356 results about "Adjunctive treatment" patented technology

The invention discloses injectable hydrogel for photo-thermal adjuvant therapy of periodontitis and a preparation method, and belongs to the technical field of high polymer material preparation, the preparation method comprises the following steps: reacting MXene dispersion liquid with epigallocatechin gallate and MgSO4; then sequentially carrying out ultrasonic treatment, centrifugation, washing and freeze-drying to obtain a multifunctional nanosheet MP-Mg; adding the multifunctional nanosheet MP-Mg into an oxidized gellan gum aqueous solution, and carrying out a mixed reaction to obtain a solution A; mixing the quaternary ammonium salt chitosan aqueous solution and the carboxymethyl chitosan aqueous solution in equal volume, and reacting to obtain a solution B; and mixing the solution A and the solution B in equal volume for reaction. The hydrogel prepared by the preparation method disclosed by the invention has injectability, photo-thermal responsiveness, biological membrane penetrability, synergistic antibacterial property and long-acting anti-inflammatory property, and an innovative and practical photo-thermal adjuvant therapy platform is provided for clinical treatment of periodontitis.

The invention belongs to the technical field of microorganisms, and particularly relates to application of bifidobacterium longum in improving immunity and preparing products for preventing, treating and / or assisting in treating rhinitis. The preservation number of the bifidobacterium longum is GDMCC No: 65969, and the bifidobacterium longum can reduce the levels of MDA and NO in serum of mice and improve the activity of SOD and CAT and the content of GSH so as to relieve oxidative stress injury; inflammatory cell infiltration of nasal mucosa is reduced, and lung tissue inflammatory mediator level and inflammation-related gene expression are reduced to inhibit inflammation; th1 / Th2 immune balance is regulated, Th2 type cytokines are reduced, Th1 type cytokines are increased, and the high-dosage effect is close to that of loratadine. The strain has a treatment effect on allergic rhinitis through multiple mechanisms, and a new choice is provided for treatment of the strain.

The invention relates to application of bifidobacterium animalis in preparation of a product for preventing, treating or adjunctively treating pneumonia, and belongs to the technical field of microorganisms. The invention aims to solve the technical problem that the existing treatment of acute lung injury (ALI) / acute respiratory distress syndrome (ARDS) is mainly based on supportive means and lacks special-effect treatment drugs. According to the key point of the technical scheme, a new strain, namely the Bifidobacterium animalis ORG01 is provided, the preservation number is GDMCC NO: 67122, and the strain has good technical effects in the aspects of improving the acute lung injury effect, the strain stability, the product application convenience and the like. According to an experimental test, the bifidobacterium animalis ORG01 disclosed by the invention can be used for remarkably recovering the lung organ index of an LPS-induced acute lung injury model mouse, the TNF-alpha content in serum and the mRNA expression level of IL-6 in lung tissues to normal levels.

The invention provides a radix asparagi homogeneous acidic polysaccharide. The radix asparagi homogeneous acidic polysaccharide contains pectic polysaccharide which is shown as a formula 1, takes rhamnogalacturonidan I (RG-I) as a core and has a homopolygalacturonic acid (HG) structural domain. The invention further provides a preparation method and application of the radix asparagi homogeneous acidic polysaccharide. The asparagi pectin polysaccharide with a new structure is found for the first time, and the asparagi pectin polysaccharide has the effect on acute lung injury. The acidic polysaccharide disclosed by the invention has the advantage of anti-ALI activity, realizes synergistic protection of intestine-lung double target regions, has anti-inflammatory and anti-oxidation double activities, is natural in source and high in biological safety, and is suitable for long-term adjuvant therapy of acute lung injury.

The invention discloses a composite combined preparation for synergistically treating and conditioning diabetes, relates to the technical field of foods, health foods or dietary supplements for adjuvant therapy and health care of diabetes, and in particular relates to a composite combined preparation for synergistically treating and conditioning diabetes. The preparation comprises albumin peptide, saussurea involucrata culture, vitamin B1, vitamin B2, wheat oligopeptide, corn oligopeptide, collagen peptide, mulberry leaf extract, rhizoma polygonati extract, sea-buckthorn extract, isomaltitol, maltodextrin, ginseng extract and bitter gourd extract. Through the synergistic effect of all the components, comprehensive auxiliary conditioning on diabetes is realized from multiple targets of maintaining colloid osmotic pressure and nutrition, regulating glycolipid metabolism in multiple ways, protecting pancreatic beta cell functions, enhancing insulin sensitivity, preventing nerve and blood vessel complications, meeting special diet requirements and the like. The composition can be prepared into food, health-care food or dietary supplement and other dosage forms.

The invention discloses application of a combination of probiotics GOLDGUT-M520 and GOLDGUT-LR99 in preparation of a product for relieving depression, and belongs to the technical field of biological medicines. The probiotics disclosed by the invention can be used for relieving depressive symptoms, improving related symptoms, assisting in treating depression and preventing depression, and also can be used as a nutritional supplement to help maintain the balance of intestinal microflora and promote intestinal health.

1. Name of the product in this design: Percutaneous endoscopic discectomy. 2. Purpose of this design: This design is used for observation, diagnosis and adjunctive treatment of spinal parts such as intervertebral foramina and intervertebral discs. 3. The key design feature of this product is its shape. 4. The image or photograph that best illustrates the design's key points: a 3D model.

This invention discloses a grape seed protein peptide with ACE inhibitory activity and its preparation method, belonging to the field of comprehensive utilization of wine fermentation by-products. This invention provides a grape seed protein peptide with ACE inhibitory activity, wherein the grape seed protein peptide is FFYPL, SGMFPFP, or WFFPGPR. The grape seed protein peptide of this invention can be used in pharmaceuticals; it has broad application prospects in the pharmaceutical field as a preventive or adjunctive treatment for patients with hypertension, or those with obesity, cardiovascular and cerebrovascular diseases, and other chronic metabolic disorders.

The application belongs to the technical field of medicine or cosmetics, and particularly relates to a composition for treating atopic dermatitis and application thereof. The composition is composed of polysaccharide of Arnebia euchroma and naphthoquinone of Arnebia euchroma, and the mass ratio of the polysaccharide of Arnebia euchroma to the naphthoquinone of Arnebia euchroma is 250-500:1. The polysaccharide of Arnebia euchroma and the naphthoquinone of Arnebia euchroma are compounded according to a specific ratio, and the two components have a synergistic effect, can significantly inhibit secretion of inflammatory factors, and promote expression of key proteins of a skin barrier, so that atopic dermatitis is treated from two paths of 'anti-inflammation' and 'barrier repair', and the effect is significantly better than that of a single component. The composition of the application is derived from natural plant ingredients, has high safety, can be prepared into various dosage forms, is used for auxiliary treatment or daily care of atopic dermatitis, and has a good application prospect.

1. The name of the design product: ultrasonic therapeutic instrument. 2. The use of the design product: for the auxiliary treatment of cardiovascular and cerebrovascular diseases, soft tissue contusion, and nervous system disease rehabilitation. 3. The design points of the design product: the combination of shape and pattern. 4. The picture or photo that best indicates the design points: perspective view 1.

The invention belongs to the field of traditional Chinese medicine biological medicine, and particularly relates to a medicinal and edible traditional Chinese medicine composition and a preparation method, a traditional Chinese medicine preparation and application thereof. The invention provides a medicinal and edible traditional Chinese medicine composition which comprises the following components in parts by weight: ginseng, lily, Chinese yam, angelica sinensis, poria cocos, pericarpium citri reticulatae, ginkgo, radix polygonati officinalis, rhizoma zingiberis and honey-fried licorice root. The preparation method comprises the following steps: mixing the raw materials, adding water for soaking, extracting with water, filtering an extracting solution, concentrating filtrate, and collecting paste to obtain a semi-solid extract or a liquid extract; and further drying the obtained semi-solid extract or liquid extract to obtain the solid extract of the traditional Chinese medicine composition. The traditional Chinese medicine composition provided by the invention adopts an all-medicine-food homologous formula, has no toxic or side effect, is suitable for being taken by various people for a long time, has definite functionality, and is creatively compatible aiming at chronic respiratory system diseases, especially chronic obstructive pulmonary disease in a stable phase complex pathogenesis; the traditional Chinese medicine composition can be applied to health-care products for adjuvant therapy of chronic obstructive pulmonary disease or drugs for treatment of chronic obstructive pulmonary disease.

The utility model relates to finger flexor tendon rehabilitation auxiliary equipment, and relates to the technical field of rehabilitation. The finger flexor tendon rehabilitation auxiliary apparatus comprises a seat body and a fingerstall assembly. A sliding groove is formed in the base body. The fingerstall assembly comprises a sliding piece and a belt body, and the sliding piece is slidably installed in the sliding groove; two limiting pieces are arranged on the face, away from the sliding groove, of the sliding piece in a spaced mode. The belt body sequentially penetrates through the two limiting pieces, a cavity is formed between the two limiting pieces, and the belt body and the limiting pieces can be relatively fixed. When the finger flexor tendon rehabilitation auxiliary equipment is used, training can be carried out according to different positions of different fingers of a patient, the limiting and fixing of the equipment on the fingers in the training process are reliable, and the position fixing is accurate. A therapist does not need to carry out auxiliary treatment on a patient, the work intensity of the therapist is reduced, and the risk that the therapist suffers from related hand occupational diseases is also reduced.

1. Name of the product in this design: Microneedle Ear Patch. 2. Application of this design: In the field of medical and nursing devices, it is mainly used in hospitals, clinics, traditional Chinese medicine clinics and home care scenarios for ear acupoint application, ear acupoint stimulation and daily health care, which can meet the needs of clinical auxiliary treatment, rehabilitation care and health management. 3. The key design features of this product are the combination of shape and pattern. 4. The image or photograph that best illustrates the design's key points: a 3D model. 5. This design is for a thin product; other views are omitted.

The invention discloses an intelligent high-precision weighing device for dietary therapy food materials of diabetics and gestational patients, which can provide balanced and reasonable structured diet recipes for the diabetics and gestational patients in a high-standard manner and accurately provide high-precision evaluation levels for various food materials. An accurate analysis data basis is provided for subsequent related therapy or nutriology research; the food materials eaten by the diabetes mellitus and gestational patients can be guaranteed to be sound in structure and balanced in multi-dimensional information with high precision; comprehensive recipes which can be adopted by the diabetes mellitus and gestational patients and are different in height, weight and other information can be output; replaceable similar food materials can be provided according to different types; according to the high-precision food material weighing device, diabetes mellitus and gestational patients can be prevented from eating improper and even taboo food materials, the accurate weight of each type of food materials can be known and determined, recipes can be intelligently changed according to blood sugar changes and disease development, complications can be prevented, and treatment can be assisted.

The application discloses a compression hemostat, and relates to the technical field of medical devices, and the compression hemostat comprises a pressing device, a fixing part and a temperature adjusting module, the pressing device comprises a pressing part and an adjusting mechanism for adjusting the contact pressure of the pressing part, the pressing device is installed on the fixing part, the fixing part is used for being fixed on a patient, so that the pressing device is kept fixed with the patient's limbs when the pressing device works, and the temperature adjusting module is used for adjusting the temperature of the pressing part, and the temperature adjusting module comprises a display screen used for displaying at least one kind of information in temperature, pressure and bleeding state, through the adjustment of the temperature of the pressing part, the patient can upgrade passive hemostasis to active auxiliary treatment according to the sensitivity and feeling of cold and heat.

The invention belongs to the field of food nutrition and pharmacy, and particularly relates to folium mori crude polysaccharide and application thereof. An extract rich in mulberry leaf polysaccharide is extracted from mulberry leaves through a specific extraction process, and it is found through an in-vitro antibacterial experiment that the crude mulberry leaf polysaccharide has the direct inhibiting and killing effect on helicobacter pylori (Helicobacter pylori). In-vitro intestinal flora fermentation research shows that the folium mori crude polysaccharide can effectively correct intestinal flora disorder caused by triple antibiotics for treating helicobacter pylori, meanwhile, the short-chain fatty acid level is remarkably improved, and the helicobacter pylori abundance in intestinal flora is reduced. The application field of mulberry leaf polysaccharide is widened, and important reference is provided for developing products for adjuvant therapy of H.pylori infection and intestinal microecology regulation based on natural polysaccharide.

The invention discloses an application of ametinib in preparation of a lung cancer treatment medicine, belongs to the technical field of biological medicines, and aims to widely research the direct anti-tumor effect of ametinib in lung cancer at present. The invention provides a new action mechanism of the ametinib for regulating intestinal flora to influence glutamine metabolism so as to inhibit lung cancer development, and experiments prove that the ametinib treatment increases the abundance of flora related to amino acid metabolism in intestinal tracts, so that the content of glutamine in the intestinal tracts is reduced; the invention has reference significance in research and development of adjuvant therapy drugs or combined therapy drugs for lung cancer, preparation of antitumor drugs and the like.

The invention belongs to the field of gout prevention and treatment, and particularly relates to alpinia oxyphylla and turmeric tabletted sweets as well as a preparation method and application thereof. According to the alpinia oxyphylla and turmeric composition disclosed by the invention, alpinia oxyphylla and turmeric are taken as main components, the beautiful millettia root, the poria cocos, the kudzuvine root, the lithocarpus litseifolius, the purslane, the cassia seed, the black pepper and the dandelion are reasonably combined, and all the components are synergistically interacted, so that the prepared composition can remarkably improve the xanthine oxidase inhibition activity, can effectively relieve gout symptoms, and can be used for treating gout. The composition can be used for adjuvant therapy of gout patients. The tablet candy prepared by adding a sweetening agent into the alpinia oxyphylla turmeric composition disclosed by the invention is simple in preparation process, can be eaten for a long time as an auxiliary food in a gout treatment process, and has a great promoting effect on relieving gout symptoms.

The invention discloses polygonatum cyrtonema polysaccharide as well as a preparation method and application thereof, and relates to the technical field of plant polysaccharide extraction. The invention relates to the technical field of biological medicine, in particular to polygonatum cyrtonema polysaccharide as well as a preparation method and application thereof. The polygonatum cyrtonema polysaccharide is composed of fructose and glucose according to the molar ratio of 27.5: 1, the main chain of the polygonatum cyrtonema polysaccharide is of a 1-beta-D-Fruf-(2-) structure, and the side chain of the polygonatum cyrtonema polysaccharide comprises-> 6-beta-D-Fruf-(2-) and-> 1, 6-beta-D-Fruf-(2-). The polygonatum cyrtonema polysaccharide provided by the invention has the activity of reducing blood sugar, reducing blood fat and relieving insulin resistance, and has a wide application prospect in the aspect of developing functional foods or medicines for adjuvant therapy of diabetes mellitus.

The invention discloses an esophageal cancer prognosis scoring method combined with RSK pathway activity, and belongs to the fields of bioinformatics, molecular prediction models and medical diagnosis assistance. Aiming at clinical requirements proposed in the technical background, the invention mainly aims to provide a risk scoring model constructed based on RSK pathway related genes and an application method thereof, survival prognosis and auxiliary treatment decision can be predicted in esophageal cancer patients, and the model has relatively good generalization ability, stability and mechanism interpretability.

The invention relates to the technical field of medical auxiliary instruments, in particular to an auxiliary sepsis treatment device which comprises an outer tube, an occlusion seat sleeve is arranged on the outer side of the middle of the outer tube, an inner tube and a sleeve are arranged on the inner side of the outer tube, the sleeve is arranged between the inner tube and the outer tube and slidably connected into the outer tube, and the head of the sleeve is rotatably connected with a lantern ring and an opening part. The multiple distraction pieces are arranged on the lantern ring in an annular array mode, the distraction pieces wrap the outer side of the head of the inner pipe, and the problems that in the prior art, due to the fact that a device for auxiliary treatment of sepsis does not have a special fixing structure designed for a pipeline, the pipeline is prone to displacement and is indirectly pressed, the ventilation effect is affected, and the pipeline cannot be directly pressed are solved. And when the patient unconsciously occludes, no active early warning and resetting functions exist, the unconscious occlusion behavior of the patient cannot be monitored, resetting cannot be achieved through active actions of the patient, manual intervention of medical staff is needed, the nursing workload is increased, and discomfort is brought to the patient.

The invention belongs to the technical field of biological medicines, and particularly relates to application of cardiac glycoside medicines or pharmaceutically acceptable salts or derivatives thereof in preparation of products for inhibition, relief, adjuvant therapy or treatment of cancers and medicines. The invention provides application of cardiac glycoside drugs or pharmaceutically acceptable salts or derivatives of the cardiac glycoside drugs in preparation of products for inhibition, alleviation, adjuvant therapy or treatment of cancers and the drugs, and the cardiac glycoside drugs comprise deacetylated chaenoside, deacetylated chaenoside, deacetylated chaenoside, deacetylated chaenoside, deacetylated chaenoside, deacetylated chaenoside, deacetylated chaenoside and deacetylated chaenoside. According to the application disclosed by the invention, the effects of inhibiting, relieving, assisting in treating or treating cancers and potential mechanisms of the Deslanoside are researched in SH-SY5Y and SK-N-SH neuroblastoma cell lines, and results show that the Deslanoside can be used for inhibiting proliferation of SH-SY5Y cells and SK-N-SH cells, promoting apoptosis and respectively inducing a cell cycle to stop at a G0 / G1 phase; and G1 / S and G2 / M periods.

The invention belongs to the technical field of gene editing and disease model construction, and particularly relates to a construction method and application of a Wilson disease animal model. Aiming at a large fragment deletion mutation type which exists clinically in Wilson disease but lacks a corresponding animal model, a CRISPR / Cas9 gene editing technology is utilized, a pair of sgRNAs is specifically designed, an eighth exon region of a mouse Atp7b gene is precisely cut and deleted, and a WD mouse model with deletion mutation (c.2333340delGACGGTGG) of eight basic groups of the eighth exon of the Atp7b gene is successfully constructed. The method can be used for research on pathogenesis of WD, screening of novel diagnostic markers and evaluation of curative effect of therapeutic drugs, is particularly suitable for preclinical evaluation of gene therapy strategies and development of adjuvant therapeutic drugs of targeted NLRP3 inflammasomes, and has great scientific research value and clinical transformation prospect.

The application discloses a kind of Baicalein-loaded mPEG-PLGA nanoparticles based on tumor microenvironment and its preparation method and application.The method is: ultrasonic dispersion preparation Baicalein uniform solution;Then mPEG-PLGA is prepared;Emulsion evaporation method is prepared Baicalein-loaded mPEG-PLGA nanoparticles (PMs-Ba);The nanoparticles can be accumulated in tumor site, improve tumor microenvironment, so as to enhance the sensitivity of breast cancer to chemotherapeutic drugs.The method is simple to operate, provides a new idea for traditional Chinese medicine to be used as adjuvant therapy, and the method has great application potential in early cancer clinical treatment.

The utility model discloses a rhinitis adjuvant therapy device, which comprises a head-mounted structure, an air processor, a control assembly, a filter part, a fan assembly and a cambered mask plate, and is characterized in that the air processor, the control assembly, the filter part and the fan assembly are mounted in the head-mounted structure; the head-mounted structure is provided with a first flow channel located in the head-mounted structure, an air inlet communicated with the first flow channel and an outer connector used for being connected with an atomization piece, the mask plate is provided with a second flow channel located in the head-mounted structure and an air outlet communicated with the second flow channel, the two ends of the mask plate are connected with the head-mounted structure, and the first flow channel is communicated with the second flow channel; the air processor is located between the first flow channel and the air inlet and connected with the external connector, a fan assembly is arranged in the first flow channel, the filtering piece is arranged between the air processor and the fan assembly, and the control assembly is electrically connected with the air processor and the fan assembly. The rhinitis auxiliary treatment device solves the problems that an existing rhinitis auxiliary treatment device lacks portability and is single in function.

The present invention provides anti-CD73 binding molecules, such as antibodies and their antigen-binding fragments. [Solution] Provided are isolated binding molecules or antigen-binding fragments thereof that contain an antibody VL and specifically bind to CD73 having a specific sequence. Furthermore, pharmaceutical formulations comprising the disclosed composition, as well as methods for diagnosing and treating diseases associated with CD73 expression, such as cancer, are also provided. Such diseases can be treated, for example, by direct therapy with the disclosed anti-CD73 binding molecule (e.g., a naked antibody or antibody-drug conjugate that binds to CD73), by adjuvant therapy with other antigen-binding anticancer agents such as immune checkpoint inhibitors (e.g., anti-CTLA-4 and anti-PD-1 monoclonal antibodies), and / or by combination therapy in which the anti-CD73 molecule is administered before, after, or concurrently with chemotherapy.

1. The name of the design product: specific electromagnetic wave therapeutic instrument (HT-TDP-A). 2. The use of the design product: for physiotherapy and health care, such as auxiliary treatment for diseases such as soft tissue injury, rheumatoid arthritis, lumbar muscle strain, and pediatric diarrhea. 3. The design points of the design product: in shape. 4. The picture or photo that best indicates the design points: perspective view. 5. The bottom of the design product is not easily visible or not visible during use, and the top view is omitted.

The invention relates to the technical field of arthritis treatment jackets, in particular to a rheumatoid arthritis hand auxiliary treatment jacket which comprises a glove, the glove is divided into a palm face and a hand back face, a wrist is constructed on one side of the glove, and a pressure control piece is arranged on the glove; the pressure control part comprises a cavity constructed in the glove, the cavity divides the glove into an outer layer and an inner layer, the outer layer is made of a heat preservation material, and the inner layer is made of an elastic material; a water injection valve communicated with the cavity is arranged on the glove, and liquid is allowed to enter and exit from the cavity by opening and closing the water injection valve; the three pressure control modes of wrist air bag pressurization and hand movement dynamic pressurization are adjusted through the liquid medicine injection amount, a patient can autonomously select pressure gears according to the illness state and the scene, low-gear mild pressurization is conducted during daily office mild movement, slight aching pain is relieved, operation is not affected, middle-gear moderate pressurization is conducted when joint swelling pain is aggravated, and therefore the patient can feel more comfortable. During night rest, middle and low gears can be flexibly selected, and morning stiffness is relieved while constraint feeling is avoided.

This application relates to the field of biotechnology, specifically disclosing the application of immune cell subsets in the preparation of detection products for assessing the efficacy of neoadjuvant therapy and the risk of recurrence and metastasis in breast cancer. The detection method described in this application is non-invasive and convenient, requiring only peripheral blood, and is easy to repeat sampling and dynamic monitoring. This application also provides a predictive model for the efficacy of neoadjuvant therapy in breast cancer, and a predictive model for the risk of recurrence and metastasis in breast cancer treated with neoadjuvant therapy. The constructed predictive model has a high AUC value (0.82-0.87), and good sensitivity and specificity. Furthermore, through regular postoperative monitoring, abnormal dynamic changes in immune cell subsets can be detected, potentially indicating signs of recurrence earlier than imaging and traditional tumor markers. This helps identify advantageous populations before treatment and high-risk populations after treatment, enabling optimization of treatment plans and individualized adjustment of follow-up density.

The invention discloses a rehabilitation treatment evaluation method and system based on wearable equipment, and relates to the technical field of medical rehabilitation. The system comprises a wearable sensing module, a wireless communication module, a cloud data processing module, a man-machine interaction module and an auxiliary stimulation module. The wearable sensing module collects joint movement, muscle movement and stress parameters in a non-invasive mode. According to the method, through closed-loop processes of equipment preprocessing and personalized configuration, adaptive model training, real-time data acquisition, cloud quantitative evaluation and multi-dimensional feedback adjustment, full-chain coverage of'perception-analysis-evaluation-feedback 'of rehabilitation treatment is realized. According to the method, the defect that a cognitive movement therapy lacks quantitative indexes is overcome, the problems that traditional rehabilitation evaluation is subjective and a sensor can only detect and cannot assist in treatment are solved, rehabilitation treatment standardization, individuation and high efficiency are achieved, the labor cost is reduced, the rehabilitation quality is improved, and the method is suitable for rehabilitation scenes such as cerebral apoplexy and movement injury.