The invention relates to a corrosion method of a 5xxx series Al-Mg alloy grain boundary, which mainly comprises the following steps: 1, preparing a corrosion liquid which comprises the following components: 80-110 mL, 15-20 mL, 0.5-3.5 mL of HF, 0.5-3 mL of HCl and 2-5 g of HCl; 2, embedding an aluminum alloy sample; 3, polishing the embedded samples sequentially with abrasive paper from low meshes to high meshes; 4, polishing the ground sample; 5, cleaning the polished sample with absolute ethyl alcohol; 6, corroding the sample for 60-90 seconds by using the prepared corrosive liquid; and 7, after corrosion patterns appear on the surface of the sample, cleaning the sample with absolute ethyl alcohol and carrying out drying treatment. After the method is used for corroding the 5xxx series Al-Mg alloy, the grain boundary of the alloy can be clearly observed, and the method is low in equipment requirement, simple in operation step, capable of saving cost, good in stability and suitable for researching the grain morphology, the grain size, the microstructure performance and the like of the Al-Mg alloy.