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Application of N-acetylserotonin in preparation of drug for treating intraventricular hemorrhage

A technology of serotonin and ventricles, applied in the field of biomedicine

Inactive Publication Date: 2020-07-07
SUZHOU UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Considering that subarachnoid hemorrhage is significantly different from intraventricular hemorrhage in terms of bleeding site and cause, and is two different types of intracranial hemorrhage, whether N-acetyl serotonin can exert neuroprotective effects in the intraventricular hemorrhage model and related molecules The mechanism has not been reported in the literature

Method used

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  • Application of N-acetylserotonin in preparation of drug for treating intraventricular hemorrhage
  • Application of N-acetylserotonin in preparation of drug for treating intraventricular hemorrhage
  • Application of N-acetylserotonin in preparation of drug for treating intraventricular hemorrhage

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Experimental program
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Embodiment 1

[0039] (1) Drug preparation and administration method: referring to the previous research basis and preliminary experimental results, NAS (Sigma-Aldrich Company, product number: A1824) was prepared into three concentrations: 5 mg / kg, 10 mg / kg and 15 mg / kg. The preparation method is as follows: according to the instructions, first use absolute ethanol to dissolve NAS at a concentration of 50 mg / ml, and then use 0.9% saline (saline) to dilute to 5, 10 and 15 mg / kg for use. NAS was administered by intraperitoneal injection 1 h after IVH, once a day until the day before sacrifice. And use TrkB specific antagonist ANA-12 (Sigma-Aldrich company, product number: SML0209), to prove whether ANA-12 can eliminate the influence of NAS on p-TrkB protein expression after IVH, dilute through 0.9% normal saline (saline) into 0.5mg / kg standby. The preparation method of Hemin is as follows: use PBS to make Hemin solid powder (Sigma-Aldrich company, product number: H9039) into 25mmol / L Hemin so...

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Abstract

The invention discloses application of N-acetylserotonin in preparation of a drug for treating intraventricular hemorrhage and belongs to the technical field of biomedicines. The invention discloses and proves that the N-acetylserotonin can relieve cerebral edema and blood brain barrier destruction caused by the intraventricular hemorrhage; it is discovered that the N-acetylserotonin has an improvement effect on sports and learning memory disorder induced by the intraventricular hemorrhage; it is disclosed that a protection effect of the N-acetylserotonin is related to relief of oxidative stress, inhibition of ferroptosis and improvement on synaptic plasticity; and in addition, in a primary cortex neuron haemorrhage cell model, it is proven that the NAS can obviously inhibit neuron death induced by Hemin and relieve axon injury. According to the application, a scientific basis is provided for utilizing the N-acetylserotonin to treat the intraventricular hemorrhage as a novel drug.

Description

technical field [0001] The invention relates to the application of N-acetyl serotonin in the preparation of medicines for treating intraventricular hemorrhage, and belongs to the technical field of biomedicine. Background technique [0002] Intraventricular hemorrhage (IVH) refers to the syndrome caused by the rupture of intracranial blood vessels caused by non-traumatic factors and blood entering the ventricular system. Its prognosis is poor, disability rate and mortality rate are high, especially in patients with severe intraventricular hemorrhage, the mortality rate can reach 80%. As a common type of intracranial hemorrhage, the incidence of IVH in patients with primary intracranial hemorrhage is as high as 50%, and it is an important predictor for evaluating the prognosis of intracranial hemorrhage. Intraventricular hemorrhage is an independent factor for the poor prognosis of intracranial hemorrhage, and the prognosis of survivors is poor. It is an emergency and severe...

Claims

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Application Information

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IPC IPC(8): A61K31/4045A61P9/10A61P25/28A61P25/00
CPCA61K31/4045A61P9/10A61P25/28A61P25/00
Inventor 罗承良李倩倩芮同宇宋顺晨陶陆阳
Owner SUZHOU UNIV
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