9 results about "Animal brain" patented technology

This invention involves, among other things, elements that stimulate an immune response. Which includes: a) one or more antigens of Avibacterium paragallinarum and One or more antigens of avian brain and spinal cord rhizomatous virus and one antigen. or more of avian porcine ... Furthermore, this invention relates to a method for immunizing animals which includes administration. The animal drug contains components that stimulate the immune response of this invention; moreover, This invention relates to a method of treating or preventing clinical signs caused by Avibactericum. Paragallinarum, a viral infection that causes encephalitis and spinal cord inflammation in birds and avian pox virus in animals. Essential, a method that involves administering medication to animals in effective dosages as a form of treatment. The components that stimulate an immune response are consistent with this invention;

This invention relates to the field of animal experimental equipment technology. It discloses a stereotactic injection device for small animal brains, comprising a main structure, a limiting structure, and a head-fixing structure. The limiting structure is fixedly mounted on the main structure, and the head-fixing structure is fixedly mounted on the limiting structure. This invention allows for easy mounting on a tabletop using the main structure. The limiting structure can limit the animal's body position, making its head more stable, and allows for adjustment of the animal's position during experiments according to usage needs. The limiting unit can also be used to elevate the animal's body. The head-fixing structure allows for adjustment and fixation of the head of animals of stationary size, enhancing overall practicality.

The utility model discloses a kind of electromagnetic shielding's mouse brain deep electrical stimulation and collection device, including protective shell and shielding shell, protective shell bottom is equipped with opening, top is equipped with connecting port, opening is fixedly adhered with animal skull surface, electrode main body, adapter terminal wire and USB conversion interface connected in sequence are equipped in protective shell, electrode main body implants in animal brain through opening;Shielding shell is inserted with connecting port, shielding shell is inserted with connecting port in, USB interface and preamplifier are equipped in shielding shell, USB interface connects USB conversion interface, preamplifier is connected host computer by data line and passes out shielding shell.The utility model, the production and composition of electrode are modularized split, standardization production and surgical implantation process;Modularization installed USB conversion interface hardware cost is very small, improve the Omnetics interface utilization of host computer;USB conversion interface and electrode main body between using adapter terminal wire, namely soft line connection, can avoid the screw drop caused by multiple plug and unplug, prolongs the implantation time of electrode.

The application discloses a kind of multi-mode optical fiber slow ring scanning endoscopic imaging method and device, comprising: long-term implant, pluggable imaging probe and driving mechanism;The long-term implant is rigid transparent tube with bottom end sealed and upper end opened, for forming long-term indwelling guide channel in organism and preventing body fluid from entering lumen;The pluggable imaging probe includes optical fiber and lateral emission element fixed to the end of optical fiber, can be inserted and extracted long-term implant, and obtains the lateral imaging signal of peritubular tissue when being inserted;The driving mechanism is used to drive the imaging probe to generate rotary motion around its own axis and reciprocating displacement along the axial direction, form slow ring scanning scanning track, realize large field of view lateral imaging of peritubular tissue.The application can provide more reliable imaging means for biomedical research and minimally invasive diagnosis and treatment, and is suitable for repeated, stable and large field of view lateral imaging observation of deep tissue in animal brain tissue and other organisms.

The application provides an animal brain metabolite identification method based on mass spectrometry imaging technology and application, and establishes a mouse brain tissue slice endogenous metabolite DESI-MSI analysis method based on mass spectrometry imaging technology, which comprises the following steps: after preparing metabolite control sample imaging samples and brain tissue slice imaging samples, multiple animal brain tissues are attached to the same glass slide, mass spectrometry imaging condition optimization is carried out by using the control sample imaging samples, and mass spectrometry imaging analysis is carried out by using the brain tissue slice imaging samples; the image of the biological sample is divided into multiple structure regions in combination with tissue morphological characteristics; for the structure regions, multivariate statistical analysis is carried out to obtain different metabolites in different structure regions; metabolite identification is carried out based on parent ions and characteristic daughter ion profiles; and the method is used for disease mechanism research and drug intervention effect evaluation on diseases.

This invention discloses a non-human primate visual-spatial working memory testing cage. This invention uses a non-human primate visual-spatial working memory testing cage to measure the learning, discrimination, and reversal abilities, or cognitive and memory abilities, of non-human primates, providing a more comprehensive evaluation of changes in animal brain function and behavior. It can provide a model evaluation tool for central nervous system diseases such as Alzheimer's disease and stroke, and offer new methods for disease research and new drug development.

The application discloses an addictive drug relapse related regulatory gene after drug withdrawal and a screening method thereof. The method comprises the following steps: constructing a drug addiction animal model; performing drug withdrawal treatment on the drug addiction animal model; dividing the drug addiction animal model after the drug withdrawal treatment into three groups, i.e., group A, group B and group C; the group A is a group of addictive drug CPP, the group B is a group of reverse addictive drug CPP, and the group C is a group of food reward CPP; collecting brain tissues of the addictive drug CPP, the reverse addictive drug CPP and the food reward CPP, performing second-generation sequencing, analyzing transcriptome and proteome expression, and obtaining the addictive drug relapse related regulatory gene after drug withdrawal. In the past, the drug addiction mechanism research usually only divides experimental animals into two groups, i.e., a drug group and a saline group, and the application increases environmental variables on the basis of the grouping, so that the related regulatory gene can be more accurately found.

The application discloses a method for constructing a microwave radiation animal brain injury model based on a medial septum-hippocampus CA3 cholinergic nerve loop regulation, comprising the following steps: setting electromagnetic radiation conditions, and performing electromagnetic radiation treatment on test animals; comparing whether a cholinergic nerve loop between the medial septum and the hippocampus CA3 is activated before and after the electromagnetic radiation treatment; and if the cholinergic nerve loop is activated, constructing an electromagnetic radiation animal brain injury model by using the electromagnetic radiation conditions. The application can accurately construct the electromagnetic radiation animal brain injury model, and increases the possibility of elucidating the molecular mechanism of the electromagnetic radiation brain injury effect and the research and development of prevention and treatment drugs.

This invention discloses an integrated fixation system for animal brain-computer interfaces, belonging to the fields of biomedical engineering and animal robotics. It includes a protective helmet that fits snugly against the front of the target animal's head via cushioning pads; an electrode shield positioned above the electrode implantation points on the target animal; and a flexible circuit board disposed inside the protective helmet. The electrode implantation points on the electrode shield are connected to the flexible circuit board via short pins, and the flexible circuit board is connected to a main control device mounted on the back of the target animal via a data bus. This invention absorbs and isolates external impacts step by step, effectively protecting the implanted electrodes and ensuring their long-term stability in place.