361results about How to "Prolong survival time" patented technology

Methods for slowing disease progression in an individual suffering from familial ALS are provided. Also provided are methods of increasing the survival time of an individual suffering from familial ALS. These methods employ antisense oligonucleotides targeted to SOD1, for use in inhibiting the expression of SOD1 in the central nervous system of an individual suffering from familial ALS.

A blade server 2 is provided with a processor 6 for executing program instructions and an electrical connector 12 for connecting to a blade enclosure 22. The blade server 2 also includes a power controller 18 connected to a plurality of power supply batteries 14, 16 which are provided on the blade server 2 itself. If the power controller 18 detects that the main power supply supplied via the electrical connector 12 has been interrupted, then a backup power supply to the processor is provided from the on-board power supply batteries 14, 16. The batteries 14, 16 on each blade are periodically discharged and recharged in turn to check their proper function.

The present invention relates to pharmaceutical compositions and dietary supplement comprising yeast cells that can produce a healthful benefit in a subject inflicted with prostate cancer. The biological compositions can be used to retard the growth of prostate cancer cells and/or prolonging the time of survival of the subject. The invention also relates to methods for manufacturing the biological compositions.

The present invention relates to pharmaceutical compositions and dietary supplement comprising yeast cells that can produce a healthful benefit in a subject inflicted with brain cancer. The biological compositions can be used to retard the growth of brain cancer cells and/or prolonging the time of survival of the subject. The invention also relates to methods for manufacturing the biological compositions.

Variant immunoglobulins with one or more amino acid modifications in the Fc region that have increased in vivo half-lives, and methods of using the same are provided.

The present invention relates to pharmaceutical compositions and dietary supplement comprising yeast cells that can produce a healthful benefit in a subject inflicted with pancreatic cancer. The biological compositions can be used to retard the growth of pancreatic cancer cells and/or prolonging the time of survival of the subject. The invention also relates to methods for manufacturing the biological compositions.

The present invention relates to pharmaceutical compositions and dietary supplement comprising yeast cells that can produce a healthful benefit in a subject inflicted with bladder cancer. The biological compositions can be used to retard the growth of bladder cancer cells and/or prolonging the time of survival of the subject. The invention also relates to methods for manufacturing the biological compositions.

The present invention relates to pharmaceutical compositions and dietary supplement comprising yeast cells that can produce a healthful benefit in a subject inflicted with breast cancer. The biological compositions can be used to retard the growth of breast cancer cells and/or prolonging the time of survival of the subject. The invention also relates to methods for manufacturing the biological compositions.

On substrate of electrode made from organic insulating material, conducting material is printed through spraying method so as to form working electrode and basal body, and a layer of polycarbonate insulator is coated on surfaces of intermediate part between them. Lower part of basal body of working electrode is coated a conversion zone formed through integrated application including techniques of high polymer built up film or ferrocene covering, embedding enzyme, nano technique, and diffusing astriction so as to fabricate biologic enzyme electrode. The invention raises each performance of biologic sensor and practicability integrally.

Provided herein are combinations that include an HDACi and a PD-1 inhibitor that are useful for treating cancer, including reducing and/or preventing cancer metastasis. The combination is also useful for treating cancer that has been previously treated with a PD-L1 inhibitor.

Disclosed herein are methods of treating benign, pre-cancerous, or non-metastatic tumors using an anti-VEGF-specific antagonist. Also disclosed are methods of treating a subject at risk of developing benign, pre-cancerous, or non-metastatic tumors using an anti-VEGF-specific antagonist. Also disclosed are methods of treating or preventing recurrence of a tumor using an anti-VEGF-specific antagonist as well as use of VEGF-specific antagonists in neoadjuvant and adjuvant cancer therapy.

The invention provides a multi-node collaboration based storage method for a sensor network. The method comprises the following steps: (1) determining a node collaboration mode, which is to extract image characteristics and identification images on nodes of the sensor network, and determine a node set for data fusion; (2) determining an updating mode for storing and exhausting the nodes of the sensor network; (3) dynamically calculating the size of the most appropriate data of the nodes of the sensor network in each time of data updating or data transiting; (4) solving appropriate positions ofSink nodes by using a genetic algorithm; (5) constructing a hierarchical network topology structure to optimize a user search processing process by improving the TopDisc algorithm; and (6) optimizinga data searching process, which is to establish the data searching process driven by messages by establishing and managing multiple data transcriptions. The method is used for solving the problems ofmore events detected by a single node and unbalanced consumption of energy and storage among different nodes, and prolongs the life time of the network.

The invention discloses a stem cells preparation for repairing a wound surface and preparation method thereof, wherein the stem cells preparation uses umbilical cords, placentae or mesenchymal stem cells between amniotic membranes as living cells, and is added with high polymer material sodium alginate with excellent biocompatibility, sodium hyaluronate, chitosan and hydroxyethyl starch as cell stabilizer. The stem cells preparation for repairing the wound surface has higher cell viability and is durable in action, and breaks through technical limitations of effectiveness of the mesenchymal stem cells for treating.

The present invention relates to chimeric Factor VII polypeptides and methods of using the same.

The invention discloses a medium access control method for prolonging network lifetime in a wireless body area network, which mainly solves the problem that network topology lacks the self-adaptive adjustment capability based on the current residual energy of a node in the existing research on the medium access control of the wireless body area network. The method is implemented by the steps as follows: under a normal communication state, a node immediately requests a relay towards a network coordinating point when detecting the current residual energy is lower than an energy threshold value; the network coordinating point selects the relay for the relay request node in the whole network through a relay selection superframe structure; the network topology is changed from a star structure into a tree structure; and a medium access control layer adjusts a next-hop superframe structure in accordance with the topology. Compared with the existing method for prolonging network lifetime in a wireless body area network, the invention can realize the self-adaptive adjustment of the network topology without increasing additional relay nodes, thereby prolonging the network lifetime of the whole wireless body area network.

The invention discloses modified polyurethane suspended filler which comprises, by weight, 10 parts to 80 parts of polyhydroxyalkanoate, 10 parts to 80 parts of activated carbon, 60 parts to 80 parts of polyurethane, 1 part to 10 parts of water-soluble polyurethane solutions, 0 part to 10 parts of bioactivator, 0 part to 1 part of inorganic metal salt, 0 part to 20 parts of organic high-molecular polymer and 0 part to 10 parts of inorganic flocculate. A preparation method of the modified polyurethane suspended filler includes the steps of taking the 10 parts to 80 parts of polyhydroxyalkanoate, the 10 parts to 80 parts of activated carbon, the 0 part to 10 parts of bioactivator, the 0 part to 1 part of inorganic metal salt, the 0 part to 20 parts of organic high-molecular polymer and the 0 part to 10 parts of inorganic flocculate, dissolving the mixture in the 1 part to 10 parts of water-soluble polyurethane solutions, soaking the 60 parts to 80 parts of polyurethane in the solution to obtain the loaded polyurethane suspended filler, and conducting secondary drying after primary drying is conducted to obtain the modified polyurethane suspended filler. The modified polyurethane suspended filler has the advantages of being high in porosity and large in specific area.

The invention relates to a singlet state oxygen generation method, and belongs to the technical field of chemical oxygen-iodine lasers. The method comprises the following steps: mixing an alkaline ionic liquid insoluble in water with an aqueous hydrogen peroxide solution to form a two phase transfer system, and reacting the transferred ionic liquid phase with chlorine to generate singlet state oxygen in order to realize water and singlet state oxygen isolation. The method is helpful for reducing the quenching effect of water on singlet state oxygen, and reduces the content of water in the singlet state oxygen, and the alkaline ionic liquid has an enrichment effect on hydrogen peroxide to make effective solving of the bottleneck problem of hydrogen peroxide concentration restriction in the raw material regeneration process of chemical oxygen-iodine lasers under traditional technological conditions be possible, so the method is of great significance to improve the singlet state oxygen yield of the chemical oxygen-iodine lasers, reduce the water content of the singlet state oxygen and solve the raw material regeneration problem.

The present invention discloses a wireless sensor network energy conservation method which is designed basing on the cross-layer, a MCU Active mode and a MCU Sleep mode are arranged on the processor MCU in the wireless sensor network, an ADC Active mode and an ADC Sleep mode are arranged on an analog-to-digital converter ADC, a MTRU Sleep mode, a WTRU Tx mode and a WTRU Rx mode are arranged on a wireless date sending module/receiving module respectively, and sent from a surveillance center according to the control command designed by the primitive to control the accesses of the different modes after being sent by the processor MCU, so as to conduct a cross-layer energy conservation optimization from an application layer, a network layer, a link layer and a physical layer of the wireless sensor network. Under the premise of not influencing the application performance and function, the present invention reaches the effect of reducing the whole energy consumption of the nodes, and greatly prolongs the use life of the batteries used on the nodes and greatly lengthens the life span of the network.

The invention discloses a data collection method based on AUV position prediction in an underwater sensor network. The data collection method comprises the following steps: the AUV cruises in the network according to a pre-determined helical orbit to perform data collection and adjusts the orbit, wherein the helical orbit can be decomposed into circling motion on the horizontal direction and a uniform linear motion on the vertical direction, a node calculates whether itself is within the collection area of the AUV according to its own position and the orbit of the AUV, the node within the collection area waits for the AUV to arrive at vicinity of the node and performs with the AUV, and the node beyond the collection area forwards data to the collection area through multiple hops. The data collection method supports the AUV to cruise in the network to perform data collection, thereby reducing the energy consumption of the node, and the AUV does not need to broadcast a data packet while cruising in the network, thereby reducing the communication cost.

The invention discloses a feed additive for improving the reproductive capacity of a boar. The feed additive comprises the following raw materials in percentage by weight: 40 to 50 percent of epimedium, 8 to 10 percent of cynomorium songaricum, 8 to 10 percent of codonopsis pilosula, 8 to 10 percent of angelica sinensis, 8 to 10 percent of medlar, 0.5 to 1 percent of vitamin A, 0.1 to 0.2 percent of vitamin D3, 1 to 4 percent of vitamin E, 0.1 to 0.3 percent of vitamin B2 and the balance of zeolite powder. A preparation method for the feed additive comprises the following steps of: mixing the epimedium, the cynomorium songaricum, the codonopsis pilosula, the angelica sinensis and the medlar; smashing a mixture to a particle size of between 25 and 40 microns; adding the vitamin A, the vitamin D3, the vitamin E, the vitamin B2 and the zeolite powder; and mixing uniformly. The feed additive prepared by the method has the characteristics of remarkable improvement on boar sexual desire, ejaculatory amount, sperm concentration, survival time and oestrum conception rate without any adverse effect, less additive amount, low cost and obvious effect.

The invention provides a wireless sensor network topology control method based on an artificial neural network (ANN). The method is characterized in that the aim of saving energy is achieved by simulating an information processing system of a biological neutral network; when the total vector of the signals input by senor nodes is more than the threshold of a neurone, the neurone is activated and gives out pulses, thus outputting the signals; the nodes are selected to become the cluster heads according to the output signals and the dump energy to primarily form a network topology map; other nodes select the nearest cluster heads and join in the clusters and transfer own information to the cluster heads; the network topology map is optimized in combination with power control; and the transmitting power of the cluster heads is controlled so as to balance the number of the sensor nodes covered by the network, thus reducing collision during communication and improving the communication efficiency. The method has the following beneficial effects: under the condition of ensuring the network connectivity and coverage, the network energy is reasonably and efficiently used as far as possible, the life time of the whole network is lengthened and the nodes in each cluster are balanced to reduce communication interference among the nodes and improve the network communication efficiency.

The invention discloses a distributed fault-tolerant topology control method based on dump energy sensing. The distributed fault-tolerant topology control method based on the dump energy sensing mainly solves the problem that balance of dump energy between nodes and network topology fault-tolerant capability can not be guaranteed at the same time in the prior art. The distributed fault-tolerant topology control method based on the dump energy sensing comprises the steps of broadcasting a HELLO package of each node in a network and receiving the HELLO package of an initial neighbor node, and establishing a local topology subgraph; construing a shortest path tree based on the local topology subgraph and according to link cost weight and constructing a local k communication generation subgraph by traversing all directed edges according to distance weight from small to large; adjusting emission power according to a one-hop neighbor node in the local k communication generation subgraph, and connecting non-logic neighbor nodes within the emission power range; and finally construing a whole network topology according to all the nodes in the network and links between the nodes and the logic neighbor nodes. The process can be repeatedly executed according to the updating cycle T of the topology. The distributed fault-tolerant topology control method based on the dump energy sensing has the advantages that life cycle of the network is prolonged, and fault-tolerant capability of the network is enhanced. The distributed fault-tolerant topology control method based on the dump energy sensing can be applied to a wireless self-organizing network.

The invention discloses a chimeric antigen receptor, a gene and a recombinant expression vector thereof, CAR30-NKT cell and a preparation method and application thereof. The chimeric antigen receptor is CD30ScFv-CD8-CD137-CD3 zeta, and comprises a rat growth hormone signal peptide, CD30ScFv, a hinge region and a transmembrane domain of CD8, an intracellular signaling structural domain of CD137 and an intracellular signaling structural domain of CD3 zeta, which are in series connection. The CAR30-NKT cells have good specific killing activity on lymphoma cells in the treatment of CD30 positive hodgkin lymphoma and non-hodgkin lymphoma, and have certain treatment effect on the patients with CD30 positive hodgkin lymphoma, which have been repeatedly treated (such as CD30 monoclonal antibody combined with cytotoxic drugs or radioactive isotope therapy) but without obvious effect.

The invention provides a wireless multimedia sensor network node clustering method based on related coefficients, comprising the following steps: utilizing related coefficients of a node to cluster; and electing a cluster head node according to node rest energy and node transmission cost; and therefore, the network management can be efficiently performed, and the redundancy of transmission data is reduced. According to the scheme, the related coefficients of the node are firstly obtained, a related coefficient matrix of the whole network is utilized for constructing clustering, then the election of a cluster head based on cost is performed inside a cluster, and the switching of the cluster head is performed at a proper moment. Through the scheme, the clustering problem in the wireless multimedia sensor network is efficiently solved, cluster head election and switching mechanism is provided, the node energy consumption inside the network is balanced, and the life cycle of the whole network is prolonged.

The invention discloses a method for reducing redundant routing packet in a tree ZigBee network. The method comprises the steps of: according to node distribution in the tree ZigBee network, computing the network address of a node through the node position and the network depth of the tree ZigBee network; judging whether a destination node to which data from a source node is transmitted is a father node or a son node or neither a father node nor a son node of the source node; limiting the routing request (RREQ)-grouped transmission range with a routing inquiring function according to a judgment result; and reducing the forwarding times of the redundant routing packet. By adopting a node position judging mechanism, the method is flexible, reduces the forwarding times of the redundant routing packet in the tree ZigBee network greatly on the premise of guaranteeing the smooth network communication and reduces the routing expenditure of the whole network, thereby reducing power consumption of the node and prolonging the survival time of the node.

The invention discloses culture solution for primary culture of newly born rat hippocampal neuron and a method for primarily culturing the rat hippocampal neuron. The culture solution is formed by adding 1,6 diphosphonic acid fructose, fructose and nutrition additive into base culture solution Neurobasalmedium. The method for primarily culturing the rat hippocampal neuron comprises the following steps: 1 preparing hippocampal neuron culture solution; 2 drawing materials and digesting the materials; 3 preparing single cell suspension; and 4 conducting inoculating and cultivating. The method for primarily culturing the rat hippocampal neuron is simple, convenient and capable of obtaining hippocampal neuron with good growth state and high purity by adopting the culture solution and has important application value and economical value.

The invention provides a wireless sensor network data acquisition method based on multi-hop routing and mobile elements. The method includes obtaining a network through wireless sensor nodes and a base station, by means of sensor node position determination and identifier determination, planing the mobile element walking routes, completing the information transmission between the wireless sensor nodes and the mobile elements, and allowing the mobile elements to transmit the information acquired during walking to the base station until the network dies. The method is adaptive to large scale, self organization, random arrangement, environment complexity and other characteristics of the wireless sensor network and can be arranged and used in a large amount in the field which is populated sparsely, the mobile elements and the traditional clustering algorithm are combined, the data can be transmitted effectively and accurately, the energy consumption of the sensor nodes is reduced, the topology structure changes while the nodes die, the cluster head node and the second level cluster head are re-selected, the energy consumption of the cluster head node is reduced to the utmost extent, and the total survive time of the network is prolonged.

The invention discloses a self-adaptive networking communication method of an underwater vehicle. According to the relative distance between AUV nodes, a linear topological transmission mode is adopted for the nodes which are away from a pilot AUV node and close to other following AUV, and a one-to-many competition topological transmission mode is adopted for other AUV nodes. In the linear topological transmission process, the pilot AUV and all the following AUV realize time synchronization through a broadcast and response mode, and then the nodes select to be responsible for communication or sleep of the peripheral nodes according to the distance to the pilot AUV and the data transmission effect so that energy consumption of the pilot AUV can be reduced and survival time of the whole AUV formation networking can be enhanced. The one-to-many competition self-adaptive communication method includes a four-way handshake transmission method. The packet loss rate of transmission can be reduced and throughput of the network can be enhanced by the self-adaptive networking communication method.

The invention provides a routing method based on an AODV (Ad hoc On-demand Distance Vector) protocol, comprising steps: a target node obtains a path routing metric according to routing hops as well as the transmission power and the residual energy of the transmission node, extracted from a physical layer and an MAC (Media Access Control) layer by a network layer of the transmission node; a source node forwards an RREQ (Routing Request) for adding the energy entry to the target node; and the target node, after receiving the RREQ for adding the energy entry, judges the residual energy level of each transmission node; and according to the judgement result, the path with a minimum routine metric is regarded as the data transmission path, an RREP (Routing Response) for adding the routing metric is sent to the source node through the data transmission path, and the routing is established. The routing method has advantages of better energy-saving effect, stronger network survival time, better network performance and etc. and can be widely applied to an Ad Hoc network.

The crab separating transportation box consists of box body with ventilation holes in the side walls, and crab holding notches. The notches have depth to limit the motion of crabs and shape fitting crabs with withdrawn feet. The present invention has great transportation capacity, low cost, high survival rate, no cross infection and other advantages.