5 results about "Coenzyme A" patented technology

The invention relates to the technical field of agricultural herbicides, and discloses a herbicide suitable for cnidium monnieri planting in southern districts and a preparation method thereof, the herbicide is composed of 4-8% by mass of nicosulfuron, 16-20% by mass of atrazine and 8-12% by mass of quizalofop-p-ethyl, and the balance is water. The mass ratio of nicosulfuron to atrazine is (1: 3)-(1: 5). The nicosulfuron and the atrazine have a dual mechanism of inhibiting the activity of acetolactate synthetase of weeds and blocking photosynthesis, the control effect within 30 days after application reaches 85% or above, gramineae weeds such as digitaria sanguinalis and barnyard grass and broadleaf weeds such as chenopodium album and amaranth can be effectively prevented and removed, only slight phytotoxicity such as transient leaf chlorosis is caused to cnidium monnieri plants, and the effect is remarkable. The quizalofop-p-ethyl inhibits the activity of weed acetyl-coenzyme A carboxylase and blocks fatty acid synthesis, and has a good control effect on green bristlegrass, eleusine indica and other grassy weeds.

The application provides a single-chain super-small fluorescent polymer nanodot modified Bacillus subtilis derived nanometer calcium carbonate composite material (SC-PNPs@CaCO3) as a high-sensitivity fluorescent sensing platform for choline acetyltransferase (ChAT) activity detection. The composite material is synthesized through biological mineralization of Bacillus subtilis, the free radical polymerization method is used to prepare the SC-PNPs with positive charges on the surface, and a stable fluorescent sensing system is constructed through self-assembly. Coenzyme A (CoA) is generated in the ChAT catalytic reaction, which can significantly quench the fluorescent signal of the material, realize high-sensitivity detection of the ChAT activity change, and the detection limit reaches 0.00074 mU / mL. The fluorescent sensing platform can realize real-time monitoring of the ChAT activity change, and reveal the regulation effect of the cholinergic signal pathway in the repair process in a skin repair model. The application provides an innovative technical means for choline acetyltransferase activity analysis, and provides a new research direction for exploring the function of the cholinergic system in skin repair and other physiological and pathological processes.

The invention discloses a synergistic composition containing isoxazoline insecticidal and acaricide, which is composed of a compound I and a compound II, the compound I is CCXN-15-005-S (S configuration) or an agrochemically acceptable salt thereof, and the compound II is CCXN-15-005-S (S configuration) or an agrochemically acceptable salt thereof. The compound II is selected from any one of a nicotinic acetylcholine receptor agonist, a chordinal TRPV channel regulator, an acetyl-coenzyme A carboxylase (ACCase) inhibitor, a mitochondrial electron transfer inhibitor, a calcium-activated potassium ion channel regulator and trifluoroethyl thioether (sulfoxide) or an agrochemically acceptable salt thereof. The synergistic composition can be used for preventing and treating pests and harmful mites of thysanoptera, hemiptera and acarus and has a wider agricultural application prospect.

This invention provides compounds of Formulae (IA), (IB), (IC), (ID), (IE), (IF), (IG), (IH), (IJ), (IK), (IL), (II), (III), (IIIA), and (IIIB); pharmaceutically acceptable salts and solvates thereof; and compositions thereof. This invention further provides methods for treating a disease, including but not limited to, liver disease or an abnormal liver condition; cancer (such as hepatocellular carcinoma or cholangiocarcinoma); a malignant or benign tumor of the lung, liver, gall bladder, bile duct or digestive tract; an intra- or extra-hepatic bile duct disease; a disorder of lipoprotein; a lipid-and-metabolic disorder; cirrhosis; fibrosis; a disorder of glucose metabolism; a cardiovascular or related vascular disorder; a disease resulting from steatosis, fibrosis, or cirrhosis; a disease associated with increased inflammation (such as hepatic inflammation or pulmonary inflammation); hepatocyte ballooning; a peroxisome proliferator activated receptor-associated disorder; an ATP citrate lyase disorder; an acetyl-coenzyme A carboxylase disorder; obesity; pancreatitis; or renal disease.

The invention discloses an innovative histone acetylation transferase ultraviolet colorimetric sensor which is based on a silver ion (Ag < + >) and 3, 3 ', 5, 5'-tetramethyl benzidine (TMB) system. Under the action of Ag < + >, TMB is oxidized into a blue oxidized form (oxTMB), and shows a strong ultraviolet absorption peak at the wavelength of 652nm, so that the visual quantitative detection of Ag < + > is realized. When coenzyme A (CoA) is added to form a CoA-Ag < + > coordination polymer, or through the catalytic action of histone acetylated transferase (HAT p300), the concentration of free Ag < + > is reduced, the oxidation effect on TMB is correspondingly inhibited, the color of a solution is changed from blue to colorless, and then reduction of absorbance is observed at 652 nm. The process further analyzes and detects HAT p300 in breast cancer cells, compared with normal cells and high expression of HAT p300 in cancer cells, a simple, convenient, rapid, high-sensitivity and high-selectivity unmarked visual analysis strategy is provided, and the method is used for researching the histone acetylation process and has important scientific research and application value.