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1 results about "Coenzyme A" patented technology
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Coenzyme A (CoA, SCoA, CoASH) is a coenzyme, notable for its role in the synthesis and oxidation of fatty acids, and the oxidation of pyruvate in the citric acid cycle. All genomes sequenced to date encode enzymes that use coenzyme A as a substrate, and around 4% of cellular enzymes use it (or a thioester) as a substrate. In humans, CoA biosynthesis requires cysteine, pantothenate (vitamin B₅), and adenosine triphosphate (ATP).
Study on the sensing platform of SC-PNPs modified nano calcium carbonate and its application in skin repair
The application provides a single-chain super-small fluorescent polymer nanodot modified Bacillus subtilis derived nanometer calcium carbonate composite material (SC-PNPs@CaCO3) as a high-sensitivity fluorescent sensing platform for choline acetyltransferase (ChAT) activity detection. The composite material is synthesized through biological mineralization of Bacillus subtilis, the free radical polymerization method is used to prepare the SC-PNPs with positive charges on the surface, and a stable fluorescent sensing system is constructed through self-assembly. Coenzyme A (CoA) is generated in the ChAT catalytic reaction, which can significantly quench the fluorescent signal of the material, realize high-sensitivity detection of the ChAT activity change, and the detection limit reaches 0.00074 mU / mL. The fluorescent sensing platform can realize real-time monitoring of the ChAT activity change, and reveal the regulation effect of the cholinergic signal pathway in the repair process in a skin repair model. The application provides an innovative technical means for choline acetyltransferase activity analysis, and provides a new research direction for exploring the function of the cholinergic system in skin repair and other physiological and pathological processes.
Owner:NINGBO COLLEGE OF HEALTH SCI