183 results about "Thioamide" patented technology

The present invention relates to 3-substituted-2-(arylalkyl)-1-azabicycloalkanes, methods of preparing the compounds and methods of treatment using the compounds. The azabicycloalkanes generally are azabicycloheptanes, azabicyclooctanes, or azabicyclononanes. The aryl group in the arylalkyl moiety is a 5- or 6-membered ring heteroaromatic, preferably 3-pyridinyl and 5-pyrimidinyl moieties, and the alkyl group is typically a C_1-4 alkyl. The substituent at the 3-position of the 1-azabicycloalkane is a carbonyl group-containing moiety, such as an amide, carbamate, urea, thioamide, thiocarbamate, thiourea or similar functionality. The compounds exhibit activity at nicotinic acetylcholine receptors (nAChRs), particularly the α7 nAChR subtype, and are useful towards modulating neurotransmission and the release of ligands involved in neurotransmission. Methods for preventing or treating conditions and disorders, including central nervous system (CNS) disorders, which are characterized by an alteration in normal neurotransmission, are also disclosed. Also disclosed are methods for treating inflammation, autoimmune disorders, pain and excess neovascularization, such as that associated with tumor growth.

The inventions disclosed herein relate to genuses of non-naturally occurring small molecule compounds which comprise two or optionally three organic moieties of limited size “linked” by certain structurally related “linker” functional groups. Suitable linker groups include ester, amine, ether, keto, imino, thioamide, thioether, sulfonamide, sulfonate ester, sulfone, guanidine, and thiourea groups. The compounds are capable, when contacted with comestible food or drinks or pharmaceutical compositions, at concentrations preferably on the order of about 100 ppm or lower, of serving as savory (“umami”) or sweet taste modifiers, savory or sweet flavoring agents and savory or sweet flavor enhancers, for use in foods, beverages, and other comestible or orally administered medicinal products or compositions, optionally in the presence of or in mixtures with conventional flavoring agents such as monosodium glutamate or known natural or artificial sweeteners.

The present invention relates to novel thioamide derivatives of formula (I) and formula (Ia):

wherein, R₃, R₄, R₅, R₆, R₇, P, Q, T, V, W, X, Y, Z, a, m and n are as defined in the description, compositions thereof, processes for their preparation and their uses as pesticides.

An additive for an alkaline zinc or zinc alloy electroplating bath medium, the additive comprising a random co-polymer comprising the reaction product of: (i) one or more di-tertiary amines including an amide or thioamide functional group, and (ii) optionally, one or more saturated second di-tertiary amines and/or one or more second di-tertiary amines including an unsaturated moiety, with (iii) one or more saturated or unsaturated linking agents capable of reacting with said di-tertiary amines (i) and (ii), provided that, where all the linking agents are saturated, an unsaturated di-tertiary amine must he present. Preferably, the polymer has the general formula n(2x+2y+zE_p)j-.

The invention belongs to the technical field of preparing a sulfur-containing organic polymer, and discloses an alkyne, sulfur and amine multi-component polymerization method for preparing poly-thioamide. The method includes the steps that under the condition of inert gas shielding, primary amine monomers containing aromatic groups or aromatic derivatives, terminal diyne monomers containing aromatic groups or aromatic derivatives and elemental sulfur are added into solvent to be dissolved, heated to the temperature of 50 DEG C-120 DEG C so as to react fully, and then cooled to the room temperature, precipitant is added into a reaction mother solution for precipitation, and a precipitate is collected and dried until the weight is constant to obtain the poly-thioamide. The poly-thioamide has a structural general formula shown as the formula (1), wherein n is an integer ranging from two to two hundred, and Ar1 and Ar2 are the same or different aromatic groups or aromatic derivatives. The poly-thioamide has the special photoelectric property and potential application value in biological and chemical fluorescence detection fields.

The invention discloses a synthesis of an addition reaction which uses accelerant to catalyze alkali and hydrogen sulfide in order to synthesize relevant thioamide compounds by high yield. The concrete things are thioacetamide, propanethioamide, thioisonicotinamide, thiobenzamide, 2-cyanothioacetamide, 4-chlorphenylthioacetamide, 4-methylthiobenzamide. The process of this invention is: dissolving nitrile in a suitable organic solvent, adding alkali solution and phase transfer catalyst, mixing adequately to homogeneous phase, then importing hydrogen sulfide until the reaction end and getting thioamide.

Described herein are hydrogen sulfide (H₂S) generating polymers and polymer systems suitable for coating or forming medical devices and methods for making and using the same. More specifically, described are H₂S generating polymers comprising at least one thioamide group. The H₂S generating polymers can provide controlled site-specific release of H₂S once implanted at or within the target surgical site by hydrolysis of the thioamide group in physiological media. The H₂S generating polymers can be coated onto a medical device, formed into a medical device or combined with one or more other polymers to form a polymer system. Also described are methods of treating restenosis and inflammation and promoting vasodilation utilizing such medical devices.

The invention discloses an iridium complex-containing phosphorescent material and a preparation method thereof and application thereof in mercury ion detection, and belongs to the technical field of photoelectric phosphorescent materials. The iridium complex-containing phosphorescent material comprises a main ligand and an auxiliary ligand, wherein the main ligand is a 4-substituted phthalazine derivative; and the auxiliary ligand is an N-(diphenyl thiophosphino)-P, P-diphenylphosphino thioamide derivative. Through ligand exchange of Hg2+ and the auxiliary ligand of an iridium complex, the color, ultraviolet absorption and phosphorescence spectrum of the iridium complex are changed so as to achieve an aim of detecting the Hg2 + by a phosphorescent chemical sensor. The invention phosphorescent chemical sensor has the advantages of visible Hg2 + recognition, high phosphorescent response speed, ratiometric response, high sensitivity, good selectivity and applicability to Hg2 + detection in a variety of environments.

The invention discloses a hyperbranched polythioamide compound as well as a preparation method and application thereof. The preparation method of the hyperbranched polythioamide compound comprises thefollowing steps: in the presence of nitrogen or an inert gas, by taking an organic solvent I as a reaction medium, uniformly mixing a polyalkyne compound, a polyamine compound and elemental sulfur, carrying out a polymerization reaction at 80-120 DEG C, and carrying out purification, so as to obtain the hyperbranched polythioamide compound. The preparation method disclosed by the invention is easy in reaction raw material obtaining, gentle in polymerization condition, simple in process and high in polymerization efficiency. The hyperbranched polythioamide compound is applied to fields of goldion adsorption and photoelectric devices.

The present invention provides an antiproliferative compound having a structural formula

where X and Y independently are oxygen, nitrogen or sulfur; R¹ is alkyl, alkenyl, alkynyl, aryl, heteroaryl, carboxylic acid, carboxylate, carboxamide, ester, thioamide, thiolacid, thiolester, saccharide, alkoxy-linked saccharide, amine, sulfonate, sulfate, phosphate, alcohol, ethers or nitrites; R² and R³ are hydrogen or R⁴; R⁴ is methyl, benzyl carboxylic acid, benzyl carboxylate, benzyl carboxamide, benzylester, saccharide or amine; and R⁵ is alkenyl; where when Y is nitrogen, said nitrogen is substituted with R⁶, wherein R⁶ is hydrogen or methyl. Also provided are methods for treating a cell proliferative disease and for inducing apoptosis in a cell comprising administering this compound is also provided.

The invention discloses a method for preparing a thioamide derivative. The method comprises the following steps: adding substituted aromatic aldehyde ketone compounds, elemental sulfur, 1,8-diazabicyclo(5.4.0)undec-7-ene and N,N-dimethyl formamide into a reaction container, mixing, and heating and stirring the prepared solution under an oil bath condition; and separating and purifying to obtain the thioamide derivative. The novel method for preparing the thioamide derivative is simple, easily available in raw materials, few in steps, high in yield and friendly to environment, and has a wide application prospect.

The invention belongs to the technical field of organic synthesis and discloses a preparation method of aryl thioamides. According to the method, corresponding aryl thioamides are generated from aromatic alkynes, elemental sulfur and amides as raw materials through a reaction of the three components under alkaline condition without catalysis by transition metals. The synthetic system has a wide application range and is compatible with terminal alkynes and internal alkynes, and is also compatible with formamide, acetamide and propionamide derivatives. The method has the advantages that raw materials are economical and easily available, the process is simple, the substrate application range is wide, the yield is high, and the method is suitable for industrial popularization and application.

To provide cytokine production inhibitors useful as preventive or therapeutic medicines for diseases accompanied by hyperactivated immune functions.

A cytokine production inhibitor containing, as an active ingredient, a thioamide compound represented by the formula (I) or a salt thereof:

• wherein A is N, NO, C—NO₂ or C—CN; Hal is a halogen; M¹ is alkyl, alkenyl, alkynyl, cycloalkyl, cycloalkenyl, aryl, heterocyclyl, amino, O, S, SO or SO₂; M² is amino, O, S or a single bond; R¹ is a halogen, alkyl or the like; each of R², R³, R⁴ and R⁵ is independently H, alkyl or the like; R⁶ is a halogen, alkyl or the like; Cy is cycloalkyl, cycloalkenyl, aryl or heterocyclyl; each of k, p and q is independently an integer of from 0 to 3; and r is an integer of from 0 to 5.