72 results about "Thioamide" patented technology

The invention relates to an impact-resistant chlorinated polyvinyl chloride composite material and a preparation method thereof, and belongs to the technical field of polymer composite materials. The composite material comprises the following components: 100 parts of CPVC resin, 6.5 to 9.5 parts of a modified impact modifier, 2.6 to 3.2 parts of a heat stabilizer, 1.5 to 2 parts of a lubricant, 1.2 to 1.6 parts of a processing aid, 0.2 to 0.25 part of a light stabilizer and 8 to 11 parts of a filler, the modified impact modifier takes a POSS cage structure as a core, a branch chain sequentially contains thioamide-secondary amine-tertiary amine structures, a polarity gradient is formed and fully extends into a macromolecular chain of CPVC to transmit and dissipate impact energy, meanwhile, the amine structure interacts with chlorine groups in a molecular chain of CPVC to form molecular anchoring, expansion of crazes is inhibited, and the impact strength of the CPVC is improved. The continuity and the stability of a bonding interface are maintained, so that the composite material keeps relatively high mechanical strength and thermal stability.

The invention discloses a method for synthesizing thioamide through photocatalysis. According to the method, sulfur powder, ketonic acid and amine are taken as starting raw materials, and the thioamide compound is synthesized in a green and efficient manner through dehydration condensation, photooxidation reduction decarboxylation and coupling sulfur insertion at room temperature under blue light irradiation. The method designed by the invention is novel and efficient, the raw materials are green and odorless, the synthesis method is simple, the conditions are mild, the yield is higher, the substrate application range is wide, and the method has very strong popularization potential.

This invention discloses a method for preparing a cyclic peptide compound containing a cisamide bioelectron isosteric cyclic peptide. The method involves introducing a thioamide unit at a specific position on the peptide backbone, making it a potential activatable reaction site. This site is selectively activated by a metal salt and undergoes an intramolecular condensation reaction with an acylhydrazine group located in the same peptide chain, generating a 1,2,4-triazole heterocyclic structure in situ. In a single reaction process, the cyclization of the peptide and the precise construction of the cisamide bioelectron isosteric group in the peptide backbone are achieved simultaneously.

The invention discloses a method for synthesizing heterocyclic thioamide by a one-pot method. The method comprises the following steps: under the protection of argon, adding morpholine, sodium trifluoromethanesulfinate, diphenyl phosphorus chloride and triphenylphosphine into a sealed anhydrous oxygen-free tube, reacting at room temperature, adding a boric acid compound and a catalyst Ni (cod) 2 under the protection of nitrogen, taking tetrahydrofuran as a solvent, and fully reacting at 50-80 DEG C to obtain corresponding thioamide products. The method is simple and safe in process operation, high in reaction conversion rate, economical and practical in used raw materials, few in three wastes and environment-friendly.

The invention discloses an application of compounds N-(1-naphthyl)-2-phenoxy acetamide and N-(1-naphthyl)-2-(phenylamino) ethyl thioamide in preparation of cryptosporidium resisting medicines, and belongs to the technical field of medicines and veterinary medicines of anti-parasitic medicines. The compound is obtained through functional group modification by taking NSC158011 as a pilot structure and can efficiently inhibit the activity of cryptosporidium parvum lactic dehydrogenase, and the inhibition rates respectively reach 60-70% and gt; 90%. An in-vitro experiment shows that parasite load is obviously reduced in HCT-8 cells by the two; in vivo, in a gamma-interferon gene knockout mouse and calf infection model, the fecal oocyst load is reduced by 40-100 times, the intestinal barrier repair can be promoted, and the safety is good. The invention reveals that the compound has efficient insect-resistant activity, high safety and intestinal protection effect for the first time, and provides important material basis and technical support for developing a new generation of cryptosporidium-resistant drugs.

This disclosure relates to processes for the synthesis of organic compounds, and more particularly to methods for the synthesis of thioamides from nitriles using a thiol catalyst.

The invention belongs to the technical field of medicinal chemistry, and particularly relates to an N-thioacyl homoserine lactone compound and a preparation method thereof, the compound is an analogue of a natural self-inducer N-acyl homoserine lactone AHLs, and thioamide is used as a biological isostere of amide to replace an amide group in the natural self-inducer. The compound has an obvious inhibition effect on a Vibrio fischeri Lux system and related toxic gene phenotypes regulated by the Vibrio fischeri Lux system and can be used as a Vibrio fischeri quorum sensing activity inhibitor, and thioamide is more stable in chemical structure than dithiocarbamate and has better enzyme hydrolysis stability.

The present application provides an extractant and a method for purifying alkaline gold-containing wastewater, belonging to the field of wastewater purification. The extractant uses a rigid bisphenol fluorene ring to replace the traditional aliphatic long-chain skeleton. Its unique V-shaped spatial configuration forms a molecular pre-organized cavity through phenolic bond bridging, accurately matching the linear / planar geometric configuration of the gold-cyanide complex, and significantly enhancing the coordination binding ability. Through the molecular structure, the π electron system of the bisphenol fluorene skeleton works synergistically with the thioamide group, weakening the Au-CN bond through π-d electron coupling, while constructing a sulfur-oxygen dual active site to hierarchically capture Au. + / Au 3+ , achieving directional dissociation of the complex and adaptive chelation of the valence state. This application optimizes interface regulation, forms a gradient interfacial tension layer through the hydrophobic segments connected by phenolic bonds, greatly accelerates the phase separation process, achieves a gold recovery rate of >95%, overcomes the synergistic problem of highly selective extraction and deep purification, and achieves the purpose of purifying alkaline cyanide gold-containing wastewater.

The invention relates to the technical field of corrosion inhibitors in the pickling industry, in particular to a preparation method and application of a Mannich base thiadiazole quaternary ammonium salt corrosion inhibitor for methanesulfonic acid pickling. According to the method, amino thiadiazole is modified by Mannich, quaternization is further performed, and the thiadiazole corrosion inhibitor with the advantages of Mannich base and quaternary ammonium salt is obtained. Quaternary ammonium salt groups in corrosion inhibitor molecules endow the corrosion inhibitor with good water solubility, and the dispersity and adsorbability of the corrosion inhibitor in an acid solution are improved; thiadiazole ring, thioamide and the like contained in the corrosion inhibitor contain N and S atom groups, so that coordination with metal is facilitated, and the adsorption performance of the corrosion inhibitor is improved; and the tail alkyl chain can effectively isolate corrosive substances from being in contact with a metal matrix. The preparation method is simple in synthesis step and low in raw material cost, and the obtained corrosion inhibitor is excellent in corrosion inhibition effect. Under the condition of 353 K, the highest corrosion inhibitor efficiency on Q235 steel in methanesulfonic acid with the molar concentration of 0.5 M reaches 99.8%.

Heterocyclic compounds with a novel pyrazole thioamide-based NNSN structural motif, having highly effective zinc- or copper-activated toxicity against microbial infections at micromolar or nanomolar minimum inhibitory concentrations (MIC), and methods of making and using the same.

The present application relates to metal covalent organic framework Cu3-PA-MCOF photocatalyst and its application in synthesis of thioamide derivatives. θ =3.15° appears (100) crystal face diffraction peak. Under visible light irradiation, it is applied to the conversion of thioamide and its derivatives as a photocatalyst, the prepared Cu3-PA-MCOF material exhibits excellent photocatalytic conversion capacity, can realize the efficient and high-selectivity conversion of thioamide and its derivatives to 1,2,4-thiadiazole compounds, and the substrate has wide universality. Through the technology of the present application, the efficiency and selectivity of photocatalytic organic conversion reaction can be improved, which provides a new technical scheme for developing environment-friendly and sustainable chemical synthesis method.

The invention belongs to the technical field of organic compound process synthesis and application, and discloses a thioamide derivative and a synthesis method thereof. According to the preparation method, the gem-difluoroolefin which is simple and convenient to prepare and the cheap and abundant amine compound are used as raw materials, the green and economical sulfur salt is used as the vulcanizing reagent, and the thioamide derivative can be obtained at a relatively high yield by reacting in the organic solvent at a proper temperature; the structural formula of the thioamide derivative is # imgabs0. The synthesis method has the characteristics of simplicity and convenience in operation, mild conditions, greenness, economy and wide substrate compatibility, and solves the technical problem that the synthesis conditions of the thioamide derivative are complex and harsh. On one hand, the method is short in reaction period, can be amplified to gram scale, is insensitive to water and air, and is expected to be used for industrial production; on the other hand, the synthesis method is good in selectivity, can be efficiently used for modification of medicine molecules, and has a good application prospect in the field of medicine.

A corrosion inhibitor composition is described. The corrosion inhibitor composition includes 1 to 15 weight percentage (wt. %) of a polymer having at least one vinylpyrrolidone unit and at least one vinyl acetate unit, 0.1 to 1 wt. % of a thioamide having 2 to 20 carbon atoms, 1 to 5 wt. % of a thioalcohol having 2 to 8 carbon atoms, 1 to 3 wt. % of a surfactant, 0 to 15 wt. % of an aliphatic alcohol having 1 to 8 carbon atoms, 30 to 60 wt. % of a solvent, and each wt. % based on a total weight of the corrosion inhibitor composition. The present disclosure also describes a method for inhibiting corrosion of a metal with the corrosion inhibitor composition of the present disclosure.

The invention belongs to the technical field of recovery of precious metals by a solvent extraction method, and particularly relates to an aromatic thioether amide extraction agent as well as a preparation method and application thereof. The invention provides an aromatic thioether amide extracting agent, which has a structure as shown in a formula I or a formula II. Compared with a thioether extraction agent, the aromatic thioether amide extraction agent not only has single-bond S atoms, but also has double-bond S atoms, thioamide has the characteristics of higher electronegativity and extranuclear electron distribution, so that the chemical property of thioamide is more active than that of thioether, the capability of complexing Au (III) and Pd (II) is enhanced, and the aromatic thioether amide extraction agent has high selectivity and high extraction capability on Au (III) and Pd (II); and in addition, the catalyst is insoluble in water, and has high stability and reusability. # imgabs0 #

The application provides a method for simultaneously synthesizing thioether compounds and nitrile compounds, and belongs to the technical field of organic synthesis; the thioamide compound, fluoride and acetonitrile are mixed, then a phenylacetylene precursor is added, so that the thioether compound and the nitrile compound are simultaneously synthesized at room temperature; the method is simple and fast, does not need transition metal catalysis, has a wide substrate range, the fluoride source used is cheap and easy to obtain, and does not cause environmental pollution; the method has the advantages of simple process, mild reaction condition, good universality and the like, and the yield of the synthesized thioether compound and nitrile compound is very high, the thioether compound and the nitrile compound can reach 98% at most, and has extremely high industrial popularization value.

The invention relates to a nano-enzyme antibacterial technology, and discloses a nano-composite material as well as a preparation method and application thereof. The nano composite material comprises an inner core containing molybdenum disulfide and an iron-cobalt prussian blue analogue attached to the surface of the inner core. The preparation method of the nano composite material comprises the following steps: mixing the iron-cobalt prussian blue analogue with molybdate and thioamide, and then carrying out a reaction I; the nano composite material has more excellent peroxidase mimetic activity, and has relatively strong antibacterial activity.

The invention relates to a compound of general formula (I)in which A. together with the Z2-Z3 bond of the bicyclic system to which it is fused, represents a C4-C7-cycloalkyl group, a monocyclic heteroaryl or a monocyclic heterocycle of 4 to 7 members, comprising from one to three heteroatoms selected from 0, S and N, including the atoms Z2 and Z3, Z1, Z5, Z6, Z7 and Z8 represent, independently of one another, a nitrogen atom, a carbon atom or a group C-R2, Z2, Z3, Z,4 and Z9 represent, independently of one another, a nitrogen atom or a carbon atom, and Z1, Z2, Z3, Z4, Z5, Z6, Z7, Z8 and Z9 together form a bicyclic heteroaryl which is bonded to the nitrogen atom of the amide or thioamide of formula (I) via the positions Z5, Z8, Z7 or Z8 when these positions correspond to a carbon atom, with one at least of Z4, Z5, 4, Z7, Z8 and Z9 corresponding to a nitrogen atom; W represents an oxygen or sulphur atom; and P represents an indolyl, pyrrolo[2,3-c]pyridinyl, pyrrolo[2,3-b] pyridinyl, pyrrolo[3,2-b]pyridinyl or pyrrolo[3,2cjpyridinyl group, this group being substituted, preparation process and pharmaceutical compositon comprising thereof.

The present invention relates to the field of ionizable lipids and compositions thereof. More particularly, the present invention relates to ionizable lipids or pharmaceutically acceptable salts thereof comprising a moiety, the moiety comprising an ionizable nitrogen attached adjacent to a thioamide group. The present invention further relates to a method for preparing said ionizable lipids, lipid nanoparticles comprising said ionizable lipids, and medical uses thereof (e.g, to deliver biologically active agents, such as nucleic acids, to cells and tissues).

This invention relates to an electromagnetic radiation-resistant flame-retardant control cable and its preparation method, belonging to the field of control cable technology. The control cable includes a core, a metal foil, and a modified sheath. The modified sheath uses PVC resin as a base material and adds a reinforcing agent of 10-15 phr. The reinforcing agent is prepared via a four-step process: N-phenyl-p-phenylenediamine reacts with trifluoroacetic anhydride to obtain a passivated matrix, which is then oxidized with 4,4-diaminodiphenylamine to obtain a tetramer intermediate. This intermediate is then protected by alkali desorption to obtain a terminal amino tetramer monomer, which is finally polymerized with thiodiacetic acid to obtain the final product. This agent chelates onto the surface of the metal foil through a thioamide structure, forming an aniline tetramer enrichment layer. This imparts excellent bending resistance, self-healing shielding performance, and a synergistic effect of high-temperature charring and flame retardancy to the cable, effectively solving the problems of easy bending and damage to the metal foil shielding layer and shielding failure under continuous ignition.

The application discloses a high-efficiency wastewater mercury removal agent and a preparation method thereof, belongs to the field of wastewater mercury removal, and comprises 20-50 parts of inorganic particles, wherein the inorganic particles are at least one of bentonite, zeolite or molecular sieve, the surface of the inorganic particles is chemically modified by using 1-5 parts of a silane coupling agent, and then the surface is adsorbed by 1-10 parts of an organic thioamide reagent; the bentonite is calcium-based bentonite or sodium-based bentonite with a blue absorption capacity of 40-50 g / 100 g and an expansion ratio of 20-40, the zeolite is clinoptilolite or mordenite, and the molecular sieve is 3A or 4A molecular sieve; the silane coupling agent is at least one of gamma-aminopropyl triethoxysilane, gamma-glycidyl ether oxygen propyl trimethoxysilane, methacryloyl trimethoxysilane, 2-(3,4-epoxy cyclohexyl) ethyl trimethoxysilane and 3-mercapto propyl trimethoxysilane; and the organic thioamide reagent is one or both of thiosemicarbazide and dithizone.

The invention provides a preparation method of nano cuprous sulfide and the nano cuprous sulfide, and particularly relates to the technical field of preparation of inorganic nano materials. The preparation method of the nano cuprous sulfide comprises the following steps: adding a sulfur source solution into an acidic complex solution of cuprous ions to obtain an intermediate suspension; then carrying out ultrasonic reaction on the intermediate suspension, continuing to react for 1-2 hours after the system becomes black suspension, then stopping the reaction, and carrying out solid-liquid separation on the system to obtain a precipitate; and finally, washing the precipitate, and carrying out vacuum drying to obtain the nano cuprous sulfide. Wherein a sulfur source in the sulfur source solution comprises a thioamide compound. According to the preparation method, the intermediate suspension serving as a precursor of cuprous sulfide has good stability, formation and conversion of an intermediate are promoted under the ultrasonic action, the particle size of nano cuprous sulfide is effectively controlled, and the nano cuprous sulfide is uniform in distribution, small in size and good in uniformity and dispersity.

The invention relates to a spin crossover complex with a press-card effect and a preparation method and application thereof, 5-fluoro-salicylaldehyde and thiosemicarbazide react to obtain a ligand (5-fluoro-2-hydroxybenzylidene) hydrazino thioamide, the ligand and iron ions are mixed and self-assembled to obtain the spin crossover complex, and the expression of the spin crossover complex is [FeIII (H-5-F-thsa) (5-F-thsa); the spin crossover complex can be used as a pressing and clamping material, can realize reversible switching of a spin state under low pressure of 1000bar, and stabilizes a phase change temperature zone near room temperature; the material can generate isothermal entropy change as high as 40J K <-1 > kg <-1 > under the stimulation of low-pressure stress, has extremely high pressure sensitivity of 25K kbar <-1 >, provides an innovative material basis for developing solid-state refrigeration devices with low driving energy consumption and wide temperature range compatibility, and has a good application prospect.

The invention relates to a thiophene-modified copper-cluster metal covalent organic framework material and application of the thiophene-modified copper-cluster metal covalent organic framework material in photocatalysis of organic conversion of thioamide into thiadiazole. According to the invention, a cyclic trinuclear copper cluster unit is used as a raw material, and the cyclic trinuclear copper cluster unit, 2, 5-bis (thiophene-2-yl) benzene-1, 4-diamine (alpha SPA) and 2, 5-bis (thiophene-3-yl) benzene-1, 4-diamine (beta SPA) are prepared into two types of thiophene modified copper cluster metal covalent organic framework (M-COF) materials with efficient charge separation efficiency through a solvothermal method. The material is applied to the field of photocatalytic organic conversion, and thioamide cyclization and conversion of derivatives of thioamide are achieved under irradiation of a white light LED. The prepared M-COF has excellent charge separation efficiency and electron mobility, the catalyst is applied to performance research of photocatalytic thioamide cyclization reaction, and the synthesis strategy of the catalyst has wide substrate universality and functional group compatibility. The activity is not obviously attenuated after continuous and repeated recycling, and the efficient and sustainable photocatalytic conversion performance is manifested.

The present application discloses an interface layer with high diffusion coefficient, the raw material of the interface layer includes carbon material, organic compound with thioamide group. The interface layer of the present application can effectively reduce the local current density of anode and improve the diffusion ability of Li + The interface layer of the present application can effectively prevent the accumulation of electric charge, promote the diffusion ability of anode and improve the diffusion ability of Li + The interface layer of the present application can effectively prevent the accumulation of electric charge, promote the diffusion ability of anode and improve the diffusion ability of Li The interface layer of the present application can be used in batteries to improve the electrical performance and safety performance of the batteries.

The invention relates to a crosslinked polyethylene composition, an insulating material, a preparation method and application thereof, and a high-voltage cable. The crosslinked polyethylene composition provided by the invention comprises the following components in parts by weight: 100 parts of low density polyethylene; 1.2 to 1.8 parts of a cross-linking agent; 0.15 to 0.2 part of an antioxidant; 0.2 to 0.4 part of an anti-scorching agent; 0.1-0.3 part of a space charge inhibitor; wherein the anti-scorching agent is a thioamide type compound; the space charge inhibitor is polar oxidized polyethylene wax. The scorching-resistant high-voltage cross-linked cable insulating material capable of being extruded for a long time is prepared by virtue of a multi-component compound system, and the core function is that a thioamide group in the scorching-resistant agent is subjected to nucleophilic addition reaction with free radicals generated by decomposition of peroxide through lone pair electrons to generate a stable sulfur-oxygen free radical intermediate, so that a cross-linked chain reaction is blocked, and the stability of the cable insulating material is improved. Intermolecular entanglement is reduced, and scorching performance and breakdown field strength of the compound composition are effectively improved.

The present invention relates to an application of a thioamide compound in regulating circadian rhythm. The thioamide compound of the present invention has been subjected to in vitro and in vivo experiments, showing obvious rapid regulation of circadian rhythm disorders, reduction of synchronization time of circadian rhythm phase shifts, and regulation of the expression of hypothalamic circadian clock proteins Per2, Bmal1 and related phosphorylated proteins P‑Per2, P‑CaMKII. Therefore, it can be used to treat jet lag, shift work, continuous multi-day and night work or circadian rhythm-related sleep disorders, and has the characteristics of high efficiency and low toxicity, can improve and guarantee work ability, and is of great significance for people with circadian rhythm disorders who work in night shifts, shift work, and long-distance cross-time zone flights.

The application belongs to the technical field of electrochromic materials, and provides a red-transparent display electrochromic polymer and a preparation method thereof.The method comprises the following steps: N-(2,5-dibromophenyl)-2-ethylhexylthioamide, potassium hexacyanoferrate and sodium hydroxide are subjected to ring formation reaction to obtain 4,7-dibromo-2-(heptane-3-yl)benzothiazole; EDOT, n-butyllithium and tributyltin chloride are subjected to substitution reaction to obtain EDOT-Sn; 4,7-dibromo-2-(heptane-3-yl)benzothiazole and EDOT-Sn are subjected to Stille coupling reaction and then electrochemical polymerization reaction to obtain the electrochromic polymer.The method obtains a pure donor (D) type organic molecule, and the corresponding electrochromic film is prepared by electrochemical polymerization, reversible switching between red and transparent is realized, and good cycle stability and relatively fast color change response speed are achieved.

The invention relates to the technical field of functional luminescent materials, in particular to a multi-color fluorescence conversion material based on a single luminophore as well as a preparation method and application of the multi-color fluorescence conversion material. The maximum emission wavelength change of a multi-color fluorescence conversion material based on a single luminophore under external stimulation is difficult to exceed 50nm, so that the signal recognition degree is easy to be insufficient. Aiming at the technical problems, the invention provides the multi-color fluorescence conversion material based on the single luminophore, a rigid conjugated skeleton is constructed through thioamide cyclization, the problems of energy transfer failure, component phase separation and the like in a traditional multi-component system are avoided, the maximum emission wavelength change reaches up to 150 nm or above under the stimulation of mechanical stress or an acid solution, and the fluorescence conversion material has the advantages of high fluorescence conversion efficiency, high fluorescence conversion efficiency and the like. Therefore, the method can be applied to the fields of high-end anti-counterfeiting, multi-dimensional information encryption and the like with high requirements on high signal-to-noise ratio and multi-level coding.