33results about How to "Improves oxidative stress" patented technology

The invention provides a culture method for improving immunity of fishes. The culture method comprises the following steps: S1, selection of culture points; S2, specification and layout of net cages; S3, selection and throwing of fish fries; according to the fry disinfection method disclosed by the invention, the fry are soaked and disinfected by using a compound disinfectant prepared from povidone iodine, polysorbate, citric acid and vitamin C in a specific proportion, so that pathogenic microorganisms on the surfaces and gill parts of fish bodies are effectively killed. According to the breeding management, the immunity of the fish body is comprehensively enhanced by feeding the fish with an immune conditioner composed of campesterol palmitate, immunomodulatory peptide, beta-glucan and astaxanthin in a specific proportion. According to the bottom mud management, the content of harmful substances is reduced by putting a bottom mud modifier composed of sodium molybdate, nitrifying bacteria, photosynthetic bacteria, tetrandrine and sodium alginate in a specific proportion, growth of pathogenic bacteria is inhibited, nutrient substance circulation is promoted, the water quality environment is optimized, and healthy growth of fry is promoted.

The invention provides sequoia sempervirens stem fermentation liquor and a preparation method and application thereof, and the preparation method specifically comprises the following steps: (1) crushing dried bark of sequoia sempervirens, adding inulin, a carbon source, a nitrogen source, inorganic salt and water, and sterilizing to obtain a dried bark culture medium of sequoia sempervirens; and (2) inoculating saccharomyces cerevisiae and bacillus subtilis into the sequoia sempervirens dry bark culture medium for fermentation, and then sterilizing and centrifuging to obtain sequoia sempervirens stem fermentation liquor. Experiments show that the sequoia sempervirens stem fermentation liquor prepared by the method provided by the invention is high in active ingredient content, and has various effects of resisting inflammation, relieving and resisting allergy, promoting wound healing, resisting aging and the like. The fermentation liquor prepared by the method provided by the invention can be widely applied to preparation of cosmetics with anti-aging, anti-allergy and repairing effects.

The invention discloses an application of inulin in preparation of a medicine for treating polycystic ovarian syndrome, especially the polycystic ovarian syndrome caused by high fat diet. Starting from the pathogenesis of the PCOS, research is carried out in the direction of'regulating host-intestinal dialogue by dietary fibers, promoting a tryptophan-quinolinic acid metabolic pathway to enhance an NAD + de novo synthesis pathway and improving PCOS oxidative stress and insulin resistance ', pathophysiology of the PCOS is researched from a brand new perspective, and the pathogenesis of a patient suffering from the PCOS is comprehensively researched in combination with metabonomics. And a new thought and a new target spot are provided for subsequent treatment.

The invention provides a blood purification adsorbent and a preparation method thereof, the blood purification adsorbent takes macroporous resin containing an epoxy group as a carrier, the epoxy group on the carrier reacts with polyethyleneimine, the polyethyleneimine is immobilized on the carrier, the polyethyleneimine is taken as a spacer arm, and the epoxy group on the carrier reacts with the polyethyleneimine to prepare the blood purification adsorbent. Superoxide dismutase and lipoic acid are connected to the spacer arm through a dehydration condensation reaction, so that the superoxide dismutase and the lipoic acid are immobilized on the carrier. The blood purification adsorbent can remove superoxide, free radicals and inflammatory factors at the same time, and can effectively improve oxidative stress and microinflammation states.

The composition for repairing the meniscus comprises a growth differentiation factor and emodin, and is used for improving inflammation and oxidative stress in a microenvironment and promoting a cell chondrogenic differentiation process. Through verification, according to the core-shell co-delivery nano-carrier provided by the invention, two bioactive compounds, namely emodin and a growth differentiation factor, are wrapped by mesoporous silicon dioxide nano-particles, and the two bioactive compounds are used for promoting fibrocartilage differentiation. The double-drug nano delivery system provides continuous release of emodin and GDF, synergistically regulates severe inflammation and oxidation environments, and promotes in-vitro and in-vivo fibrous cartilage regeneration. Benefited from this, according to the invention, a three-dimensionally printed meniscus-shaped PCL framework is combined with the composition by using cartilage-specific matrix hydrogel, a stability-enhanced meniscus replacement model is constructed, a cartilage immune microenvironment is synergistically adjusted, and successful repair of animal (rabbit) full meniscus replacement is realized.

The application belongs to the technical field of biological medicine, and relates to application of a mannose peptide in preparation of an alcoholic gastric ulcer medicine. The application discloses that the mannose peptide can significantly relieve bleeding lesions and ulcer conditions of an alcoholic gastric ulcer, and the mechanism comprises the following aspects: reducing active oxygen generated by alcohol toxicity, improving body oxidation stress by improving the activity of antioxidant enzymes of gastric tissue; regulating the inflammation response of the body by regulating the Akt / NF-kappa B pathway; inhibiting the Bax-related apoptosis pathway to protect gastric mucosal cells from alcohol-induced apoptosis, so as to protect the integrity of the gastric mucosa; regulating the intestinal flora disorder caused by alcohol intake, and preventing acute alcoholic gastric ulcer by improving the intestinal flora composition of the alcoholic gastric ulcer. The application widens the application of the mannose peptide, and provides more solutions for the prevention or treatment of acute alcoholic gastric ulcer.

The invention belongs to the field of pharmaceutical preparations. The invention relates to lipid nanoparticles modified by probiotic coupled galactose and coated with diammonium glycyrrhizinate, L-arginine and copper tannic acid nano enzyme as well as a preparation method and application of the lipid nanoparticles. The lipid nanoparticles prepared by coupling and wrapping the diammonium glycyrrhizinate, the L-arginine and the copper tannic acid nano-enzyme with the probiotics have good biocompatibility, the preparation method is simple, the particle size distribution of the nanoparticles is uniform, the half-life period of a medicine circulating in a body can be prolonged, the inherent beneficial functions of the probiotics are cooperated, and the bioavailability of the medicine is improved. The potential application value is realized in the fields of treating the metabolic dysfunction related steatohepatitis and the like.

The invention provides stem cell-derived apoptotic extracellular vesicles (ApoEVs) with an iron homeostasis regulation effect and application of the stem cell-derived apoptotic extracellular vesicles in preparation of a medicine for treating iron-deficiency anemia, and belongs to the technical field of biological medicines. The ApoEVs is an outer vesicle separated from apoptotic cells derived from human periodontal ligament stem cells, and can effectively recover the iron level in low-iron cells induced by DFOM, up-regulate the expression of iron storage protein and regulate the level of iron export protein, thereby improving the iron homeostasis of the cells. Meanwhile, the ApoEVs have good biocompatibility and safety, and a new strategy is provided for treatment of iron-deficiency anemia.

The invention discloses a preparation method of a polymer / Ti3C2-CeO2 composite scaffold with an anti-tumor function. Comprising the following steps: loading CeO2 by utilizing Ti3C2, synthesizing Ti3C2-CeO2 powder by a hydrothermal synthesis method, grinding and uniformly mixing degradable high-molecular polymer poly-L-lactic acid (PLLA) powder with the mass percent of 95% and Ti3C2-CeO2 powder with the mass percent of 5%, and preparing the PLLA / Ti3C2-CeO2 composite scaffold by utilizing a selective laser sintering technology. The prepared PLLA / Ti3C2-CeO2 composite scaffold is used as an artificial implant material for treating bone tumor diseases, and the problem that the curative effect based on reactive oxygen species (ROS) therapy is limited due to oxygen deficit and glutathione overexpression in a tumor microenvironment is solved. CeO2 relieves oxygen deficit, promotes the photodynamic process and generates hydroxyl radicals to amplify oxidative stress, and over-expressed glutathione can be consumed through the oxidation-reduction reaction of CeO2. In addition, the photothermal effect of Ti3C2 enhances the enzymatic activity of CeO2 in turn. The antitumor efficiency of the composite scaffold can be effectively improved by combining the dual enzyme activity, the photothermal effect and the photodynamic effect.

This invention provides a post-makeup, post-makeup removal, and post-sun exposure repair composition containing purslane extract and its application, belonging to the field of cosmetic technology. The composition of this invention comprises the following components in parts by weight: 1.0–10.0 parts purslane extract, 1.0–8.0 parts fermented mung bean sprout extract, 0.1–3.0 parts immortelle extract, and 0.1–3.0 parts ectoine. This invention uses purslane extract as a soothing and repairing base; fermented mung bean sprout extract to improve oxidative stress after makeup, makeup removal, and sun exposure; immortelle extract to improve redness, burning sensation, and discomfort after irritation; and ectoine to enhance the skin's stress resistance and tolerance. These four components synergistically form a complex care system of "soothing redness—antioxidant stabilization—plant repair—anti-stress tolerance," which can effectively improve problems such as redness after makeup, tightness after makeup removal, burning sensation, stinging, dryness, and unstable skin barrier after sun exposure. The composition of this invention is mild and can be prepared into various dosage forms such as essence water, wet compress water, spray, gel mask, gel, sheet mask, cream mask, serum, lotion, etc., which are suitable for industrial production and daily skin care use.

The invention discloses a selenium-iron co-doped hydroxyapatite reinforced polylactic acid scaffold and a preparation method thereof, and the preparation method comprises the following steps: co-doping SeO3 < 2-> and Fe < 3 + > into HAP through a co-precipitation method to obtain SF-HAP powder; sF-HAP and PLLA are dispersed in ethyl alcohol, and PLLA / SF-HAP composite powder is obtained through stirring, centrifuging, drying and the like; the PLLA / SF-HAP biological scaffold is prepared through an additive manufacturing technology, in order to endow the PLLA / HAP bone scaffold with an anti-tumor function, Fe is doped into HAP, a Fenton reaction can be promoted in an osteosarcoma environment so that ROS can be generated to kill tumor cells, but overexpressed GSH existing in the tumor cells can consume the ROS to weaken the anti-tumor effect, and doping of Se and Fe can reduce the crystallinity of HAP crystals, so that the anti-tumor effect is improved. The SeO3 < 2-> and the Fe < 3 + > are added into the tumor cells, so that the sustained release of functional ions is facilitated, meanwhile, the consumption of the SeO3 < 2-> and the Fe < 3 + > on the over-expressed GSH and H2O2 in the tumor cells can effectively destroy the redox balance in the tumor cells, and the death of the tumor cells is promoted.

The invention relates to application of rhizoma bletillae polysaccharide in preparation of a medicine for treating gastric mucosal lesion and a preparation method of the rhizoma bletillae polysaccharide, the rhizoma bletillae polysaccharide is prepared, and when an organism intakes excessive ethanol, the rhizoma bletillae polysaccharide can achieve the effect of preventing acute alcoholic gastric mucosal lesion by protecting the integrity of gastric mucosa. By regulating expression disorder of inflammatory factors, the inflammatory factors can be maintained at a normal level, so that a preventive protection effect on gastric mucosal lesion is achieved; a foundation is laid for further exploration of a repair mechanism of the rhizoma bletillae polysaccharide on gastric mucosal lesion, and an experimental basis is provided for further development and application of rhizoma bletillae polysaccharide health food or medicine.

The invention relates to an application of a sargassum fusiforme aqueous extract, in particular to an application of the sargassum fusiforme aqueous extract in preparation of a medicine for treating type 2 diabetes mellitus and an application of the sargassum fusiforme aqueous extract in preparation of a medicine for improving cell oxidative stress and insulin resistance. The sargassum fusiforme aqueous extract is prepared by the following steps: soaking sargassum fusiforme in water, desalting, washing and removing impurities for later use; adding deionized water into the sargassum fusiforme, and heating at 100 DEG C in a pressure cooker; cooling the tap water to normal temperature after heating is finished, collecting the solution, centrifuging to take supernate, concentrating the supernate, and freeze-drying to obtain the sargassum fusiforme aqueous extract SFE. The prepared sargassum fusiforme aqueous extract can effectively promote consumption of IR-HepG2 extracellular glucose, effectively improve the oxidative stress state of IR-HepG2 cells and remarkably reverse down-regulation of key proteins (HO-1 and Keap1) in insulin resistance MOD group cells, can be used for preparing drugs for treating type 2 diabetes mellitus, and has the advantages of being safe and free of toxic and side effects.

The invention belongs to the technical field of traditional Chinese medicines, and particularly provides a traditional Chinese medicine composition for treating hepatic fibrosis and a preparation method thereof. According to the invention, astragalus membranaceus, vinegar-processed curcuma zedoary, salvia miltiorrhiza, moutan bark, radix paeoniae rubra, angelica sinensis, curcuma aromatica, fructus amomi, bran-fried atractylodes macrocephala koidz, poria cocos, fingered citron, vinegar-processed bupleurum chinense and honey-fried licorice root are adopted as raw materials and are subjected to proper weight proportioning; wherein the astragalus membranaceus is a monarch drug, and the vinegar curcuma zedoary, the salvia miltiorrhiza, the moutan bark, the red paeony root, the angelica sinensis, the radix curcumae, the fructus amomi and the bran-fried rhizoma atractylodis macrocephalae are The vinegar bupleurum chinense, fingered citron and poria cocos are used as adjuvant drugs, and the liquorice is used as conductant drug; all the medicines are combined to achieve the effects of replenishing qi to invigorate the spleen, soothing the liver, regulating qi and promoting blood circulation to remove blood stasis. Under the synergistic effect of all the medicine components, the traditional Chinese medicine composition has a good curative effect on liver fibrosis, especially liver fibrosis common clinically with liver depression, spleen deficiency and blood stasis syndromes, and is small in toxic and side effect and worthy of clinical application and popularization.

The invention discloses a lactobacillus rhamnosus CQFP202457 and application of the lactobacillus rhamnosus CQFP202457 and ellagic acid in relieving exercise fatigue, and belongs to the technical field of microorganisms. The preservation number of the lactobacillus rhamnosus CQFP202457 is CGMCC (China General Microbiological Culture Collection Center) No. 29784. The composition provided by the invention contains ellagic acid and lactobacillus rhamnosus CQFP202457, and can significantly prolong the exercise exhaustion time, reduce the content of fatigue-related metabolites in serum, improve the total antioxidant ability of serum, liver and skeletal muscle and the antioxidant enzyme gene expression level, and improve the exercise-induced liver and skeletal muscle tissue damage. The strain and the composition thereof provided by the invention can be used as exercise synbiotics for preparing products for relieving exercise-induced fatigue, improving exercise performance, reducing exercise-induced oxidative stress or relieving exercise-induced muscle injury.

The invention discloses a preparation method and application of an acid-responsive aggregated carrot-source nano antioxidant, and belongs to the technical field of medical treatment. The carrot source nano antioxidant is prepared by five steps of cleaning, crushing, filtering, gradient centrifuging and extruding, can be applied to improvement of oxidative stress, promotion of good bone remodeling and effective treatment of osteoporosis, and has good practical application value.

The invention provides an application of icariin in preparation of a medicine for preventing and treating cataract, the icariin can relieve oxidative stress and inhibit apoptosis, and the icariin has a potential treatment value for cataract. The icariin can obviously improve cataract grading of cataract rats and reduce pathological scores.

The invention belongs to the technical field of biological medicines, and discloses an organic photosensitive nano material as well as a preparation method and application thereof. The organic photosensitive nano material is of a shell-core structure; the shell structure comprises an amphiphilic polymer, and the core structure comprises an organic conjugate and an electron sacrificial agent; the preparation method of the organic photosensitive nano-material comprises the following steps: self-assembling the organic conjugate, the electron sacrificial agent and the amphiphilic polymer to obtain the organic photosensitive nano-material. Due to the unique structural design and excellent GSH consumption performance of the organic photosensitive nano material, endogenous GSH in tumor cells can be consumed, loss of ROS by the endogenous GSH is reduced, and oxidative stress in the tumor cells is further enhanced; the level of GSH in tumor cells can be jointly regulated and controlled, the utilization rate of ROS in hypoxic tumors is increased, and as a medication scheme for achieving GSH consumption, the compound is applied to PDT to promote the treatment effect of the hypoxic tumors.

The application discloses a screening method of a lipid-lowering peptide of Suaeda salsa and target point prediction, relates to the technical field of bioactive peptide processing and application, and discloses that the amino acid sequence of the lipid-lowering peptide is GGPSWNVK; the lipid-lowering target points are microsomal triglyceride transfer protein, 3-hydroxy-3-methylglutaryl coenzyme A reductase and proprotein convertase subtilisin 9; the active peptide GGPSWNVK with a clear lipid-lowering target point is screened from Suaeda salsa, stable combination of the active peptide with the three target points of MTP, HMGR and PCSK9 is verified through molecular docking and molecular dynamics simulation, the active peptide has low binding energy and good safety, can effectively improve lipid accumulation and oxidative stress, and provides an important candidate molecule for development of a new lipid-lowering drug, a special medical food and a health product.

This invention discloses a method for establishing a largemouth bass model susceptibility to iron overload pathogens using inorganic iron, belonging to the field of biotechnology. The method includes: a) after acclimatizing 4-5cm largemouth bass to a normal diet for one week, the normal diet is replaced with a FeSO4·7H2O-supplemented diet (FeSO4·7H2O supplementation amount: 800-3200 mg / kg), while the control group continues to be fed a normal diet; b) after feeding the FeSO4·7H2O-supplemented diet for 14-56 days, the mortality rate from Aeromonas hydrophila infection increases, indicating successful establishment of the largemouth bass model susceptibility to pathogens. This method for establishing a largemouth bass model susceptibility to iron overload pathogens using inorganic iron has advantages such as simple operation, high success and survival rates, good stability, and obvious pathological characteristics.

The invention provides an anti-tumor composition and a preparation method thereof, and belongs to the technical field of medicines. Poria cocos and radix astragali are subjected to enzymolysis boiling water extraction and filtration, filter residues are subjected to fermentation, filtration and solid washing to obtain bacterial liquid, the bacterial liquid and filtrate are mixed, dried and embedded, and embedded microspheres are prepared; adding the washed solid into a culture medium, inoculating lactobacillus plantarum for fermentation, filtering, carrying out ethanol precipitation on filtrate, carrying out amination to obtain aminated selenium-rich extracellular polysaccharide, and reacting with carboxylated geraniol and dihydroartemisinin to obtain the active component selenium-rich extracellular polysaccharide. Uniformly mixing the water extract of the poria cocos and the astragalus membranaceus, the active components, namely the selenium-rich exopolysaccharide, the embedded microspheres, genipin and berberine, so as to obtain the anti-tumor composition. The traditional Chinese medicine composition has good anti-inflammatory, anti-oxidation and anti-tumor effects and is wider in application range.

The present invention belongs to the field of new drug research and development, and specifically relates to a microneedle loaded with polyvinyl pyrrolidone-modified iridium nanoparticles and basic fibroblast growth factor and its application. The microneedle has good mechanical strength, can effectively deliver IrNP and bFGF to the epidermis and dermis, IrNP plays a strong anti-oxidative stress role, removes free radicals around hair follicles, bFGF reshapes microvessels around hair follicles and promotes vascularization, the two cooperate with each other to improve the hair follicle microenvironment, promote hair growth, and have good cell compatibility, promote endothelial cell vascularization, and resist damage caused by oxidative stressors.

The invention relates to a phloroglucinol compound, separation and application of the phloroglucinol compound in preparation of drugs for resisting acute myeloid leukemia, and belongs to the technical field of medicines. The novel compound long-column polycycline A separated from the plant hypericum has good anti-tumor activity, especially has good anti-tumor activity on AML cell lines, and can be used as a lead compound for development of anti-AML drugs. The invention provides an alternative compound for research and development of new drugs for resisting acute myeloid leukemia cells, and has very important significance for development and utilization of natural product resources.

The invention discloses application of 6RK73 in preparation of a medicine for preventing or treating atrial fibrillation and a medicine composition for preventing or treating atrial fibrillation. According to the application disclosed by the invention, by injecting the 6RK73 into the intraperitoneal cavity of an atrial fibrillation (especially Ang II induced) mouse for pretreatment, the 6RK73 is found to be capable of obviously reducing the atrial fibrillation area, improving inflammatory response and oxidative stress in atrial tissues and relieving atrial structure remodeling so as to prevent and treat atrial fibrillation, and a new medicine and a new treatment scheme are provided for clinical treatment of atrial fibrillation patients.

The present invention provides an application of a polypeptide in the preparation of a feed additive for reducing the expulsion stress response of poultry, and belongs to the field of feed technology. The present invention finds through in vitro tests that duck heat shock regulatory factor 3 polypeptide can significantly reduce the heat stress response of duck small intestinal epithelial cells, and improve the ability of duck small intestinal epithelial cells to cope with cell apoptosis caused by heat stress; and can improve the oxidative stress of duck small intestinal epithelial cells caused by ultraviolet light irradiation, reduce the cell MDA level, and increase the cell SOD level. The present invention finds through clinical trials that duck heat shock regulatory factor 3 polypeptide as a feed additive can effectively reduce the impact of expulsion stress on the egg laying rate of chickens, ducks, and geese, significantly improve the egg laying rate of laying poultry under expulsion stress environment, and increase the benefits of laying poultry breeding.

The invention discloses a lipid droplet nano-composite for treating tumors as well as a preparation method and application of the lipid droplet nano-composite. The preparation method comprises the following steps: firstly, loading an NRF-2 protein inhibitor and ferritin targeting peptide onto a two-dimensional nanosheet, then wrapping lipid droplets on the surface of the two-dimensional nanosheet, and then modifying tumor targeting peptide on the surface of the lipid droplets to obtain the nano compound for treating tumors. The nano-composite can effectively inhibit tumor proliferation and metastasis and inhibit tumor postoperative recurrence in cooperation with multiple therapies such as photodynamic therapy, ferroptosis and oxidative stress, can effectively promote tumor cell death under the hypoxia condition, improves the tumor treatment effect, and provides a new strategy for cancer treatment.

The invention discloses an application of a mulberry flavonol extract in preparation of a hypoglycemic drug, and belongs to the technical field of biology. According to the application of the mulberry flavonol extract in the preparation of the hypoglycemic drug, an insulin resistance model is established by utilizing HepG2 cells, and the mulberry flavonol extract acts on IR-HepG2 cells; the influence of the mulberry flavonol extract on cell glucose consumption, glycogen synthesis, glycometabolism, lipid metabolism, oxidative stress and glycolysis key enzyme gene expression quantity is analyzed, and the insulin resistance improving effect of the mulberry flavonol extract is verified from the cell level.

[Problem] The purpose of the present invention is to provide a jejunum MDA concentration decrease-promoting agent, 8-OHdG concentration decrease-promoting agent, ZIP4 concentration increase-promoting agent, or serum zinc concentration increase-promoting agent so as to be able to promote a jejunum MDA concentration decrease, a jejunum 8-OHdG concentration decrease, a jejunum ZIP4 concentration increase, and a jejunum serum zinc concentration increase, and to provide a jejunum MDA concentration decrease-promoting agent, a jejunum 8-OHdG concentration decrease-promoting agent, a jejunum ZIP4 concentration increase-promoting agent, and a jejunum serum zinc concentration increase-promoting agent. The oxidative stress state is improved. [Solution] The present invention has, as an active ingredient, 3, 5-dihydroxy-4-methoxybenzyl alcohol (3, 5-dihydroxy-4-methoxybenzyl alcohol), and has an 8-OHdG concentration reduction promoting effect that reduces the 8-OHdG concentration in the jejunum.

Application of a multifunctional supramolecular nanoplatform drug: The application of a multifunctional supramolecular nanoplatform in the preparation of drugs for liver ischemia-reperfusion injury. The multifunctional supramolecular nanoplatform is a GalAC4A supramolecular carrier loaded with naringenin (NAR). The multifunctional supramolecular nanoplatform is prepared from naringenin (NAR), galactose (Gal), and CAC4A from azocalixarene. The multifunctional supramolecular nanoplatform is a NAR@GalAC4A nanocomposite. The multifunctional supramolecular nanoplatform achieves hepatocyte-specific targeting through desialyl glycoprotein receptor-mediated endocytosis. This invention proposes a novel "receptor recognition-hypoxia response-synergistic therapy" three-pronged design strategy, successfully constructing a GalAC4A supramolecular carrier loaded with naringenin (NAR) to form a NAR@GalAC4A nanocomposite.

The invention discloses application of a transcription factor Bach1 in promoting renal ischemia-reperfusion injury and mitochondrial glutathione depletion, and belongs to the technical field of biology. An ischemia-reperfusion renal injury mouse model is adopted, and kidney inflammatory response, renal injury and mitochondrial dysfunction of a mouse can be remarkably improved through BACH1 gene knockout. Cell experiments verify that BACH1 gene silencing can significantly improve mouse kidney injury and kidney inflammatory response, and increase the mitochondrial reduced glutathione content by up-regulating the SLC25A39 content so as to improve mitochondrial dysfunction, BACH1 overexpression can aggravate mouse kidney injury and kidney inflammatory response, inhibit SLC25A39 expression so as to reduce the mitochondrial reduced glutathione content, and BACH1 overexpression can inhibit SLC25A39 expression so as to improve mitochondrial dysfunction. The invention proves that BACH1 has a regulation effect on SLC25A39, and can provide a new intervention target for renal ischemia-reperfusion injury.