Dry, comfortable, antibacterial and itching-relieving protection pad and preparation method thereof

Abstract

The invention discloses a dry, comfortable, antibacterial and itching-relieving protection pad. The protection pad is formed by compounding a base layer and a surface layer, and the base layer is a non-woven fabric layer; and the surface layer is a medicine-carrying composite non-woven fabric layer. The protection pad surface layer is located above the base layer, the area of the protection pad surface layer is smaller than that of the base layer, and active ingredients extracted from radix sophorae flavescentis, cortex phellodendri, radix stemonae, cortex dictamni and golden larch bark and an antibacterial material polyhexamethylene biguanide are introduced into the skin-attaching non-woven fabric of the protection pad surface layer, so that the protection pad has the effects of resisting bacteria, relieving itching, clearing damp, expelling parasites and the like; the disposable disposable diaper is suitable for anorectal postoperative wound repair, prostate disease urine leakage, obesity and hidrosis and other field operation people, is particularly beneficial to tinea corporis and rotten crotch in special occasions, and has a good application prospect. The invention further discloses a preparation method of the protection pad.

Description

Technical Field

[0001] The present invention relates to the field of pharmaceutical technology, and particularly relates to a dry, antibacterial and antipruritic sanitary napkin and a preparation method thereof. Background Art

[0002] Most patients with anorectal diseases need surgical treatment, and most of the postoperative wounds are open type II incisions. The wound healing takes a long time, and symptoms such as excessive secretion and pain are likely to occur. At present, gauze is mostly used clinically for isolation, but the disadvantages are that it is not easy to fix, easy to shift, and has poor water absorption effect, and it is easy to breed bacteria and contaminate the wound.

[0003] Men suffering from prostate diseases may have a series of symptoms, including frequent urination, urgency of urination, increased nocturia, weakened urine flow, and a feeling of incomplete urination. In some cases, these symptoms may cause patients to experience urine leakage and require sanitary napkins to absorb urine. Especially for patients after prostate cancer surgery, the short-term urine leakage rate is more than 70%, and the lifelong urine leakage rate is 30%.

[0004] Obese and sweaty people, sports enthusiasts, people working outdoors, and people in special occasions are prone to local itching, eczema and skin diseases such as tinea corporis, and even the situation of "festering crotch" due to wearing airtight pants for a long time and excessive sweating.

[0005] Based on the above situations, developing a dry, antibacterial and antipruritic sanitary napkin that can well solve all the above problems at present is one of the research directions that those skilled in the art are committed to. Summary of the Invention

[0006] The purpose of the present invention is to provide a dry, antibacterial and antipruritic sanitary napkin and a preparation method thereof to solve the deficiencies in the prior art.

[0007] According to an embodiment, a dry, antibacterial and antipruritic sanitary napkin provided by the present invention is composed of a base layer and a surface layer laminated together; the base layer is a non-woven fabric layer; the surface layer is a drug-loaded composite non-woven fabric layer, and the drug loaded is a traditional Chinese medicine composition made of Sophora flavescens, Phellodendron amurense, Stemona japonica, Dictamnus dasycarpus, and Pseudolarix kaempferi in a mass ratio of 1-5:1-5:1-5:1-5:1-5; the area of the surface layer is smaller than that of the base layer; the surface layer is located above the base layer.

[0008] As a further technical solution: the non-woven fabric layer is formed by melting and extruding polypropylene particles in an extruder, then metering by a metering pump and melt-spinning by a spinneret, and then under the traction and stretching action of hot air; wherein: the traction speed is 120 m / min; the hot air temperature is 80 °C; the melt index of the polypropylene particles is 1200 g / 10 min.

[0009] As a further technical solution: the surface layer is formed by melting and extruding the drug-loaded composite polypropylene particles in an extruder, metering them by a metering pump, and melt-blowing them through a spinneret. Subsequently, under the traction and stretching action of hot air, a composite non-woven fabric is formed. Among them: the traction speed is 135 m / min; the hot air temperature is 80 °C; the melt index of the polypropylene particles is 1500 g / 10 min.

[0010] As a further technical solution: the preparation method of the drug-loaded composite polypropylene particles includes the following technological steps:

[0011] Weigh 1-5 parts by weight of the raw drug Sophora flavescens, 1-5 parts by weight of Phellodendron amurense, 1-5 parts by weight of Stemona japonica, 1-5 parts by weight of Dictamnus dasycarpus, and 1-5 parts by weight of Pseudolarix kaempferi; crush the raw drugs, and then extract them with 5-50 times the amount (i.e., the solvent dosage per 1 g of raw medicinal material is 5-50 ml) of 50%-95% ethanol for 0.5-10 hours. The extract is filtered, concentrated, dried, and crushed to obtain a mixed Chinese medicine extract; in this step, the weight ratio of the Chinese medicine dosage is preferably 1-3 parts by weight of Sophora flavescens, 1-3 parts by weight of Phellodendron amurense, 1-3 parts by weight of Stemona japonica, 1-3 parts by weight of Dictamnus dasycarpus, and 1-3 parts by weight of Pseudolarix kaempferi; most preferably, 1 part by weight of Sophora flavescens, 1 part by weight of Phellodendron amurense, 1 part by weight of Stemona japonica, 1 part by weight of Dictamnus dasycarpus, and 1 part by weight of Pseudolarix kaempferi;

[0012] Add sodium silicate to deionized water, stir and mix evenly, then dropwise add hydrochloric acid until a gel is formed, stop adding hydrochloric acid, add acetone, fully stir and mix, and then stand for aging for 4-5 hours to obtain a preliminary aging material;

[0013] Mix the mixed Chinese medicine extract with absolute ethanol evenly, then add it to the preliminary aging material, stir and mix evenly, continue to stand for 10-12 hours, then dry at 75 °C for 5 hours, then raise the temperature to 125 °C and continue to dry for 3 hours, and after crushing, obtain a drug-loaded material;

[0014] Add the drug-loaded material, polyhexamethylene biguanide, and polypropylene resin to a twin-screw extruder in sequence for melting and extrusion granulation to obtain drug-loaded composite polypropylene particles;

[0015] The mixing mass ratio of the drug-loaded material, polyhexamethylene biguanide, and polypropylene resin is 2.5-5:12-18:60.

[0016] As a further technical solution: the mixing mass ratio of the sodium silicate and deionized water is 12.3:25; the concentration of the hydrochloric acid is 3.5 mol / L; the addition amount of the acetone is 30% of the mass of the deionized water; the mixing mass ratio of the mixed Chinese medicine extract, absolute ethanol, and the preliminary aging material is 0.3-0.5:10:25.

[0017] As a further technical solution: the thickness range of the non-woven fabric layer is 0.2 mm - 0.4 mm, and the gram weight range is 20 g / m 2 -30 g / m 2 。

[0018] As a further technical solution: the thickness range of the non-woven fabric layer is 0.4 mm - 0.6 mm, and the gram weight range is 40 g / m 2 -50 g / m 2 。

[0019] According to the embodiment, a preparation method of a dry, antibacterial, antipruritic and anti-itching sanitary napkin provided by the present invention includes the following steps: using drug-loaded composite polypropylene particles as raw materials to make a drug-loaded composite non-woven fabric layer to obtain a surface layer; using polypropylene particles as raw materials to make a non-woven fabric layer to obtain a base layer; respectively cutting the drug-loaded composite non-woven fabric layer and the drug-loaded composite non-woven fabric layer into specified shapes, then laminating them together with the surface layer on the top and the base layer on the bottom, and then performing sterilization and packaging.

[0020] Compared with the prior art, by mixing and extracting active ingredients from Chinese herbs Sophora flavescens, Phellodendron amurense, Stemona japonica, Dictamnus dasycarpus, and Pseudolarix kaempferi, and the antibacterial material polyhexamethylene biguanide, and introducing them into the non-woven fabric of the skin-friendly layer of the sanitary napkin, the present invention can enable the sanitary napkin to have the effects of antibacterial, antipruritic, dampness-removing, and insect-repelling, etc., and is suitable for use by people in the post-rectal surgery wound repair, prostate disease urine leakage, obesity and hyperhidrosis, and other field operation populations. It is especially helpful for tinea corporis and "crotch rot" in special occasions. The Chinese herbal materials and antibacterial materials have good bactericidal effects on fungi, Staphylococcus aureus, Escherichia coli, etc.

[0021] Compared with the prior art, the sanitary napkin made of a double-layer non-woven fabric structure by the present invention not only has excellent air permeability, can better allow air to pass through, has good skin-fitting property, and is soft, light and thin. At the same time, when in use, it can maintain a continuous dry effect, effectively reduce the occurrence of wound infection problems, can maintain the dryness and comfort of the skin for a long time, and will not affect the normal respiration of skin cells.

[0022] Through a large number of experimental studies, by using the compatibility of Sophora flavescens, Phellodendron amurense, Stemona japonica, Dictamnus dasycarpus, and Pseudolarix kaempferi, and through a large number of skin tests, the present invention can enable the sanitary napkin to have better skin friendliness, will not cause allergies or other skin problems, can be suitable for most people to use, and is very hygienic and convenient.

[0023] By combining the active ingredients extracted from the mixture of Sophora flavescens, Phellodendron amurense, Stemona japonica, Dictamnus dasycarpus, and Pseudolarix kaempferi with a drug-loading material to form a drug-loading material, through the multi-void adsorption structure of the carrier, the present invention can enable the active ingredients to be released persistently, maintain an excellent sustained-release mechanism, so as to ensure the comfort and health benefits of continuous drug release throughout the use period. Detailed implementation mode

[0024] The technical solutions in the embodiments of the present invention will be clearly and completely described below. Obviously, the described embodiments are only a part of the embodiments of the present invention, rather than all embodiments. All other embodiments obtained by those of ordinary skill in the art based on the embodiments of the present invention without creative efforts shall fall within the protection scope of the present invention.

[0025] Embodiment 1

[0026] A dry, antibacterial, antipruritic sanitary pad is composed of a base layer and a surface layer compounded together;

[0027] Among them, the base layer is made of a non-woven fabric layer;

[0028] The surface layer is made of a drug-loaded composite non-woven fabric layer;

[0029] The area of the surface layer is smaller than that of the base layer;

[0030] The surface layer is located above the base layer.

[0031] The non-woven fabric layer is formed by melting and extruding polypropylene particles in an extruder, then metering by a metering pump and melt-blowing through a spinneret, and then under the traction and stretching action of hot air;

[0032] The traction speed is 120 m / min;

[0033] The hot air temperature is 80 °C;

[0034] Among them, the melt index of the polypropylene particles is 1200 g / 10 min.

[0035] The surface layer is formed by melting and extruding drug-loaded composite polypropylene particles in an extruder, then metering by a metering pump and melt-blowing through a spinneret, and then under the traction and stretching action of hot air to form a composite non-woven fabric;

[0036] The traction speed is 135 m / min;

[0037] The hot air temperature is 80 °C;

[0038] Among them, the melt index of the polypropylene particles is 1500 g / 10 min.

[0039] The preparation method of the drug-loaded composite polypropylene particles is as follows:

[0040] Weigh 10 g of Sophora flavescens, 10 g of Phellodendron amurense, 10 g of Stemona sessilifolia, 10 g of Dictamnus dasycarpus, and 10 g of Pseudolarix kaempferi respectively; crush the raw medicinal materials, and then extract them with 15 times (that is, the solvent dosage per 1 g of raw medicinal material is 15 ml) of 75% ethanol by ultrasonic extraction for 2 hours. Filter the extract, concentrate, dry, and crush to obtain a traditional Chinese medicine mixed extract;

[0041] Add sodium silicate to deionized water, stir and mix evenly, then add hydrochloric acid dropwise until a gel is formed, stop adding hydrochloric acid, then add acetone, stir and mix well, let it stand and age for 4 hours to obtain a preliminarily aged material. Then mix the traditional Chinese medicine mixed extract with absolute ethanol evenly, and add it to the preliminarily aged material, stir and mix well, continue to let it stand for 10 hours, then dry at 75°C for 5 hours, then raise the temperature to 125°C and continue to dry for 3 hours, and after pulverization, obtain the drug-loaded material;

[0042] Add the drug-loaded material, polyhexamethylene biguanide, and polypropylene resin to a twin-screw extruder in sequence for melt extrusion granulation to obtain drug-loaded composite polypropylene particles;

[0043] The mixing mass ratio of the drug-loaded material, polyhexamethylene biguanide, and polypropylene resin is 3:12:60.

[0044] The mixing mass ratio of sodium silicate and deionized water is 12.3:25;

[0045] The concentration of the hydrochloric acid is 3.5 mol / L;

[0046] The added amount of the acetone is 30% of the mass of the deionized water;

[0047] The mixing mass ratio of the traditional Chinese medicine mixed extract, absolute ethanol, and the preliminarily aged material is 0.3:10:25.

[0048] The thickness range of the non-woven fabric layer is 0.3 mm.

[0049] The thickness range of the non-woven fabric layer is 0.6 mm.

[0050] A preparation method of a dry, antibacterial and antipruritic sanitary pad includes the following steps:

[0051] First, use the drug-loaded composite polypropylene particles as raw materials to make a drug-loaded composite non-woven fabric layer to obtain the surface layer;

[0052] Use polypropylene particles as raw materials to make a non-woven fabric layer to obtain the base layer;

[0053] Cut the drug-loaded composite non-woven fabric layers into specified shapes respectively, then stack them with the surface layer on top and the base layer at the bottom, bond them together, and then perform sterilization and packaging.

[0054] Example 2

[0055] A dry, antibacterial and antipruritic sanitary pad is composed of a base layer and a surface layer compounded;

[0056] Among them, the base layer is a non-woven fabric layer;

[0057] The surface layer is a drug-loaded composite non-woven fabric layer;

[0058] The area of the surface layer is smaller than that of the base layer;

[0059] The surface layer is located above the base layer.

[0060] The non-woven fabric layer is formed by melting and extruding polypropylene particles in an extruder, metering by a metering pump and melt-spinning through a spinneret, and then under the traction and stretching action of hot air, forming a non-woven fabric;

[0061] The traction speed is 120 m / min;

[0062] The hot air temperature is 80 °C;

[0063] Among them, the melt index of the polypropylene particles is 1200 g / 10 min.

[0064] The surface layer is formed by melting and extruding drug-loaded composite polypropylene particles in an extruder, metering by a metering pump and melt-spinning through a spinneret, and then under the traction and stretching action of hot air, forming a composite non-woven fabric;

[0065] The traction speed is 135 m / min;

[0066] The hot air temperature is 80 °C;

[0067] Among them, the melt index of the polypropylene particles is 1500 g / 10 min.

[0068] The preparation method of the drug-loaded composite polypropylene particles is as follows:

[0069] First, weigh 25 g of Sophora flavescens, 10 g of Phellodendron amurense, 15 g of Stemona sessilifolia, 20 g of Dictamnus dasycarpus, and 10 g of Pseudolarix kaempferi respectively; crush the raw medicinal materials, and then extract with 80% ethanol 30 times (that is, the solvent dosage per 1 g of raw medicinal material is 30 ml) by ultrasonic extraction for 1 hour. Filter the extract, concentrate, dry, and crush to obtain an extraction material;

[0070] Add sodium silicate to deionized water, stir and mix evenly, then dropwise add hydrochloric acid until a gel is formed, stop adding hydrochloric acid, add acetone, fully stir and mix, stand and age for 4.5 hours to obtain a preliminary aged material. Then mix the traditional Chinese medicine mixed extraction material with absolute ethanol evenly, add it to the preliminary aged material, stir and mix evenly, continue to stand for 11 hours, then dry at 75 °C for 5 hours, then raise the temperature to 125 °C and continue to dry for 3 hours, and after crushing, obtain a drug-loaded material;

[0071] Add the drug-loaded material, polyhexamethylene biguanide, and polypropylene resin to a twin-screw extruder in sequence for melt extrusion granulation to obtain drug-loaded composite polypropylene particles;

[0072] The mixing mass ratio of the drug-loaded material, polyhexamethylene biguanide, and polypropylene resin is 2.5:12:60.

[0073] The mixing mass ratio of sodium silicate and deionized water is 12.3:25;

[0074] The concentration of the hydrochloric acid is 3.5 mol / L;

[0075] The added amount of acetone is 30% of the mass of deionized water;

[0076] The mixing mass ratio of the traditional Chinese medicine mixed extract, absolute ethanol and the preliminary aging material is 0.35:10:25.

[0077] The thickness range of the non-woven fabric layer is 0.3 mm.

[0078] The thickness range of the non-woven fabric layer is 0.6 mm.

[0079] A preparation method of a dry, antibacterial and antipruritic sanitary pad, comprising the following steps:

[0080] First, using the drug-loaded composite polypropylene particles as raw materials, a drug-loaded composite non-woven fabric layer is made to obtain the surface layer;

[0081] Using polypropylene particles as raw materials, a non-woven fabric layer is made to obtain the base layer;

[0082] The drug-loaded composite non-woven fabric layers are respectively cut into specified shapes, and then, with the surface layer on the top and the base layer on the bottom, they are bonded together, and then sterilized and packaged.

[0083] Example 3

[0084] A dry, antibacterial and antipruritic sanitary pad is composed of a base layer and a surface layer;

[0085] Among them, the base layer is a non-woven fabric layer;

[0086] The surface layer is a drug-loaded composite non-woven fabric layer;

[0087] The area of the surface layer is smaller than that of the base layer;

[0088] The surface layer is located above the base layer.

[0089] The non-woven fabric layer is formed by melting and extruding polypropylene particles in an extruder, metering by a metering pump and melt-blowing through a spinneret, and then, under the traction and stretching action of hot air, forming a non-woven fabric;

[0090] The traction speed is 120 m / min;

[0091] The hot air temperature is 80 °C;

[0092] Among them, the melt index of the polypropylene particles is 1200 g / 10 min.

[0093] The surface layer is formed by melting and extruding the drug-loaded composite polypropylene particles in an extruder, metering them with a metering pump, and melt-blowing them through a spinneret. Subsequently, under the traction and stretching action of hot air, a composite non-woven fabric is formed.

[0094] The traction speed is 135 m / min.

[0095] The hot air temperature is 80 °C.

[0096] Among them, the melt index of the polypropylene particles is 1500 g / 10 min.

[0097] The preparation method of the drug-loaded composite polypropylene particles is as follows:

[0098] First, weigh 40 g of Sophora flavescens, 30 g of Phellodendron amurense, 10 g of Stemona sessilifolia, 50 g of Dictamnus dasycarpus, and 15 g of Pseudolarix kaempferi respectively; crush the raw medicinal materials, then reflux and extract with 50 times (i.e., the solvent dosage per 1 g of raw medicinal material is 50 ml) of 95% ethanol for 0.5 hours, filter the extract, concentrate, dry, and crush to obtain the extraction material.

[0099] Add sodium silicate to deionized water, stir and mix evenly, then add hydrochloric acid dropwise until a gel is formed, stop adding hydrochloric acid, add acetone, stir and mix well, let it stand and age for 4 hours to obtain the preliminary aged material. Then, mix the traditional Chinese medicine mixed extraction material with absolute ethanol evenly, add it to the preliminary aged material, stir and mix well, continue to let it stand for 11 hours, then dry at 75 °C for 5 hours, then raise the temperature to 125 °C and continue to dry for 3 hours, and after crushing, obtain the drug-loaded material.

[0100] Add the drug-loaded material, polyhexamethylene biguanide, and polypropylene resin to a twin-screw extruder in sequence for melting and extrusion granulation to obtain the drug-loaded composite polypropylene particles.

[0101] The mixing mass ratio of the drug-loaded material, polyhexamethylene biguanide, and polypropylene resin is 4:15:60.

[0102] The mixing mass ratio of sodium silicate and deionized water is 12.3:25.

[0103] The concentration of the hydrochloric acid is 3.5 mol / L.

[0104] The added amount of the acetone is 30% of the mass of the deionized water.

[0105] The mixing mass ratio of the traditional Chinese medicine mixed extraction material, absolute ethanol, and the preliminary aged material is 0.4:10:25.

[0106] The thickness range of the non-woven fabric layer is 0.3 mm.

[0107] The thickness range of the non-woven fabric layer is 0.6 mm.

[0108] A preparation method of a dry, antibacterial and antipruritic sanitary pad, comprising the following steps:

[0109] First, using drug-loaded composite polypropylene particles as raw materials, a drug-loaded composite non-woven fabric layer is made to obtain the surface layer;

[0110] Using polypropylene particles as raw materials, a non-woven fabric layer is made to obtain the base layer;

[0111] The drug-loaded composite non-woven fabric layers are respectively cut into specified shapes, and then the surface layer is on the top and the base layer is on the bottom, and they are bonded together, and then sterilized and packaged.

[0112] Example 4

[0113] A dry, antibacterial and antipruritic sanitary pad, which is composed of a composite of a base layer and a surface layer;

[0114] Among them, the base layer is a non-woven fabric layer;

[0115] The surface layer is a drug-loaded composite non-woven fabric layer;

[0116] The area of the surface layer is smaller than that of the base layer;

[0117] The surface layer is located above the base layer.

[0118] The non-woven fabric layer is formed by melting and extruding polypropylene particles in an extruder, then metering by a metering pump and melt-blowing through a spinneret, and then under the traction and stretching action of hot air, a non-woven fabric is formed;

[0119] The traction speed is 120 m / min;

[0120] The hot air temperature is 80 °C;

[0121] Among them, the melt index of the polypropylene particles is 1200 g / 10 min.

[0122] The surface layer is formed by melting and extruding drug-loaded composite polypropylene particles in an extruder, then metering by a metering pump and melt-blowing through a spinneret, and then under the traction and stretching action of hot air, a composite non-woven fabric is formed;

[0123] The traction speed is 135 m / min;

[0124] The hot air temperature is 80 °C;

[0125] Among them, the melt index of the polypropylene particles is 1500 g / 10 min.

[0126] The preparation method of the drug-loaded composite polypropylene particles is:

[0127] First, weigh 50 g of Sophora flavescens, 15 g of Phellodendron amurense, 30 g of Stemona japonica, 10 g of Dictamnus dasycarpus Turcz., and 50 g of Pseudolarix kaempferi Gord. respectively; crush the raw medicinal materials, and then reflux and extract with 50% ethanol at 5 times (i.e., the solvent dosage for every 1 g of raw medicinal material is 5 ml) for 8 hours. Filter the extract, concentrate, dry, and crush it to obtain an extraction material;

[0128] Add sodium silicate to deionized water, stir and mix evenly, then dropwise add hydrochloric acid until a gel is formed, stop adding hydrochloric acid, add acetone, fully stir and mix, let it stand and age for 5 hours to obtain a preliminarily aged material. Then mix the traditional Chinese medicine mixed extraction material with absolute ethanol evenly, and add it to the preliminarily aged material, stir and mix evenly, continue to let it stand for 10 hours, then dry at 75 °C for 5 hours, then raise the temperature to 125 °C and continue to dry for 3 hours. After crushing, a drug-loaded material is obtained;

[0129] Add the drug-loaded material, polyhexamethylene biguanide, and polypropylene resin to a twin-screw extruder in sequence for melt extrusion granulation to obtain drug-loaded composite polypropylene particles;

[0130] The mixing mass ratio of the drug-loaded material, polyhexamethylene biguanide, and polypropylene resin is 5:17:60.

[0131] The mixing mass ratio of sodium silicate and deionized water is 12.3:25;

[0132] The concentration of the hydrochloric acid is 3.5 mol / L;

[0133] The added amount of the acetone is 30% of the mass of the deionized water;

[0134] The mixing mass ratio of the traditional Chinese medicine mixed extraction material, absolute ethanol, and the preliminarily aged material is 0.4:10:25.

[0135] The thickness range of the non-woven fabric layer is 0.3 mm.

[0136] The thickness range of the non-woven fabric layer is 0.6 mm.

[0137] A preparation method of a dry, antibacterial, and antipruritic sanitary pad includes the following steps:

[0138] First, use the drug-loaded composite polypropylene particles as raw materials to make a drug-loaded composite non-woven fabric layer to obtain a surface layer;

[0139] Use polypropylene particles as raw materials to make a non-woven fabric layer to obtain a base layer;

[0140] Cut the drug-loaded composite non-woven fabric layers into specified shapes respectively, then stack them with the surface layer on top and the base layer at the bottom, bond them together, and then sterilize and package them.

[0141] Example 5

[0142] A dry, antibacterial, antipruritic sanitary pad is composed of a base layer and a surface layer laminated together;

[0143] Among them, the base layer is made of a non-woven fabric layer;

[0144] The surface layer is made of a drug-loaded composite non-woven fabric layer;

[0145] The area of the surface layer is smaller than that of the base layer;

[0146] The surface layer is located above the base layer.

[0147] The non-woven fabric layer is formed by melting and extruding polypropylene particles in an extruder, followed by metering with a metering pump and melt-blowing through a spinneret, and then under the traction and stretching action of hot air;

[0148] The traction speed is 120 m / min;

[0149] The hot air temperature is 80 °C;

[0150] Among them, the melt index of the polypropylene particles is 1200 g / 10 min.

[0151] The surface layer is formed by melting and extruding drug-loaded composite polypropylene particles in an extruder, followed by metering with a metering pump and melt-blowing through a spinneret, and then under the traction and stretching action of hot air to form a composite non-woven fabric;

[0152] The traction speed is 135 m / min;

[0153] The hot air temperature is 80 °C;

[0154] Among them, the melt index of the polypropylene particles is 1500 g / 10 min.

[0155] The preparation method of the drug-loaded composite polypropylene particles is as follows:

[0156] First, weigh 10 g of Sophora flavescens, 10 g of Phellodendron amurense, 10 g of Stemona sessilifolia, 10 g of Dictamnus dasycarpus, and 10 g of Pseudolarix kaempferi respectively; crush the raw medicinal materials, and then percolate and extract with 60% ethanol at 50 times (i.e., the solvent dosage per 1 g of the raw medicinal material is 50 ml) for 10 hours. Filter the extract, concentrate, dry, and crush to obtain an extraction material;

[0157] Add sodium silicate to deionized water, stir and mix evenly, then add hydrochloric acid dropwise until a gel is formed, stop adding hydrochloric acid, add acetone, stir and mix well, let it stand and age for 5 hours to obtain a preliminary aged material. Then mix the traditional Chinese medicine mixed extraction material with absolute ethanol evenly, add it to the preliminary aged material, stir and mix well, continue to stand for 12 hours, then dry at 75 °C for 5 hours, then raise the temperature to 125 °C and continue to dry for 3 hours, and after crushing, obtain a drug-loaded material;

[0158] The drug-loaded material, polyhexamethylene biguanide, and polypropylene resin are sequentially added to a twin-screw extruder for melt extrusion granulation to obtain drug-loaded composite polypropylene particles;

[0159] The mixing mass ratio of the drug-loaded material, polyhexamethylene biguanide, and polypropylene resin is 4:18:60.

[0160] The mixing mass ratio of sodium silicate and deionized water is 12.3:25;

[0161] The concentration of the hydrochloric acid is 3.5 mol / L;

[0162] The addition amount of acetone is 30% of the mass of deionized water;

[0163] The mixing mass ratio of the traditional Chinese medicine mixed extract, absolute ethanol, and the preliminary aging material is 0.5:10:25.

[0164] The thickness range of the non-woven fabric layer is 0.3 mm.

[0165] The thickness range of the non-woven fabric layer is 0.6 mm.

[0166] A preparation method of a dry, antibacterial, and antipruritic sanitary pad, comprising the following steps:

[0167] First, using the drug-loaded composite polypropylene particles as raw materials, a drug-loaded composite non-woven fabric layer is made to obtain the surface layer;

[0168] Using polypropylene particles as raw materials, a non-woven fabric layer is made to obtain the base layer;

[0169] The drug-loaded composite non-woven fabric layers are respectively cut into specified shapes, and then, with the surface layer on top and the base layer below, they are bonded together, and then sterilized and packaged.

[0170] Comparative Example 1:

[0171] The difference from Example 1 is that the drug-loaded composite polypropylene particles do not add the drug-loaded material, and the rest of the technical solutions remain unchanged.

[0172] Comparative Example 2:

[0173] The difference from Example 1 is that the drug-loaded composite polypropylene particles do not add polyhexamethylene biguanide, and the rest of the technical solutions remain unchanged.

[0174] Test Example 1 - Skin Irritation Safety Test Experiment

[0175] Materials: 70 experimental rabbits, half male and half female, with a body weight of 2.25 ± 0.50 kg, randomly divided into 8 groups, including the example group and the comparative example groups, with 10 rabbits in each group.

[0176] Method: Remove the rabbit hair on the buttocks of the experimental rabbits in an area of 3×3 cm², keep the skin of the experimental rabbits intact without damage, and the skin in the experimental area is healthy. In the example group, pads of Examples 1-5 with an area of 3×3 cm² are pasted, and in the comparative example group, pads of Comparative Examples 1-2 with an area of 3×3 cm² are pasted, and keep them for 3 days without falling off. After 3 days, observe whether there are phenomena such as skin redness, itching, skin roughness, and spotting: Table 1. Test results of sample irritation

[0177] Sample Skin irritation safety test Example 1 No irritation Example 2 No irritation Example 3 No irritation Example 4 No irritation Example 5 No irritation Comparative Example 1 No irritation Comparative Example 2 No irritation

[0178] As can be seen from Table 1, the pads of Examples 1-5 and Comparative Examples 1-2 have no irritation

[0179] Test Example 2 - Air permeability test

[0180] Test: Place the sample of the example flat on a fully automatic air permeability tester for detection

[0181] Table 2. Test results of sample air permeability

[0182] Sample Air permeability mm / s Example 1 386 Example 2 382 Example 3 380 Example 4 385 Example 5 381

[0183] As can be seen from Table 2, the pads of Examples 1-5 of the present invention have high air permeability

[0184] Test Example 3 - Antibacterial experiment

[0185] According to the detection method of GB 15979-2002 "Hygiene Standards for Disposable Sanitary Products", test the antibacterial properties of Staphylococcus aureus, Escherichia coli, and Candida albicans on the pads of Examples 1-5 and Comparative Examples 1-2

[0186] Table 3. Test results of sample antibacterial properties

[0187]

[0188] As can be seen from Table 3, the pads of Examples 1-5 of the present invention have strong antibacterial properties

Claims

1. A dry, antibacterial and antipruritic sanitary pad, characterized in that, It is composed of a base layer and a surface layer; the base layer is a non-woven fabric layer; the surface layer is a drug-loaded composite non-woven fabric layer, and the loaded drug is a traditional Chinese medicine composition made of Sophora flavescens, Phellodendron amurense, Stemona japonica, Dictamnus dasycarpus, and Pseudolarix kaempferi in a mass ratio of 1-5:1-5:1-5:1-5:1-5; the area of the surface layer is smaller than that of the base layer; the surface layer is located above the base layer.

2. The dry antibacterial and antipruritic sanitary napkin according to claim 1, wherein: The loaded drug is a traditional Chinese medicine composition made of Sophora flavescens, Phellodendron amurense, Stemona japonica, Dictamnus dasycarpus, and Pseudolarix kaempferi in a mass ratio of 1:1:1:1:

1.

3. The dry, antibacterial and itch-relieving sanitary napkin according to claim 1 or 2, wherein: The thickness range of the non-woven fabric layer is 0.2 mm - 0.4 mm, and the grammage range is 20 g / m 2 - 30 g / m 2 .

4. The dry, antibacterial and antipruritic sanitary napkin according to claim 1 or 2, characterized in that: The thickness range of the non-woven fabric layer is 0.4 mm - 0.6 mm, and the grammage range is 40 g / m 2 - 50 g / m 2 .

5. The dry, antibacterial and antipruritic sanitary napkin according to claim 3, characterized in that: The non-woven fabric layer is formed by melting and extruding polypropylene granules in an extruder, metering by a metering pump, and melt-blowing through a spinneret, and then under the traction and stretching action of hot air, a non-woven fabric is formed; among them: the traction speed is 120m / min; the hot air temperature is 80°C; the melt index of polypropylene granules is 1200g / 10min.

6. The dry, antibacterial and antipruritic sanitary napkin according to claim 4, wherein: The surface layer is formed by melting and extruding drug-loaded composite polypropylene granules in an extruder, metering by a metering pump, and melt-blowing through a spinneret, and then under the traction and stretching action of hot air, a composite non-woven fabric is formed; among them: the traction speed is 135m / min; the hot air temperature is 80°C; the melt index of polypropylene granules is 1500g / 10min.

7. The dry antibacterial and antipruritic sanitary napkin according to claim 6, wherein: The preparation method of the drug-loaded composite polypropylene granules includes the following steps: Weigh the raw materials Sophora flavescens, Phellodendron amurense, Stemona japonica, Dictamnus dasycarpus, and Pseudolarix kaempferi. Crush the raw materials, extract with 50%-95% ethanol 5-50 times the weight of the raw materials for 0.5-10 hours, filter the extract, concentrate, dry, and crush to obtain a traditional Chinese medicine mixed extract. Add sodium silicate to deionized water, stir and mix evenly, then dropwise add hydrochloric acid until a gel is formed, stop dropping hydrochloric acid, add acetone, fully stir and mix, and then stand and age for 4-5 hours to obtain a preliminary aged material. Mix the traditional Chinese medicine mixed extract with absolute ethanol evenly, then add it to the preliminary aged material, stir and mix evenly, continue to stand for 10-12 hours, then dry at 75°C for 5 hours, then raise the temperature to 125°C and continue to dry for 3 hours, and after crushing, obtain a drug-loaded material. Add the drug-loaded material, polyhexamethylene biguanide, and polypropylene resin to a twin-screw extruder in sequence for melt extrusion and granulation to obtain drug-loaded composite polypropylene granules. The mass ratio of the drug-loaded material, polyhexamethylene biguanide, and polypropylene resin is 2.5-5:12-18:

60.

8. The dry antibacterial and antipruritic sanitary napkin according to claim 7, characterized in that: The mass ratio of the mixture of sodium silicate and deionized water is 12.3:25; the concentration of hydrochloric acid is 3.5mol / L; the addition amount of acetone is 30% of the mass of deionized water; the mass ratio of the mixture of the traditional Chinese medicine mixed extract, absolute ethanol, and the preliminary aged material is 0.3-0.5:10:

25.

9. The preparation method of the dry, antibacterial and antipruritic sanitary napkin according to any one of claims 1-8, characterized in that, It includes the following steps: using the drug-loaded composite polypropylene granules as raw materials to make a drug-loaded composite non-woven fabric layer to obtain the surface layer; using polypropylene granules as raw materials to make a non-woven fabric layer to obtain the base layer; respectively cut the drug-loaded composite non-woven fabric layer and the drug-loaded composite non-woven fabric layer into specified shapes, then stack them with the surface layer on top and the base layer below, bond them together, then sterilize and package to obtain a dry, antibacterial and antipruritic sanitary napkin.

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