107results about How to "Improves oxidative stress" patented technology

The present invention relates to compositions without added iron and methods for prophylactic nutritional supplementation and therapeutic nutritional supplementation. Specifically, the method involves administering to an individual a composition comprising carotenoids, vitamin E, vitamin D, vitamin C, thiamine, riboflavin, niacin, folic acid, pyridoxine, biotin, pantothenic acid, cobalamin, magnesium, manganese, zinc, selenium, chromium, copper, alpha lipoic acid, and lutein, wherein the composition is free of added iron.

The present invention relates to oral compositions which are useful for nutrient supplementation. The dietary supplements and pharmaceutical products and methods of the present invention are particularly useful in the treatment of patients in various stages of chronic kidney disease and supplementing levels of physiological anti-oxidants, vitamins, and minerals in subjects requiring dialysis therapy.

The present invention relates to compositions and methods for prophylactic nutritional supplementation and therapeutic nutritional supplementation. Specifically, the composition provides a nutritional supplement with a beneficial increased supplementation of vitamin D and the method involves administering to an individual a composition comprising carotenoids, vitamin E, vitamin D, vitamin C, thiamine, riboflavin, niacin, folic acid, pyridoxine, biotin, pantothenic acid, cobalamin, magnesium, manganese, zinc, selenium, chromium, copper, alpha lipoic acid, and lutein.

This invention relates to an external structuring agent for application in liquid detergent and personal care products. It has been found that cellulose based particles, which comprise cell wall material and their networks of cellulose based fibers and nanofibrils can advantageously be used to structure liquid detergent and personal care products, providing certain benefits that are much sought after in the design of such products. It is assumed that the organization of the cellulose fibrils, as it exists in the parenchymal cell walls, is at least partly retained in the cellulose based particles of the invention, even though part of the pectin and hemicellulose is removed there from. The process of making the structuring agent involves processing under relatively mild conditions, of a biological material that is currently considered a by-product.

The invention discloses a drug carrier system, which is obtained by the following steps: taking hollow manganese dioxide (HMDN) as a matrix, loading a coordination polymer (GA-Fe) of gallic acid and iron, encapsulating by branched polyethyleneimine (PEI), and encapsulating by polyaspartic acid (PASP-API) grafted with imidazole. According to the drug carrier system provided by the invention, through ionization of imidazolyl, charge reversal of the drug carrier can be realized to overcome an EPR effect to reach a tumor site. Meanwhile, the drug carrier system is decomposed in a tumor cell subacid environment, GA-Fe is released to serve as a catalyst of a Fenton reaction, hydrogen peroxide in tumor cells can continuously generate hydroxyl radicals (.OH), and the tumor cells are killed; and HMDN can react with glutathione (GSH) in tumor cells, .OH consumed by GSH is effectively inhibited, oxidative stress in the cells is enhanced, and the treatment effect is greatly improved.

The invention provides an application of manganese type high-stability superoxide dismutase with the sequence as shown in SEQ ID NO:4 in treating autism. The manganese type high-stability superoxide dismutase adopted in the invention can improve the ecological unbalance of the intestinal flora, and regulate the expression of intestine barrier associated protein, so that the oxidation pressure of the intestinal tract and the brain can be improved, thus the purpose of alleviating and improving the autism behavior is achieved, and therefore, a novel path is provided for treating autism.

The invention relates to the technical field of biological medicines. That miR-144 can specifically inhibit the gene expression of Nrf2 is disclosed for the first time, the expression of miR-144 is closely related to heart disease, and the high expression of miR-144 can promote myocardial oxidative stress to cause myocardial damage related diseases. The invention provides miR-144 and application of an inhibitor of miR-144 in preparation of medicines for preventing or treating myocardial oxidative stress and damage diseases, especially diabetes caused myocardial oxidative stress and damage diseases; a new target spot is provided for the diagnosis and prevention and treatment of heart diseases.

The invention belongs to the technical field of nutrient foods, and particularly relates to a nutrient food for breast cancer and a preparation method thereof. The nutrient food for breast cancer is aformula food which is designed based on the pathogenesis and chemotherapy side effects of breast cancer patients at 18-64. In that premise that heat is guaranteed, suitable raw materials are selectedto form a food with high protein, low carbohydrate, low fat, high-content active functional substances with specific matching, vitamins and mineral elements. The comprehensive synergistic effect of elements are utilized, and the body and the mind of the patients are regulated from the aspects of oxidative stress, immunity and chemotherapy side effects, and the food plays a role in nutrient supplementation and regulation effect during the chemotherapy of the breast cancer patients. In addition, the price of the product can be reduced by the selecting and matching of element forms and the simplification of sales methods. The food can be used as a single nutrient source to meet the nutritional requirement of the patients, and can be used in combination with other daily diet so as to enrich the diet type and eating mode and to stimulate patient's dietary interest.

The invention discloses an application of gastrodin for preventing and treating osteoporosis, gastrodin has nontoxic effect to osteoblast precursor cells, and has no influence on cell proliferation; gastrodin has protection effect on apoptosis of MC3T3-E1 caused by hydrogen peroxide; improves oxidative stress state induced by H2O2 in a differentiation process of the MC3T3-E1, and has protective function on MC3T3-E1 osteogenic differentiation inhibition caused by H2O2; besides, gastrodin can inhibit expression of a bone absorption factor. Therefore, gastrodin can play a role of protecting osteoporosis through improvement on osteoblast apoptosis and differentiation inhibition, and indirect inhibition of osteoclast activation. In an osteoporosis model of castrated mice, gastrodin can improve oxidative stress state in serum, improves a bone micro-structure of cancellous bone of distal femur and lumbar vertebra, and increases osteogenesis rate of distal femur, so that gastrodin can improve bone micro-structure by inhibiting the oxidative stress state and has the effect for preventing and treating osteoporosis.

The invention provides a nutrient supplement for first-delivery sows, and belongs to the technical field of breeding of first-delivery sows. The nutrient supplement comprises 100-200 parts of poly-isomaltose, 100-200 parts of baking soda, 50-100 parts of probiotics, 60-150 parts of chitosan oligosaccharides, 100-150 parts of L-Lysine monohydrochloride, 50-100 parts of methionine, 50-120 parts of calcium lactate, 0.1-0.3 part of zinc glycinate, 0.08 -0.12 part of manganese glycinate, 0.01-0.03 part of cupric glycinate, 50-100 parts of an acidulant, 150-200 parts of vitamin E, 10-15 parts of vitamin A, 2-3 parts of vitamin D3 and 10-500 parts of silicon dioxide. A preparation method of the nutrient supplement comprises the following steps of weighing the components in parts by weight, sequentially adding the components in parts by weight to a mixing machine in the sequence from the big components to the small components, performing uniform mixing, and performing subpacking with a non-toxic bag. According to the nutrient supplement, the physical development of the first-delivery sows can be promoted, the firstborn stress of the first-delivery sows can be reduced, the body storage of the first-delivery sows can be strengthened, the food consumption of the sows at the early period of a lactation period can be increased, the disease resistance of the first-delivery sows at a perinatal period can be strengthened, the syndromes of the sows for second pregnancy can be alleviated, the service life of the sows can be prolonged, and the rejection rate of the sows can be reduced.

The invention relates to a user of polyphenols from pomegranate flowers in the preparation of medicaments for treating non-alcoholic fatty liver. A large number of experiments prove that the polyphenols from the pomegranate flowers can obviously reduce rat serum Flns (fluorescence line-narrowing spectroscopy) and IRI (insulin resistance index), delay the first hit in two-hit theory, play a role in preventing further denaturation, putrescence and fibrosis of liver, significantly increase the expression of PON1 (paraoxonase 1) in rat liver tissues, increase the content of HDL (high density lipoprotein) and improve the oxidative stress state in rat bodies.

The invention relates to the medicinal application of NAM, specifically to application of NAM to preparation of drugs used for preventing and treating diabetic nephropathy and regulating blood pressure, belonging to the field of compounds. The experimental results of intervention of NAM in type 2 diabetes model mice prove NAM has obvious protective effect on diabetic kidneys and can alleviate therenal fibrosis, inflammations and oxidative stress in diabetic mice, and the protection effect is achieved independent of blood sugar reduction and weight improvement. Further, NAM can be used for preparing drugs for preventing and treating diabetic nephropathy and regulating blood pressure. The application of NAM in the invention provides a novel target and a novel idea for clinical prevention and treatment of diabetic nephropathy and improvement of renal lesions, and further proves that the improvement of renal oxidative stress plays an important role in the prevention and treatment of diabetic nephropathy.

The application of the invention discloses an edible bird's nest composition having efficacy of resisting ageing and a preparation method and application of the edible bird's nest composition. The edible bird's nest composition comprises the following components in parts by mass of 1-10 parts of edible bird's nest products, 100-500 parts of oligosaccharide, 0-100 parts of antioxidation components,1-10 parts of elastin peptide and 200-800 parts of cartilage collagen peptide or fish skin collagen peptide. According to the edible bird's nest composition disclosed by the invention, the problem that conventional edible bird's nest products are poor in the function of resisting ageing is solved.

The invention discloses application of exogenous glutamic acid in alleviating cadmium stress of rice and reducing cadmium content of rice plants. It is proved that by adding exogenous glutamic acid toa water culture solution for culturing rice seedlings, the exogenous glutamic acid has the effects of promoting the growth of rice under cadmium stress and reducing the toxicity of cadmium to the rice; under the cadmium stress, the biosynthesis of chlorophyll of the rice is improved, the biomass of the rice is increased, and oxidative stress induced by cadmium is alleviated. Furthermore, it is further found that the exogenous glutamic acid can inhibit the absorption and transport of cadmium, correspondingly the accumulation of cadmium in the rice plants is reduced, and the toxicity of cadmiumto rice is reduced.

The invention provides structurally similar carrier peptides, which can be linked to a B cell epitope or a peptide semiantigen to constitute peptide immunogen, and simplifies the preparation of an antigen for immunization and has important applications in medicine and immunology. The peptide immunogen containing the carrier peptide of the present invention is used for immunizing different mice, and the immunogenicity of the B cell epitope or the peptide semiantigen is remarkably enhanced, and a Th2 antibody having a high specific binding to the target antigen protein is produced, after immunization with the peptide immunogen, the specific Th2 antibody can be prepared by a hybridoma technology or antibody preparation methods such as antibody libraries and single cells, the immune regulationof Th2 is significantly enhanced, enzyme activity or related protein function can be inhibited, and the condition can be improved. Meanwhile, the carrier peptide and the carrier peptide-containing immunogen provided by the present invention can also be used for recombinant microorganisms and transgenic animals or plants and cells thereof, and can be used as a production plant to prepare vaccinesor to prepare oral vaccines or to prepare the specific antibodies and alterations for the control of Th1 dominant or peptide epitope-related diseases including but not limited to diabetes and complications, and for the development of detection reagents.

The invention relates to application of an oral hypoglycemic peptide. The application is used for preparing a medicine or a medicine composition for treating or preventing diabetes complicated with cardiovascular diseases. The oral hypoglycemic peptide is polypeptide OHP2. The polypeptide can effectively improve myocardial hypertrophy and fibrosis damage caused by the diabetes, reduce the contentof related myocardial enzymes, adjust the lipid metabolism level and improve myocardial cell oxidative stress and mitochondrial damage, so that the effect of protecting the heart is achieved; and therefore, the polypeptide can be used as a candidate molecule for treating or preventing the diabetes complicated with the cardiovascular diseases (especially diabetic cardiomyopathy), and has a good application prospect.

The invention discloses a pear peel extract as well as an extraction method and an application thereof in blood glucose-reduction health products. The extraction method comprises the following steps: carrying out freezing and drying or vacuum drying on pear peels, mixing the dried pear peel and a methyl alcohol aqueous solution or ethyl alcohol aqueous solution with the concentration of 50-80% in a mass ratio of 1:(10-100), ultrasonically extracting for 0.5-2h for 2-3 times, combining extraction solutions, concentrating, and drying at 40-60 DEG C to enable methyl alcohol or ethyl alcohol to be completely volatilized to obtain extract. The pear peel extract has an obvious effect on reducing blood glucose of diabetic mice, and also has obvious effects on glucose tolerance adjustment, postprandial blood glucose delaying, and improving oxidative stress (improving SOD (superoxide dismutase) activity and reducing MDA (Methane Dicarboxylic Aldehyde) content) of the diabetic mice through in-vivo tests; and the pear peel extract has a remarkable inhibition effect on alpha-glycosidase through in-vitro tests, therefore, the pear peel extract has the effect on postprandial blood glucose delaying.

The invention provides a linear 23 peptide molecule. The linear 23 peptide molecule can be used for coupling a single B cell epitope or hapten to prepare immunomodulating peptide. The immunomodulatingpeptide immunizes animals and can produce an antibody with a high titer that can specifically bind to a protein containing a B cell epitope. A Th2 antibody or a single-chain antibody can be preparedby a hybridoma technology, or an antibody library or single-cell and binding genetic engineering and other technologies. The immunomodulating peptide and the antibody both significantly enhance the immunoregulation deflecting toward Th2, inhibit the activity or function of protease containing the B cell epitope, and improve related diseases. At the same time, the 23 peptide and a coupling or fusion protein or a composition / polymer thereof provided by the invention can also be used in recombinant microorganisms and transgenic animals or plants and cells thereof, so that the 23 peptide and the coupling or fusion protein or the composition / polymer thereof can be produced in production plants to produce vaccines or oral vaccines or produce specific antibodies, and the above peptides and antibodies can be used in the development of drugs to prevent and treat diseases with high Th1, including but not limited to diabetes, hyperuricemia and complications, as well as in the development of detection reagents to detect proteins or peptides containing B cell epitopes.

The invention discloses an application of a plant selenium peptide in preparation of a composition for improving obesity and metabolic syndrome. The composition comprises foods, health care products,medicines, nutritional supplements, food additives and beverages. The plant selenium peptide is preferably an organic selenium source extracted from cruciferous plants, the organic selenium content ishigher than 90%, and the peptide content is higher than 10%. An embodiment proves that the plant selenium peptide can improve oxidative stress, enhance the activity of antioxidant enzymes such as GPx, SOD, CAT and TAOC and reduce the MDA level. The expression levels of inflammatory factors IL-6, TNF-alpha, IL-1 beta and MCP-1 are inhibited, the expression of genes FABP4, FAS, PPAR-gamma, SREBP1,HMGR and ACAT is inhibited, and the expression of lipid decomposition genes PPAR-alpha, PGC1-alpha, LPL, GPX and LCAT is promoted, the integrity of intestinal mucosa is maintained, and the expressionlevels of tight junction proteins ZO-1 and ccludin are up-regulated, the composition of intestinal microorganisms is regulated and controlled, the production of beneficial bacteria, namely Blauia, Blauia and Lactobacillus, is promoted, and the preparation method has a wide application prospect.

The invention discloses application of N-acetylserotonin in preparation of a drug for treating intraventricular hemorrhage and belongs to the technical field of biomedicines. The invention discloses and proves that the N-acetylserotonin can relieve cerebral edema and blood brain barrier destruction caused by the intraventricular hemorrhage; it is discovered that the N-acetylserotonin has an improvement effect on sports and learning memory disorder induced by the intraventricular hemorrhage; it is disclosed that a protection effect of the N-acetylserotonin is related to relief of oxidative stress, inhibition of ferroptosis and improvement on synaptic plasticity; and in addition, in a primary cortex neuron haemorrhage cell model, it is proven that the NAS can obviously inhibit neuron death induced by Hemin and relieve axon injury. According to the application, a scientific basis is provided for utilizing the N-acetylserotonin to treat the intraventricular hemorrhage as a novel drug.

The present invention discloses a method to induce fatty liver in an animal. The steps of the method comprise: feeding an animal with a high calorie diet, and injecting a mitochondrial inhibitor into the animal to inhibit the mitochondrial activity of the animal, then resulting in fat accumulation and inflammation in the liver of the animal.

The invention discloses a medicinal application of epimedin C in treatment on diabetic liver injury, and belongs to the technical field of biological medicines. The invention discloses that epimedin Ccan improve the cholesterol level of high-density lipoprotein in the liver of a diabetic model animal for the first time, the cholesterol level of low-density lipoprotein in the liver is reduced, theproblem of lipid metabolism disorder is relieved, a liver index is reduced, the activity of superoxide dismutase and glutathione peroxidase in the liver is enhanced, the content of malondialdehyde isreduced, the oxidative stress state of the liver is improved, normal forms and structures of hepatocytes and tissues are maintained, the activity levels of glutamic-pyruvic transaminase and glutamicoxalacetic transaminase in the liver are reduced, and liver function repair is promoted, so that the epimedin C can be used for preparing medicines for treating diabetic liver injury. The epimedin C is used for preparing the medicine for treating diabetic liver injury in the form of a medicinal preparation, and comprises buccal tablets, coated tablets and hard capsules. The invention provides a basis for treatment on diabetic liver injury, and also provides an idea for deep development and utilization of epimedium resources.

The invention discloses an application of ginsenoside Rb2 to protection of an osteoblast precursor cell. The ginsenoside Rb2 is non-toxic to the osteoblast precursor cell, does not influence cell proliferation, has a protecting effect on apoptosis of the osteoblast precursor cell (MC3T3-E1) caused by hydrogen peroxide (H2O2), can be used for improving the H2O2 induced oxidative stress status in the differentiation process, has a protecting effect on inhibition of MC3T3-E1 osteogenic differentiation caused by H2O2, and can inhibit expression of bone absorption factors, so that osteoporosis can be protected by improving osteoblast apoptosis and differential inhibition and indirectly inhibiting osteoclast activation. The ginsenoside Rb2 can improve the oxidative stress status in serum, improve the trabecular microstructure of the distal femur and the fourth lumbar vertebra, and reduce the mineral deposition rate of the distal femur, which indicates that the ginsenoside Rb2 can improve the bone microstructure by inhibiting oxidative stress to play the effect of preventing and treating osteoporosis.

The present invention provides a premix for preventing and treating fatty liver of dairy cattle in a perinatal period and a related application thereof. The premix simultaneously contains a certain amount of ruminal choline and selenium, creatively utilizes a combination of the two materials to have a double protection function for liver, groundbreakingly realizes a synergic effect of the two materials added in the premix at the same time, is prefect in liver protection, antioxidant and lactating performances of the dairy cattle in the perinatal period, and realizes an one-plus-one-is-greater-than-two effect.

The invention discloses application of stilbeneglycoside (TSG) to prophylaxis and treatment of osteoporosis. TSG has no toxic effect on osteoblast precursor cells, and does not affect cell proliferation; TSG has protective function on apoptosis of osteoblast precursor cells (MC3T3-E1) caused by hydrogen peroxide (H2O2), improves oxidative stress state induced by H2O2 in a differentiation process of the MC3T3-E1, and has protective function on MC3T3-E1 osteogenic differentiation inhibition caused by H2O2; besides, TSG can inhibit expression of a bone absorption factor. Therefore, TSG can play a role of protecting osteoporosis through improvement on osteoblast apoptosis and differentiation inhibition, and indirect inhibition of osteoclast activation.

The invention discloses an inflammation targeting and microenvironment responsiveness nano system as well as a preparation method and application thereof, and relates to the technical field of molecular imaging. The nano system comprises a targeting functional molecule, a nano carrier and a core crystal, the targeting functional molecule is CD163 targeting binding oligopeptide, and the oligopeptide is connected with polyethylene glycol on the surface of the nanoparticle in a covalent connection manner; and the core crystal is entrapped in the nano-carrier in a biomineralization manner. After intravenous injection of the nanosystem, the targeted CD163 positive macrophages are enriched in epilepsy focuses and react with H < + > and H2O2, so that magnetic resonance T1 signals of the epilepsyfocuses are enhanced and imaged, idiopathic / cryptogenic epilepsy focuses are accurately and visually displayed, and clinical improvement of treatment accuracy and safety is facilitated; active oxygensubstances in epileptic focuses can be catalytically removed, oxidative stress is relieved, oxygen is generated, the local hypoxic microenvironment is improved, and the neuron activity of epileptic regions is protected.

The present disclosure provides the use of mesenchymal stem cells (MSC) in the treatment of viral infection and / or complications caused by the viral infection. MSC can highly express multiple antioxidative stress genes and secrete multiple antioxidative stress factors under the stimulation of oxidative stress, inhibit inflammatory reaction and excessive activation of immune cells, thus improving inflammatory indexes and myocardial injury indexes of human bodies. MSC can regulate the expression profile of monocyte genes and monocyte toxicity genes in patients with viral infection, inhibit the excessive immune response, protect alveolar function, and reduce the damage of lung and whole body organs in patients with viral infection. MSC can regulate the expression of antivirus-related genes and coagulation-related genes of terminally differentiated cell subsets in patients with viral infection, inhibit the excessive activation of monocytes in patients with viral infection, and effectively treat the complications of patients with viral infection.

The invention provides a bioactive peptide prepared from snails as well as a preparation method and application of the bioactive peptide, and belongs to the technical field of bioactive peptides. Comprising the following steps: S1, treating snails; s2, preparation of helicase; s3, preparing minced snail meat; s4, performing enzymolysis by using helicase; s5, performing color protection treatment; s6, compound enzyme enzymolysis; s7, preparing a culture medium; s8, activating the strain; s9, performing fermentation; and S10, complexing. The prepared bioactive peptide can promote in-vivo environment balance, improve the immune function of the body, improve oxidative stress, improve anti-aging activity and inhibit generation of inflammatory factors, can also achieve an obvious anti-tumor effect, has excellent physiological activity and has a wide application prospect.

The invention discloses an application of hydroxytyrosol in preparation of healthy food and a drug for preventing and treating Alzheimer disease. Hydroxytyrosol can cross the blood brain barrier so as to remarkably improve cerebral nerve functions and learning and memory abilities of a mouse with the Alzheimer disease; besides, hydroxytyrosol can also reverse mitochondrial dysfunction and mitochondrial protein carbonylation abnormity in the brain of the mouse with the Alzheimer disease, SOD-2 protein expression is improved, and system steady states of two enzymes are improved. More importantly, due to the fact that the mouse with the Alzheimer disease has long-term inflammatory injury in the brain, the inflammatory injury in the brain of the mouse with the Alzheimer disease is remarkably relieved with JNK / MAPK (Jun N-terminal kinase / Mitogen-activated protein kinase) as a target under intervention of hydroxytyrosol, and the functions of preventing and treating occurrence and development of the Alzheimer disease are realized.