The present invention relates to newly identified nucleic acids and polypeptides present in normal and neoplastic
prostate cells, including fragments, variants and derivatives of the nucleic acids and polypeptides. The present invention also relates to antibodies to the polypeptides of the invention, as well as agonists and antagonists of the polypeptides of the invention. The invention also relates to compositions comprising the nucleic acids, polypeptides, antibodies, variants, derivatives, agonists and antagonists of the invention and methods for the use of these compositions. These uses include identifying, diagnosing, monitoring, staging, imaging and treating
prostate cancer and non-cancerous
disease states in
prostate tissue, identifying prostate tissue, monitoring and identifying and / or designing agonists and antagonists of polypeptides of the invention. The uses also include
gene therapy, production of transgenic animals and cells, and production of engineered prostate tissue for treatment and research.