A high performance imaging
system for diffuse
optical tomography is disclosed. A dense grid utilizing sources, e.g., light emitting diodes (“LEDs”), that achieve high performance at high speed with a
high dynamic range and low inter-channel
crosstalk are complemented by a
system of discrete, isolated receivers, e.g., avalanche photodiodes (“
APDs”). The source channels have dedicated reconfigurable encoding control signals, and the
detector channels have reconfigurable decoding, allowing maximum flexibility and optimal mixtures of frequency and time encoding and decoding. Each
detector channel is analyzed by dedicated, isolated, high-bandwidth
receiver circuitry so that no
channel gain switching is necessary. The resulting improvements to DOT
system performance, e.g., increased
dynamic range and decreased
crosstalk, enable higher density imaging arrays and provide significantly enhanced DOT
image quality. A processor can be utilized to provide sophisticated three
dimensional modeling as well as
noise reduction.