The invention discloses a karst tunnel bottom filling beaded type karst cave steel pipe pile grouting hole forming method. The method comprises the following steps that firstly, tunnel bottom karst detection is conducted, specifically, tunnel bottom beaded type karst detection is conducted through a geological radar, for a section with determined karst, geological drilling is adopted for detectionconfirmation to determine beaded type karst distribution conditions including the number of karst caves, the sizes of the karst caves, the positions of the karst caves and karst cave filling conditions; and secondly, steel pipe pile grouting hole design is conducted, specifically, according to the beaded type karst distribution conditions, steel pipe pile grouting parameters are determined. According to the method, the hole forming problem of grouting reinforcement of karst tunnel filling beaded type karst cave steel pipe piles is well solved, through the arrangement of multiple stages of casing pipes, collapse of filler is effectively prevented, drilled holes can be relatively easily formed, drilling equipment is easy to machine on site, the cost is low, mounting and dismounting are easy, the construction speed is high, the hole forming rate is high, the construction period is greatly shortened, and the economic benefit and social benefit are obvious.