The invention belongs to the technical field of super-long pile construction of engineering construction, and discloses a large-diameter super-long pile construction method in the karst area through full-casing pipe full rotating and rotary drilling. The method comprises the steps of selecting the types of full casing pipes, rotating the installing casing pipes by 360 degrees, pressing the first casing pipe, checking the perpendicularity, alternately using a punching grab hand and an impact hammer, grabbing land rocks through a grab bucket, drilling the casing pipes to the hole bottoms, measuring the hole depth, carrying out hole cleaning for the first time, installing manufactured reinforcement cages, carrying out butt joint on the reinforcement cages, installing manufactured guide pipes subjected to pressure-bearing tests and sealing tests, arranging water isolation bolts, carrying out hole cleaning for the second time, pouring manufactured concrete, measuring the height of the concrete, pulling the guide pipes and the casing pipes sequentially, verifying the perpendicularity and pulling the casing pipes before initial setting of the concrete. According to the method, the pile driving efficiency of projects is improved, and the total cost of the projects is lowered.