that the situation that a small energy converter is easy to fracture in thepressing process is avoided, the requirements that the weight is low, the size is small, focused focal points are small, and the composite physical focused energy converter is head-mounted are met under the condition that the energy is equivalent, the composite physical focused energy converter is applied to a research of ultrasound stimulation on mouse behaviors, movement behaviors of a mouse arenot affected by the energy converter in the stimulation process, and it is guaranteed that the research is carried out scientifically and advantageously.

The present application discloses an automatic positioning system and method for human body transcranial ultrasound stimulation based on a mechanical arm. The system is used to automatically perform ultrasonic stimulation to a preset position of the head and comprises an input module, a spatial positioning module, an ultrasonic stimulation module, a safety ellipsoid determination module and a control module; the input module is used to input brain CT or magnetic resonance scan data of subjects; the spatial positioning module is used to obtain real-time three-dimensional coordinate informationof the head and to obtain real-time three-dimensional coordinate information of the ultrasound stimulation module; the safety ellipsoid determination module is used to determine a safety ellipsoid that surrounds the entire head and forms a predetermined safe distance from an outer surface of the head; and the control module is used to control a multi-degree-of-freedom mechanical arm to drive a ultrasound transducer coupling device to move, so that the ultrasonic transducer coupling device and the head form a fit contact at a preset position of the scalp. The automatic positioning system and method have advantages of high spatial accuracy and high reliability.

The invention discloses sound-sensitive response nano-particles and application thereof. The particle size of the sound-sensitive response nano-particles is about 250nm, and the sound-sensitive response nano-particles are uniform in size and good in stability; after ultrasonic stimulation, toxicity of glioma cells can be obviously caused, green fluorescence can be observed in the cells, and the probe has excellent sound-sensitive characteristics and can effectively induce cell death; under the action of ultrasonic cavitation, tumor-associated antigens can be effectively released, and the antigens are observed to be successfully ingested and treated by immature dendritic cells and effectively promote the maturation of the dendritic cells, which is beneficial to the generation of subsequent induced immune response. The invention can provide a new way for effective treatment of glioma.