The invention discloses a comprehensive geological prediction method for karst tunnel construction, which includes the following steps: (1) long-distance detection; (2) geological radar detection: on the basis of the long-distance detection, adopting a geological radar to review a long-distance prediction result within a short-distance detection range; (3) adopting a horizontal protruded drill hole to carry out direct detection according to a review result; and (4) supplementary protruded blasthole detection: when a direct detection result is that a geologically abnormal body exists in the current tunneling construction area, a protruded blasthole needs to be adopted to carry out supplementary detection, and a supplementary detection result is used as supplementary detection data for the direct horizontal protruded drill hole detection result. The design of the comprehensive geological prediction method is rational, the comprehensive geological prediction method is easy and convenient to operate, and is highly operable, moreover, the mutual relation among a variety of chosen prediction methods is clear, the comprehensive detection effect is good, and the invention provides a systematic, rational and standard comprehensive prediction method for karst tunnel construction.