73 results about "Carbonyl derivatives" patented technology

This invention relates to aryl carbonyl derivativeswhich are activators of glucokinase which may be useful for the management, treatment, control, or adjunct treatment of diseases, where increasing glucokinase activity is beneficial.

A grease composition containing: (a) the reaction product of: (i) a calcium containing overbased organic acid; and (ii) at least one acid producing compound or derivatives thereof selected from the group consisting of: (1) a non-polymeric hydrocarbyl substituted dicarbonyl derivative selected from the group consisting of an acid, an ester, a salt, an anhydride, ester-acid, acid-salt and mixtures thereof; (2) a copolymer derived from monomers containing (1) an olefin; and (2) an unsaturated dicarboxylic acid anhydride or derivatives thereof; and (3) an inorganic acid containing about 2 or more acidic hydrogens; and (b) an oil of lubricating viscosity, wherein the overbased calcium sulphonate contains colloidally dispersed calcium carbonate is selected from the group consisting of calcite, vaterite and mixtures thereof. The invention further relates to the process to make the composition and its use in greases to increase water resistance.

The present invention relates to a resin material for an electrical insulating material, an electrical insulating material and electric wire and cable using the same. A resin material for an electrical insulating material according to present invention is characterized in that the resin component thereof comprises an ethylene alpha-olefin copolymer (A) which satisfies specific conditions, such as a density of 0.92~0.96 g/cm3, a melt flow rate (MFR) of 0.01~200 g/10 minutes, a molecular weight distribution (Mw/Mn) of 1.5~5.0, and possessing only one peak in terms of the number of peaks observed in an elution temperature-eluted amount curve as measured by the temperature raising elution fractionation (TREF) method, etc., wherein said resin component contains a unit derived from at least one type of monomer selected from among a carbonyl or carbonyl derivative group-containing monomer, a hydroxyl group-containing monomer, a nitro group-containing monomer, a nitrile group-containing monomer, an aromatic ring-containing monomer, and a compound or monomer containing two or more ethylenic linkages. This resin material for an electrical insulating material is suitable for use in an electrical insulating material for an electric wire and cable, as it exhibits excellent processability and electrical insulating properties without degradation of the mechanical strength, and even after cross-linking, exhibits superior electrical insulating properties.

The invention relates to preparation methods of sulphonylaminocarbonyl derivatives and compositions containing the same component and a use of the sulphonylaminocarbonyl derivatives as FXR and/or TGR5 agonists; the agonists are the sulphonylaminocarbonyl derivatives represented by the formula I, or pharmaceutically acceptable salts, prodrugs, solvates, hydrates, polymorphs, isomers, and stable isotope derivatives thereof. The compounds can be used for treatment of diseases and symptoms mediated by FXR and/or TGR5 and other therapeutic fields, wherein the diseases and symptoms include primary biliary cirrhosis, nonalcoholic fatty liver, portal hypertension, bile acid diarrhea and cholestasis, type II diabetes and obesity.

The invention provides a novel metallocene catalyst and a green catalytic synthesis method of a polyarylate substituted 1,3-dicarbonyl compound developed by the catalyst. Zirconium atoms in the metallocene catalyst are connected with each other through two isopropyl-substituted cyclopentadienyl rings to display tetravalence; the zirconium atoms are coordinated with three hydrones; and the overall organic zirconium cationic part and the corresponding anions form an ion bond. The green synthesis method comprises the following steps: with a 1,3-dicarbonyl compound with active hydrogen as a reaction raw material, and aryl alcohol as an alkylation agent, carrying out intramolecular dehydration alkylation reaction under catalysis of perfluorooctane sulfonate isopropyl cyclopentadienyl zirconium; and obtaining a series of multiaryl-substituted 1,3-dicarbonyl compounds at a relatively low temperature and high yield. The method has the main advantages of being mild in reaction condition, simple to test and operate, high in yield and the like; the reaction is suitable for kinds of 1,3-dicarbonyl derivatives and different aryl alcohol; with perfluorooctane sulfonate isopropyl cyclopentadienyl zirconium as a catalyst, the catalyst can be recycled and used for a plurality of times; and meanwhile, the sole by-product is water, and has the advantages of being green, free of pollution and the like.

A polishing method is achieved comprising the following steps. A layer made of material containing a metal as a main component over a substrate having recessed portions on a surface thereof so as to fill the recessed portions with the metal layer is formed. The metal is Cu, a Cu alloy, Al, or an Al alloy. The metal layer is polished by a chemical mechanical polishing method using a slurry including a polishing agent. The polishing agent contains a chemical agent and an etching agent. The chemical agent includes at least a carbonyl derivative of benzotriazole and is responsible for forming a protective film on the surface of the metal layer by reacting with the material containing a metal as a main component. The etching agent is responsible for etching the material containing a metal as a main component.

The invention discloses aryl substituted piperazine carbonyl derivative as well as a preparation method and application thereof. The aryl substituted piperazine carbonyl derivative is free alkali or salt of a compound adopting a general formula (I) shown in the Specification, wherein the salt is one of hydrochloride, hydrobromide, sulfate, trifluoroacetate, tartrate, lactate or mesylate; Ar independently represents aryl, substituted heterocyclic ring or substituted aryl; R1 independently represents (-O-CH2-) or (-CH=CH-); R2 and R3 can be the same or different, and respectively and independently represents H, halogen, alkyl, halogen substituted alkyl, nitro, amino, nitrile group, hydroxyl, alkoxy, aryl alkoxy, heterocyclic ring alkoxy, aryl, substituted heterocyclic ring or substituted aryl. The aryl substituted piperazine carbonyl derivative can be applied to the preparation of drugs for treating cerebral arterial thrombosis.

The invention discloses a method for preparing a 2-phosphonic acid ester base-1, 3-dicarbonyl derivative. A 1, 3-dicarbonyl derivative and trialkyl phosphite ester are used as starting materials, and a great variety of raw materials are easy to obtain. Varied types of products are obtained through the method, can be directly used, and can also be used for other further reactions. In addition, the reaction is performed in air, the condition is mild, the reaction time is short, the target product yield is high, pollution is small, the reaction operation and aftertreatment process is simple, and the method is suitable for industrial production.

The invention relates to a phenolic hydroxyl derivative, a benzene ring substituted derivative and a carbonyl derivative of astilbin, and also provides a preparation method for the derivatives.

In one aspect, there is provided a protein-drug conjugate compound comprising a protein covalently attached by a linker to one or more drug moieties, wherein the linker has a half-life of from 1 hour to 50 hours in phosphate buffered saline at 37° C. A carbonyl derivative of LU103793 is also described that can be used in a protein-drug conjugate compound comprising an antibody covalently attached by a linker to the drug moiety comprising, consisting or consisting essentially of the carbonyl derivative.

The invention discloses a method for preparing a 1,4-dicarbonyl derivative. The method comprises the following step of performing an oxidative coupling reaction on olefins in an organic solvent by taking a styrene derivative and a bromine-containing compound as reactants, a metallic cobalt compound as a catalyst and tertiary butanol hydrogen peroxide as an oxidizing agent, thereby preparing the 1,4-dicarbonyl derivative. The method disclosed by the invention is moderate in reaction condition, and simple in reaction process and aftertreatment because being only performed in the air, so that the 1,4-dicarbonyl derivative can be obtained by performing a simple column chromatography after the reaction is finished. In addition, raw materials for the reaction can be obtained widely, so that the method conforms to the requirement and the direction of the modern environment-friendly chemical development. Thus, the method has an industrial application value.

The present invention relates to a preparation of β-γ ene carboxylic or ketone derivatives, which may also have particular requirement on the configuration of the carbon-carbon double bond. The method requires a thermal treatment of α-β unsaturated malonate or acetylacetonate derivatives in the presents of at least one carboxylic acid and at least one alkaline, alkaline-earth or lanthanide halide or carboxylates.

The invention relates to a novel method for preparing a chiral dicarbonyl derivative by catalysis, needs to overcome various defects in the conventional method for preparing the chiral dicarbonyl derivative and provides an environment-friendly, economic, efficient and nontoxic method for preparing the chiral dicarbonyl derivative. The method of the invention is characterized in that a chiral diamine derivative is used as a catalyst, the molar ratio of the catalyst to raw materials is 1:10-20 and the target product, namely the chiral dicarbonyl derivative is obtained by performing reaction at the normal pressure and the room temperature in a non-polar solvent; the raw materials are an achiral dicarbonyl derivative and a nitroolefin derivative and the molar ratio of the using amount of the achiral dicarbonyl derivative to the using amount of the nitroolefin derivative is 1:1; the non-polar solvent is toluene; and the catalyst is one of the following catalysts from a to i.

The invention discloses a synthesis method of a 4-chlorothiophene-2-carbonyl derivative. A thiophene-2-carbonyl derivative is used as a raw material and reacts with symclosene and aluminum trichloride, and liquid separation and concentration are performed to obtain the 4-chlorothiophene-2-carbonyl derivative. The synthesis method adopts one-step reaction, the yield is not lower than 80%, the production process is decreased while the yield is improved, and the cost is reduced; the used raw materials and reagents are easy to obtain, reaction conditions are mild, post-treatment and purification is easy to operate, and large-scale production can be achieved.

To provide a liquid crystal compound satisfying at least one of physical properties such as a high stability to heat, light and so forth, a high clearing point, a low minimum temperature of a liquid crystal phase, a small viscosity, a suitable optical anisotropy, a large dielectric anisotropy, a suitable elastic constant and an excellent compatibility with other liquid crystal compounds; a liquid crystal composition containing the compound; and a liquid crystal display device including the composition. The compound is represented by formula (1):

wherein, for example, Ra and Rb are alkyl having 1 to 10 carbons, alkenyl having 2 to 10 carbons or alkoxy having 1 to 9 carbons; A¹, A² and A³ are 1,4-cyclohexylene or 1,4-phenylene; Z¹ and Z² are single bonds, —(CH₂)₂—, —CH═CH—, —COO—, —OCO—, —CF₂O—, —OCF₂—, —CH₂O— or —OCH₂—; Y¹ is —CF₂H or —CF₃; Y² is fluorine; and a, b and d are 0, 1, 2 or 3, and c is 1 or 3.

The invention discloses a synthesis and an application of a naphthalenone-sulfoxide ylide hybrid and belongs to the technical field of organic chemistry. Firstly, the naphthalenone-sulfoxide ylide hybrid is synthesized through the cascade reaction between aryl formyl sulfoxide ylide and Alpha-diazo carbonyl compound. The hybrid is capable of efficiently generating 4-hydroxy-1- naphthalene carbonylderivative under the action of raney nickel, generating 3-hydroxy-4-oxo-1- naphthalene carbonyl derivative under the action of p-toluenesulfonic acid, efficiently synthesizing 4-hydroxy-3-sulfinyl-1-naphthalene carbonyl derivative under the action of lithium chloride and methanesulfonic acid and synthesizing 3,4-dioxo-1-naphthalene carbonyl derivative under the action of lithium chloride and sulfuric acid. Thus, the naphthalenone-sulfoxide ylide hybrid has deriving diversity and has an excellent application prospect.

The invention provides a secondary amine functional group-containing phosphonamine and diamine ligand transition metal complex catalyst, and a preparation method and an application thereof, and relates to a metal complex catalyst capable of efficiently catalyzing hydrogenation of esters, aldehydes, ketones and other carbonyl derivative molecules at a low dosage of an assistant to produce alcohols.The metal center of the catalyst is coordinated with an o-PPh2C6H4NHR1 ligand and an o-PPh2C6H4NHR2 ligand or o-PPh2C6H4NHR1 ligand and an R2HNCH2CH2NHR3 ligand, and the catalyst can be prepared by asimple two-step synthesis method. The catalyst can achieve an excellent catalytic hydrogenation performance only through using a small amount of the assistant alkali when participating in the catalytic hydrogenation reaction, and effectively overcomes the defect of a large amount of the assistant needed by conventional catalysts composed of primary amine ligands.

A reactive dye compound comprising: (a) at least one chromophore moiety, (b) at least one nitrogen-containing heterocycle, (c) a linking group to link each chromophore moiety to each nitrogen-containing heterocycle; characterised in that at least one nitrogen-containing heterocycle is substituted with at least one oxy- or thio-carbonyl derivative wherein the oxy- or thio-carbonyl derivative is selected from Y wherein Y is -A(CO)R* wherein A is selected from O or S and wherein R* is an organic residue which comprises at least one nucleophilic group, and salts thereof. The compounds herein have high Exhaustion Values (E), high Efficiency Values (T) and show significant improvements in terms of reducing spent dyestuff in effluent, increasing dye affinity to the substrate, increasing the dye-substrate covalent bonding, increasing the ability to dye substrates at room temperature, decreasing the amount of the dye that is removed during the post dyeing 'soaping off process' and therefore simplifying the post dyeing 'soaping off process' traditionally associated with dyeing cotton with fibre reactive dyes and reduction of staining of adjacent white fabrics. In addition, the compounds prepared above provide more intense dyeings and require less levels of salt for dyeing cotton substrates.

The invention discloses a method for preparing a 2-methyl-1,3-dicarbonyl derivative. A 1,3-dicarbonyl derivative serves as an initiator, raw materials are easy to obtain, and a great variety of raw materials are available. The product obtained through the method has high type diversity and can be used directly or used for other further reactions. Besides, only organic peroxides and a catalytic amount of inorganic copper salt are used, so that cost is low. According to the method, a reaction is conducted in air, reaction conditions are mild, pollution is small, reaction time is short, the yield of the target product is high, reaction operation and aftertreatment are easy, and the method is suitable for industrial production.

A composition that can be activated by irradiation and cured by moisture comprises (A) one or more moisture-curable compounds from the group of alkoxy silanes, (B) at least one acid generator releasing an acid when exposed to actinic radiation, and (C) at least one carbonyl compound and/or carbonyl derivative selected from the group of aldehydes, ketones, hemiacetals and hemiketals. Moreover, the compositions according to the present invention can additionally contain an alcohol and/or thiol (D), a catalyst for moisture-curing (E), a radiation-curable compound (F), a photoinitiator for radical polymerization (G), and further additives (H). After activation of the acid generator the composition cures even in high layer thicknesses independently of the ingress of external moisture.

Furthermore, a method for the bonding, molding, sealing and coating of substrates using the composition is described.