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926 results about "Flavoring Agents" patented technology

Substances added to foods and medicine to improve the taste.

Freshwater fish flavored pet flavoring agent and production method thereof

The invention relates to the technical field of flavor agents, and provides a freshwater fish flavor pet flavor agent and a production method thereof, and the freshwater fish flavor pet flavor agent comprises the following components: freshwater fish, an enzyme preparation, reducing sugar, vitamins, amino acids, auxiliary materials and a herbaceous plant aqueous extract. Through scientific raw material selection, enzymic preparation proportion control, multi-element reducing sugar matching, comprehensive vitamin combination, balanced amino acid screening, herbaceous plant aqueous extract addition, nanotechnology wrapping operation and careful adjustment of auxiliary materials, the pet flavoring agent has the effects of special fragrance, rich taste, good palatability, immunity enhancement and the like.
Owner:BEIJING CENT BIOLOGY CO LTD +2

Upatinib oral solution as well as preparation method and application thereof

The invention relates to the technical field of pharmaceutical preparations, in particular to an upatinib oral solution as well as a preparation method and application thereof. The oral upatinib solution is prepared from the following components in percentage by weight: 0.1%-1.5% of upatinib, 1%-20% of hydroxypropyl beta-cyclodextrin, 0.5%-5% of a flavoring agent and the balance of water, wherein the oral upatinib solution is prepared from the following components in percentage by weight: 0.1%-1.5% of upatinib, 1%-20% of hydroxypropyl beta-cyclodextrin, 0.5%-5% of a flavoring agent and the balance of water; the degree of substitution of the hydroxypropyl beta-cyclodextrin is 4.0 to 5.5. The oral upatinib solution overcomes the problems of overlarge tablet diameter, poor oral compliance, low solubility in water and low bioavailability of upatinib tablets in the prior art, and has the advantages of simplicity in preparation and convenience in use.
Owner:杭州和康药业有限公司

Brine without phosphates and either salt free or low salt

A first brine free of salt and phosphate for treating a food product by injection of the brine into the food product. The brine is formed from an emulsion consisting of water, saltless flavoring and protein. The protein is from the same type of food product as the food product being injected with the brine. A second brine especially for ham with the bine being similar to the first brine, but with a low sodium content of a maximum of 0.5% to 1.0% of the weight of the food product. A third brine for pork bellies without phosphate.
Owner:KEMIN PROTEINS LLC

Neutral calcium supplement preparation

The invention relates to the technical field of medicines, in particular to a neutral calcium supplement preparation. The neutral calcium supplement preparation is prepared from the following raw materials in parts by weight: 20-30 parts of a calcium source, 3-6 parts of multivitamins, 3-5 parts of corn starch, 2-4 parts of magnesium stearate, 4-7 parts of mannitol and 2-5 parts of a flavoring agent, the neutral calcium supplement preparation is prepared by taking a calcium source, multivitamins, corn starch, magnesium stearate, mannitol, a flavoring agent and the like as raw materials. The neutral calcium supplement preparation prepared by the invention not only has better solubility, can relieve the burden of the stomach, but also has excellent easy-to-absorb performance, is convenient to absorb by a human body and has no toxic or side effect, and the quality of the neutral calcium supplement preparation is effectively ensured.
Owner:HUBEI XIANG HU BIOLOGICAL ENG CO LTD

Mouthwash containing agilawood extract and preparation method thereof

The invention discloses mouthwash containing agilawood extract and a preparation method of the mouthwash, and particularly belongs to the technical field of oral cleaning and nursing materials. The mouthwash is prepared from the following components: a composition containing an agilawood extract, a cosolvent, a flavoring agent and a solvent, the composition containing the agilawood extract comprises 5.3 to 7.6 parts of the agilawood extract, 1.1 to 2.5 parts of a cortex dictamni extract, 1.6 to 3.1 parts of a boxthorn root bark extract and 10.0 to 15.0 parts of oriental cherry water. The composition composed of the agilawood extract, the dictamnus dasycarpus root and bark extract, the boxthorn root and bark extract and the oriental cherry water provided by the invention has an excellent effect of inhibiting the growth of harmful bacteria in the oral cavity; the mouthwash provided by the invention can significantly reduce the production of methyl mercaptan after being co-cultured with saliva for 12 hours, which indicates that the mouthwash has the effects of freshening breath, reducing ozostomia and removing breath for 12 hours.
Owner:GUANGDONG ZHAOXI HEALTH IND INVESTMENT CO LTD

Fruity yoghurt powder formula and preparation method thereof

The invention discloses a fruity yoghurt powder formula and a preparation method thereof, and relates to the technical field of food processing.The fruity yoghurt powder formula comprises milk, white granulated sugar, fruit juice, a yoghurt leavening agent, a stabilizer, a sweetening agent, an emulsifying agent, an acidity adjusting agent and water, the stabilizer is one of modified starch, gelatin, pectin and a yoghourt modifier. The stabilizer is added to improve the texture and stability of the yoghurt and reduce the problems of whey separation, texture roughness and the like, so that the formula of the fruity yoghurt powder is optimized, the taste can be ensured, the stability and quality of the yoghurt are enhanced, the layering or precipitation phenomenon of the yoghurt in the storage and transportation process is prevented, and the quality of the yoghurt is improved. Streptococcus thermophilus and lactobacillus bulgaricus in a mass ratio of 2: 1 are selected as yoghurt leavening agents, so that the fermentation process is stable, and the yoghurt is fine and smooth in texture.
Owner:GUIZHOU CISHA BIOTECHNOLOGY CO LTD

Ramelteon liquid preparation as well as preparation method and application thereof

The invention relates to the field of pharmaceutical preparations, in particular to a ramelteon liquid preparation as well as a preparation method and application thereof. The preparation comprises the following components: ramelteon, a first solvent, a second solvent and a third solvent, and optionally comprises one or more of water, a solubilizer, a surfactant, a polymer film-forming material, a plasticizer, a flavoring agent and a diluent. The preparation is high in stability, convenient to take and high in bioavailability, effectively overcomes the defects in the prior art, and has commercial application value.
Owner:HUNAN HUIZE BIO PHARMA CO LTD

Veterinary florfenicol solution as well as preparation method and application thereof

The invention provides a florfenicol solution for veterinary use as well as a preparation method and application of the florfenicol solution for veterinary use. The mass percent of the florfenicol is 20%-35%, the mass percent of the inclusion agent is 6%-15%, the mass percent of the cosolvent is 5%-10%, the mass percent of the solubilizer is 10%-15%, the mass percent of the wetting agent is 0.05%-0.2%, the mass percent of the pH regulator is 0.8%-1.5%, the mass percent of the antioxidant is 0.8%-2.5%, and the mass percent of the flavoring agent is 1.0%-5.0%. The veterinary florfenicol solution disclosed by the invention is simple in preparation process, relatively good in solubility of florfenicol, clear in solution and free from precipitation after being placed for a long time. Test results show that the veterinary florfenicol solution has a remarkable treatment effect on chicken colibacillosis, and can effectively control symptoms of swine enzootic pneumonia and improve the mental state and the respiratory rate.
Owner:SHANDONG JINGLY BIOTECH

Compositions of grapiprant and methods for using the same

The present disclosure provides a method for treating pain or inflammation in a non-human animal in need thereof. The method comprises administering to a non-human animal a pharmaceutical composition comprising a therapeutically effective amount of grapiprant. Also provided herein are pharmaceutical compositions for treating pain or inflammation in a non-human animal in need thereof. The pharmaceutical compositions comprise a therapeutically effective amount of grapiprant and an excipient, including flavorants.
Owner:ELANCO US INC

Cooking processing method and system of self-learning cooking robot

The invention relates to the technical field of data identification, and provides a cooking processing method and system of a self-learning cooking robot, the method is applied to the cooking robot, and the method comprises the steps: obtaining the type, shape and weight information of a to-be-processed food material, querying the type information and the shape information, and obtaining a recipe candidate list; selecting a cooking recipe and obtaining cooking steps according to the recipe candidate list and the cuisine preference of the user, obtaining condiment dosage based on the cuisine preference and food material weight information, inputting the condiment dosage and the cooking steps into a cooking robot to pre-cook food materials, obtaining feedback information of the user on a pre-cooking result, and sending the feedback information to the user. And after adjusting the dosage of the flavoring agent and cooking steps, performing formal cooking. By introducing the self-learning mechanism, the cooking robot can select the cooking recipe according to the type, shape and weight information, adjustment is carried out in combination with the cuisine preference of the user, and the problem that adjustment cannot be carried out according to changes of different food materials and instant feedback of the user in practical application is solved.
Owner:SHENZHEN HONGBO ZHICHENG TECH CO LTD

Compositions of grapiprant and methods for using the same

The present disclosure provides a method for treating pain or inflammation in a non-human animal in need thereof. The method comprises administering to a non-human animal a pharmaceutical composition comprising a therapeutically effective amount of grapiprant. Also provided herein are pharmaceutical compositions for treating pain or inflammation in a non-human animal in need thereof. The pharmaceutical compositions comprise a therapeutically effective amount of grapiprant and an excipient, including flavorants.
Owner:ARATANA THERAPEUTICS INC

Ratoon rice organic flavor enhancer and flavor enhancement method

The invention relates to the technical field of rice and ratooning rice aroma enhancement, and discloses a ratooning rice organic aroma enhancer and an aroma enhancement method, the ratooning rice organic aroma enhancer comprises the following raw materials by mass: 6-8 parts of EDTA-Zn, 3-5 parts of monosodium glutamate residue, 1-3 parts of a hair extract, 85 parts of potassium nitrate, 0.5-1.5 parts of ammonium dihydrogen phosphate and 0.5-1.5 parts of diethyl aminoethyl hexanoate. According to the scheme, the ratooning rice organic flavor enhancer adopts various organic substances such as the aginomoto residues and the hair extract, the content of 2-acetyl-1-pyrroline (2-AP) of the aroma of the ratooning season brown rice can be remarkably increased, the quality of the ratooning season rice can be effectively improved, meanwhile, green organic cultivation practice is achieved, and the nutrition and economic value of the ratooning season rice are improved.
Owner:CHONGQING ACAD OF AGRI SCI

Moisturizing and repairing collagen dressing and preparation method thereof

The invention relates to the technical field of collagen dressings, in particular to a moisturizing and repairing collagen dressing and a preparation method thereof. The moisturizing and repairing collagen dressing is prepared from the following components in parts by mass: 10 to 30 parts of recombinant human fibronectin, 10 to 20 parts of recombinant collagen, 5 to 15 parts of beta-glucan, 5 to 10 parts of compound hexanediol, 40 to 50 parts of carbomer, 5 to 15 parts of a flavoring agent, 80 to 120 parts of purified water, 10 to 30 parts of a modified recombinant human III type collagen solution and 10 to 20 parts of a modified chitosan solution. The recombinant human fibronectin disclosed by the invention can be deposited at an injured part to form a blood clot, so that the aim of stopping bleeding is fulfilled, and the subcutaneous tissue is protected; the recombinant collagen has high biological activity and can inhibit inflammation and improve the conditions of pachulosis, damage and the like of the skin; the beta-glucan can generate cytokines, promote healing of skin with laser-dependent dermatitis or barrier damage, and realize anti-allergic and anti-inflammatory effects.
Owner:LANKE YIMEI SCI & TECH (JILIN) CO LTD

Liquid oral composition

The disclosure provides liquid compositions configured for oral use, the liquid composition comprising water in an amount of about 40% by weight or higher, based on total weight of the composition, a flavoring agent or an active ingredient or both a flavoring agent and an active ingredient, and one or more additional components selected from the group consisting of sweeteners, humectants, and alkali metal salts, wherein the composition has a water activity (Aw) of about 0.85 or lower. The liquid compositions are generally suitable for spraying into the oral cavity.
Owner:NICOVENTURES TRADING LTD

Konjac vegetarian meat processing technology

The invention relates to the field of food preparation, in particular to a konjak vegetarian meat processing technology which comprises the following steps: cleaning and grinding konjak, then pouring the ground konjak pulp into an ethanol-citric acid solution, soaking for 3-5 hours, performing microwave treatment in the soaking process, and then centrifuging, washing and drying to obtain pretreated konjak powder; adding water into the pretreated konjaku flour, uniformly mixing, and adding a compound enzyme for enzymolysis to obtain enzymolysis konjaku; adding soybean protein powder, vital gluten, fermented starch, mulberry leaf powder and a flavoring agent into the enzymolysis konjak, and uniformly stirring and mixing to obtain a mixture; heating the mixture, and continuously stirring in the heating process until the mixture is formed to obtain a vegetarian meat semi-finished product; and cutting the vegetarian meat semi-finished product into strips, and frying to obtain the konjac vegetarian meat. In the processing process of the konjak vegetarian meat, the probiotic effect of the konjak glucomannan in intestinal tracts is effectively improved, and the health value of the konjak vegetarian meat is improved.
Owner:CHENGDU VOCATIONAL COLLEGE OF AGRI SCI & TECH

Cefixime granules and preparation method thereof

The invention discloses cefixime granules and a preparation method thereof, the granules comprise cefixime, a filler, an adhesive, a wetting agent, a flavoring agent and pharmaceutically acceptable auxiliary materials, and the filler is a calcium hydrophosphate-hydroxyethyl cellulose compound. The cefixime granules prepared by the invention are simple in preparation method, stable in quality, non-degradable, not easy to generate impurities, better in suspension performance, better in dissolution performance, qualified and stable in quality after long-term storage, simple in preparation process and suitable for industrial mass production under damp and hot conditions.
Owner:GUANGDONG HUANAN PHARMACEUTICAL GROUP CO LTD +1

Mabloxvir directly-taken granules and preparation method thereof

The invention belongs to the technical field of medicines, and particularly relates to macloxvir direct granules and a preparation method thereof. The taste is improved by adding the flavoring agent and a multi-layer coating technology, and the effect of direct swallowing is realized; by controlling the particle size of the raw materials and the variety and dosage of the auxiliary materials, the obtained macloxvir direct-taking granules are excellent in dissolution performance; and the stabilizer is added, so that the obtained macloxvir direct-taking granules are excellent in stability. In addition to providing a product which can be divided into doses and can be directly swallowed, the macloxvir directly-taken granules disclosed by the invention are stable and controllable in prescription process, excellent in dissolution performance, relatively good in mouth feel, taste masking effect and stability, suitable for large-scale production and good in market prospect.
Owner:南京康川济医药科技有限公司

Ready to mix green coffee and method of processing thereof

The present invention relates to a composition of a ready to mix drink with green coffee extract as the main component. The current embodiment of our present invention includes three types of composition to provide flavour difference. Namely, mocha coffee, roasted coffee and cappuccino coffee flavour. The main components of the composition include the following ingredients in all the variants namely green coffee extract (50%), pullulan, propylene glycol, maltodextrin, polyethylene oxide, glycerol, polysorbate 80, sorbitol, nuesilin UFL2. Di basic calcium phosphate anhydrous, with only the flavoring agent as the changeable component to the composition.
Owner:LN LAB PVT LTD

Stable buccal product based on pH regulator controlled release and preparation method thereof

PendingCN119302443ANot easy to oxidize and deteriorateno sour tasteTobacco preparationTobacco treatmentPharmacologyAnti oxidant
The invention discloses a stable buccal product based on pH regulator controlled release and a preparation method thereof, and relates to the technical field of nicotine buccal product preparation. The buccal product comprises the following components in parts by weight: 1-10 parts of a binder, 1-5 parts of a first filler, 2-5 parts of a wetting agent, 0.2-2 parts of a disintegrating agent, 1-2 parts of a pH regulator, 1-10 parts of nicotine ditartrate salt, 1-10 parts of nicotine resin, 30-50 parts of a second filler, 5-15 parts of a humectant, 0.3-1.5 parts of a sweetening agent, 0.5-5 parts of a cooling agent, 2-10 parts of a flavoring agent, 0.2-4 parts of an antioxidant and 1-5 parts of sodium chloride. And the pH regulator is carbonate. On the basis of the nicotine resin, the nicotine ditartrate salt which is comfortable in mouth feel and quick in head feeling is selected, meanwhile, the pH value of the buccal product powder is adjusted to be 6-6.5, and the technical effects of being stable in storage, free of sour taste, quick in head feeling and comfortable are achieved.
Owner:东莞市吉纯生物技术有限公司

Compositions of grapiprant and methods for using the same

The present disclosure provides a method for treating pain or inflammation in a non-human animal in need thereof. The method comprises administering to a non-human animal a pharmaceutical composition comprising a therapeutically effective amount of grapiprant. Also provided herein are pharmaceutical compositions for treating pain or inflammation in a non-human animal in need thereof. The pharmaceutical compositions comprise a therapeutically effective amount of grapiprant and an excipient, including flavorants.
Owner:ARATANA THERAPEUTICS INC

Pet dog flavor agent powder and preparation method thereof

The invention relates to the technical field of pet food, in particular to flavoring agent powder for pet dogs and a preparation method of the flavoring agent powder. Comprising the following raw materials: 40 parts of beef liver, 10 parts of hairtail, 7-40 parts of ricefield eel, 1 part of protease, 0.5-1 part of lipase, 0.5-1 part of flavor enzyme, 5-10 parts of saccharides, 10 parts of fish oil, 5-10 parts of maltodextrin, 0.5-1 part of sodium hydroxide, 5 parts of phosphoric acid, 3 parts of amino acid, 2 parts of thiamine, 1 part of yeast extract and 0.5-1 part of lactoferrin. The dog feed can increase the appetite of dogs from the sense of smell, maintain the health balance of intestinal flora of dogs and improve the micro-ecological environment of intestinal tracts.
Owner:SHANDONG PAILERT BIOTECHNOLOGY CO LTD

Preparation method of seafood flavoring agent and shrimp paste

The application provides a preparation method of seafood flavoring agent and shrimp paste, and relates to the technical field of food flavoring agents. The slurry of shrimp offal is subjected to enzymolysis by using a combination of neutral protease, flavor protease, nuclease and lipase, and then subjected to Maillard reaction, so that the seafood flavoring agent with high freshness, low bitterness and good flavor is obtained, and the seafood flavoring agent can be used for preparing shrimp paste.
Owner:FUJIAN PURE FLAVOR BIO TECH CO LTD

Dexketoprofen trometamol oral solution and preparation method thereof

The invention provides a dexketoprofen trometamol oral solution and a preparation method thereof. According to the dexketoprofen trometamol oral solution, polyethylene glycol 400 and hydroxypropyl methylcellulose are used as stabilizing agents, methylparaben and propyl hydroxybenzoate are used as bacteriostatic agents, sucralose and ammonium glycyrrhizinate are used as sweetening agents, essence is used as a flavoring agent, and the pH value of the solution is controlled to be 6.2-6.8 through a pH value regulator. The increase of the impurity A, the impurity B, the impurity C, the impurity E and the total impurity is obviously reduced, so that the product stability is obviously improved.
Owner:NANJING STERIL PHARM TECH CO LTD

Flurala chewable tablet as well as preparation method and application thereof

The invention discloses a fluralan chewable tablet as well as a preparation method and application thereof, and belongs to the field of pharmaceutical preparations. The flurala chewable tablet disclosed by the invention comprises the following components in parts by weight: 30-60 parts of flurala self-micelle solid dispersion; 20 to 60 parts of a filling agent; 1-15 parts of a disintegrating agent; 1-5 parts of a lubricant; 1-5 parts of a flavoring agent; the fluralan self-micelle solid dispersion is prepared from the following components in parts by weight: 5-15 parts of fluralan, 1-5 parts of an emulsifier, 1-5 parts of a crosslinking agent, 1-5 parts of a crosslinking agent and the balance of water. 25 to 35 parts of a polyethylene caprolactam-polyvinyl acetate-polyethylene glycol grafted copolymer; 1 to 6 parts of a DSPE-PEG material modified by an RRRRRRRR peptide; and 1 to 6 parts of an ATS peptide modified DSPE-PEG material. The chewable tablet disclosed by the invention has the advantages of high drug dissolution rate, high oral bioavailability, half-life period of longfluralana and the like.
Owner:JINAN GUANGSHENGYUAN BIOTECH

Rebamipide TBPH ion pair compound freeze-dried flash release tablet and preparation method thereof

The invention relates to a rebamipide TBPH ion pair compound freeze-dried flash release tablet and a preparation method thereof, and belongs to the technical field of pharmaceutical preparations. Comprising the following components in parts by weight: 80-90 parts of a rebamipide TBPH ion pair compound, 60-100 parts of a proppant, 8-20 parts of a stabilizer, 8-15 parts of an acidulant, 1-5 parts of a sweetening agent and 3-8 parts of a flavoring agent. The rebamipide TBPH ion pair compound has the advantages that in order to improve the solubility and bioavailability of rebamipide, the rebamipide is firstly prepared into the rebamipide TBPH ion pair compound, so that the hydrophilicity and lipophilicity of the rebamipide TBPH ion pair compound are effectively improved, the solubility of the rebamipide TBPH ion pair compound in water or lipid can be remarkably improved, and then quick release and dissolution are realized through a freeze-drying technology; the tablet can be rapidly disintegrated and dissolved in a short time, is good in molding, free of cracking and collapse phenomena, free of water during taking, convenient to take, instant to dissolve in the mouth, good in taste, free of grit feeling, free of peculiar smell, convenient to take by a patient, rapid in effect taking, capable of reducing waiting time after taking, and capable of improving the bioavailability of the tablet.
Owner:JILIN UNIVERSITY

Lucid ganoderma-derived protein oral soluble film as well as preparation method and application thereof

The invention belongs to the technical field of pharmaceutical preparations, and particularly relates to a lucid ganoderma-derived protein oral soluble film as well as a preparation method and application thereof. The protein oral soluble film derived from the lucid ganoderma is prepared from the following raw materials in percentage by mass: 1 to 10 percent of GMI (Microspore Ganoderma Immunoprotein), 25 to 50 percent of a film forming material, 5 to 20 percent of a plasticizer, 5 to 30 percent of a mucous membrane adhesive, 1 to 20 percent of a penetration enhancer, 5 to 20 percent of a flavoring agent, 0.1 to 1 percent of a coloring agent and 0.5 to 3 percent of an acidity regulator. According to the invention, by optimizing the types and proportions of the components in the formula, the oral soluble film not only has excellent appearance quality, but also has relatively good folding resistance and relatively short disintegration time, so that the use experience of the product is further improved.
Owner:SHANGHAI WANLIANGCHENGKE PHARM TECH CO LTD

Butter type bacterium-enzyme co-promoted cheese flavor agent with good sensory characteristics and preparation method thereof

PendingCN119632212AImprove sensory propertiesStrong buttery flavorFood scienceLactic acid bacteriumStaphylococcus lactis
The invention relates to the technical field of flavor agents, in particular to a butter type bacterium-enzyme co-promoted cheese flavor agent with good sensory characteristics and a preparation method. The flavor agent is composed of hydrolase and active lactic acid bacteria, the hydrolase is prepared from Protease M 'Amano' SD protease, the active lactic acid bacteria are prepared from lactococcus lactis BL-19 (preserved in the China General Microbiological Culture Collection Center, the preservation number is CGMCC 16242), and the fermentation substrate is butter.
Owner:INNER MONGOLIA AGRICULTURAL UNIVERSITY

Nicotine-containing gel as well as preparation method and application thereof

The invention provides a nicotine-containing gel and a preparation method thereof. The nicotine-containing gel comprises the following components: a nicotine microcapsule, a penetrant, a gel matrix, a flavoring agent and water. The gel has excellent biocompatibility and slow release performance through combination of the nicotine microcapsules and the gel matrix, the skin permeability of nicotine can be improved by adding the penetrant, and the gel has the advantages of freshening the oral cavity and keeping fragrance for a long time by adding the flavoring agent. Therefore, a new consumption choice can be provided for smoking cessation groups and patients needing nicotine medicine.
Owner:CHINA TOBACCO JIANGSU INDAL

Traditional Chinese medicine granule as well as preparation method and application thereof

The invention discloses traditional Chinese medicine granules as well as a preparation method and application thereof, and belongs to the technical field of preparation of traditional Chinese medicine granules. The traditional Chinese medicine granules are prepared from extracts of traditional Chinese medicine formula raw materials, a filling agent, a disintegrating agent, a sustained release agent and a flavoring agent, wherein the traditional Chinese medicine formula raw materials are prepared from radix rehmanniae preparata, fructus corni, radix cyathulae, rhizoma alismatis, poria cocos, roasted rhizoma atractylodis macrocephalae, obscured homalomena rhizome, radix clematidis, rhizoma corydalis and liquorice root. The traditional Chinese medicine formula granules with good treatment significance on cartilage repair are obtained, the traditional Chinese medicine formula granules are convenient to carry and store and have positive treatment significance on cartilage repair, the innovative process formula has a slow release effect, and compared with a water decoction, the medicine release time is prolonged, the administration frequency can be reduced, and the life quality of a patient can be improved.
Owner:WANGJING HOSPITAL OF CHINA ACAD OF CHINESE MEDICAL SCI