3results about How to "Regulate immunity" patented technology

The invention belongs to the technical field of food, and relates to application of breast milk oligosaccharide in regulating brain immunity. Specifically, the invention relates to the non-therapeutic purpose of adjusting brain immunity by adjusting polarization of microglial cells M1 / M2, and the breast milk oligosaccharide is any one of 3-fucosyllactose, lactose-N-tetraose, lactose-N-neotetraose, 3 '-sialic acid lactose and 6'-sialic acid lactose. Research results show that a specific variety of breast milk oligosaccharides (especially 3-FL) can obviously inhibit the generation of neurotoxic factors NO, inflammatory factors TNF-alpha and IL-1beta in microglial cells, and promote the generation of anti-inflammatory cytokines IL-10 in the microglial cells, so that the state of the microglial cells is improved, damage repair is promoted, and the microglial cells are prevented from being damaged. Therefore, the effect of regulating brain immunity is achieved.

The invention discloses a composite probiotic preparation for treating secretory otitis media, comprising: kumiss-like lactobacillus, long bifidobacterium and other acceptable drugs or food excipients. The kumiss-like lactobacillus is kumiss-like lactobacillus ZW3, which has been deposited in the strain collection center of the Institute of Microbiology, Chinese Academy of Sciences on December 18, 2008, with a deposit number of CGMCC2809. The long bifidobacterium is preferably CGMCC 15014. The composite probiotic preparation of the invention has precise ingredients and is safe, and is particularly effective in treating secretory otitis media.