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Focused ultrasonic regulation and control device and method for positioning stimulation of brain functional area of small animal

A brain functional area and focused ultrasound technology, applied in ultrasound therapy, treatment, etc., can solve problems such as inability to achieve different depths of stimulation in different brain regions, large weight and volume, unfavorable research, etc., to make up for the excessive size of the ultrasound transducer , easy replacement operation and convenient connection

Active Publication Date: 2021-10-29
SHAANXI NORMAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The ultrasonic equipment used in the prior art has a large weight and volume, so it is not conducive to the relevant research in the case of small animals being awake and free; especially the existing devices can only fixedly stimulate a certain position in the brain area of ​​small animals, and cannot realize Stimulation of different depths in different brain regions, resulting in limited action

Method used

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  • Focused ultrasonic regulation and control device and method for positioning stimulation of brain functional area of small animal
  • Focused ultrasonic regulation and control device and method for positioning stimulation of brain functional area of small animal
  • Focused ultrasonic regulation and control device and method for positioning stimulation of brain functional area of small animal

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Experimental program
Comparison scheme
Effect test

specific Embodiment 1

[0041] Before the first experiment, the surface 1 of the skull of the small animal and the ultrasonic action device including the head fixer 2, the ultrasonic collimator 3, the ultrasonic transducer 4, the positioner 5 and the protector 6 are firstly disinfected; The target small animal skull plane 1 is surgically treated, and the head immobilizer 2 is fixed on the small animal skull surface 1 with the assistance of the positioner 5 through the ion cement, and the experiment is performed after the mice are adapted.

[0042] In the first experiment, the ultrasonic wave was adjusted to the required ultrasonic intensity of the experiment, and an ultrasonic collimator 3 composed of a conical beam-condensing tube 31 with a height of 2 mm and a cylindrical collimating tube 32 with a diameter of 6.2 mm was selected and connected together by threads, and then the ultrasonic collimator 3 was used. The ultrasonic collimator 3 is connected to the head holder 2 through the first clamping p...

specific Embodiment 2

[0046] For the second and multiple experiments, just remove the protector 5 with tweezers, then adjust the ultrasonic to the target parameters, select the ultrasonic collimator 3 of the appropriate size, and connect the ultrasonic transducer 4 and the ultrasonic collimator 3 through the thread Together, the ultrasonic collimator 3 is connected to the head holder 2 through the first clamping post 13 and the clamping slot 12, and the experiment is carried out. After the experiment is completed, the ultrasonic collimator 3 and the ultrasonic transducer 4 are removed in turn, and the protector 6 is connected to the head holder 2 through the third clamping post and the clamping slot 12, and the protector 6 is passed through the tweezers. The groove on the top is locked to organize and store all the experimental equipment.

[0047] Preferably, the test stand 7 can also be used for auxiliary operation.

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Abstract

The invention discloses a focused ultrasound regulation and control device and method for positioning stimulation of the brain function area of a small animal. The focused ultrasound regulation and control device comprises a head fixator connected to the skull plane of the small animal, wherein the head fixator is connected with an ultrasonic collimator and an ultrasonic transducer in sequence; the head fixator, the ultrasonic collimator and the ultrasonic transducer are coaxially arranged; and the ultrasonic collimator is adjustably connected with the ultrasonic transducer. The focused ultrasound regulation and control device also comprises a positioner and a protector which can be connected with the head fixator, wherein the positioner is used for conducting coordinate positioning on the skull plane of the small animal, and the protector is used for preventing the skull plane of the small animal from being in contact with the outside to cause infection under a non-experimental condition. Under the condition that the small animal is conscious and freely moves, ultrasonic stimulation with different parameters can be achieved on different positions and depths of the brain function area of the small animal.

Description

technical field [0001] The invention belongs to the field of ultrasonic biological applications, and relates to a device for ultrasonic nerve stimulation, in particular to a focused ultrasonic control device and method for locating and stimulating small animal brain functional areas. Background technique [0002] In recent years, low-intensity focused ultrasound has attracted widespread attention as a means of neuromodulation due to its advantages of non-invasiveness, high spatial resolution, and high penetration depth. However, due to the small size of the brain of small animals and the fragility of the skull, the stimulation of the brain regions of small animals by existing ultrasound equipment is limited. At present, the relevant technologies and devices used in animal nerve ultrasonic stimulation experiments cannot take into account non-invasive, precise positioning, adjustable ultrasonic parameters and stimulation depth. In the research work related to ultrasonic stimu...

Claims

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Application Information

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IPC IPC(8): A61N7/00
CPCA61N7/00A61N2007/0026Y02A40/70
Inventor 韩静张俊敏尹冠军任维郭建中
Owner SHAANXI NORMAL UNIV
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