83 results about "Ultrasound stimulation" patented technology

Ultrasound stimulation devices and related techniques are disclosed. An ultrasound transducer for generating ultrasound energy is carried by a transducer housing that seals the transducer and may also include a positioning element for positioning the transducer proximate an application area to which generated ultrasound energy is to be applied. The transducer housing may also carry such components as a battery, a wireless receiver, and a controller. The same housing or a separate sensor housing may include an ultrasound sensor that provides feedback to the ultrasound transducer or its controller, illustratively through a wireless transmitter.

Systems and methods are disclosed for providing therapeutic treatment using vibrational stimulation, ultrasound stimulation and electro-stimulation. The combined therapeutic treatment allows for more flexible and effective treatment of bone-loss related and other ailments and conditions by providing one or a combination of vibrational, ultrasound and/or electro-stimulation to a patient.

A medical device comprising a medical device body having drug-loaded vesicles thereon. The vesicles are ultrasound sensitive and release the drug upon ultrasound stimulation. Also provided is a method for controlling drug release from a medical device using drug-loaded vesicles that are ultrasound sensitive.

The invention discloses albumen powder richening in antimicrobial peptide fly maggot, a preparation method for the albumen powder and a feed additive of the albumen powder. The albumen powder richening in the antimicrobial peptide fly maggot is prepared by a method comprising the following steps of: (1) feeding flies, luring the flies to lay eggs and feeding larva by using feed after incubation; (2) conducting ultrasound induction on the larva; (3) continuously feeding, collecting the larva, washing, conducting disinfection treatment, and conducting tissue homogenate smashing; and (4) filtering, treating filtrate at 0-5 DEG C, removing surface lipid compositions, drying to obtain the albumen powder; adding auxiliary materials in the albumen powder, pelletizing to obtain the feed additive. A ultrasound stimulation mode under specified conditions is adopted to induce the larva to enable an antimicrobial peptide active ingredient content in a body of a housefly to obviously improve, and the feed additive has certain growth promotion and disease-resistant strengthening effects on litopenaeus vannamei, crucian and the like.

The present invention discloses an ultrasonic diagnosis and treatment method and system. The system comprises a plurality of biological signal processing devices, an ultrasonic wave transmitting device and a central processing device. The biological signal processing devices calculate the difference between the biological signals of a positioning target before and after the excitation of difference frequency ultrasound, generates a first index change amount, and calculate the difference between the biological signals of a positioning target before the excitation of the difference frequency ultrasound and after ablation of differential frequency ultrasound stimulation, and generates a second index change amount. The central processing apparatus transmits corresponding instructions to the ultrasonic wave transmitting device based on a comparison result of the first index change amount and a first preset index change amount as well as a comparison result of the second index change amount and a second preset index change amount, wherein the instructions include a target positioning instruction and a difference frequency ultrasound stimulation instruction, the same frequency ultrasound ablation instruction or a difference frequency ultrasound ablation instruction to achieve the diagnosis of a positioning target and the evaluation of ablation effect for the integration and automation of diagnosis and treatment.

The invention relates to a wearable transcranial ultrasound nerve stimulation and electrophysiological recording combined system and method. The combined system comprises a computer control and data processing unit, a digital-to-analog/analog-to-digital conversion unit, a power amplifier, a wearable ultrasound transducer and an electrode assembly and a signal amplification unit. A signal instruction is sent out through the computer control and data processing unit; after the digital-to-analog/analog-to-digital conversion unit receives the instruction, a corresponding waveform is generated; the power amplifier amplifies the signal into a high-voltage signal; the ultrasound transducer is driven to emit ultrasound waves; and the goal of nerve stimulation is achieved. The electrophysiological signal recorded by the electrode assembly is amplified by the signal amplifier, and is then transmitted to the digital-to-analog/analog-to-digital conversion unit to be converted into a digital signal; through the control by a computer, the digital signal is received by the data processing unit; and the data processing and the display are performed. The goal of completing complicated ultrasound stimulation and electrophysiological signal synchronous recording by one set of system is well achieved; and the technical support is provided for brain scientific research.

A system for treating at least one sensory capacity of a person with the help of a stimulation device comprises an electronic converter of a sensory signal into an electronic signal for controlling at least one transducer for emitting signals that are images of the sensory signal. The stimulation device for direct ultrasound stimulation of the sensory cortex of a brain comprises at least one support that is implantable in a skull and that includes at least one internal wall and at least one ultrasound transducer carried by the support. Means for emitting focused ultrasound waves through the internal wall of the support towards a determined zone of the sensory cortex of the patient's brain in order to generate modulation of the brain activity in the cortex are provided. The ultrasound transducer is driven by the electronic converter to emit focused ultrasound signals that are images of the sensory signal.

The invention relates to a method for promoting macrophages to polarize to M1 type by utilizing a piezoelectric effect and application. According to the method, a piezoelectric material is combined with ultrasound to trigger non-contact and non-invasive electrical stimulation, and the important role of the electrical stimulation in immune regulation is verified; by taking the piezoelectric material as a cell culture substrate, and combining with ultrasound stimulation, M1 type polarized macrophages are cultured in vitro, and compared with a common biochemical method, the method does not need to introduce external polarized macrophages (PMAPs); and by utilizing the commercialized piezoelectric material, macrophages can be rapidly promoted to polarize to the M1 type by a method for applyingthe ultrasound; The method has a good effect of promoting the macrophages to polarize to the M1 type by utilizing the piezoelectric effect, and has the clinical application potential of tumor immunotherapy and anti-infective therapy. The method disclosed by the invention can be used for producing the M1 type polarized macrophages in batches so as to promote application of the piezoelectric material in immunotherapy.

The invention relates to the technical field of medical equipment, and provides a wearable ultrasound stimulation apparatus for median nerve. The wearable ultrasound stimulation apparatus for median nerve comprises a wearable sleeve ring and a plurality of ultrasound transducer assemblies, wherein each ultrasound transducer assembly comprises an ultrasound stimulation part, and an ultrasound imaging part arranged at the outer side of the corresponding ultrasound stimulation part in a sleeve manner. The ultrasound transducer assemblies are fixed by the wearable sleeve ring worn on a wrist, andthereby the apparatus is simple and convenient, and realizes the stable output of the ultrasonic energy of the ultrasound transducer assemblies. At the same time, the ultrasound imaging parts in the ultrasound transducer assemblies are used to emit and receive the ultrasonic energy to obtain position images of the median nerve, a position is adjusted by rotating the wearable sleeve ring, and finally the ultrasound stimulation parts in the ultrasound transducer assemblies are used to emit the ultrasonic energy to the median nerve to regulate the median nerve.

An ultrasound stimulation helmet (100) configured to regulate an endogenous neurotrophic factor in a brain or expression of proteins related to a neurodegenerative disease comprises: a main body (1) having a forehead perimeter adjustment knob (12), a back head perimeter adjustment knob (13), a fastening support frame (14), and multiple position adjustment knobs (15); and multiple ultrasound probes (2) detachably mounted on the main body (1), wherein the ultrasound probe (2) has a frequency adjustment button and an intensity adjustment button to respectively control an output frequency and output intensity of the ultrasound probe (2), and other ultrasound parameters and an angle of the ultrasound probe (2) itself are adjustable as well. The fastening support frame (14) can be used to adjust the length of the main body (1) according to the size of a head of a patient, and the ultrasound probes (2) are connected to the position adjustment knobs (15) to enable the ultrasound probes (2) to move upward, downward, or toward the left or right with respect to the head of the patient.

The invention provides a closed-loop transcranial brain stimulation system and method. The system comprises a transcranial ultrasonic signal generation module, a transcranial ultrasonic stimulation module, an electroencephalogram and electromyogram signal acquisition and processing module and an electrode module; the electrode module is used for collecting brain muscle signals of an experimental subject; the electroencephalogram and electromyographic signal collecting and processing module is configured to be used for collecting signals of the electrode module, processing the signals and then sending detection signals to the transcranial ultrasonic signal generating module; the transcranial ultrasonic signal generation module is configured to receive the detection signal, generate a stimulation signal according to the detection signal and an adjustment strategy, and send the stimulation signal to the transcranial ultrasonic stimulation module; the transcranial ultrasonic stimulation module is configured to emit ultrasonic stimulation to the experimental subject according to the stimulation signal. The beneficial effects of the invention are that the transcranial ultrasonic signal generation module adjusts the signal parameters of the transcranial ultrasonic stimulation module to the experimental subject next time according to the brain and muscle signals collected by the electrode module and a system expected value through a configuration strategy, thereby achieving the closed-loop control of the transcranial brain stimulation.

Methods for the treatment of stroke, such as stroke of undetermined origin, by administration of xenon (Xe)-loaded liposome compositions are provided. In some aspects, Xe is encapsulated in echogenic liposomes and release of Xe can be enhanced by application of ultrasound stimulation. Compositions for use in treating stroke, such as liposomes loaded with Xe or Xe in combination with H2 or H2S, are also provided.

The invention provides a closed-loop electroencephalogram regulation and control method and system. The method comprises the following steps: receiving an electroencephalogram signal of an experimental subject; preprocessing the electroencephalogram signal to obtain a preprocessed electroencephalogram signal; calculating and processing the preprocessed electroencephalogram signal to obtain a theta rhythm electroencephalogram signal and an electroencephalogram characteristic value; processing the theta rhythm electroencephalogram signal and the electroencephalogram characteristic value to obtain an ultrasonic stimulation parameter and a theta rhythm set stimulation phase; and according to the ultrasonic stimulation parameters and the theta rhythm, setting a stimulation phase, and sending ultrasonic stimulation to the experimental subject to perform electroencephalogram regulation and control. By collecting and analyzing the electroencephalogram signals of the experimental subject in real time and using the closed-loop ultrasonic stimulation technology, electroencephalogram regulation and control on the experimental subject with the electroencephalogram theta rhythm as the marker are achieved.

The invention discloses a focused ultrasound regulation and control device and method for positioning stimulation of the brain function area of a small animal. The focused ultrasound regulation and control device comprises a head fixator connected to the skull plane of the small animal, wherein the head fixator is connected with an ultrasonic collimator and an ultrasonic transducer in sequence; the head fixator, the ultrasonic collimator and the ultrasonic transducer are coaxially arranged; and the ultrasonic collimator is adjustably connected with the ultrasonic transducer. The focused ultrasound regulation and control device also comprises a positioner and a protector which can be connected with the head fixator, wherein the positioner is used for conducting coordinate positioning on the skull plane of the small animal, and the protector is used for preventing the skull plane of the small animal from being in contact with the outside to cause infection under a non-experimental condition. Under the condition that the small animal is conscious and freely moves, ultrasonic stimulation with different parameters can be achieved on different positions and depths of the brain function area of the small animal.

The invention is suitable for the technical field of focused ultrasound, and discloses a composite physical focused energy converter and a manufacturing method thereof. The energy converter comprisesa housing and a plurality of composite energy conversion units; a plurality of through holes are formed in the front end of the housing; the composite energy conversion units are arranged in the through holes in an inserting manner; the axes of the multiple composite energy conversion units are directed to the same point; and the composite energy conversion units are connected with electrode leads. The manufacturing method is used for manufacturing the previous composite physical focused energy converter. With the adoption of the composite physical focused energy converter and the manufacturing method thereof, the various composite energy conversion units are not required to be subjected to compression forming, so that the situation that a small energy converter is easy to fracture in thepressing process is avoided, the requirements that the weight is low, the size is small, focused focal points are small, and the composite physical focused energy converter is head-mounted are met under the condition that the energy is equivalent, the composite physical focused energy converter is applied to a research of ultrasound stimulation on mouse behaviors, movement behaviors of a mouse arenot affected by the energy converter in the stimulation process, and it is guaranteed that the research is carried out scientifically and advantageously.

The present application discloses an automatic positioning system and method for human body transcranial ultrasound stimulation based on a mechanical arm. The system is used to automatically perform ultrasonic stimulation to a preset position of the head and comprises an input module, a spatial positioning module, an ultrasonic stimulation module, a safety ellipsoid determination module and a control module; the input module is used to input brain CT or magnetic resonance scan data of subjects; the spatial positioning module is used to obtain real-time three-dimensional coordinate informationof the head and to obtain real-time three-dimensional coordinate information of the ultrasound stimulation module; the safety ellipsoid determination module is used to determine a safety ellipsoid that surrounds the entire head and forms a predetermined safe distance from an outer surface of the head; and the control module is used to control a multi-degree-of-freedom mechanical arm to drive a ultrasound transducer coupling device to move, so that the ultrasonic transducer coupling device and the head form a fit contact at a preset position of the scalp. The automatic positioning system and method have advantages of high spatial accuracy and high reliability.

The invention discloses sound-sensitive response nano-particles and application thereof. The particle size of the sound-sensitive response nano-particles is about 250nm, and the sound-sensitive response nano-particles are uniform in size and good in stability; after ultrasonic stimulation, toxicity of glioma cells can be obviously caused, green fluorescence can be observed in the cells, and the probe has excellent sound-sensitive characteristics and can effectively induce cell death; under the action of ultrasonic cavitation, tumor-associated antigens can be effectively released, and the antigens are observed to be successfully ingested and treated by immature dendritic cells and effectively promote the maturation of the dendritic cells, which is beneficial to the generation of subsequent induced immune response. The invention can provide a new way for effective treatment of glioma.

The invention discloses a multi-frequency ultrasonic stimulator, and particularly relates to the field of multi-frequency ultrasonic stimulators, the multi-frequency ultrasonic stimulator comprises awater tank and a generator mechanism, the generator mechanism is movably arranged in the water tank, the bottom of the generator mechanism is movably provided with a needle type hydrophone, and the top of the water tank is fixedly provided with a control box; the generator mechanism comprises an ultrasonic transducer and an animal skull, the animal skull is located at the bottom of the ultrasonictransducer, a water bag and a probe are fixedly arranged at the bottom of the ultrasonic transducer, and the probe is located in the water bag; an interactive interface, a signal control module, a parameter control module, a signal source, a power amplifier and an impedance matcher are installed in the control box, the signal control module, the parameter control module and the signal source are all connected to the connecting end of the interactive interface, and the power amplifier is connected to the connecting end of the signal source. The test range is large, test data is direct and accurate, and better test performance and control operation performance are achieved.