Ginkgo leaf extract oral freeze-dried slices and preparation thereof

Abstract

The invention belongs to the Chinese materia medica preparation field, disclosing a ginkgo biloba leaf extract oral lyophilisate and a method for preparing the same. Main active ingredient of the oral lyophilisate is ginkgo biloba leaf extracts which are added with an appropriate amount of excipient to be prepared into a solution. The solution is subject to vacuum freeze drying to form the oral lyophilisate. The drug of the invention has the advantages of excellent mouth feeling, rapid disintegration, desirable mechanical strength, convenient use, etc.

Description

technical field [0001] The invention provides an oral freeze-dried tablet of ginkgo leaf extract with excellent taste and a preparation method thereof, belonging to the technical field of traditional Chinese medicine preparations. Background technique [0002] At present, as the number of patients with cardiovascular and cerebrovascular diseases increases year by year, people pay more and more attention to the prevention and treatment of cardiovascular and cerebrovascular diseases, especially for middle-aged and elderly people. Ginkgo biloba extract, which is used as a clinical treatment for this disease, has the function of promoting blood circulation and removing blood stasis. , can relax the collaterals, and is mainly used for the prevention and treatment of coronary insufficiency, angina pectoris, myocardial infarction, cerebral embolism, and cerebral vasospasm caused by arteriosclerosis and hypertension, and protects every healthy brain and heart of people. As a traditi...

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Problems solved by technology

However, the traditional ordinary tablet has its own defects that are difficult to solve, such as slow disintegration and slow absorption of the tablet, thus resulting in low bioavailability of ginkgo biloba extract tablets

As a drug taken by the elderly, it cannot achieve the effect of rapid treatment and is convenient for taking

[0003] In order to obtain a convenient and highly bioavailable dosage form clinically, people have developed Ginkgo biloba extract dispersible tablets, Ginkgo biloba extract sustained-release tablets and Ginkgo biloba extract chewable tablets, but these Ginkgo biloba oral preparations are still All there is the defective that is difficult to solve, and the problem of taste correction is not all mentioned when the preparation of the ginkgo leaf extract dispersible tablet described in Chinese patent 02134126.5 and 02116223.9, this brings very big discomfort to the medicine taker

In the preparation of ginkgo biloba extract chewable tablets described in Chinese patent 00126538.5, sweeteners and flavoring agents are all used to solve the mouthfeel, and the excessive use of sweeteners is to make the patient ingest at the same time. The downside of the high amount of carbohydrates, these tablets are absorbed somewhat faster, but not fast enough

Since the orally disintegrating tablet disintegrates in the mouth when taken, it is required to cover up the bad taste of the medicine in the mouth. However, most medicines have an unpleasant taste, especially traditional Chinese medicine. Unacceptable taste, in the field of pharmaceutical preparations, the effect of drug taste masking is mainly achieved through flavoring and taste masking, and flavoring is mainly obtained by adding sweeteners or essences to obtain a good taste; but for drugs with heavy bitterness Adding sweeteners or flavors alone cannot completely cover up the bitterness of the drug, mainly through coating or inclusion of the drug to achieve good results, such as β-cyclodextrin inclusion, solid dispersion technology, or in Methods such as adding flavoring agents to the composition, and the final product must also be verified, such as X-diffraction, differential thermal analysis (DSC), etc., the process is complicated

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