18results about How to "Improves oxidative stress" patented technology

The invention provides a blood purification adsorbent and a preparation method thereof, the blood purification adsorbent takes macroporous resin containing an epoxy group as a carrier, the epoxy group on the carrier reacts with polyethyleneimine, the polyethyleneimine is immobilized on the carrier, the polyethyleneimine is taken as a spacer arm, and the epoxy group on the carrier reacts with the polyethyleneimine to prepare the blood purification adsorbent. Superoxide dismutase and lipoic acid are connected to the spacer arm through a dehydration condensation reaction, so that the superoxide dismutase and the lipoic acid are immobilized on the carrier. The blood purification adsorbent can remove superoxide, free radicals and inflammatory factors at the same time, and can effectively improve oxidative stress and microinflammation states.

The composition for repairing the meniscus comprises a growth differentiation factor and emodin, and is used for improving inflammation and oxidative stress in a microenvironment and promoting a cell chondrogenic differentiation process. Through verification, according to the core-shell co-delivery nano-carrier provided by the invention, two bioactive compounds, namely emodin and a growth differentiation factor, are wrapped by mesoporous silicon dioxide nano-particles, and the two bioactive compounds are used for promoting fibrocartilage differentiation. The double-drug nano delivery system provides continuous release of emodin and GDF, synergistically regulates severe inflammation and oxidation environments, and promotes in-vitro and in-vivo fibrous cartilage regeneration. Benefited from this, according to the invention, a three-dimensionally printed meniscus-shaped PCL framework is combined with the composition by using cartilage-specific matrix hydrogel, a stability-enhanced meniscus replacement model is constructed, a cartilage immune microenvironment is synergistically adjusted, and successful repair of animal (rabbit) full meniscus replacement is realized.

The application belongs to the technical field of biological medicine, and relates to application of a mannose peptide in preparation of an alcoholic gastric ulcer medicine. The application discloses that the mannose peptide can significantly relieve bleeding lesions and ulcer conditions of an alcoholic gastric ulcer, and the mechanism comprises the following aspects: reducing active oxygen generated by alcohol toxicity, improving body oxidation stress by improving the activity of antioxidant enzymes of gastric tissue; regulating the inflammation response of the body by regulating the Akt / NF-kappa B pathway; inhibiting the Bax-related apoptosis pathway to protect gastric mucosal cells from alcohol-induced apoptosis, so as to protect the integrity of the gastric mucosa; regulating the intestinal flora disorder caused by alcohol intake, and preventing acute alcoholic gastric ulcer by improving the intestinal flora composition of the alcoholic gastric ulcer. The application widens the application of the mannose peptide, and provides more solutions for the prevention or treatment of acute alcoholic gastric ulcer.

The invention belongs to the field of pharmaceutical preparations. The invention relates to lipid nanoparticles modified by probiotic coupled galactose and coated with diammonium glycyrrhizinate, L-arginine and copper tannic acid nano enzyme as well as a preparation method and application of the lipid nanoparticles. The lipid nanoparticles prepared by coupling and wrapping the diammonium glycyrrhizinate, the L-arginine and the copper tannic acid nano-enzyme with the probiotics have good biocompatibility, the preparation method is simple, the particle size distribution of the nanoparticles is uniform, the half-life period of a medicine circulating in a body can be prolonged, the inherent beneficial functions of the probiotics are cooperated, and the bioavailability of the medicine is improved. The potential application value is realized in the fields of treating the metabolic dysfunction related steatohepatitis and the like.

This invention provides a post-makeup, post-makeup removal, and post-sun exposure repair composition containing purslane extract and its application, belonging to the field of cosmetic technology. The composition of this invention comprises the following components in parts by weight: 1.0–10.0 parts purslane extract, 1.0–8.0 parts fermented mung bean sprout extract, 0.1–3.0 parts immortelle extract, and 0.1–3.0 parts ectoine. This invention uses purslane extract as a soothing and repairing base; fermented mung bean sprout extract to improve oxidative stress after makeup, makeup removal, and sun exposure; immortelle extract to improve redness, burning sensation, and discomfort after irritation; and ectoine to enhance the skin's stress resistance and tolerance. These four components synergistically form a complex care system of "soothing redness—antioxidant stabilization—plant repair—anti-stress tolerance," which can effectively improve problems such as redness after makeup, tightness after makeup removal, burning sensation, stinging, dryness, and unstable skin barrier after sun exposure. The composition of this invention is mild and can be prepared into various dosage forms such as essence water, wet compress water, spray, gel mask, gel, sheet mask, cream mask, serum, lotion, etc., which are suitable for industrial production and daily skin care use.

The invention relates to application of rhizoma bletillae polysaccharide in preparation of a medicine for treating gastric mucosal lesion and a preparation method of the rhizoma bletillae polysaccharide, the rhizoma bletillae polysaccharide is prepared, and when an organism intakes excessive ethanol, the rhizoma bletillae polysaccharide can achieve the effect of preventing acute alcoholic gastric mucosal lesion by protecting the integrity of gastric mucosa. By regulating expression disorder of inflammatory factors, the inflammatory factors can be maintained at a normal level, so that a preventive protection effect on gastric mucosal lesion is achieved; a foundation is laid for further exploration of a repair mechanism of the rhizoma bletillae polysaccharide on gastric mucosal lesion, and an experimental basis is provided for further development and application of rhizoma bletillae polysaccharide health food or medicine.

The invention relates to an application of a sargassum fusiforme aqueous extract, in particular to an application of the sargassum fusiforme aqueous extract in preparation of a medicine for treating type 2 diabetes mellitus and an application of the sargassum fusiforme aqueous extract in preparation of a medicine for improving cell oxidative stress and insulin resistance. The sargassum fusiforme aqueous extract is prepared by the following steps: soaking sargassum fusiforme in water, desalting, washing and removing impurities for later use; adding deionized water into the sargassum fusiforme, and heating at 100 DEG C in a pressure cooker; cooling the tap water to normal temperature after heating is finished, collecting the solution, centrifuging to take supernate, concentrating the supernate, and freeze-drying to obtain the sargassum fusiforme aqueous extract SFE. The prepared sargassum fusiforme aqueous extract can effectively promote consumption of IR-HepG2 extracellular glucose, effectively improve the oxidative stress state of IR-HepG2 cells and remarkably reverse down-regulation of key proteins (HO-1 and Keap1) in insulin resistance MOD group cells, can be used for preparing drugs for treating type 2 diabetes mellitus, and has the advantages of being safe and free of toxic and side effects.

The invention belongs to the technical field of traditional Chinese medicines, and particularly provides a traditional Chinese medicine composition for treating hepatic fibrosis and a preparation method thereof. According to the invention, astragalus membranaceus, vinegar-processed curcuma zedoary, salvia miltiorrhiza, moutan bark, radix paeoniae rubra, angelica sinensis, curcuma aromatica, fructus amomi, bran-fried atractylodes macrocephala koidz, poria cocos, fingered citron, vinegar-processed bupleurum chinense and honey-fried licorice root are adopted as raw materials and are subjected to proper weight proportioning; wherein the astragalus membranaceus is a monarch drug, and the vinegar curcuma zedoary, the salvia miltiorrhiza, the moutan bark, the red paeony root, the angelica sinensis, the radix curcumae, the fructus amomi and the bran-fried rhizoma atractylodis macrocephalae are The vinegar bupleurum chinense, fingered citron and poria cocos are used as adjuvant drugs, and the liquorice is used as conductant drug; all the medicines are combined to achieve the effects of replenishing qi to invigorate the spleen, soothing the liver, regulating qi and promoting blood circulation to remove blood stasis. Under the synergistic effect of all the medicine components, the traditional Chinese medicine composition has a good curative effect on liver fibrosis, especially liver fibrosis common clinically with liver depression, spleen deficiency and blood stasis syndromes, and is small in toxic and side effect and worthy of clinical application and popularization.

The invention discloses a lactobacillus rhamnosus CQFP202457 and application of the lactobacillus rhamnosus CQFP202457 and ellagic acid in relieving exercise fatigue, and belongs to the technical field of microorganisms. The preservation number of the lactobacillus rhamnosus CQFP202457 is CGMCC (China General Microbiological Culture Collection Center) No. 29784. The composition provided by the invention contains ellagic acid and lactobacillus rhamnosus CQFP202457, and can significantly prolong the exercise exhaustion time, reduce the content of fatigue-related metabolites in serum, improve the total antioxidant ability of serum, liver and skeletal muscle and the antioxidant enzyme gene expression level, and improve the exercise-induced liver and skeletal muscle tissue damage. The strain and the composition thereof provided by the invention can be used as exercise synbiotics for preparing products for relieving exercise-induced fatigue, improving exercise performance, reducing exercise-induced oxidative stress or relieving exercise-induced muscle injury.

The invention discloses a preparation method and application of an acid-responsive aggregated carrot-source nano antioxidant, and belongs to the technical field of medical treatment. The carrot source nano antioxidant is prepared by five steps of cleaning, crushing, filtering, gradient centrifuging and extruding, can be applied to improvement of oxidative stress, promotion of good bone remodeling and effective treatment of osteoporosis, and has good practical application value.

The application discloses a screening method of a lipid-lowering peptide of Suaeda salsa and target point prediction, relates to the technical field of bioactive peptide processing and application, and discloses that the amino acid sequence of the lipid-lowering peptide is GGPSWNVK; the lipid-lowering target points are microsomal triglyceride transfer protein, 3-hydroxy-3-methylglutaryl coenzyme A reductase and proprotein convertase subtilisin 9; the active peptide GGPSWNVK with a clear lipid-lowering target point is screened from Suaeda salsa, stable combination of the active peptide with the three target points of MTP, HMGR and PCSK9 is verified through molecular docking and molecular dynamics simulation, the active peptide has low binding energy and good safety, can effectively improve lipid accumulation and oxidative stress, and provides an important candidate molecule for development of a new lipid-lowering drug, a special medical food and a health product.

This invention discloses a method for establishing a largemouth bass model susceptibility to iron overload pathogens using inorganic iron, belonging to the field of biotechnology. The method includes: a) after acclimatizing 4-5cm largemouth bass to a normal diet for one week, the normal diet is replaced with a FeSO4·7H2O-supplemented diet (FeSO4·7H2O supplementation amount: 800-3200 mg / kg), while the control group continues to be fed a normal diet; b) after feeding the FeSO4·7H2O-supplemented diet for 14-56 days, the mortality rate from Aeromonas hydrophila infection increases, indicating successful establishment of the largemouth bass model susceptibility to pathogens. This method for establishing a largemouth bass model susceptibility to iron overload pathogens using inorganic iron has advantages such as simple operation, high success and survival rates, good stability, and obvious pathological characteristics.

The invention relates to a phloroglucinol compound, separation and application of the phloroglucinol compound in preparation of drugs for resisting acute myeloid leukemia, and belongs to the technical field of medicines. The novel compound long-column polycycline A separated from the plant hypericum has good anti-tumor activity, especially has good anti-tumor activity on AML cell lines, and can be used as a lead compound for development of anti-AML drugs. The invention provides an alternative compound for research and development of new drugs for resisting acute myeloid leukemia cells, and has very important significance for development and utilization of natural product resources.

The invention discloses an application of a mulberry flavonol extract in preparation of a hypoglycemic drug, and belongs to the technical field of biology. According to the application of the mulberry flavonol extract in the preparation of the hypoglycemic drug, an insulin resistance model is established by utilizing HepG2 cells, and the mulberry flavonol extract acts on IR-HepG2 cells; the influence of the mulberry flavonol extract on cell glucose consumption, glycogen synthesis, glycometabolism, lipid metabolism, oxidative stress and glycolysis key enzyme gene expression quantity is analyzed, and the insulin resistance improving effect of the mulberry flavonol extract is verified from the cell level.

[Problem] The purpose of the present invention is to provide a jejunum MDA concentration decrease-promoting agent, 8-OHdG concentration decrease-promoting agent, ZIP4 concentration increase-promoting agent, or serum zinc concentration increase-promoting agent so as to be able to promote a jejunum MDA concentration decrease, a jejunum 8-OHdG concentration decrease, a jejunum ZIP4 concentration increase, and a jejunum serum zinc concentration increase, and to provide a jejunum MDA concentration decrease-promoting agent, a jejunum 8-OHdG concentration decrease-promoting agent, a jejunum ZIP4 concentration increase-promoting agent, and a jejunum serum zinc concentration increase-promoting agent. The oxidative stress state is improved. [Solution] The present invention has, as an active ingredient, 3, 5-dihydroxy-4-methoxybenzyl alcohol (3, 5-dihydroxy-4-methoxybenzyl alcohol), and has an 8-OHdG concentration reduction promoting effect that reduces the 8-OHdG concentration in the jejunum.

Application of a multifunctional supramolecular nanoplatform drug: The application of a multifunctional supramolecular nanoplatform in the preparation of drugs for liver ischemia-reperfusion injury. The multifunctional supramolecular nanoplatform is a GalAC4A supramolecular carrier loaded with naringenin (NAR). The multifunctional supramolecular nanoplatform is prepared from naringenin (NAR), galactose (Gal), and CAC4A from azocalixarene. The multifunctional supramolecular nanoplatform is a NAR@GalAC4A nanocomposite. The multifunctional supramolecular nanoplatform achieves hepatocyte-specific targeting through desialyl glycoprotein receptor-mediated endocytosis. This invention proposes a novel "receptor recognition-hypoxia response-synergistic therapy" three-pronged design strategy, successfully constructing a GalAC4A supramolecular carrier loaded with naringenin (NAR) to form a NAR@GalAC4A nanocomposite.

The invention provides a morchella polysaccharide MP1-1, and also provides a preparation method and application of the morchella polysaccharide. The research finds that the morchella esculenta polysaccharide has a good anti-fatigue effect.

This invention discloses the application of *Lactobacillus mucosa* vesicles in the preparation of drugs for treating MAFLD, belonging to the field of microbial medicine. The *Lactobacillus mucosa* strain is deposited at the China General Microbiological Culture Collection Center (CGMCC) with accession number CGMCC NO.37136, and its 16S rDNA gene sequence is shown in SEQ ID NO: 1. The *Lactobacillus mucosa* strain was isolated from fecal samples of healthy adults. This strain exhibits significant antioxidant, anti-inflammatory, and lipid metabolism regulating activities in vitro. Its secreted EVs are non-cytotoxic and non-immunogenic in vivo, and animal experiments have verified its good in vivo safety and liver-targeted enrichment characteristics.