53 results about "Thioamide" patented technology

The invention relates to an impact-resistant chlorinated polyvinyl chloride composite material and a preparation method thereof, and belongs to the technical field of polymer composite materials. The composite material comprises the following components: 100 parts of CPVC resin, 6.5 to 9.5 parts of a modified impact modifier, 2.6 to 3.2 parts of a heat stabilizer, 1.5 to 2 parts of a lubricant, 1.2 to 1.6 parts of a processing aid, 0.2 to 0.25 part of a light stabilizer and 8 to 11 parts of a filler, the modified impact modifier takes a POSS cage structure as a core, a branch chain sequentially contains thioamide-secondary amine-tertiary amine structures, a polarity gradient is formed and fully extends into a macromolecular chain of CPVC to transmit and dissipate impact energy, meanwhile, the amine structure interacts with chlorine groups in a molecular chain of CPVC to form molecular anchoring, expansion of crazes is inhibited, and the impact strength of the CPVC is improved. The continuity and the stability of a bonding interface are maintained, so that the composite material keeps relatively high mechanical strength and thermal stability.

This invention discloses a method for preparing a cyclic peptide compound containing a cisamide bioelectron isosteric cyclic peptide. The method involves introducing a thioamide unit at a specific position on the peptide backbone, making it a potential activatable reaction site. This site is selectively activated by a metal salt and undergoes an intramolecular condensation reaction with an acylhydrazine group located in the same peptide chain, generating a 1,2,4-triazole heterocyclic structure in situ. In a single reaction process, the cyclization of the peptide and the precise construction of the cisamide bioelectron isosteric group in the peptide backbone are achieved simultaneously.

The invention discloses an application of compounds N-(1-naphthyl)-2-phenoxy acetamide and N-(1-naphthyl)-2-(phenylamino) ethyl thioamide in preparation of cryptosporidium resisting medicines, and belongs to the technical field of medicines and veterinary medicines of anti-parasitic medicines. The compound is obtained through functional group modification by taking NSC158011 as a pilot structure and can efficiently inhibit the activity of cryptosporidium parvum lactic dehydrogenase, and the inhibition rates respectively reach 60-70% and gt; 90%. An in-vitro experiment shows that parasite load is obviously reduced in HCT-8 cells by the two; in vivo, in a gamma-interferon gene knockout mouse and calf infection model, the fecal oocyst load is reduced by 40-100 times, the intestinal barrier repair can be promoted, and the safety is good. The invention reveals that the compound has efficient insect-resistant activity, high safety and intestinal protection effect for the first time, and provides important material basis and technical support for developing a new generation of cryptosporidium-resistant drugs.

The invention relates to the technical field of corrosion inhibitors in the pickling industry, in particular to a preparation method and application of a Mannich base thiadiazole quaternary ammonium salt corrosion inhibitor for methanesulfonic acid pickling. According to the method, amino thiadiazole is modified by Mannich, quaternization is further performed, and the thiadiazole corrosion inhibitor with the advantages of Mannich base and quaternary ammonium salt is obtained. Quaternary ammonium salt groups in corrosion inhibitor molecules endow the corrosion inhibitor with good water solubility, and the dispersity and adsorbability of the corrosion inhibitor in an acid solution are improved; thiadiazole ring, thioamide and the like contained in the corrosion inhibitor contain N and S atom groups, so that coordination with metal is facilitated, and the adsorption performance of the corrosion inhibitor is improved; and the tail alkyl chain can effectively isolate corrosive substances from being in contact with a metal matrix. The preparation method is simple in synthesis step and low in raw material cost, and the obtained corrosion inhibitor is excellent in corrosion inhibition effect. Under the condition of 353 K, the highest corrosion inhibitor efficiency on Q235 steel in methanesulfonic acid with the molar concentration of 0.5 M reaches 99.8%.

Heterocyclic compounds with a novel pyrazole thioamide-based NNSN structural motif, having highly effective zinc- or copper-activated toxicity against microbial infections at micromolar or nanomolar minimum inhibitory concentrations (MIC), and methods of making and using the same.

The present application relates to metal covalent organic framework Cu3-PA-MCOF photocatalyst and its application in synthesis of thioamide derivatives. θ =3.15° appears (100) crystal face diffraction peak. Under visible light irradiation, it is applied to the conversion of thioamide and its derivatives as a photocatalyst, the prepared Cu3-PA-MCOF material exhibits excellent photocatalytic conversion capacity, can realize the efficient and high-selectivity conversion of thioamide and its derivatives to 1,2,4-thiadiazole compounds, and the substrate has wide universality. Through the technology of the present application, the efficiency and selectivity of photocatalytic organic conversion reaction can be improved, which provides a new technical scheme for developing environment-friendly and sustainable chemical synthesis method.

A corrosion inhibitor composition is described. The corrosion inhibitor composition includes 1 to 15 weight percentage (wt. %) of a polymer having at least one vinylpyrrolidone unit and at least one vinyl acetate unit, 0.1 to 1 wt. % of a thioamide having 2 to 20 carbon atoms, 1 to 5 wt. % of a thioalcohol having 2 to 8 carbon atoms, 1 to 3 wt. % of a surfactant, 0 to 15 wt. % of an aliphatic alcohol having 1 to 8 carbon atoms, 30 to 60 wt. % of a solvent, and each wt. % based on a total weight of the corrosion inhibitor composition. The present disclosure also describes a method for inhibiting corrosion of a metal with the corrosion inhibitor composition of the present disclosure.

The application provides a method for simultaneously synthesizing thioether compounds and nitrile compounds, and belongs to the technical field of organic synthesis; the thioamide compound, fluoride and acetonitrile are mixed, then a phenylacetylene precursor is added, so that the thioether compound and the nitrile compound are simultaneously synthesized at room temperature; the method is simple and fast, does not need transition metal catalysis, has a wide substrate range, the fluoride source used is cheap and easy to obtain, and does not cause environmental pollution; the method has the advantages of simple process, mild reaction condition, good universality and the like, and the yield of the synthesized thioether compound and nitrile compound is very high, the thioether compound and the nitrile compound can reach 98% at most, and has extremely high industrial popularization value.

The invention relates to a compound of general formula (I)in which A. together with the Z2-Z3 bond of the bicyclic system to which it is fused, represents a C4-C7-cycloalkyl group, a monocyclic heteroaryl or a monocyclic heterocycle of 4 to 7 members, comprising from one to three heteroatoms selected from 0, S and N, including the atoms Z2 and Z3, Z1, Z5, Z6, Z7 and Z8 represent, independently of one another, a nitrogen atom, a carbon atom or a group C-R2, Z2, Z3, Z,4 and Z9 represent, independently of one another, a nitrogen atom or a carbon atom, and Z1, Z2, Z3, Z4, Z5, Z6, Z7, Z8 and Z9 together form a bicyclic heteroaryl which is bonded to the nitrogen atom of the amide or thioamide of formula (I) via the positions Z5, Z8, Z7 or Z8 when these positions correspond to a carbon atom, with one at least of Z4, Z5, 4, Z7, Z8 and Z9 corresponding to a nitrogen atom; W represents an oxygen or sulphur atom; and P represents an indolyl, pyrrolo[2,3-c]pyridinyl, pyrrolo[2,3-b] pyridinyl, pyrrolo[3,2-b]pyridinyl or pyrrolo[3,2cjpyridinyl group, this group being substituted, preparation process and pharmaceutical compositon comprising thereof.

The present invention relates to the field of ionizable lipids and compositions thereof. More particularly, the present invention relates to ionizable lipids or pharmaceutically acceptable salts thereof comprising a moiety, the moiety comprising an ionizable nitrogen attached adjacent to a thioamide group. The present invention further relates to a method for preparing said ionizable lipids, lipid nanoparticles comprising said ionizable lipids, and medical uses thereof (e.g, to deliver biologically active agents, such as nucleic acids, to cells and tissues).

This invention relates to an electromagnetic radiation-resistant flame-retardant control cable and its preparation method, belonging to the field of control cable technology. The control cable includes a core, a metal foil, and a modified sheath. The modified sheath uses PVC resin as a base material and adds a reinforcing agent of 10-15 phr. The reinforcing agent is prepared via a four-step process: N-phenyl-p-phenylenediamine reacts with trifluoroacetic anhydride to obtain a passivated matrix, which is then oxidized with 4,4-diaminodiphenylamine to obtain a tetramer intermediate. This intermediate is then protected by alkali desorption to obtain a terminal amino tetramer monomer, which is finally polymerized with thiodiacetic acid to obtain the final product. This agent chelates onto the surface of the metal foil through a thioamide structure, forming an aniline tetramer enrichment layer. This imparts excellent bending resistance, self-healing shielding performance, and a synergistic effect of high-temperature charring and flame retardancy to the cable, effectively solving the problems of easy bending and damage to the metal foil shielding layer and shielding failure under continuous ignition.

The application discloses a high-efficiency wastewater mercury removal agent and a preparation method thereof, belongs to the field of wastewater mercury removal, and comprises 20-50 parts of inorganic particles, wherein the inorganic particles are at least one of bentonite, zeolite or molecular sieve, the surface of the inorganic particles is chemically modified by using 1-5 parts of a silane coupling agent, and then the surface is adsorbed by 1-10 parts of an organic thioamide reagent; the bentonite is calcium-based bentonite or sodium-based bentonite with a blue absorption capacity of 40-50 g / 100 g and an expansion ratio of 20-40, the zeolite is clinoptilolite or mordenite, and the molecular sieve is 3A or 4A molecular sieve; the silane coupling agent is at least one of gamma-aminopropyl triethoxysilane, gamma-glycidyl ether oxygen propyl trimethoxysilane, methacryloyl trimethoxysilane, 2-(3,4-epoxy cyclohexyl) ethyl trimethoxysilane and 3-mercapto propyl trimethoxysilane; and the organic thioamide reagent is one or both of thiosemicarbazide and dithizone.

The invention provides a preparation method of nano cuprous sulfide and the nano cuprous sulfide, and particularly relates to the technical field of preparation of inorganic nano materials. The preparation method of the nano cuprous sulfide comprises the following steps: adding a sulfur source solution into an acidic complex solution of cuprous ions to obtain an intermediate suspension; then carrying out ultrasonic reaction on the intermediate suspension, continuing to react for 1-2 hours after the system becomes black suspension, then stopping the reaction, and carrying out solid-liquid separation on the system to obtain a precipitate; and finally, washing the precipitate, and carrying out vacuum drying to obtain the nano cuprous sulfide. Wherein a sulfur source in the sulfur source solution comprises a thioamide compound. According to the preparation method, the intermediate suspension serving as a precursor of cuprous sulfide has good stability, formation and conversion of an intermediate are promoted under the ultrasonic action, the particle size of nano cuprous sulfide is effectively controlled, and the nano cuprous sulfide is uniform in distribution, small in size and good in uniformity and dispersity.

The invention relates to a spin crossover complex with a press-card effect and a preparation method and application thereof, 5-fluoro-salicylaldehyde and thiosemicarbazide react to obtain a ligand (5-fluoro-2-hydroxybenzylidene) hydrazino thioamide, the ligand and iron ions are mixed and self-assembled to obtain the spin crossover complex, and the expression of the spin crossover complex is [FeIII (H-5-F-thsa) (5-F-thsa); the spin crossover complex can be used as a pressing and clamping material, can realize reversible switching of a spin state under low pressure of 1000bar, and stabilizes a phase change temperature zone near room temperature; the material can generate isothermal entropy change as high as 40J K <-1 > kg <-1 > under the stimulation of low-pressure stress, has extremely high pressure sensitivity of 25K kbar <-1 >, provides an innovative material basis for developing solid-state refrigeration devices with low driving energy consumption and wide temperature range compatibility, and has a good application prospect.

The invention relates to a thiophene-modified copper-cluster metal covalent organic framework material and application of the thiophene-modified copper-cluster metal covalent organic framework material in photocatalysis of organic conversion of thioamide into thiadiazole. According to the invention, a cyclic trinuclear copper cluster unit is used as a raw material, and the cyclic trinuclear copper cluster unit, 2, 5-bis (thiophene-2-yl) benzene-1, 4-diamine (alpha SPA) and 2, 5-bis (thiophene-3-yl) benzene-1, 4-diamine (beta SPA) are prepared into two types of thiophene modified copper cluster metal covalent organic framework (M-COF) materials with efficient charge separation efficiency through a solvothermal method. The material is applied to the field of photocatalytic organic conversion, and thioamide cyclization and conversion of derivatives of thioamide are achieved under irradiation of a white light LED. The prepared M-COF has excellent charge separation efficiency and electron mobility, the catalyst is applied to performance research of photocatalytic thioamide cyclization reaction, and the synthesis strategy of the catalyst has wide substrate universality and functional group compatibility. The activity is not obviously attenuated after continuous and repeated recycling, and the efficient and sustainable photocatalytic conversion performance is manifested.

The present application discloses an interface layer with high diffusion coefficient, the raw material of the interface layer includes carbon material, organic compound with thioamide group. The interface layer of the present application can effectively reduce the local current density of anode and improve the diffusion ability of Li + The interface layer of the present application can effectively prevent the accumulation of electric charge, promote the diffusion ability of anode and improve the diffusion ability of Li + The interface layer of the present application can effectively prevent the accumulation of electric charge, promote the diffusion ability of anode and improve the diffusion ability of Li The interface layer of the present application can be used in batteries to improve the electrical performance and safety performance of the batteries.

The invention relates to a crosslinked polyethylene composition, an insulating material, a preparation method and application thereof, and a high-voltage cable. The crosslinked polyethylene composition provided by the invention comprises the following components in parts by weight: 100 parts of low density polyethylene; 1.2 to 1.8 parts of a cross-linking agent; 0.15 to 0.2 part of an antioxidant; 0.2 to 0.4 part of an anti-scorching agent; 0.1-0.3 part of a space charge inhibitor; wherein the anti-scorching agent is a thioamide type compound; the space charge inhibitor is polar oxidized polyethylene wax. The scorching-resistant high-voltage cross-linked cable insulating material capable of being extruded for a long time is prepared by virtue of a multi-component compound system, and the core function is that a thioamide group in the scorching-resistant agent is subjected to nucleophilic addition reaction with free radicals generated by decomposition of peroxide through lone pair electrons to generate a stable sulfur-oxygen free radical intermediate, so that a cross-linked chain reaction is blocked, and the stability of the cable insulating material is improved. Intermolecular entanglement is reduced, and scorching performance and breakdown field strength of the compound composition are effectively improved.

The application belongs to the technical field of electrochromic materials, and provides a red-transparent display electrochromic polymer and a preparation method thereof.The method comprises the following steps: N-(2,5-dibromophenyl)-2-ethylhexylthioamide, potassium hexacyanoferrate and sodium hydroxide are subjected to ring formation reaction to obtain 4,7-dibromo-2-(heptane-3-yl)benzothiazole; EDOT, n-butyllithium and tributyltin chloride are subjected to substitution reaction to obtain EDOT-Sn; 4,7-dibromo-2-(heptane-3-yl)benzothiazole and EDOT-Sn are subjected to Stille coupling reaction and then electrochemical polymerization reaction to obtain the electrochromic polymer.The method obtains a pure donor (D) type organic molecule, and the corresponding electrochromic film is prepared by electrochemical polymerization, reversible switching between red and transparent is realized, and good cycle stability and relatively fast color change response speed are achieved.

The invention relates to the technical field of functional luminescent materials, in particular to a multi-color fluorescence conversion material based on a single luminophore as well as a preparation method and application of the multi-color fluorescence conversion material. The maximum emission wavelength change of a multi-color fluorescence conversion material based on a single luminophore under external stimulation is difficult to exceed 50nm, so that the signal recognition degree is easy to be insufficient. Aiming at the technical problems, the invention provides the multi-color fluorescence conversion material based on the single luminophore, a rigid conjugated skeleton is constructed through thioamide cyclization, the problems of energy transfer failure, component phase separation and the like in a traditional multi-component system are avoided, the maximum emission wavelength change reaches up to 150 nm or above under the stimulation of mechanical stress or an acid solution, and the fluorescence conversion material has the advantages of high fluorescence conversion efficiency, high fluorescence conversion efficiency and the like. Therefore, the method can be applied to the fields of high-end anti-counterfeiting, multi-dimensional information encryption and the like with high requirements on high signal-to-noise ratio and multi-level coding.

The invention discloses polythionocarbamate resin and a preparation method and application thereof.The polythionocarbamate comprises a thioamide group, an aliphatic thioether group, an aromatic thioether group and an aromatic benzene ring skeleton, and further, the polythionocarbamate is prepared from benzyl dithiocyanate, an aromatic sulfhydryl compound, an aliphatic sulfhydryl compound and a solvent; the polythionocarbamate resin provided by the invention has good processability and high refractive index performance. The invention also provides an optical lens, an optical element and an optical device containing the polythionocarbamate resin.

The invention provides a polythioamide material as well as a preparation method and application thereof, and belongs to the technical field of engineering materials with high mechanical properties. The preparation method comprises the following steps: adding one or two bifunctional amine compounds, elemental sulfur and 1, 4-phenylenediacetic acid into an organic solvent, and stirring to react; after the reaction is finished, diluting, precipitating and drying reaction liquid to obtain homopolymerized or copolymerized polythioamide; and carrying out hot press molding on the obtained polythioamide to prepare the polythioamide material. The polythioamide material prepared by the invention has excellent thermal stability, high mechanical strength and toughness, good repeated processing performance and excellent moisture-resistant hydrophobicity. By replacing carbonyl oxygen with sulfur atoms and regulating and controlling a copolymerization chain structure, an intermolecular hydrogen bond network and chain segment rigidity and flexibility are synergistically optimized, so that the toughness is remarkably improved while high rigidity of the material is maintained, and the material is endowed with excellent water resistance and recyclable processing capacity.

A polymer resin and a preparation method therefor, an optical lens, and smart glasses, relating to the technical field of resin materials. The polymer resin comprises a thioamide group, a thioether group, and an aromatic group, and is prepared from the following raw materials: a thiocyanate, a thiol compound, an organic base catalyst, and a solvent.

The invention relates to a spin crossover complex with low-pressure sensitivity and a preparation method and application thereof, 5-chlorine-salicylaldehyde reacts with thiosemicarbazide to obtain a ligand (5-chloro-2-hydroxybenzylidene) hydrazino thioamide, the ligand is mixed with iron ions, self-assembly is performed under specific conditions to obtain the spin crossover complex, and the expression of the spin crossover complex is [Fe < III > (H-5-Cl-thsa) (5-Cl-thsa). The material can trigger a spin state transition temperature (Tc) to move to a room temperature range under micro pressure, and has high pressure sensitivity, and meanwhile, the transition temperature is close to the room temperature; the spin crossover material can be used as a piezomagnetic material, can be used for a pressure sensor device, and provides an innovative solution for developing a high-precision, low-power-consumption and miniaturized pressure sensor.

A method of forming an amidine-containing compound includes reacting an amide-or thioamide-containing compound having the structure R1—C(═X)—NH—Z1 with a nitrogen-containing compound having the structure H2N—Y to form an amidine-containing compound having the structure R1—C(═N-Z1)—NH—Y, wherein X is O or S, Z1 is H or a substituted or unsubstituted organic group, Y is H or a substituted or unsubstituted organic group optionally comprising a solid support or linkage thereto, and R1 is a substituted or unsubstituted organic group optionally comprising a solid support or linkage thereto.

The invention provides a teisabatine derivative and a preparation method and application thereof.The teisabatine derivative has the structure shown in the formula I. On the basis of a derivative Leu10-Teixobactin and on the basis of the bioisostere theory, relevant amido bonds on a main peptide chain are subjected to sulfo modification, amide is replaced with sulfo amide, and the teisabatine derivative is obtained. According to the present invention, with the application of the Teixobactin derivative, the antibacterial effect of the obtained Teixobactin derivative is equivalent to or even stronger than the antibacterial effect of Leu10-Teixobactin, and the enzymatic hydrolysis resistance is stronger;

A compound represented by the following formula (1):[wherein R1 represents a hydrogen atom or a methyl group; R2 represents an aromatic ring group optionally having a substituent or an alkyl group substituted with an aromatic ring group optionally having a substituent; X1 represents a (thio)ester bond, a (thio)carbonate bond, a (thio)amide bond, a (thio)urethane bond, a (thio)urea bond, a (thio)ether bond, oxygen, sulfur, or a nitrogen atom optionally having a substituent; X2 represents oxygen, sulfur, or a nitrogen atom optionally having a substituent; A represents a divalent group optionally having a substituent; L represents an (m+1)-valent linking group optionally having a substituent; m represents an integer of 1 to 3; and n represents 0 or 1].

An aqueous coating composition comprising: (A) an emulsion polymer, the present invention relates to a composition comprising (i) from 0.48% to 1.5% by weight of structural units of an ethylenically unsaturated phosphorus-containing monomer, (ii) from 0.7% to 3% by weight of structural units of diacetone (meth) acrylamide, (iii) from 10% to 80% by weight of structural units of a vinyl aromatic monomer, (iv) from structural units of an alkyl (meth) acrylate, and (v) from 0 to 5% by weight of an alpha, beta-unsaturated phosphorus-containing monomer, a structural unit of a [beta]-ethylenically unsaturated carboxylic acid, a salt thereof, or a mixture thereof; (B) a specific dicarboxylic acid at a specific concentration, a salt thereof, or a mixture thereof; (C) from 30% to 60% by weight of a thio, amido or imidogen derivative of triphosphonic acid, a salt thereof or a mixture thereof; (D) a water-soluble alkali metal silicate present in an amount to provide a dry weight ratio of (D) to (C) of 1.2 to 3.7; and (E) from 40% to 52% by weight of tannic acid, gallic acid, pyrogallol or citric acid; salts thereof; or a combination thereof; wherein the weight percentages are relative to the weight of the emulsion polymer. A method of making a coating comprising a base coat made from the aqueous coating composition.

This invention discloses an interface passivation solution and perovskite passivation method based on synergistic bimolecular engineering. A mixed solution of choline halide and thioamide at a concentration of 1 mg / mL is prepared as the interface passivation solution and spin-coated onto the surface of a perovskite layer to control the one-dimensional perovskite phase. One-dimensional perovskite is generated through an ion exchange reaction between the organic cations in the quaternary ammonium ions and PbI2 in the perovskite, while simultaneously utilizing the quaternary ammonium ions (NR) of choline halide. 4+ The terminal -OH group forms a strong hydrogen bond with the -NH2 group of the thioamide, dispersing the formation of one-dimensional perovskite and thus successfully controlling the formation kinetics and spatial distribution of the one-dimensional perovskite phase. This successfully resolves the inherent contradiction between passivation intensity and carrier transport in traditional single-molecule passivation. Compared with single-component treatment, the synergistic bimolecular engineering (SBE) strategy achieves control over the open-circuit voltage (…). V OC The synchronous increase of the fill factor (FF) and the fill factor (FF).