30 results about "Cerebral ventricular" patented technology

The invention relates to the technical field of intracranial pressure monitoring, in particular to a multi-modal fusion-based intracranial pressure dynamic prediction method for a patient with craniocerebral injury, which comprises the following steps of: acquiring an electroencephalogram signal, extracting a peak value to a termination section path, judging whether a waveform slope is consistent with an intracranial pressure direction or not, identifying an unsynchronized response segment, and obtaining a neural migration section mark set. According to the method, the non-cooperative state between the neural activity and the pressure change is distinguished by recognizing the periodic waveform which does not cause the intracranial pressure response in the electroencephalogram signal, and the time period with the inconsistent regulation rhythm is positioned by combining the continuous expression of the ventricular volume and the arterial pressure direction deviation; the method comprises the following steps of: extracting response sequence and direction characteristics of arterial pressure, cerebral blood flow and neural signals in a continuous section, enhancing a rhythm corresponding relation among multi-modal signals, adjusting a signal alignment structure according to offset direction difference and a rhythm starting point, forming a linkage fragment sequence under a unified time reference, and obtaining a multi-modal signal sequence; and linkage and deduction of asynchronous response information on a structural level are promoted.

The utility model provides a ventricular drainage apparatus measuring and fixing device capable of quickly and accurately adjusting drainage height. The ventricular drainage apparatus measuring and fixing device comprises a hanging ruler and a clamping seat, the hanging ruler comprises a batten and a pipe clamp, a plurality of bayonets arranged in a row are arranged on the front face of the batten in the length direction, and scales capable of displaying the heights of the bayonets are arranged on the front face of the batten. The pipe clamp is arranged on the back surface of the strip plate and can be clamped on an infusion support; the clamping seat comprises a back plate and a bottle clamp; the bottle clamp is arranged on the front face of the back plate and used for clamping a ventricular drainage bottle. A buckle is arranged on the back face of the back plate, and the buckle is detachably connected to the bayonet in a clamped mode.

This invention belongs to the field of animal model technology, specifically disclosing a method for constructing a primary ciliary motor disorder hydrocephalus model, comprising the following steps: screening benzimidazole as a modeling agent; administering benzimidazole solution to experimental animals and setting up a blank control group; conducting experimental verification through pathological morphology and behavioral methods; if the experimental animals show significant ventricular enlargement and significant decrease in motor ability, the primary ciliary motor disorder hydrocephalus model is successfully constructed. This invention employs the above-mentioned novel method for constructing a primary ciliary motor disorder hydrocephalus model. The constructed hydrocephalus model exhibits good stability and repeatability, is objective and simple, and is highly operable, reducing other possible interfering factors. It provides a necessary experimental foundation for studying the mechanism of primary ciliary motor disorder hydrocephalus and developing treatment methods.

The invention relates to the field of image processing, in particular to a fetal hydrocephalus three-dimensional reconstruction and operation planning method based on multiple modalities, which comprises the following steps: obtaining key points and ventricular postures in a three-dimensional point cloud during each three-dimensional reconstruction, predicting the ventricular postures during the next three-dimensional reconstruction, and obtaining prediction residual errors; historical three-dimensional reconstruction key points are clustered based on prediction residual errors to obtain all categories, and when three-dimensional reconstruction is carried out again, the obtained three-dimensional point clouds are further deleted and added based on the categories. According to the invention, errors in a matching fusion process and errors in a prediction process during three-dimensional reconstruction are avoided, and the accuracy of a three-dimensional reconstruction result is improved.

The utility model discloses an intracranial pressure drainage control device and an external ventricular drainage system. The intracranial pressure drainage control device comprises a support, a three-way valve, a driving mechanism and a controller. The bracket comprises a first mounting part and a second mounting part, the first mounting part is provided with a first mounting hole, and the second mounting part is provided with a second mounting hole and three clamping grooves communicated with the second mounting hole; the three-way valve comprises a valve body and a valve element, the valve body comprises a main body and three connectors, the three connectors are connected to the radial side face of the main body, the main body is inserted into the second mounting hole and provided with a valve cavity, and the valve element is arranged in the valve cavity; the driving mechanism comprises a driving piece and a connecting piece and is used for driving the valve element to rotate so as to switch the communication state of the three connectors. The controller is in communication connection with the driving mechanism, so that the driving mechanism drives the valve element to rotate within the set duration so as to adjust the communication state of the three interfaces, manual operation is not needed, and then the risk that a patient is injured due to the fact that manual operation is not in time is reduced.

The utility model provides a laser-assisted ventricular puncture device. The laser-assisted ventricular puncture device comprises a guide core part and a laser transmitter, the guide core part comprises a guide core and a handheld part arranged at the tail end of the guide core, the handheld part is provided with two fixing frames, the two fixing frames are perpendicular to each other on a projection plane perpendicular to the guide core, and the intersection point is coaxial with the guide core; the number of the laser emitters is two, and the two laser emitters are fixed to the two fixing frames respectively. Accurate and visual alignment can be realized; deviation caused by visual errors is avoided.

The invention relates to a device (1) for draining cerebrospinal fluid, wherein the device (1) has a shaft (2) that can be implanted into a skull bone (14) of a human or animal, wherein the device (1) is suitable for draining cerebrospinal fluid from the subarachnoid space and / or a cerebral ventricle (15) into the diploë of the skull bone (14), and the shaft (2) has radially extending outlet openings (4), wherein a valve (17) is arranged inside the shaft (2) which connects a first chamber to a second chamber, wherein the second chamber has a fluid connection with the outlet openings (4), and a tube (5) opens into the shaft (2) at the distal end face of the shaft (2), or a tube (20) is arranged at the distal end face of the shaft (2) to which a tube (5) is connected.wherein the tube (5) in its proximal section or the pipe (20) is in fluid communication with the first chamber and the tube (5) has at least one distal inlet opening (8) for cerebrospinal fluid, wherein the inlet openings (8) can be placed in the subarachnoid space and / or in the region of a cerebral ventricle (15) and the tube (5) has a lumen (9) into which a wire (6) can be inserted, wherein the wire (6), when inserted, protrudes from the proximal end face of the device (1). The invention allows the treating physician to position and adjust the device (1) according to the requirements for draining the cerebrospinal fluid into the diploë of the skull bone (14). Placement is possible under local anesthesia.

The invention relates to an MRI image-based early-stage paraphrase softening risk prediction method and an MRI image-based early-stage paraphrase softening risk prediction system. The method comprises the following steps: acquiring a clinical MRI image and a clinical medical history of a to-be-predicted risk patient; preprocessing the clinical MRI image to obtain a to-be-detected MRI image; and inputting a to-be-detected MRI image and the clinical medical history into the ventricular paraphrine softening prediction model to obtain a ventricular paraphrine softening risk prediction result. By adopting the method, the disease risk of the child patient can be reflected more comprehensively through the risk prediction result, and more accurate support is provided for clinical decision making.

The invention discloses a multifunctional fixing device for mouse ventricular micro-injection and a using method. The multifunctional fixing device comprises an operation table, a height adjusting assembly, a fixing plate, a cranial height adjusting frame, a mounting base, an incisor hook and an ear rod. Wherein the operation table comprises a bottom plate and a vertical plate which are vertically connected, a sinking groove is formed in the bottom plate, and a lifting table is arranged in the groove; the height adjusting assembly is parallel to the vertical plate and close to the bottom plate side; the fixed plate is provided with two symmetrical extension strips at the moving end of the adjusting assembly and on the deviating side, the other surface of the fixed plate is provided with a length adjusting groove, and a first driving piece is arranged in the groove; the cranial height adjusting frame is connected with the first driving piece and provided with a second driving piece. A fixing hole is formed in the far end of the mounting seat; and the incisor hook is arranged on the mounting seat and is positioned above the fixing hole. The two ear rods are symmetrically arranged at the far end of the extension strip. The scheme has the effects of reducing damage to mice, reducing experimental pollution and improving operation stability.

The invention relates to the technical field of tearable tube sheaths, in particular to a tearable shunt tube sheath for ventricular jugular vein shunt, which comprises a catheter sheath and a mounting base inserted into the upper end of the catheter sheath, the catheter sheath is detachably connected with the mounting base, and an expansion catheter is fixedly mounted at the upper end of the mounting base. A hemostasis valve is mounted at the lower end of the mounting base; mechanical locking and pressing force adjustment are conducted on the two tearable tubes through the connecting piece, the situation that a traditional tube sheath needs to be torn open is avoided by pulling the pulling-out unit, the connecting piece is stably and linearly pulled out as a whole, and in the process, instant traction force and vibration generated due to material tearing and buckle separation when a sheath tube is torn in a traditional mode are completely avoided; the risk of tiny displacement of the tip of the accurately positioned shunt tube caused by sheath tube removal operation is eliminated, the shunt tube is always stabilized at the optimal position in the middle of the right atrium, and the operation success rate is increased.

Methods for identifying, isolating and enriching neural stem and progenitor cells (NSPC) such as ventricular radial glia, outer radial glia, astrocytes, pre-oligodendrocyte precursor cells, oligodendrocyte precursor cells, oligodendrocytes, early excitatory neurons, late excitatory neurons, bipotent glial progenitors, and inhibitory neurons are provided. These methods find use in transplantation, to eliminate specific cell subsets, for experimental evaluation, as a source of lineage and cell-specific products, and the like, for example for use in treating human disorders of the central nervous system (CNS).

The invention relates to the technical field of medical image processing and artificial intelligence, and discloses a brain iron deposition spatial distribution pattern intelligent identification and typing method and system, and the method comprises the steps: carrying out the spatial standardization and brain region segmentation of a whole-brain QSM image; generating a spatial distribution feature vector through a multi-scale spatial attention feature extraction network; an iron deposition mode is divided into a cortex type, a deep nuclei type, a ventricular surrounding type and a diffuse type by adopting a fuzzy clustering algorithm of spatial neighborhood constraint; establishing a mapping relation between the iron deposition mode and the vascular cognitive impairment etiology subtype; according to the method, automatic recognition and typing of the brain iron deposition space distribution mode are achieved, the mode recognition accuracy rate reaches 85% or above, and an auxiliary diagnosis basis is provided for vascular cognitive impairment pathogenesis typing.

The invention relates to a device (1) for draining cerebrospinal fluid, wherein: the device (1) comprises a shaft (2) which can be implanted into a cranial bone (14) of a human or animal; the device (1) is suitable for draining cerebrospinal fluid from the subarachnoid space and / or a cerebral ventricle (15) into the diploe of the cranial bone (14), and the shaft (2) has outlet openings (4) pointing in the radial direction; a valve (17) is arranged in the interior of the shaft (2) and connects a first chamber (21) to a second chamber (22); the second chamber (22) is fluidically connected to the outlet openings (4), and a tube (5) joins the shaft (2) at the distal end face of the shaft (2) or a conduit (20) to which a tube (5) is connected is arranged on the distal end face of the shaft (2); the tube (5), in its proximal portion, or the conduit (20) is fluidically connected to the first chamber (21), and the tube (5) distally has at least one inlet opening (8) for cerebrospinal fluid; the inlet openings (8) can be placed in the subarachnoid space (6) and / or in the region of a cerebral ventricle (15), and the tube (5) has a lumen (9) into which a wire (6) can be introduced; the wire (6), in the introduced state, protrudes from the device (1) at the proximal end face thereof. The invention allows the treating doctor to place and adjust the device (1), according to requirements, in order to conduct the cerebrospinal fluid into the diploe of the cranial bone (14). Placement is possible under local anaesthesia.

The invention discloses an anti-bending fixing device of a drainage catheter for external ventricular drainage, relates to the field of cerebral drainage auxiliary instruments, and solves the problems that the drainage catheter is easy to bend due to the subscalp hidden trend, the drainage is unsmooth, the intracranial pressure measurement is inaccurate, and the existing fixing mode needs frequent human intervention. The device comprises a contact piece surrounding a drainage catheter, the contact piece is provided with a first adhesion layer and an inner side limiting protrusion, and the outer side is rotationally connected with a locking piece with a first connecting hole; the anti-bending supporting plate with the bending angle of 90-180 degrees is connected with the locking piece through a pin, and the auxiliary supporting plate is assembled to be matched with the trend of the guide pipe. The locking piece is connected with the telescopic connecting frame and the mounting frame, a reverse control shaft in the mounting frame is connected with two sliding frames, and the sliding frames are provided with supporting pieces with flexible bags and second adhesion layers. The device achieves accurate bending prevention and stable supporting, manual operation is reduced, drainage and pressure measurement accuracy is guaranteed, and adaptability is high.

The invention discloses an external ventricular drainage regulation and control device, and relates to the technical field of medical health. The external ventricular drainage operation through hole is formed in the top surface of the helmet; the drainage tube accommodating groove is embedded in the top surface of the helmet; the drainage bag accommodating groove is embedded in the top surface of the helmet; the flow velocity sensor is used for collecting the flow velocity of the drainage tube and the change condition of the flow velocity; a flow rate adjusting device; and the drainage control module is in signal connection with the flow velocity sensor and the transmission motor. The drainage device is fixed on the basis of a hardware structure, the flow speed regulation and control component is matched, drainage work is monitored in real time, automatic adjustment is carried out, and it is effectively guaranteed that the drainage work is safely and reliably carried out.

The utility model relates to a ventricular puncture positioning auxiliary device, and belongs to the technical field of ventricular puncture auxiliary instruments. Which comprises a bottom plate and an angle measuring plate and is characterized in that the bottom plate is an arc-shaped plate capable of being attached to the head of a human body, the bottom plate is divided into a left half area and a right half area, an open notch is formed in the front end of the plate face of the right half area, the bottom edge of the angle measuring plate is connected to the convex face side of the bottom plate, and the plate face of the angle measuring plate is located in the radial face of the arc-shaped bottom plate. The angle measuring plate is connected with a pointer or a guide plate which can rotate. The blind puncture guiding device has the advantages that the blind puncture guiding device can provide guidance for blind puncture in the puncture direction, the accuracy of blind puncture is greatly improved, and damage to surrounding brain tissue caused by repeated puncture due to blind puncture failure is avoided; the device is simple in structure, low in cost and easy and convenient to use.

The WNT-ACTIVATED ADIPOSE-DERIVED STEM CELL APPARATUSES, METHODS AND SYSTEMS (hereinafter “WAADSC”) disclosed herein in various embodiments provide for production of an isolated and enriched population of mesenchymal stem cells that have an active Wnt signaling demonstrated by the elevated expression of Lgr5 marker and / or Nestin in more than 50% of the population. Such an autologous cell population may, in embodiments, be injected into cerebral ventricles of patients with neurodegenerative diseases to yield therapeutic results, such as halting the progression of certain conditions and / or ameliorating specific symptoms thereof.

Mechanical circulatory support systems that employ a connector cable for transmitting power and data are disclosed. A mechanical circulatory support system includes a ventricular cuff, a ventricular assist device, an external module, and a connector cable. The ventricular cuff is configured for attachment to a heart. The ventricular assist device is configured for attachment to the ventricular cuff and includes a housing, a rotor, a stator assembly, and control electronics. The external module includes an internal battery and is configured to power and control operation of the mechanical circulatory support system. Power and data are transmitted from the external module to the ventricular assist device over the connector cable. The connector cable includes two redundant pairs of electrical conductors.

The disclosure provides example apparatus and methods for monitoring EVD and LD drainage systems and generating alerts. The example apparatus includes (a) a U-shaped housing having a first end and a second end, where the first end and the second end of the U-shaped housing are configured to be arranged on opposing sides of a vessel, (b) a photodiode coupled to the first end of the U-shaped housing, (c) a laser diode coupled to the second end of the U-shaped housing, where the laser diode and the photodiode are arranged in the housing facing each other such that a contact layer of the photodiode is configured to receive a laser beam emitted from the laser diode, and (d) an alert processor electrically coupled to the photodiode and to at least one alert generator.

The utility model relates to medical instrument technical field especially a ventricular peritoneal shunt pass bar. The utility model discloses pass bar subassembly, handle, guide piece and shunt tube fixed subassembly, pass bar subassembly includes the pass bar body of being placed in the patient's skin and the installation sleeve of being fixed in the pass bar body front end end portion, shunt tube fixed subassembly includes the installation post of being detachably installed in the inside of installation sleeve, the disc that is fixed in the installation post front end end face and with installation sleeve front end end face abuts and the plug rod of rotating being arranged in the disc front disc surface middle part and being inserted in the shunt tube spout, the guide piece detachably sets up in the installation sleeve outside, the handle is fixed in the pass bar body rear end. The device can reduce the external diameter of pass bar subassembly whole under the condition of keeping the shunt tube diameter invariable to reduce the injury to the child when puncturing.

A ventricle precise puncture orientation instrument belongs to the technical field of medical instruments and comprises a fixing arm, a positioning arm, a fixing arm positioning mechanism, a positioning arm positioning mechanism and an orientation tube mechanism, and the fixing arm and the positioning arm are of an integrally nested arch structure; a fixed arm positioning mechanism and a directional pipe mechanism are arranged at the upper part of the fixed arm; a positioning arm positioning mechanism is arranged at the top end of the positioning arm; the fixing arm positioning mechanism comprises a fixing fork and fixing arm head nails, the fixing fork is movably connected to the upper portion of the fixing arm, the fixing fork is divided into two side arms, and the fixing arm head nails are arranged on the side arms respectively; the positioning arm positioning mechanism comprises a positioning arm head nail, and the positioning arm head nail and two fixed arm head nails are fixed to the head of a patient. According to the puncture orientation device, the orientation device can be directly fixed to the scalp and skull surface through a stable structure formed by the fixing arm positioning mechanism and the positioning arm positioning mechanism, so that accurate positioning is achieved, and the puncture orientation device has the advantages of being high in operability and accurate in puncture.

The invention relates to the technical field of health care instruments, in particular to a multifunctional ventricular drainage tube fixing device, and aims to solve the problems that an existing brain drainage tube fixing device is limited in adjusting function and prone to local compression. The multifunctional ventricular drainage tube fixing device comprises a fixing body, a fixing support, a movable mechanism and a plurality of adjusting mechanisms. The fixing support is movably connected to the fixing body. The movable mechanism is slidably arranged on the fixed support. The movable mechanism comprises two movable blocks, a mounting sleeve, two positioning sleeve groups, two positioning rods and a rotating rod; the two positioning rods penetrate through the corresponding positioning sleeve groups in a sliding manner; the rotating rod rotationally penetrates through the positioning sleeve set and is located between the two positioning rods. According to the multifunctional ventricular drainage tube fixing device, the drainage tube can be prevented from being bent and pressed through the fixing mechanism, and the position of the drainage tube can be rapidly adjusted through the limiting assembly.

The present application relates to the technical field of medical image processing and artificial intelligence, and discloses a brain iron deposition spatial distribution pattern intelligent recognition and typing method and system, which comprises: spatial standardization and brain region segmentation of whole brain QSM images; generating a spatial distribution feature vector through a multi-scale spatial attention feature extraction network; dividing the iron deposition pattern into a cortical type, a deep nuclear group type, a periventricular type and a diffuse type by using a fuzzy clustering algorithm with spatial neighborhood constraints; establishing a mapping relationship between the iron deposition pattern and the etiological subtype of vascular cognitive impairment; and evaluating the bilateral hemisphere iron deposition asymmetry, wherein the present application realizes automatic recognition and typing of the brain iron deposition spatial distribution pattern, the pattern recognition accuracy reaches more than 85%, and provides an auxiliary diagnosis basis for etiological typing of vascular cognitive impairment.

The invention relates to a ventricular drainage device which comprises a stand column, moving grooves, moving units, a laser pen, a display screen, keys and a fixing support, the moving grooves are formed in the two sides of the stand column, the moving units are installed on the stand column through the moving grooves, the laser pen is installed on the fixing support, the fixing support is installed on the moving units, and the laser pen is installed on the display screen. The display screen and the keys are mounted on the moving unit; firstly, the moving unit is controlled to move on the stand column through the key and is positioned through the laser pen, after positioning is completed, the relative moving distance of the moving unit is adjusted through the key and displayed through the display screen, and then the moving unit moves to a preset position and is firmly fixed. The mobile unit, the display screen and the keys are arranged, the mobile unit is controlled to move on the stand column through the keys, the relative distance of the mobile unit to be moved can be adjusted by operating the keys and displayed in real time through the display screen, and the mobile unit can be more reliably fixed to the stand column.

This invention relates to the field of medical device technology and discloses a fixation device for an external ventricular drainage tube and an intracranial pressure probe, including a side plate and a top plate. An adjustment assembly is provided between the side plate and the top plate, and a fixation mechanism is provided on the outer side of each side plate and the top plate. This invention secures the device to the patient's head by fastening the fixation sleeve formed by the side plate and the top plate to the outside of the patient's head. Then, the first and second fixation straps are pulled and secured using the round and barbed surfaces of the Velcro. The fixation is convenient and quick. The breathable padding improves the comfort and breathability of the device after fixation, preventing discomfort or allergic reactions caused by stuffiness. Furthermore, during fixation, adjustments can be made by pulling the two sets of side plates, allowing the limiting rod to move within the cavity, thus facilitating adjustment of the fixation sleeve size. This allows for adjustment according to the patient's head size, resulting in high applicability.

The invention provides an intracranial measurement-external ventricular drainage integrated device which comprises a drainage catheter (1) used for external ventricular drainage, the drainage catheter (1) is provided with a hollow tube cavity, and a sensor assembly (3; 4); a mounting seat (7) integrated with the drainage catheter (1) for mounting and connecting the drainage catheter (1) and the sensor assembly (3; 4); a signal processing and wireless transmitting module (6), which is provided with a wireless transmitting module and a signal processing circuit and is used for processing the signal of the sensor assembly (3; 4) and sending the collected signals to monitoring equipment through the wireless transmitting module, the signal processing and wireless transmitting module (6) is configured to be detachably fixed on the mounting seat (7) and send the signals to the sensor assembly (3; and 4) supplying power and communicating with the power supply.

Embodiments disclose systems and apparatus that provide neurogenesis activation by FUS stimulation including activating quiescent NSCs in the subventricular zone of the lateral ventricles and promoting the proliferation of NSCs and subsequent differentiation into newly regenerated neurons. Also disclosed is a conventional MRI guided tFUS system programmed for use with ultrasonic activation of NSCs. A wireless electronic driving configuration for transcranial use under MRI guidance is provided and a cylindrically distributed ultrasound transducer array design to provide increased steering range in at least two axes. A close integration of tFUS with MRI navigation, achieved by a novel wearable thin-film MRI coil array tightly integrated with the transducer array, enables full navigation performance of MRI in real time during FUS treatment.

A cerebral apparatus 100 comprising a housing; a processor 120 positioned in the housing 118; and an electrode bundle 122 coupled to the processor and suitable for insertion into a ventricular pathway of a patient. Wherein the electrode bundle is configured to, in response to insertion into the cerebral ventricular pathway expand to at least partially contact a wall of at least one cerebral ventricle of the cerebral ventricular pathway and communicate an electrical signal between the processor and one or more cerebral structures adjacent to the cerebral ventricular pathway. The electrode bundle may comprise a resilient structure. The cerebral apparatus may comprise a chemical injector system.

The application discloses a ventricular drainage regulator, belongs to the field of drainage devices, and is used for ventricular drainage and comprises a liquid storage tank provided with a tank body connecting pipe, wherein the liquid storage tank is connected with a negative pressure tank provided with a main piston through a threaded structure, the main piston is connected with an auxiliary rack through a main piston rod, the auxiliary rack is in mesh transmission with a driving gear of a rack driving motor, a main cavity in the negative pressure tank is communicated with an auxiliary cavity in a negative pressure auxiliary pipe through a cavity connecting hole, an auxiliary piston is arranged in the auxiliary cavity, the auxiliary piston blocks the cavity connecting hole in an initial state, the auxiliary piston is connected with an auxiliary piston rod, the auxiliary piston rod is connected with a linkage rod, the linkage rod is connected with a linkage plate, the linkage plate is connected with the auxiliary rack, and the application can generate and fine tune a negative pressure environment through structural adjustment, can effectively guarantee the stability of the negative pressure environment, can increase and fine tune the negative pressure, has better flexibility and adaptability, and is convenient for ventricular drainage and observation of drainage volume.

An irrigation assembly for an external ventricular drainage tube (EVD) system, comprising: a collapsible upper body and a base, the irrigation assembly connected to an external ventricular drainage tube using a connector adjacent a bottom end of the irrigation assembly; the connector intersects with the collapsible upper body and / or a base, the base intersects with the connector, and wherein the irrigation assembly stores fluid in an internal fluid reservoir, and when the irrigation assembly is activated, the irrigation assembly is coupled to the connector. The collapsible upper body pushes fluid from the inner fluid reservoir to an irrigation site to perform irrigation of the external ventricular drainage tube.