46 results about "Prostate disease" patented technology

The invention belongs to the technical field of biological medicines, and particularly relates to an umbilical cord mesenchymal stem cell preparation and application thereof in treating prostate diseases. According to the umbilical cord mesenchymal stem cell preparation, the umbilical cord mesenchymal stem cells of the third generation to the sixth generation and the neurofilament peptide serve as active components, pharmaceutically acceptable auxiliary materials are matched, the prostate index can be remarkably reduced, the concentration of PACP and SRD5A2 can be reduced, and the umbilical cord mesenchymal stem cell preparation has a remarkable curative effect on prostatic hyperplasia. And the umbilical cord mesenchymal stem cells of the third generation to the sixth generation and the neurofilament peptide supplement each other and have a synergistic effect, so that a remarkable progress is generated.

This invention relates to a non-invasive predictive kit and method for the progression of benign prostatic hyperplasia (BPH) based on prostatic fluid. The invention provides the application of FGF9 as a non-invasive predictive biomarker for the progression of BPH based on prostatic fluid, wherein the concentration of FGF9 in prostatic fluid serves as an indicator of BPH progression. The invention also provides a method for detecting the concentration of FGF9 in prostatic fluid for non-disease diagnostic purposes. Compared with existing technologies, the non-invasive BPH detection method based on prostatic fluid of this invention has advantages such as non-invasiveness, accuracy, simplicity, practicality, and scalability, and is expected to be widely used in the clinical diagnosis and treatment of prostate diseases.

The invention discloses a dry, comfortable, antibacterial and itching-relieving protection pad. The protection pad is formed by compounding a base layer and a surface layer, and the base layer is a non-woven fabric layer; and the surface layer is a medicine-carrying composite non-woven fabric layer. The protection pad surface layer is located above the base layer, the area of the protection pad surface layer is smaller than that of the base layer, and active ingredients extracted from radix sophorae flavescentis, cortex phellodendri, radix stemonae, cortex dictamni and golden larch bark and an antibacterial material polyhexamethylene biguanide are introduced into the skin-attaching non-woven fabric of the protection pad surface layer, so that the protection pad has the effects of resisting bacteria, relieving itching, clearing damp, expelling parasites and the like; the disposable disposable diaper is suitable for anorectal postoperative wound repair, prostate disease urine leakage, obesity and hidrosis and other field operation people, is particularly beneficial to tinea corporis and rotten crotch in special occasions, and has a good application prospect. The invention further discloses a preparation method of the protection pad.

This application relates to solabegron zwitterion useful for the treatment of lower urinary tract symptoms such as, for example, overactive bladder and prostate disorders. Additionally, this application relates to pharmaceutical compositions and methods of treatment utilizing the solabegron zwitterion for treating lower urinary tract symptoms. This application also relates to methods of preparing solabegron hydrochloride from the solabegron zwitterion.

The present application relates to the technical field of stem cell medicine, in particular to a mesenchymal stem cell composition for treating prostate diseases and a preparation method and application thereof. The mesenchymal stem cell composition for treating prostate diseases comprises mesenchymal stem cells treated by low oxygen and an anti-inflammatory peptide WYPWMKKHHRRRRRRRRR. The prostate diseases are selected from prostatitis, prostate calcification, sexual function improvement, frequent urination and urgency, etc. The mesenchymal stem cell composition can significantly improve the symptoms of prostate diseases, and the curative effect is remarkable.

The present invention relates to the technical field of health care, and specifically relates to the preparation and use of a magnetic silicone health care material. The magnetic silicone health care material sequentially comprises, from the inside to the outside, a magnetically conductive layer, a silicone magnetic material layer, and a magnetic shielding coating layer. The silicone magnetic material layer consists of a magnetic material, microporous silicone, a traditional Chinese medicine extract, an iron silicide, graphene, and calamine, and can generate a magnetic field and has health care functions; the magnetically conductive layer consists of a hydrogel-graphene composite material, and can enhance the magnetic field according to acupuncture points, improving treatment and health care effects; and the magnetic shielding coating layer contains a magnetic shielding filler, and can prevent an externally applied magnetic field from causing the magnetism of the magnetic material to weaken or disappear. Further provided in the present invention is a preparation method for the magnetic silicone health care material. The prepared magnetic silicone health care material has strong magnetism and good health care effects, is skin-friendly, and has permanent magnetism and is not prone to demagnetization. The magnetic silicone health care material of the present invention can be used in the treatment of alopecia, low back pain, and prostate disease.

The use of a Morus alba extract in the preparation of a drug for treating and / or preventing prostate diseases. The Morus alba extract contains an alkaloid with a weight content of 3% or more, and / or a polysaccharide with a weight content of no more than 70%, and / or a flavone with a weight content of no more than 10%, and / or an amino acid with a weight content of no more than 50%, and / or other components. The Morus alba extract has a significant therapeutic effect on prostate-related diseases.

The invention provides a prostate MRI registration method based on dense convolution and a gated feature extraction network, and the method comprises the steps: obtaining a prostate MRI image sequence of each target user, and the MRI image sequence comprises a fixed image and a moving image; preprocessing the fixed image and the moving image; inputting the pre-processed fixed image and the pre-processed moving image into a gating residual fusion module, and respectively extracting coarse features of the fixed image and the moving image through different convolutional networks; the coarse features and the corresponding source images are subjected to slice cross splicing and then input into a registration network, and a deformation field is output; the registration network comprises a dense convolution module and a Swin Transform module; and according to the deformation field, obtaining a registered image through a spatial transformation network. According to the method, the accuracy and efficiency of multi-modal medical image registration are effectively improved, and important technical support is provided for diagnosis and treatment of prostate diseases.

The invention discloses a medical biological dressing suppository matrix and a preparation method thereof, and relates to the technical field of suppositories, the medical biological dressing suppository matrix is prepared by taking gelatin, glycerol, polyethylene glycol derivatives and chitosan quaternary ammonium salt as raw materials, the biocompatibility of the suppository matrix is good, and stimulation and anaphylactic reaction cannot be generated on a medication cavity; and after the suppository matrix is dissolved in the cavity, a film with good adhesion can be formed on the mucous membrane of the cavity, so that the released medicine is fully contacted with the focus for a long time, the curative effect and bioavailability of the medicine are improved, and the suppository is suitable for preparing suppositories for treating gynecological diseases, anorectal diseases and prostate diseases.

The invention provides an analysis kit and a detection method of prostate small body leaked protein, and relates to the technical field of kits.The analysis kit comprises a kit body, a heating cavity is formed in the portion, adjacent to the lower portion of a storage groove, in the kit body, and an electric heating piece is fixedly installed on the top face of the inner end of the heating cavity; the microcontroller synchronously starts the failure judgment timing module, if the detection articles are not used within one hour, the module feeds back a signal to enable the microcontroller to control the micro motor to lock the box cover again, and the electric heating sheet in the heating cavity of the box body is started to forcibly discard the reagent, so that the detection error caused by the active failure reagent is prevented; according to the present invention, the accurate detection is ensured through the preparation before the detection and the reagent aging control, and the problems that the accuracy of the detection result is affected due to the lack of the temperature balance control mechanism and the reagent aging control function of the current prostate small body leakage protein detection kit so as to interfere the prostate disease clinical diagnosis and illness state evaluation are solved.

The present invention provides a composition for improving, preventing, or treating prostate disease, comprising hemp seed oil as an active ingredient. A functional composition comprising hemp seed oil as an active ingredient, according to the present invention, reduces the prostate weight of benign prostatic hyperplasia patients, reduces blood prostate-specific antigen (PSA), dihydrotestosterone (DHT), and 5-alpha reductase I levels, and also has excellent cell growth inhibitory ability with respect to prostate cancer cells. Thus, the functional composition comprising hemp seed oil as an active ingredient, according to the present invention, is expected to be capable of exhibiting a preventive, relieving, or therapeutic effect on prostate disease including benign prostatic hyperplasia and prostate cancer.

The invention relates to the technical field of stem cell medicines, in particular to a mesenchymal stem cell composition for treating prostate diseases as well as a preparation method and application of the mesenchymal stem cell composition. The mesenchymal stem cell composition for treating the prostate diseases, disclosed by the invention, is prepared from mesenchymal stem cells subjected to hypoxia treatment and an anti-inflammatory peptide WYPWMKKHRRRRRRRR. The prostate diseases are selected from prostatitis, prostate calcification, sexual function improvement, frequent micturition, urgent micturition and the like. The mesenchymal stem cell composition disclosed by the invention can be used for remarkably improving symptoms of prostate diseases and is remarkable in curative effect.

The invention relates to the technical field of medicinal liquor, in particular to medicinal liquor special for treating prostate diseases. 420g to 500g of Chinese yam; 420 g to 500 g of prepared rehmannia root; 420g to 500g of semen euryales; the weight of the cornus officinalis is 450 to 500 grams; 150 g to 180 g of syngnathus; 390-450 g of lotus seeds; and 5000-5500 g of sorghum liquor with the alcohol content of 62%. The medicinal liquor contains effective components of Chinese yam, gordon euryale seed, dogwood, lotus seed, syngnathus and stir-fried Chinese chive seed, 62-degree kaoliang spirit is selected as a solvent, the alcoholic strength is moderate, the effective components in the medicinal materials are fully extracted, the medicinal liquor has a remarkable treatment effect, and related symptoms of prostate diseases can be effectively relieved; after the medicinal liquor is prepared, a patient only needs to take the medicinal liquor according to the specified taking time and dosage, complicated operation or additional treatment equipment is not needed, and the medicinal liquor is suitable for patients with various types of prostate diseases, including prostatitis, prostatic hyperplasia and the like, has a wide application prospect, and has a cure effect of 100%.

The invention belongs to the technical field of food, and discloses endurance sports nutritious food, which is characterized by being prepared from the following raw materials by weight: 3g of raspberry, 1g of fructus lycii, 1g of fructus alpiniae oxyphyllae, 0.1 mg of vitamin B1, 0.1 mg of vitamin B2, 1mg of vitamin E, 0.5 mg of zinc, 0.05 g of stevia rebaudiana, and 0.01 g of edible essence. The traditional Chinese medicine has the effects of tonifying kidney, nourishing blood, protecting ovary and regulating menstruation. The traditional Chinese medicine composition can protect testis, prevent sexual hypofunction and prostate diseases, delay senescence, blacken hair and treat amnesia, tinnitus and hypopsia. And enuresis and dripping are carried out.

The present invention discloses a preparation process and application of a compound preparation of astaxanthin, lycopene and proanthocyanidins for anti-aging and prevention of prostate diseases, belonging to the field of biomedicine. The preparation is composed of astaxanthin (1-10 parts), proanthocyanidins (5-30 parts), lycopene (2-15 parts), black cumin seed oil (0.5-3 parts), Phyllanthus emblica extract (3-8 parts) and Withania somnifera extract (1-5 parts), and is prepared by high-efficiency wet granulation technology. The components act synergistically to significantly enhance antioxidant, anti-inflammatory and anti-cancer activities, and have dual effects of anti-aging and prevention and treatment of prostate diseases. Experiments show that the hydroxyl radical scavenging rate of the compound preparation is 2.3 times higher than that of the single ingredient, the inflammatory factors in the prostatitis model are reduced by 68%, the skin antioxidant capacity is increased by 55%, and the combination with finasteride can reduce the dosage of chemical drugs by 80% and reduce the risk of sexual dysfunction. Black cumin seed oil significantly improves the bioavailability of lycopene (29.7%), and the drug concentration in the prostate tissue reaches 6.5 times that in the blood, achieving high efficiency with low dosage.

The invention belongs to the technical field of preparation and application of small molecule drugs, and particularly relates to a pharmaceutical composition for treating prostate diseases and glandular nodules and application of the pharmaceutical composition. The pharmaceutical composition comprises a heterocyclic compound with the structure shown in the formula I or pharmaceutically acceptable salt and a pharmaceutically acceptable carrier of the heterocyclic compound; # imgabs0 # wherein at least one of X1, X2, X3 and X4 is a nitrogen atom, and the remainder is a carbon atom; x5 is an oxygen atom or a carbon atom; and X6 is a nitrogen atom or a carbon atom.

The purpose of this invention is to establish a single-particle inductively coupled plasma mass spectrometry (ICP-MS) method for analyzing single magnetic microspheres, which can effectively avoid signal fluctuations caused by errors during absolute quantification, achieving stable and accurate quantification of two prostate cancer biomarkers. The principle of this invention is: using... + Fe 58 The frequency signals of isotopes are used to unify the number of magnetic microspheres, and the results are obtained by evaluating the frequency signals of individual magnetic microspheres. + Au 197 and + Pt 194 The intensity distribution, calculated through average intensity or fitted intensity, yields stable analytical results unaffected by changes in the number of magnetic microspheres detected. This is achieved using the intensity distribution on a single magnetic microsphere. + Au 197 and + Pt 194 The linear relationship between intensity and tPSA and fPSA demonstrates that this analytical method enables the simultaneous detection of two prostate cancer biomarkers and can be applied to the simultaneous analysis of the concentrations of the two biomarkers in the serum of patients with prostate disease.

The invention relates to the technical field of urinary system disease diagnosis, in particular to a prostate tumor onset risk prediction method and system. By combining multiple groups of indexes and image group feature data, the prostate diseases, especially the prostate tumors, can be effectively evaluated, score data reflecting the state of the prostate tumors can be obtained, and the incidence probability and the staging result degree of the endometrial diseases can be more intuitively determined through the score data. Therefore, the overall automatic prediction of the prostate disease is realized.

The invention discloses an automatic segmentation method for a prostate transrectal ultrasound image, and relates to the technical field of machine learning, and the method comprises the following steps: S201, obtaining a prostate transrectal ultrasound image set of a patient; s202, creating a machine learning model for segmenting the prostate transrectal ultrasound image; s203, the obtained prostate transrectal ultrasound image set is preprocessed; s204, the machine learning model is used for automatically segmenting the preprocessed prostate transrectal ultrasound image set, and the prostate area is determined. The prostate image segmentation process is completely obtained through autonomous learning of the machine learning model, and a doctor with rich experience does not need to manually segment the prostate image; according to the prostate image segmentation method and device, the dependence on the professional level of a doctor is reduced, the burden of the doctor on diagnosing prostate diseases is greatly reduced, meanwhile, manual calibration can be carried out on the automatically segmented prostate image, the calibrated prostate image serves as an image sample to be stored in a database, and the accuracy of prostate image segmentation is further improved.

The traditional Chinese medicine composition is prepared from the following raw materials: astragalus membranaceus, herba artemisiae anomalae, pollen typhae, rhizoma dioscoreae septemlobae, stiff silkworm, kelp, cinnamon, curcuma zedoary, euphorbia helioscopia, tortoise plastron and liquorice. According to the traditional Chinese medicine composition or the extract of the traditional Chinese medicine composition provided by the invention, under the guidance of a new thought of prostate meridian and collateral qi and blood differentiation, inherent physiological differences of different regions of the prostate are fully considered, pathological characteristics and pathogenesis of diseases are discriminated on the basis, and a new traditional Chinese medicine formula aiming at prostate lesions is constructed and formed; the traditional Chinese medicine formula especially aims at benign prostatic hyperplasia lesions.

The invention discloses a bispecific antibody-UC-MSCs preparation for targeting prostate diseases as well as preparation and application of the bispecific antibody-UC-MSCs preparation. The preparation comprises a bispecific antibody BsAb-1 and human umbilical cord mesenchymal stem cells (UC-MSCs), the BsAb-1 is formed by connecting an anti-CD105 single-domain antibody, an anti-PSCA single-domain antibody and a flexible peptide linker in series, wherein the amino acid sequence of the BsAb-1 is as shown in SEQ ID NO: 4. According to the preparation, the UC-MSCs are delivered to a prostate focus through the targeting bridge effect of BsAb-1, the focus enrichment amount within 72 hours is increased by 6.3 times compared with that of pure UC-MSCs, and meanwhile retention of non-target organs such as the liver and the spleen is reduced. The preparation can effectively relieve inflammatory response and fibrosis of chronic prostatitis, and the curative effect of the preparation is remarkably superior to that of pure UC-MSCs treatment. Precise targeted treatment of prostate diseases is achieved, the curative effect is remarkably better than that of a traditional stem cell therapy method, and high clinical application value is achieved.

The invention provides a prostate small body leaked protein detection kit for early screening of prostate diseases, and relates to the technical field of detection kits. A moving frame is installed at the left end of the base in a threaded mode, an electric telescopic rod and an optical probe are fixedly installed at the outer end of the moving frame, an electromagnetic head is fixedly installed at the bottom of the electric telescopic rod, and a set of protective covers are slidably installed at the right end of the base; through cooperation of the limiting block and the elastic piece, rapid dismounting and accurate positioning of the detection disc are realized, and the detection disc can rapidly rotate to switch functional subareas. The moving frame is driven by the motor to link the electromagnetic head and the optical probe to complete the whole process of sample adsorption, cleaning and detection; the protective cover is quickly opened and closed through the sliding design of the elastic piece, and the detection protective performance is effectively improved; the problems that the detection precision and the service life of equipment are affected due to the fact that the detection disc of the detection box is complex in installation structure and tedious in disassembly and assembly process are solved; and a sample processing flow in a detection process lacks an effective partition isolation and automatic control mechanism.

1. The name of this design product: USB flash drive (Commemorative Edition of the Integrated Prostate Disease Diagnosis and Treatment Center). 2. Purpose of this design product: used for quick access to data. 3. The key point of the design of this product lies in its shape. 4. The picture or photo that best illustrates the design points: Stereoscopic drawing 1.

The invention provides a traditional Chinese medicine formula for treating prostate diseases, and relates to the field of traditional Chinese medicines. According to the invention, natural traditional Chinese medicinal materials are adopted as raw material medicines, so that the traditional Chinese medicine composition not only has obvious relieving and swelling and pain relieving effects on symptoms such as frequent micturition, urgent urination, urine drops, waiting for urination, hypogastrium or lumbosacral part swell or pain and the like caused by chronic prostatitis and benign prostatic hyperplasia, but also can improve blood circulation of prostate; the repair and regeneration of prostate tissues are promoted, so that the treatment effect of treating both symptoms and root causes is achieved; the traditional Chinese medicine is small in toxic and side effects, does not need to be taken, can be placed in the navel during use, is convenient to use, and causes little damage to the body of a patient.

This invention relates to the field of in vitro diagnostics, and particularly to a combined diagnostic kit for prostate diseases. The invention provides reagents including pH, peroxidase, elastase, lecithin bodies, citric acid, zinc, and acid phosphatase under mild reaction conditions, enabling rapid differentiation of inflammatory and non-inflammatory prostatitis, benign prostatic hyperplasia, and non-prostatic genital tract infections using a single test card. Through extensive experimentation, this invention has developed a one-step reaction scheme suitable for the dry chemical determination of acid phosphatase and lecithin bodies in seminal plasma. This method eliminates the need for a stop solution, achieving a one-step reaction under mild conditions that will not cause damage to operators or fully automated instruments. The samples used are seminal plasma or semen, allowing for large sample volumes and easy acquisition, significantly improving diagnostic efficiency for doctors and patient comfort.

The invention belongs to the technical field of processing, and particularly relates to a gallic acid-kaempferol self-assembly, a self-assembly gel candy, a preparation method and application. According to the gallic acid-kaempferol self-assembly, gallic acid and kaempferol form a reticular fiber structure through pi-pi accumulation and hydrogen bond interaction. The traditional Chinese medicine composition has the effect of improving prostate diseases. The gallic acid-kaempferol self-assembly is combined with the candy, so that the gallic acid-kaempferol self-assembly is contained in the oral cavity to be slowly dissolved, effective components in the gallic acid-kaempferol self-assembly can be slowly released, stimulation to gastrointestinal tracts is reduced, nutrition needed by human bodies can be supplemented, the effect of improving prostate diseases is achieved, the gallic acid-kaempferol self-assembly candy can meet market requirements, and the market prospect is wide.

The invention relates to application of a mulberry extract in preparation of a medicine for treating and / or preventing prostate diseases. The mulberry extract comprises alkaloid with the weight content being 3% or above, and / or polysaccharide with the weight content being not higher than 70%, and / or flavone with the weight content being not higher than 10%, and / or amino acid with the weight content being not higher than 50%, and / or other components. The mulberry extract has a remarkable treatment effect on prostate related diseases.

The present invention discloses a method, device and storage medium for detecting prostate lesion regions, which relates to the field of computer vision. Accurate automatic segmentation of prostate lesion regions is an important requirement for computer-aided diagnosis and treatment of prostate diseases. However, there is a lack of clear boundaries and high contrast between the prostate and surrounding tissues, making it difficult to accurately extract the prostate from the background. Due to the scarcity of information in medical images, multiple methods must be used for multi-dimensional information extraction, but the current methods cannot fully learn and mine hidden information. To address the above challenges, the present invention proposes a brand-new method, device and storage medium for detecting prostate lesion regions applicable to the field of computer vision. In order to improve the quality of information extraction at different scales, different convolution combinations and various attention mechanisms are used in the proposed network, enabling it to have superior performance under different imaging modalities.

The invention relates to the technical field of prostate, and discloses a prostate adjuvant therapy system and device.The prostate adjuvant therapy system comprises a needle cylinder, a bottom plate fixedly connected with the needle cylinder, a sealing sliding piece arranged in the needle cylinder in a sliding mode, a push handle connected with the sealing sliding piece, and an electric cylinder fixedly arranged at one end of the bottom plate; an output shaft of the electric cylinder is connected with the push handle; a metal tube is fixedly connected in the needle cylinder through a support, a heating inductance coil is fixedly wound at the outer side end of the metal tube, a filling through tube is connected with the metal tube in a penetrating mode, the filling through tube penetrates through the side wall of the needle cylinder, and the heating inductance coil penetrates through the side wall of the needle cylinder and is connected with a heating device. And a filling funnel is arranged at the top end of the filling through pipe in a manner of penetrating through the filling through pipe. Sealing plates are arranged at the two ends of the metal pipe in a sealed mode. The system is simple to operate, has the advantage of universal and accurate treatment of prostate diseases, and can accurately deliver treatment drugs to prostate lesions.

The invention relates to the technical field of traditional Chinese medicine, in particular to application of a traditional Chinese medicine composition in preparation of a medicine for treating prostate diseases. The traditional Chinese medicine composition takes prepared rehmannia root and poria cocos as main medicines, can assist spleen transportation and transformation to insulate a source of phlegm and can also remove dampness and turbidity to directly relieve dysuria, meanwhile, the dampness removing property of the traditional Chinese medicine composition can restrict greasy taste of the prepared rehmannia root, and the effect of treating prostate diseases is achieved. Cistanche deserticola, astragalus mongholicus and ginseng are used as auxiliary medicines to tonify yin and yang and provide motive power for lower-jiao gasification, astragalus mongholicus and ginseng greatly tonify primordial qi, invigorate the spleen, benefit qi and strengthen the postnatal root, and maca is used as auxiliary medicines to enhance the overall function. According to the traditional Chinese medicine composition, all the medicines are compatible to jointly achieve the effects of tonifying kidney and spleen to consolidate foundation, promoting diuresis and reducing phlegm, and activating blood circulation and eliminating diseases to treat symptoms, the prostate volume is effectively reduced, the urination symptom is improved and the purpose of treating prostatic hyperplasia is achieved by improving the lower-jiao gasification function, promoting water metabolism and softening and dissipating prostate phlegm and blood stasis diseases, and the traditional Chinese medicine composition attacks pathogens without hurting vital energy, tonifies deficiency without lingering pathogens and has no toxic or side effect. And specimens are considered.