A nutrition wine used for restoring gene and activating prostate cell comprises the following parts: honeysuckle flower, dandelion, purslane, cactus and barbat skullcap 25-35 parts equally, banksia rose, sword bean and cyperus tuber 25-35 parts equally, frank incense, chuanxiong rhizome, spatholobus stem, safflower and achyranthes 25-35 parts equally, cornaceae, chebula fruit, Chinese gall, lotus seed and schisandra fruit 25-35 parts equally, bee honey 4-6 parts, ganoderam lucidum karst bacterial and marasin as edible bacterial 4-6 parts equally, yeast1-2 parts, brewers' yeast 1-2 parts, 75-85 degree edible white wine is 2 times as much as the fermentation material (the fermentation material is made by the fermentation of the above material). The preparing method produces the functional nutrient food utilizing microbiological fermentation, which activates the prostate cell, restores varied cell and achieves rehabilitation of prostate.