202 results about "Ginkgo Biloba Leaf Extract" patented technology

The present invention relates to a dispersion tablet preparation containing ginkgo leaf extract and its preparation method, in which for one weight portion of extract said dispersion tablet also contains 0.5-10 weight portions of filling agent, 0.1-5 weight portions of disintegrant, 0.01-0.1 weight portion of lubricant and 0.01-0.1 weight portion of adhesive. Said invented medicine dispersion tablet mainly is used for curing diseases of cardiovascular system, and it is characterized by that it is placed in the warm water with 37 deg.C, it can be completely disintegrated within 3 min.

The invention discloses a natural anti-wrinkling anti-aging skin care composition and an application thereof in a cosmetic. The natural anti-wrinkling anti-aging skin care composition comprises the following components in percentage by weight: 1-12% of oat seed oil, 1-15% of cananga odorata oil, 1-10% of radix ophiopogonis extract, 1-13% of ginkgo biloba extract, 1-12% of adenophora stricta extract, 1-11% of Chinese herbaceous peony extract, 1-12% of ginger root extract, 1-15% of chayote extract, 1-10% of centella extract, 1-13% of salvia miltiorrhiza root extract, 1-13% of turmeric root extract and 1-10% of red wine extract; the addition amount of the natural anti-wrinkling anti-aging skin care composition in the cosmetic is 2-10wt%. The natural anti-wrinkling anti-aging skin care composition can be used for effectively scavenging free radicals, reducing fine lines on skin and delaying skin aging, can be applied to various cosmetics as an additive, is good in stability, contains no synthetic chemical substance and is safe and non-irritant in ingredients.

The invention discloses an eye protection Chinese medicinal composition with health care and treatment effects. The Chinese medicinal composition comprises the following components in parts by weight: 5-20 parts of ginkgo biloba leaf extract, 5-10 parts of ginseng, 5-10 parts of Chinese angelica, 5-10 parts of buerger pipewort flower, 5-20 parts of astragalus, 5-10 parts of honeysuckle flower, 5-10 parts of cicada shell, 5-15 parts of Chinese wolfberry and 5-10 parts of mint. The Chinese medicinal composition has the effects of relieving asthenopia, eliminating uncomfortable symptoms such as dryness, redness and swelling of eyes, blurred vision and the like, dispelling pouch, black eye, eye wrinkle and the like.

The invention discloses a health-care food having functions of assisting antidiabetics and assisting antiatheroscloresis, mainly made of propolis, balsam pear extract, ginkgo biloba leaf extract, chromium picolinate and olive oil according to a certain weight proportion. The health-care food can be prepared into as any one of the following forms for taking easily: hard capsule, tablet, oral liquidand particularly soft capsule. The health-care food can adjust internal secretion, promote the circulation of blood, reduce the viscosity of blood and has functions of assisting antidiabetics and assisting antiatheroscloresis.

The invention aims at providing a health product for preventing and treating senile dementia. The health product comprises the following components in parts by weight: 3-7 parts of fructus alpiniae oxyphyllae powder, 8-12 parts of lumbricus protein, 6-14 parts of ginkgo biloba extract, 8-12 parts of lucid ganoderma extract, 3-7 parts of cortex cinnamomi extract, 3-7 parts of phosphatidylserine, 12-18 parts of gamma-aminobutyric acid, 3-7 parts of L-tryptophan, 1-3 parts of niacin, 3-7 parts of vitamin C, 2-6 parts of vitamin E, 0.3-0.7 part of vitamin B6, 0.1-0.4 part of vitamin B12 and 0.005-0.015 part of folic acid. The dosage form of the finally formed drug can be powder, tablet or capsule. The health product for preventing and treating senile dementia is prepared from pure plants or extracts, so that no toxic and side effects are caused; and the health product for preventing and treating senile dementia is simple in prescription, low in cost and good in effect.

The invention relates to a facial mask containing a punica granatum fruit extract and a preparation method of the facial mask, wherein the facial mask is prepared by blending functional cosmetic substances with water. The facial mask consists of the following raw materials: de-ionized water, glycerol, the punica granatum fruit extract, hyaluronic acid, lipoic acid, a ginkgo biloba leaf extract, ceramide 3, an abelmoschus esculentus fruit extract, carbomer, triethanolamine and phenoxyethanol; and the punica granatum fruit extract can be used for effectively neutralizing free radicals, inhibiting the formation of melanin, promoting metabolism and eliminating toxins. The facial mask disclosed by the invention is effective on whitening, moisturizing and resisting wrinkles, and nutritional ingredients of the facial mask can be absorbed by skin, so that a beauty effect is achieved. The facial mask can be used for a long time; and the facial mask is free from any toxic and side effects and is safe and reliable.

The invention discloses a gingko drop pill for prevention and cure of cardio-cerebrovascular diseases, which mainly solves the problem of slow effect caused by the slow absorption rate of the ginkgo tablet during the disease treatment process. The drop pill comprises the following constituents with parts by weight, ginkgo leaf extract 1-60 parts, red sage root extract 0-60 parts, ground substance 20-80 parts. The content of active bilobanone ingredient in the medicament is 1-60%, the content of bilobalide is 0.5-6%.

The invention relates to a pharmaceutical composition containing one of angiotensin converting enzyme inhibitors (ACEI) and active metabolites or medical salt thereof in medicine dosage, one or more of B vitamins in medicine dosage, ginkgo biloba extracts (GbE) in medicine dosage and a medical carrier, and relates to application of the pharmaceutical composition in preparing medicines for treating, preventing or retarding stroke. The medicines prepared by the pharmaceutical composition provided by the invention are superior to the simple antihypertensive drugs in the aspect of treating, preventing or retarding stroke and facilitate the patients to take. The invention belongs to the pharmaceutical field.

The present invention discloses a medicine composition containing rhodiola root extract and ginkgo leaf extract for curing angiocardiopathy and cerebrovascular diseases of cerebral apoplexy, coronary heart disease and angina pectoris, etc. Said medicine composition can be made into oral tablet, capsule, granules and injection preparation.

The invention relates to a water-soluble ginkgo leaf extract and its preparation technology, The method of the invention comprises: taking common ginkgo biloba as a raw material, mixing with acetone and extracting, concentrating, diluting by adding water, cryoprecipitating, filtering, performing a gradient elution to a filtrate through macroporous adsorption resin, carrying out an alcohol precipitation by ethanol with high purity, water extraction and cryoprecipitating, concentrating, drying to obtain the water-soluble ginkgo leaf extract, wherein the content of total flavonol glycoside is greater than or equal to 27%; the content of lactone content is 9%-12%, wherein the content of Terpene Lactones A is greater than or equal to 2.1%, the content of Terpene Lactones B is greater than or equal to 0.9%, the content of Terpene Lactones C is greater than or equal to 1.2%, and the lactone ratio of GA:GB:GC is close to 7:3:4; the water-solubility is greater than and equal to 10%; the ginkgolic acid is less than and equal to 1ppm, which can be taken as a raw material used for injection. The invention has the advantages of simple production technology, high and stable product quality, high finished product yield, low cost and good economic benefit.

The invention provides a biological deodorant spray for pets as well as a preparation method and an application of the biological deodorant spray. The biological deodorant spray for the pets is prepared from main raw materials as follows: a micro-ecological agent and plant extract, wherein the micro-ecological agent contains one or more of a bacillus subtilis solution, a bacillus licheniformis solution, a bacillus coagulans solution, a lactobacillus acidophilus solution, a enterococcus faecalis solution and saccharomyces cerevisiae solution; the plant extract contains one or more of yucca extract, aloe extract, agastache rugosa extract, honeysuckle extract, ginkgo biloba leaf extract and tea polyphenol. The deodorant spray is safe, green, non-toxic and residue-free, has fermentation aromaand cannot cause secondary pollution to the environment, meanwhile, under the joint action of the micro-ecological agent and the plant extract, stink of excrement can be effectively reduced, air is purified, and hair odor of the pets can be removed.

The invention relate to a ginkgo biloba leaf extract injection quality control method based on quantitative analysis of multi-components by a single marker and a fingerprint spectrum. The method comprises the steps that rutin is adopted as a reference sample, flavonols kaempferol-3-O-rutinoside, isorhamnetin-3-O-rutinoside, kaempferol-3-O-rhamnose-2-glucoside, quercetin-3-O-rhamnose-2-O-(6-O-p-hydroxy cinnamoyl) glucosyl and kaempferol-3-O-rhamnose-9-O-6-O-(p-hydroxy cinnamoyl) glucosyl are quantified through quantitative analysis of multi-components by a single marker, and the ginkgo biloba leaf extract injection batched quality stability is controlled through the fingerprint spectrum. The problem that ginkgo biloba leaf extract injection multi-component quantification and multi-index quality control lack reference samples is solved, and the quality of the ginkgo biloba leaf extract injection is ensured while the product batched quality stability is controlled through the fingerprint spectrum.

The present invention belongs to the technical field of cosmetics, and particularly relates to a whitening and anti-aging face cleaner and a preparation method thereof, wherein the whitening and anti-aging face cleaner comprises lauric acid, glycerol, potassium hydroxide, squalane, sodium lauroyl glutamate, glyceryl monostearate, polyethylene glycol, a eucommia ulmoides extract, a horseradish tree leaf extract, a ophiopogon japonicus extract, a ginkgo biloba leaf extract, EDTA disodium, methylparaben, essence and water. The whitening and anti-aging face cleaner of the present invention has characteristics of mildness, good skin affinity, safety and no stimulating, and further has effects of deep skin cleaning, blood circulation promoting, moisturizing, whitening, and aging delaying.

The invention belongs to the Chinese materia medica preparation field, disclosing a ginkgo biloba leaf extract oral lyophilisate and a method for preparing the same. Main active ingredient of the oral lyophilisate is ginkgo biloba leaf extracts which are added with an appropriate amount of excipient to be prepared into a solution. The solution is subject to vacuum freeze drying to form the oral lyophilisate. The drug of the invention has the advantages of excellent mouth feeling, rapid disintegration, desirable mechanical strength, convenient use, etc.

The invention discloses a serum-free medium for mesenchymal stem cells (MSCs). The serum-free medium comprises a basic medium, recombinant human insulin, cholesterol, recombinant fibronectin, sodium linoleate, recombinant human transferrin, perilla seed protein, stilbene glycoside, resveratrol and a ginkgo biloba extract. According to the serum-free medium, the recombinant human transferrin and the plant protein perilla seed protein are added to be compounded, the stilbene glycoside, the resveratrol and the ginkgo biloba extract are compounded for use, on one hand, the serum-free medium has effects of resisting oxidation and scavenging free radicals and contributes to keeping cell activity; and on the other hand, the serum-free medium still keeps a higher proliferation speed and a better growth state of cells under the condition that exogenous serum is not added. The serum-free medium comprises clear components, the repeatability, accuracy and stability of an experiment can be improved, raw materials are easy to obtain, and the preparation cost of the serum-free medium is effectively reduced. The invention further provides a preparation method of the serum-free medium, and the preparation process is convenient and easy to operate.

The invention discloses a method for separating and purifying GA (Ginkgolide A), GB (Ginkgolide B) and bilobalide from a folium ginkg extractive. The method comprises the following steps that 1), ethyl acetate is adopted for extraction; 2), a lower alcohol-water mixed solvent is adopted for leaching; an alcohol leaching extraction solution and an undissolved substance are obtained; 3), the undissolved substance is subjected to silica gel column chromatography separation to form GA and GB; and 4), the alcohol leaching extraction solution is concentrated till no alcohol exists, cooled and filtered; a mother solution is concentrated to dryness, and then subjected to crystallization with 30-35% of methanol for 3-5 times; and bilobalide is obtained. The method for separating and purifying GA, GB and bilobalide is simple in process route and is suitable for industrial production. The purity of GA, GB and bilobalide obtained by separation and purification is greater than 98%; transfer rates of GA, GB and bilobalide are greater than 80%; the yield is high; the production cost is low.

This invention provides a ginkgo biloba leaf extract preparation method, and belongs to the technical field of extraction and separation of natural plant effective ingredients. The preparation method is based on fresh ginkgo biloba leaf as a raw material, and includes the following steps: (1) the pretreatment of ginkgo biloba leaf into ginkgo biloba leaf powder; (2) extraction and filtering of the ginkgo biloba leaf powder to obtian a leaching solution; (3) coarse filtration and suction filtration of the leaching solution to obtain filtrate; (4) distillation and concentration of the filtrate; and (5) vacuum drying and purification of the concentrated filtrate to obtain a ginkgo biloba extract; the ginkgo biloba extract contains flavonoids and lactone. The preparation method simplifies the production process, and is less in steps, simple in operation, free of use of a lot of organic solvent, high in recovery rate, and non-pollution.

The invention discloses a composition for improving the immunity. The composition comprises the following components in parts by weight: 200-300 parts of natto freeze-dried powder, 10-40 parts of a ginkgo biloba extract and 40-80 parts of sea-buckthorn powder. The invention further discloses a method for preparing a plant capsule by using the composition. As the natto freeze-dried powder, the ginkgo biloba extract and the sea-buckthorn powder are taken as main raw materials, and algal polysaccharides are taken as a plant capsule material for preparing the capsule, due to the assistant functions of the three components, the purposes of stabilizing in-vivo environments of human bodies, prompting immunity of human body fluid and cells, and removing excessive free radicals in human bodies can be achieved, and the immunity function can be effectively improved.

The invention provides a pseudo-ginseng triol set and ginkgo biloba leaf extract composition, a preparation thereof and application thereof. The composition comprises the following components in percentage by weight: 50 to 75 percent of pseudo-ginseng triol set of which the content of Rg1 is more than 55 percent, and 25 to 50 percent of ginkgo biloba leaf extract of which the content of ginkgo flavone is more than 24 percent. The preparation product of the composition comprises the following active components: the pseudo-ginseng triol set of which the content of Rg1 is more than 55 percent, and the ginkgo biloba leaf extract of which the content of the ginkgo flavone is more than 24 percent. The composition is nontoxic, does not have mutagenic action, is safe, has relatively higher stability, can be applied to insomnia, forgetfulness and aftereffect, which are caused by insufficient brain excitability, insufficient brain nutrition supply, insufficient brain oxygen supply and fatigue, can be used for treating or regulating nervous system diseases, can be prepared into preparations acceptable on medicaments or foods, and also can be prepared into various new medicaments and functional foods.

The invention relates to the technical field of wastewater treatment in the field of ginkgo biloba extracts and in particular to wastewater treatment ICBB process and device in a ginkgo biloba extract extracting process. The wastewater treatment ICBB process in the ginkgo biloba extract extracting process, provided by the invention, comprises regulating and homogenizing treatment, DSIC (disperse solubleness inorganic coagulant) coagulation-sedimentation treatment, AOPs (advanced oxidation processes), DSBB (disperse solubleness biological bacteria), anaerobic treatment, hydrolytic acidification treatment, aerobic treatment, BAF (biological aerated filter) treatment, DS terminal treatment and the like, wherein the DS terminal treatment step comprises the following sub-steps: adding a coagulant under the condition of stirring, and regulating the pH value of wastewater to be 8-11.5, wherein the coagulation time is 5-30 minutes, and the sedimentation time is 20-90 minutes; discharging the wastewater subjected to terminal treatment into a municipal wastewater pipe network. According to the wastewater treatment ICBB process disclosed by the invention, the effluent stability can be guaranteed, up-to-standard discharge or recycling of the water is realized, and the process is convenient in operation and management, high in treatment efficiency, low in investment, low in operating cost, high in adaptability and high in stability.

The invention belongs to the technical field of food production, and in particular relates to functional food for preventing and treating cardiovascular and cerebrovascular diseases and a preparation method thereof. The functional food for preventing and treating cardiovascular and cerebrovascular diseases comprises the following components by weight: 10%-20% of nattokinase, 10%-20% of nitric oxide, 5%-10% of coenzyme Q10, 30%-50% of a red yeast rice extractive and 20%-25% of a ginkgo biloba extractive. Functional components with good effects in resisting cardiovascular and cerebrovascular diseases are combined scientifically and rationally; the functional food on the basis of dissolving thrombus, garbage and toxins deposited in blood vessel can enhance the elasticity and permeability of blood vessels, so as to reach the goals of clearing blood lipids and reducing blood pressure; and the coenzyme Q10 added in the functional food can protect the heart function, and enhance the body's own ability to reduce cholesterol and blood lipid. Through LD50 acute toxicity test, 30 days feeding test, and crowd efficacy observation experiments, the functional food provided by the present invention is proved to be safe, nontoxic and effective.

The invention provides a detection method of a ginkgo dipyridamole injection preparation. The ginkgo dipyridamole injection preparation is prepared from a ginkgo leaf extract and dipyridamole, and thedetection method comprises the items of character, identification, inspection, fingerprint spectrum and content determination. Compared with the prior art, a thin-layer chromatography identificationmethod of the ginkgo biloba extract, limited quantity inspection of 5-hydroxymethylfurfural, total ginkgolic acid and the like, inspection of injection related substances, fingerprint detection and the method for determining the content of rutin, kaempferol-3-O-rutinoside, narcissoside and terpene lactones are additionally arranged, the method for determining the content of the total flavonol glycosides is optimized, the requirement for product quality detection is improved, and the method is more suitable for quality control of drugs in the future and is more beneficial to guaranteeing the drug quality and clinical efficacy.

The invention relates to a ginkgo leaf composition, in particular to a ginkgo leaf composition and application thereof for preparing a ginkgo biloba leaf extract injection. The ginkgo leaf composition is prepared from 25-43% of total flavonol glycosides, 6.5-17% of ginkgolides, 3-5% of bilobalide and smaller than 3 ppm of ginkgoic acid. According to the preparation method of the ginkgo leaf composition, two kinds of resin of DM130 and AB-8 are adopted for adsorption, the harmful ingredient total ginkgolic acid is effectively removed, and anaphylactoid reaction occurrences are reduced; meanwhile, various extracting methods and composite extracting agent repeated extraction are adopted, the target component content is high, the purity is good, and the product quality is improved. The obtained ginkgo biloba leaf extract injection is clear in compositional ratio, good in stability, good in solubility and stable in curative effect and contains few impurities.

The invention discloses a method for preparing a low-acid water-soluble ginkgo biloba extract. The method for preparing the low-acid water-soluble ginkgo biloba extract provided by the invention comprises the following steps: (1) sample loading, namely loading an aqueous solution of the water-soluble ginkgo biloba extract to a ployamide absorption column; and (2) eluting with purified water after the aqueous solution of the water-soluble ginkgo biloba extract passes through the ployamide absorption column, collecting effluent and eluent of the loaded sample, thereby obtaining the low-acid water-soluble ginkgo biloba extract. According to the ginkgo biloba extract prepared by the method disclosed by the invention, process flow steps are very few, the content of ginkgolic acid in the product is less than 1ppm, the content of active ingredients in the product is high, the eluent is concentrated and dried to obtain powder, the mass fraction of general flavones is more than 24%, and the lactone content is more than 6%.