34 results about "Thioamide" patented technology

This invention discloses a method for preparing a cyclic peptide compound containing a cisamide bioelectron isosteric cyclic peptide. The method involves introducing a thioamide unit at a specific position on the peptide backbone, making it a potential activatable reaction site. This site is selectively activated by a metal salt and undergoes an intramolecular condensation reaction with an acylhydrazine group located in the same peptide chain, generating a 1,2,4-triazole heterocyclic structure in situ. In a single reaction process, the cyclization of the peptide and the precise construction of the cisamide bioelectron isosteric group in the peptide backbone are achieved simultaneously.

The invention discloses an application of compounds N-(1-naphthyl)-2-phenoxy acetamide and N-(1-naphthyl)-2-(phenylamino) ethyl thioamide in preparation of cryptosporidium resisting medicines, and belongs to the technical field of medicines and veterinary medicines of anti-parasitic medicines. The compound is obtained through functional group modification by taking NSC158011 as a pilot structure and can efficiently inhibit the activity of cryptosporidium parvum lactic dehydrogenase, and the inhibition rates respectively reach 60-70% and gt; 90%. An in-vitro experiment shows that parasite load is obviously reduced in HCT-8 cells by the two; in vivo, in a gamma-interferon gene knockout mouse and calf infection model, the fecal oocyst load is reduced by 40-100 times, the intestinal barrier repair can be promoted, and the safety is good. The invention reveals that the compound has efficient insect-resistant activity, high safety and intestinal protection effect for the first time, and provides important material basis and technical support for developing a new generation of cryptosporidium-resistant drugs.

The invention relates to the technical field of corrosion inhibitors in the pickling industry, in particular to a preparation method and application of a Mannich base thiadiazole quaternary ammonium salt corrosion inhibitor for methanesulfonic acid pickling. According to the method, amino thiadiazole is modified by Mannich, quaternization is further performed, and the thiadiazole corrosion inhibitor with the advantages of Mannich base and quaternary ammonium salt is obtained. Quaternary ammonium salt groups in corrosion inhibitor molecules endow the corrosion inhibitor with good water solubility, and the dispersity and adsorbability of the corrosion inhibitor in an acid solution are improved; thiadiazole ring, thioamide and the like contained in the corrosion inhibitor contain N and S atom groups, so that coordination with metal is facilitated, and the adsorption performance of the corrosion inhibitor is improved; and the tail alkyl chain can effectively isolate corrosive substances from being in contact with a metal matrix. The preparation method is simple in synthesis step and low in raw material cost, and the obtained corrosion inhibitor is excellent in corrosion inhibition effect. Under the condition of 353 K, the highest corrosion inhibitor efficiency on Q235 steel in methanesulfonic acid with the molar concentration of 0.5 M reaches 99.8%.

Heterocyclic compounds with a novel pyrazole thioamide-based NNSN structural motif, having highly effective zinc- or copper-activated toxicity against microbial infections at micromolar or nanomolar minimum inhibitory concentrations (MIC), and methods of making and using the same.

The present application relates to metal covalent organic framework Cu3-PA-MCOF photocatalyst and its application in synthesis of thioamide derivatives. θ =3.15° appears (100) crystal face diffraction peak. Under visible light irradiation, it is applied to the conversion of thioamide and its derivatives as a photocatalyst, the prepared Cu3-PA-MCOF material exhibits excellent photocatalytic conversion capacity, can realize the efficient and high-selectivity conversion of thioamide and its derivatives to 1,2,4-thiadiazole compounds, and the substrate has wide universality. Through the technology of the present application, the efficiency and selectivity of photocatalytic organic conversion reaction can be improved, which provides a new technical scheme for developing environment-friendly and sustainable chemical synthesis method.

A corrosion inhibitor composition is described. The corrosion inhibitor composition includes 1 to 15 weight percentage (wt. %) of a polymer having at least one vinylpyrrolidone unit and at least one vinyl acetate unit, 0.1 to 1 wt. % of a thioamide having 2 to 20 carbon atoms, 1 to 5 wt. % of a thioalcohol having 2 to 8 carbon atoms, 1 to 3 wt. % of a surfactant, 0 to 15 wt. % of an aliphatic alcohol having 1 to 8 carbon atoms, 30 to 60 wt. % of a solvent, and each wt. % based on a total weight of the corrosion inhibitor composition. The present disclosure also describes a method for inhibiting corrosion of a metal with the corrosion inhibitor composition of the present disclosure.

The application provides a method for simultaneously synthesizing thioether compounds and nitrile compounds, and belongs to the technical field of organic synthesis; the thioamide compound, fluoride and acetonitrile are mixed, then a phenylacetylene precursor is added, so that the thioether compound and the nitrile compound are simultaneously synthesized at room temperature; the method is simple and fast, does not need transition metal catalysis, has a wide substrate range, the fluoride source used is cheap and easy to obtain, and does not cause environmental pollution; the method has the advantages of simple process, mild reaction condition, good universality and the like, and the yield of the synthesized thioether compound and nitrile compound is very high, the thioether compound and the nitrile compound can reach 98% at most, and has extremely high industrial popularization value.

The invention relates to a compound of general formula (I)in which A. together with the Z2-Z3 bond of the bicyclic system to which it is fused, represents a C4-C7-cycloalkyl group, a monocyclic heteroaryl or a monocyclic heterocycle of 4 to 7 members, comprising from one to three heteroatoms selected from 0, S and N, including the atoms Z2 and Z3, Z1, Z5, Z6, Z7 and Z8 represent, independently of one another, a nitrogen atom, a carbon atom or a group C-R2, Z2, Z3, Z,4 and Z9 represent, independently of one another, a nitrogen atom or a carbon atom, and Z1, Z2, Z3, Z4, Z5, Z6, Z7, Z8 and Z9 together form a bicyclic heteroaryl which is bonded to the nitrogen atom of the amide or thioamide of formula (I) via the positions Z5, Z8, Z7 or Z8 when these positions correspond to a carbon atom, with one at least of Z4, Z5, 4, Z7, Z8 and Z9 corresponding to a nitrogen atom; W represents an oxygen or sulphur atom; and P represents an indolyl, pyrrolo[2,3-c]pyridinyl, pyrrolo[2,3-b] pyridinyl, pyrrolo[3,2-b]pyridinyl or pyrrolo[3,2cjpyridinyl group, this group being substituted, preparation process and pharmaceutical compositon comprising thereof.

The present invention relates to the field of ionizable lipids and compositions thereof. More particularly, the present invention relates to ionizable lipids or pharmaceutically acceptable salts thereof comprising a moiety, the moiety comprising an ionizable nitrogen attached adjacent to a thioamide group. The present invention further relates to a method for preparing said ionizable lipids, lipid nanoparticles comprising said ionizable lipids, and medical uses thereof (e.g, to deliver biologically active agents, such as nucleic acids, to cells and tissues).

This invention relates to an electromagnetic radiation-resistant flame-retardant control cable and its preparation method, belonging to the field of control cable technology. The control cable includes a core, a metal foil, and a modified sheath. The modified sheath uses PVC resin as a base material and adds a reinforcing agent of 10-15 phr. The reinforcing agent is prepared via a four-step process: N-phenyl-p-phenylenediamine reacts with trifluoroacetic anhydride to obtain a passivated matrix, which is then oxidized with 4,4-diaminodiphenylamine to obtain a tetramer intermediate. This intermediate is then protected by alkali desorption to obtain a terminal amino tetramer monomer, which is finally polymerized with thiodiacetic acid to obtain the final product. This agent chelates onto the surface of the metal foil through a thioamide structure, forming an aniline tetramer enrichment layer. This imparts excellent bending resistance, self-healing shielding performance, and a synergistic effect of high-temperature charring and flame retardancy to the cable, effectively solving the problems of easy bending and damage to the metal foil shielding layer and shielding failure under continuous ignition.

The application discloses a high-efficiency wastewater mercury removal agent and a preparation method thereof, belongs to the field of wastewater mercury removal, and comprises 20-50 parts of inorganic particles, wherein the inorganic particles are at least one of bentonite, zeolite or molecular sieve, the surface of the inorganic particles is chemically modified by using 1-5 parts of a silane coupling agent, and then the surface is adsorbed by 1-10 parts of an organic thioamide reagent; the bentonite is calcium-based bentonite or sodium-based bentonite with a blue absorption capacity of 40-50 g / 100 g and an expansion ratio of 20-40, the zeolite is clinoptilolite or mordenite, and the molecular sieve is 3A or 4A molecular sieve; the silane coupling agent is at least one of gamma-aminopropyl triethoxysilane, gamma-glycidyl ether oxygen propyl trimethoxysilane, methacryloyl trimethoxysilane, 2-(3,4-epoxy cyclohexyl) ethyl trimethoxysilane and 3-mercapto propyl trimethoxysilane; and the organic thioamide reagent is one or both of thiosemicarbazide and dithizone.

The invention relates to a thiophene-modified copper-cluster metal covalent organic framework material and application of the thiophene-modified copper-cluster metal covalent organic framework material in photocatalysis of organic conversion of thioamide into thiadiazole. According to the invention, a cyclic trinuclear copper cluster unit is used as a raw material, and the cyclic trinuclear copper cluster unit, 2, 5-bis (thiophene-2-yl) benzene-1, 4-diamine (alpha SPA) and 2, 5-bis (thiophene-3-yl) benzene-1, 4-diamine (beta SPA) are prepared into two types of thiophene modified copper cluster metal covalent organic framework (M-COF) materials with efficient charge separation efficiency through a solvothermal method. The material is applied to the field of photocatalytic organic conversion, and thioamide cyclization and conversion of derivatives of thioamide are achieved under irradiation of a white light LED. The prepared M-COF has excellent charge separation efficiency and electron mobility, the catalyst is applied to performance research of photocatalytic thioamide cyclization reaction, and the synthesis strategy of the catalyst has wide substrate universality and functional group compatibility. The activity is not obviously attenuated after continuous and repeated recycling, and the efficient and sustainable photocatalytic conversion performance is manifested.

The present application discloses an interface layer with high diffusion coefficient, the raw material of the interface layer includes carbon material, organic compound with thioamide group. The interface layer of the present application can effectively reduce the local current density of anode and improve the diffusion ability of Li + The interface layer of the present application can effectively prevent the accumulation of electric charge, promote the diffusion ability of anode and improve the diffusion ability of Li + The interface layer of the present application can effectively prevent the accumulation of electric charge, promote the diffusion ability of anode and improve the diffusion ability of Li The interface layer of the present application can be used in batteries to improve the electrical performance and safety performance of the batteries.

The invention relates to a crosslinked polyethylene composition, an insulating material, a preparation method and application thereof, and a high-voltage cable. The crosslinked polyethylene composition provided by the invention comprises the following components in parts by weight: 100 parts of low density polyethylene; 1.2 to 1.8 parts of a cross-linking agent; 0.15 to 0.2 part of an antioxidant; 0.2 to 0.4 part of an anti-scorching agent; 0.1-0.3 part of a space charge inhibitor; wherein the anti-scorching agent is a thioamide type compound; the space charge inhibitor is polar oxidized polyethylene wax. The scorching-resistant high-voltage cross-linked cable insulating material capable of being extruded for a long time is prepared by virtue of a multi-component compound system, and the core function is that a thioamide group in the scorching-resistant agent is subjected to nucleophilic addition reaction with free radicals generated by decomposition of peroxide through lone pair electrons to generate a stable sulfur-oxygen free radical intermediate, so that a cross-linked chain reaction is blocked, and the stability of the cable insulating material is improved. Intermolecular entanglement is reduced, and scorching performance and breakdown field strength of the compound composition are effectively improved.

The invention provides a polythioamide material as well as a preparation method and application thereof, and belongs to the technical field of engineering materials with high mechanical properties. The preparation method comprises the following steps: adding one or two bifunctional amine compounds, elemental sulfur and 1, 4-phenylenediacetic acid into an organic solvent, and stirring to react; after the reaction is finished, diluting, precipitating and drying reaction liquid to obtain homopolymerized or copolymerized polythioamide; and carrying out hot press molding on the obtained polythioamide to prepare the polythioamide material. The polythioamide material prepared by the invention has excellent thermal stability, high mechanical strength and toughness, good repeated processing performance and excellent moisture-resistant hydrophobicity. By replacing carbonyl oxygen with sulfur atoms and regulating and controlling a copolymerization chain structure, an intermolecular hydrogen bond network and chain segment rigidity and flexibility are synergistically optimized, so that the toughness is remarkably improved while high rigidity of the material is maintained, and the material is endowed with excellent water resistance and recyclable processing capacity.

A polymer resin and a preparation method therefor, an optical lens, and smart glasses, relating to the technical field of resin materials. The polymer resin comprises a thioamide group, a thioether group, and an aromatic group, and is prepared from the following raw materials: a thiocyanate, a thiol compound, an organic base catalyst, and a solvent.

A compound represented by the following formula (1):[wherein R1 represents a hydrogen atom or a methyl group; R2 represents an aromatic ring group optionally having a substituent or an alkyl group substituted with an aromatic ring group optionally having a substituent; X1 represents a (thio)ester bond, a (thio)carbonate bond, a (thio)amide bond, a (thio)urethane bond, a (thio)urea bond, a (thio)ether bond, oxygen, sulfur, or a nitrogen atom optionally having a substituent; X2 represents oxygen, sulfur, or a nitrogen atom optionally having a substituent; A represents a divalent group optionally having a substituent; L represents an (m+1)-valent linking group optionally having a substituent; m represents an integer of 1 to 3; and n represents 0 or 1].

This invention discloses an interface passivation solution and perovskite passivation method based on synergistic bimolecular engineering. A mixed solution of choline halide and thioamide at a concentration of 1 mg / mL is prepared as the interface passivation solution and spin-coated onto the surface of a perovskite layer to control the one-dimensional perovskite phase. One-dimensional perovskite is generated through an ion exchange reaction between the organic cations in the quaternary ammonium ions and PbI2 in the perovskite, while simultaneously utilizing the quaternary ammonium ions (NR) of choline halide. 4+ The terminal -OH group forms a strong hydrogen bond with the -NH2 group of the thioamide, dispersing the formation of one-dimensional perovskite and thus successfully controlling the formation kinetics and spatial distribution of the one-dimensional perovskite phase. This successfully resolves the inherent contradiction between passivation intensity and carrier transport in traditional single-molecule passivation. Compared with single-component treatment, the synergistic bimolecular engineering (SBE) strategy achieves control over the open-circuit voltage (…). V OC The synchronous increase of the fill factor (FF) and the fill factor (FF).

The application discloses a lithium-sulfur battery electrolyte containing a functional additive and a lithium-sulfur battery. The electrolyte contains a lithium salt, a solvent and an additive. The additive is one or more of the sulfur-containing compounds shown in formula (I). In formula (I), R1 and R2 are selected from H, C1-C15 alkyl and amino; and R3 is selected from cyano, fluoroalkyl, thioamide and thiol. The lithium-sulfur battery electrolyte has a simple formula. The addition of the additive in the electrolyte helps to form stable intermolecular chemical bonds with short-chain lithium polysulfides (Li2S and Li2S2), so as to realize the dissolution of more short-chain lithium polysulfides, reduce the reduction reaction barrier of the lithium-sulfur battery in the discharging process through liquid-phase reaction, reduce the shuttling of lithium polysulfides, and significantly improve the cycle stability of the lithium-sulfur battery.

The present disclosure relates to pyridine (thio)amide compounds, processes and intermediates for their preparation as well as the uses thereof for controlling phytopathogenic microorganisms, such as phytopathogenic fungi.

The invention relates to the technical field of oilfield chemistry, and provides a sulfur-nitrogen type extreme pressure lubricant and a preparation method thereof.The lubricant is prepared from, by mass, 29%-37% of base oil, 18%-30% of cosolvent, 3%-13% of extreme pressure anti-wear additive, 11%-12% of Span-80 / Tween-20 and 22%-26% of water; the extreme pressure anti-wear additive is prepared by taking a thioamide compound and palmitic acid as raw materials through amidation and condensation reaction; the thioamide compound is at least one of thiourea and thioacetamide, efficient lubrication and protection of a rock-metal friction interface are achieved through the extreme pressure anti-wear additive formula and composite system design, and meanwhile the extreme pressure anti-wear additive has excellent temperature resistance, good compatibility with drilling fluid and stable extreme pressure bearing capacity; the method is suitable for complex well conditions such as horizontal wells and ultra-deep wells, the risks of drill jamming and well collapse are reduced, and the drilling efficiency is improved.

The present invention relates to the technical field of polymer resins. Disclosed are a polymer resin and a preparation method therefor, an optical lens and smart glasses. The polymer resin comprises a thioamido group and an aromatic group. The polymer resin is prepared from the following raw materials: a thiocyanate, an amino compound and a solvent.

The application discloses a preparation method and application of a hydrophobic alumina catalyst for efficiently synthesizing bisphenol A. The preparation method of the catalyst comprises two steps of sulfonation modification and N,N-dimethyl-heptane thioamide hydrophobic modification. The catalyst is applied to a process of preparing bisphenol A through condensation reaction of phenol and acetone, and has the advantages of high reaction efficiency, high conversion rate and high selectivity, and is favorable for improving product yield.

Compounds of formula (I):or a pharmaceutically acceptable salt, solvate or polymorph thereof, including all tautomers and stereoisomers thereof, wherein:A is monocyclic and bicyclic heteroaryl;B is alkyl, heteroalkyl, alkyl-amino, aryl, heteroaryl, cycloalkyl, heterocyclyl, or alkylene;D is aryl-amino, heteroaryl-amino, cycloalkyl-amino, heterocyclyl, heterocyclyl-amino, urea, thioamide, thiourea, sulfonamide, sulfoximine, or sulfamoyl; andE is aryl, heteroaryl, cycloalkyl, or heterocyclyl.These compounds of formula (I) are inhibitors of glutaminyl cyclase (QC, EC 2.3.2.5).

The invention provides a synthetic method of 4-piperidine sulfamide. The synthesis method of 4-piperidine sulfamide comprises the following step: in a solvent, in the presence of an iron source, a sulfur source and alkali, 4-piperidine sulfamide 2 is subjected to a reaction to obtain 4-piperidine sulfamide 1. The method has the advantages of easily available and stable raw materials, simple preparation method, easily realized reaction conditions, low cost, safety, environmental protection, high atom economy, few side reactions and high target product yield.

The invention discloses a non-aqueous electrolyte and a lithium ion battery thereof. The non-aqueous electrolyte comprises a lithium salt, a non-aqueous organic solvent and an additive, wherein the additive comprises a compound A as shown in a structural formula I; r1 is selected from substituted or unsubstituted C1-C6 alkyl, and amino with substituted or unsubstituted C1-C12 linear, branched or cyclic alkyl as a substituent. The non-aqueous electrolyte contains the additive compound A, the compound A has a trifluoromethoxy structure and a thioamide structure, and the normal-temperature cycle performance, the high-temperature cycle performance and the rate capability of the lithium ion battery can be effectively improved.

The application discloses a sulfide electrolyte material prepared based on a thioamide compound, a preparation method and a full solid-state battery, and comprises the following steps: step 1: under an inert atmosphere, a sulfur-containing organic compound is ball-milled and mixed with a lithium source to obtain a mixed precursor; the application utilizes the characteristics that a thermal decomposition byproduct of the sulfur-containing organic compound is a gas, realizes self-purification of a reaction process, and omits complicated purification steps such as washing, filtering and drying in a traditional liquid-phase method, so that the technological process is greatly simplified. Meanwhile, by using the sulfur-containing organic compound and the lithium source as raw materials and through accurately controlled solid-phase reaction conditions, large-scale preparation of high-purity electrolyte is realized, the selected raw materials are cheap and easy to obtain, and the reaction conversion rate is high, so that the preparation cost is obviously reduced while the high purity of the product is ensured.

The application relates to an impact-resistant chlorinated polyvinyl chloride composite material and a preparation method thereof, and belongs to the technical field of polymer composite materials; components of the composite material include: 100 parts of CPVC resin, 6.5-9.5 parts of modified impact-resistant agent, 2.6-3.2 parts of heat stabilizer, 1.5-2 parts of lubricant, 1.2-1.6 parts of processing aid, 0.2-0.25 parts of light stabilizer and 8-11 parts of filler; the modified impact-resistant agent takes a POSS cage structure as a core, and successively contains thioamide-secondary amine-tertiary amine structures on a branched chain; the modified impact-resistant agent forms a polarity gradient, fully extends to macromolecular chains of the CPVC, transmits and dissipates impact energy, meanwhile, the amine structure interacts with chlorine groups in the CPVC molecular chain to form molecular anchoring, the expansion of silver lines is inhibited, the continuity and stability of a bonding interface are maintained, and therefore the composite material can keep high mechanical strength and thermal stability.