299 results about "Human use" patented technology

Improved method and apparatus for hand-held portable LED illumination. The illumination source includes a plurality of LEDs, and an electrical circuit that selectively applies power from the DC voltage source to the LED units, wherein the illumination source is suitable for handheld portable operation. In some embodiments, the electrical circuit further includes a control circuit for changing a proportion of light output having the first characteristic color spectrum output to that having the second characteristic color spectrum output, and that drives the LEDs with electrical pulses at a frequency high enough that light produced has an appearance to a human user of being continuous rather than pulsed. Still another aspect provides an illumination source including a housing including one or more LEDs; and a control circuit that selectively applies power from a source of electric power to the LEDs, thus controlling a light output color spectrum of the LEDs.

The present invention provides an improved, commercially available organic working fluid, which is operable under a broad range of temperatures, is thermally stable, has a high auto-ignition temperature, low freezing point and high critical temperature and is benign to the environment, and safe for human use. Such an organic working fluid is useful in organic Rankine cycle (ORC) power plants or units and other systems of the like; as an intermediate fluid for heat-recovery wherein heat from various heat sources is transferred using the intermediate fluid to a further working fluid and converted into work, and the intermediate fluid is also exploited to produce electricity. Such organic working fluids are also operable as heat transfer fluids either in ORC power plants or units or in other heat transfer systems. For this purpose the present invention presents a working fluid comprising at least one highly branched, heavy iso-paraffin hydrocarbons, or a mixture of two or more of such hydrocarbons. Preferably, at least one highly branched iso-paraffin hydrocarbon is present as the major component (i.e. at least 50% by volume) in the working fluid. A preferred sub-class of the class of the branched iso-paraffins which are suitable to be incorporated in organic working fluids of the present invention includes 8 to 20 carbon atom-containing hydrocarbons having at least one methyl radical (CH3) arranged to achieve a highly stable compound.

A method of determining the voltage and current output required for the application of specific and selective electric and electromagnetic signals to diseased articular cartilage in the treatment of osteoarthritis, cartilage defects due to trauma or sports injury, or used as an adjunct with other therapies (cell transplantation, tissue-engineered scaffolds, growth factors, etc.) for treating cartilage defects in the human knee joint and a device for delivering such signals to a patient's knee. An analytical model of the human knee is developed whereby the total tissue volume in the human knee may be determined for comparison to the total tissue volume of the diseased tissue in the animal model using electric field and current density histograms. The voltage and current output used in the animal model is scaled based on the ratio of the total tissue volume of the diseased tissue of the human to the total tissue volume of the diseased tissue in the animal model and the resulting field is applied to the diseased tissue of the human using at least two electrodes applied to the knee or a coil or solenoid placed around the knee. The voltage of the signal applied to the electrodes, coil or solenoid is varied based on the size of the knee joint; larger knee joints require larger voltages to generate the effective electric field.

A first device, such as a PC, is enabled to receive messages from a second device, such as an application server, that does not know the address of the first device, by interaction with an intermediate man-in-the-middle (MITM) server. The first device obtains an ID, provides the ID to a human using the first device, and then the human provides the ID to the second device. The second device sends a message to the MITM server addressed to the ID. Meanwhile, the first device long polls the MITM server, and in response to one of the long polls, the MITM server sends the message from the second device to the first device. The first device is operating according to a script that was received from an external device, in response to a request for the script from the first device. The request for the script is embedded in a web page that the first device received; the script request may be launched automatically by the web page or in response to an action by the human. The human perceives an interaction experience co-ordinated across devices.

A cookie or other food product which is designed to deliver a larger dose of cinnamon or other additive such as fruit extract or rind to a human user without significant introduction of food items detrimental to additive(s)'s expected medicinal action and without an unpleasant taste sensation. The cookie is designed to be chewed as opposed to swallowed and the flavoring of the additive(s) is intended to enhance the cookie as opposed to the flavoring being covered up or concealed by other flavorings.

The method includes the steps of preparing a beard or other skin area to be shaved for shaving by first applying the tips of a bristle skin brush to the skin area of the beard to clean the skin area, the brush having an outer brushhead portion and an inner brushhead portion, wherein the first portion remains stationary in operation, wherein the second brushhead portion oscillates through a selected range 18-26° at a frequency within the range of 120-220 Hz. The tips of the bristles are applied to the skin area to be shaved following or simultaneous with the wetting of the skin area with water, and then following or simultaneous with, lathering the skin area with shaving cream or gel.

An apparatus and method for training the cognitive and memory systems in a subject is provided. The apparatus and method incorporates a number of different games to be played by the subject. The games artificially process selected portions of language elements, called phonemes, so they will be more easily distinguished by the subject, and gradually improves the subject's neurological processing and memory of the elements through repetitive stimulation. The programs continually monitor a subject's ability to distinguish the processed language elements, and adaptively configures the programs to challenge and reward the subject by altering the degree of processing. That is, the subject advances through a number of different processing or skill levels as their ability to distinguish between language elements improves. The subject's progress through the processing levels is recorded to allow an adaptive timing mechanism to optimize game play time for each of the games. As the subject advances through the processing levels in a particular game, the amount of game play time for that game is reduced. This insures that the subject spends the most time with those games s / he finds most difficult, and the least time with those games s / he has mastered.

The present invention is a quality controlled artificial eyelashes extension system having two main features. One of the method and materials for the application of artificial lash hairs onto existing natural eyelashes of a human subject to extend the length of the natural eyelash. This feature provides the training and materials to attach the eyelash extensions on a hair-by hair basis to a subject's existing natural eyelash. The second is the quality control feature of the present lash extension system which provides for assuring that practitioners of the system are appropriately trained, and the consumable materials utilized by the system are safe for human use. Quality control assurance of practitioners and consumable materials is accomplished by having programs for practitioner training and certification, and for materials quality assurance which controls the quality of the system's consumable materials made available to practitioners.

A method of determining the voltage and current output required for the application of specific and selective electric and electromagnetic signals to diseased articular cartilage in the treatment of osteoarthritis, cartilage defects due to trauma or sports injury, or used as an adjunct with other therapies (cell transplantation, tissue-engineered scaffolds, growth factors, etc.) for treating cartilage defects in the human knee joint and a device for delivering such signals to a patient's knee. An analytical model of the human knee is developed whereby the total tissue volume in the human knee may be determined for comparison to the total tissue volume of the diseased tissue in the animal model using electric field and current density histograms. The voltage and current output used in the animal model is scaled based on the ratio of the total tissue volume of the diseased tissue of the human to the total tissue volume of the diseased tissue in the animal model and the resulting field is applied to the diseased tissue of the human using at least two electrodes applied to the knee or a coil or solenoid placed around the knee. The voltage of the signal applied to the electrodes, coil or solenoid is varied based on the size of the knee joint; larger knee joints require larger voltages to generate the effective electric field.

The present invention features a facial mask including a water-insoluble, liquid-retaining layer sized and shaped to lie against and substantially coincident with a face of a human user and having at least one opening formed therethrough. The facial mask also includes an isolation layer substantially overlapping the water-insoluble, liquid-retaining layer. The isolation layer is readily separable from said water-insoluble, liquid-retaining layer. At least one opening in the water-insoluble, liquid-retaining layer is unobstructed by the isolation layer.

A surgical thread for plastic surgery which is extremely simple in structure, is safe for human use, effectively removes sagging and wrinkling of skin, and further enables the tensing action to the skin to be maintained for a long period of time, that is, a surgical thread for plastic surgery comprised of a thread shaped member comprised of a thread body, to be implanted in the inside layers of the skin, partially formed in its longitudinal direction with projections for anchoring in the inside skin layers, wherein at least the thread body is comprised of an absorbable thread, and the thread body or the projections are formed with residual film parts which will not be absorbed by the inside skin layers, and a method of imparting tension to the skin using the same.

Disclosed is a quality controlled artificial eyelashes extension system having a method and materials for the application of artificial lash hairs onto existing natural eyelashes of a human subject to extend the length of the natural eyelash. The system provides the training and materials to attach the eyelash extensions on a hair-by hair basis to a subject's existing natural eyelash, as well as a quality control feature which provides for assuring that practitioners of the system are appropriately trained, and the consumable materials utilized by the system are safe for human use. Included in the system is a fluent eyelash glue which forms a flexible, bio-compatible bond between two hairs to be adhered together.

Systems and methods are provided for monitoring use of hand washing agents to determine compliance with hand hygiene guidelines. A hand washing agent is provided with a detectable, volatile compound, such as odors, which is then rubbed onto a subject's hands using the subject's hand washing technique. After the hand washing event, the subject's hand is then exposed to an detector (such as a badge), which includes a sensor capable of detecting the volatile compound, and an indicator that communicates detection of the volatile compound, indicating use of the hand washing agent and hand hygiene compliance.

Methods for treating vascular disease in humans and generating data representing treatment plans are disclosed. A first set of clinical vascular health data from a healthcare provider and representing a vascular health condition of a patient is received at a data center server that is communicatively coupled to a public data network. One or more vascular disease analysis algorithms are applied to the first set of vascular health data, to result in creating and storing an initial treatment plan for the patient. A second set of vascular health data is received from a monitoring device that is associated with the patient and that is communicatively coupled to the data network; the second set of data include Doppler monitor data obtained from the peripheral vascular system of the patient. One or more vascular analysis algorithms are applied to result in creating one or more supplementary treatment plans for the patient. At least one of the treatment plans includes a biofeedback interaction. The treatment plans are provided to the patient over the data network. The foregoing steps are iteratively repeated one or more times as determined by the physician and patient, resulting in improved vascular health.

Disclosed are hybrid opioid compounds, mixed opioid salts, compositions comprising the hybrid opioid compounds and mixed opioid salts, and methods of use thereof. More particularly, in one aspect the hybrid opioid compound includes at least two opioid compounds that are covalently bonded to a linker moiety. In another aspect, the hybrid opioid compound relates to mixed opioid salts comprising at least two different opioid compounds or an opioid compound and a different active agent. Also disclosed are pharmaceutical compositions, as well as to methods of treating pain in humans using the hybrid compounds and mixed opioid salts.

The method includes the steps of preparing a beard or other skin area to be shaved for shaving by first applying the tips of a bristle skin brush to the skin area of the beard to clean the skin area, the brush having an outer brushhead portion and an inner brushhead portion, wherein the first portion remains stationary in operation, wherein the second brushhead portion oscillates through a selected range 18-26° at a frequency within the range of 120-220 Hz. The tips of the bristles are applied to the skin area to be shaved following or simultaneous with the wetting of the skin area with water, and then following or simultaneous with, lathering the skin area with shaving cream or gel.

The present invention is drawn to disinfectant or sterilant compositions, which are human safe, e.g., food grade, food safe, or skin safe, etc. In one embodiment, an aqueous disinfectant or sterilant composition can comprise an aqueous vehicle, including water, from 0.001 wt % to 50 wt % of a peracid, and from 0.001 wt % to 25 wt % of a peroxide. Additionally, from 0.001 ppm to 50,000 ppm by weight of a transition metal or alloy thereof based on the aqueous vehicle content can also be present. The disinfectant composition can be used in the manufacture and formulation of products for human use or consumption including disinfectant mouthwashes, toothpastes, gums, ointments, and soaps.

An apparatus suitable for imitating one or more muscle members of a human user during physical therapy, wherein the apparatus is configured to be used in conjunction with the human user having a waist and a leg having a knee. The apparatus includes an adjustable waist belt configured to be secured around the human user's waist and a lower leg support configured to encircle the human user's leg in a vicinity of the knee. The apparatus further includes an elastic member configured to provide an adjustable tensile resistance between the waist belt and the lower leg support.

Bipiperidinyl compounds and salts thereof are disclosed. The compounds include high affinity ligands for σ1 receptors. Some compounds are also highly selective for σ1 receptor compared to σ2 receptor. Compounds can comprise radioisotopes, including 18F or 11C. Radiolabeled compounds can be used as probes for imaging distribution of σ1 receptor in a subject such as a human using positron emission tomography (PET) scanning.

Disclosed is a nervous system-based emotion synthesizing apparatus which enables an emotion of a humanoid to be synthesized in a manner similar to that of a human using a nervous system-adjusting mechanism of a human body according to emotions. The human nervous system-based emotion synthesizing apparatus, includes a stimulus sensor portion having at least a stimulus sensor for sensing an external stimulus, an emotion generator for generating an predetermined emotion corresponding to the sensed external stimulus, a physiological signal generator for generating at least one artificial physiological signal in response to the sensed stimulus and the generated emotion, and an emotional behavior generator for generating at least one emotional behavior through a predetermined physical reaction in response to the sensed stimulus and the generated emotion, whereby the generated artificial physiological signal is fed back to the emotion generator and the emotional behavior generator, and the generated emotional behavior is fed back to the emotion generator and the physiological signal generator so that the emotion, the artificial physiological signal and the emotional behavior are combined to produce and express a complex emotion.

The present invention features a facial mask comprising a water-insoluble, nonwoven substrate sized and shaped to lie against the face of a human user having an Average Wet Transparency Percentage of at least about 25% and / or a Percent Increase in Transparency of at least about 50%. Methods of treating the skin using facial masks are also provided.

Described is a novel family of cell surface serpentine transmembrane antigens. Two of the proteins in this family are exclusively or predominantly expressed in the prostate, as well as in prostate cancer, and thus members of this family have been termed “STEAP” (serpentine transmembrane antigens of the prostate). Four particular human STEAPs are described and characterized herein. The human STEAPs exhibit a high degree of structural conservation among them but show no significant structural homology to any known human proteins. The prototype member of the STEAP family, STEAP-1, appears to be a type IIIa membrane protein expressed predominantly in prostate cells in normal human tissues. Structurally, STEAP-1 is a 339 amino acid protein characterized by a molecular topology of six transmembrane domains and intracellular N- and C-termini, suggesting that it folds in a “serpentine” manner into three extracellular and two intracellular loops. STEAP-1 protein expression is maintained at high levels across various stages of prostate cancer. Moreover, STEAP-1 is highly over-expressed in certain other human cancers.

Methods, devices, and systems are disclosed for simulating a large, realistic computer network. Virtual actors statistically emulate the behaviors of humans using networked devices or responses and automatic functions of networked equipment, and their stochastic actions are queued in buffer pools by a behavioral engine. An abstract machine engine creates the minimal interfaces needed for each actor, and the interfaces then communicate persistently over a network with each other and real and virtual network resources to form realistic network traffic. The network can respond to outside stimuli, such as a network mapping application, by responding with false views of the network in order to spoof hackers, and the actors can respond by altering a software defined network upon which they operate.

The present invention provides an immunogenic influenza composition in a dose volume suitable for human use, comprising an influenza virus antigen or antigenic preparation thereof and an adjuvant composition comprising an oil-in-water emulsion, wherein said oil-in-water emulsion comprises a metabolisable oil at a level of below 11 mg and an emulsifying agent at a level of below 5 mg and optionally a tocol or a sterol at a level of below 12 mg. Suitably the amount of influenza antigen per strain per dose is 15 μg HA or a low amount such as less than 15 μg HA.

This invention relates to methods and systems for generating a safe and effective oral smallpox vaccine for humans using a genetically defective strain of vaccinia virus to confer immunity following oral delivery of the vaccine. This invention is one that expands on current use of vaccinia virus propagation developed for gene therapy applications, and pharmaceuticals and nutraceuticals packaging and formualtion technologies. The vaccine invention can be delivered as a live virus with the ability to express viral proteins but unable to achieve complete, lytic virus replication, or it may be derived from such a virus, contain additional immunogens, or be delivered as viral antigens. Furthermore, the invention establishes innovative methods for formulation and packaging and for preclinical testing of the vaccine invention for safety, efficacy and potency with the use of human intestinal and other test cells and diagnostic test systems and kits.

A system for emergency crew return and down-mass orbit comprising a stowable, self-contained, deployable maneuvering reentry vehicle for automated, on-demand reentry to ground for cargo of 1-10 kilograms or up to single or multiple human use for evacuation of orbital facilities. The system includes a deployable “aeroshell” that is contiguous (a single geometric object—surface or hollow shape—that can morph in 3D shape), modular (a collection of modular components externally acting as a contiguous shape, but morphed in 3D via actuators contained in each modular member to create a general asymmetric geometry), or discontiguous (a collection of independently controlled surfaces or bodies that morph to form desirable asymmetric drag configurations). The system contains traditional spacecraft guidance, navigation and control, propulsion, and attitude control elements, in addition to communications, power, and actuator energetics systems for controlling the vehicle aeroshell shape during reentry, thus, minimizing the landing footprint of the vehicle.

An device for assisting four-legged pets to walk during periods of convalescence from foot, leg, or hip surgery or injury. A sling portion is connected to two handle grips. The sling portion may be disposed under the chest of the animal in the case of debilitated front legs, or under the abdomen in the case of debilitated hind legs, and the handle grips grasped by a human user to help support or lift the pet. The invention is particularly useful for assisting a convalescent pet to take beneficial walks without having to bear full weight on injured limbs or hips. A version of the device is disclosed which may be adjusted in length to accommodate the size of the animal and the height of the user.