14 results about "SOD1" patented technology

Provided herein are SOD1 RNAi agents and compositions comprising a SOD1 RNAi agent. Also provided herein are methods of using the SOD1 RNAi agents or compositions comprising a SOD1 RNAi agent in reducing SOD1 expression and / or treating SOD1-mediated neurological disease.

In some aspects, the disclosure relates to compositions and methods useful for inhibiting SOD1 expression in cells (e.g., cells of a subject). In some embodiments, the disclosure describes isolated nucleic acids engineered to express an inhibitory nucleic acid targeting endogenous SOD1 and an mRNA encoding a hardened SOD1 protein. In some embodiments, compositions and methods described by the disclosure are useful for treating Amyotrophic Lateral Sclerosis (ALS) in a subject.

Antibody or binding fragment thereof, fusion protein, or pharmaceutical composition directed against misfolded SOD1 epitope, or nucleic acid encoding the antibody or binding fragment thereof, fusion protein, or pharmaceutical composition, are described. Also provided are methods for using and manufacturing such antibody or binding fragment thereof, fusion protein, nucleic acid, or pharmaceutical composition, as well as methods of their use for treating a disorder in a human subject in need thereof.

Abstract Dosage regimens for SOD1-targeting antisense oligonucleotides, and salts thereof, are provided. These dosage regimens find use in the treatment of subjects having or at risk of developing amyotrophic lateral sclerosis. Abstract 20 26 20 53 14 06 J ul 2 02 6 A b s t r a c t 2 0 2 6 2 0 5 3 1 4 0 6 J u l 2 0 2 6

The present invention is directed to a pharmaceutical composition and method for treating a subj ect diagnosed amyotrophic lateral sclerosis (ALS) with a pharmaceutical composition containing dissolved or dispersed therein a SOD1 and / or TDP-43 aggregation- inhibiting amount of a rose bengal (RB) compound that is a pharmaceutically acceptable salt of RB, RB lactone, a RB amide, an aromatic RB derivative, wherein the aromatic derivative is an ester or amide formed from an alcohol or monosubstituted amine having a 5 - or 6 -membered aromatic ring, or a 5, 6 - or 6, 6 - fused aromatic ring system that contains 0, 1, or 2 hetero ring atoms that are independently nitrogen, oxygen or sulfur. This treatment method is typically repeated a plurality of times or until the subj ect no longer needs it.

Aspects of this disclosure provide compounds, compositions, and methods for regulating the expression or activity of superoxide dismutase 1 (SOD1). In some aspects, the compounds, compositions, and methods of this disclosure can be used to reduce the expression of SOD1 mRNA in cells or animals. In some aspects, the compounds, compositions, and methods of this disclosure can be used to reduce the expression of SOD1 protein in cells or animals. In certain embodiments, the animal has a CNS-related disease, disorder, or condition.

This invention relates to the field of bioactive peptide technology, and discloses a tetrapeptide with cognitive-improving function and its applications. The primary amino acid sequence of the tetrapeptide is Lys-Gly-Phe-Pro, and its molecular weight is 489.2587 Da. The tetrapeptide of this invention can be chemically synthesized or directionally prepared from sea cucumber protease hydrolysates. The tetrapeptide of this invention exhibits cognitive-improving activity, mainly through inhibiting GABA. B The expression of R activates the cAMP / PKA / CREB signaling pathway, promotes the release of the inhibitory neurotransmitter GABA, reduces oxidative stress damage, increases the gene expression of neurotrophic factors Bdnf and Nt3, and significantly upregulates the gene expression of antioxidant enzymes Sod1 and Gpx1, thereby exerting a neuroprotective effect and improving age-induced cognitive impairment.

The present invention is directed to a pharmaceutical composition and method for treating a subject diagnosed amyotrophic lateral sclerosis (ALS) with a pharmaceutical composition containing dissolved or dispersed therein a SOD1 and / or TDP-43 aggregation-inhibiting amount of a rose bengal (RB) compound that is a pharmaceutically acceptable salt of RB, RB lactone, a RB amide, an aromatic RB derivative, wherein the aromatic derivative is an ester or amide formed from an alcohol or monosubstituted amine having a 5- or 6-membered aromatic ring, or a 5,6- or 6,6-fused aromatic ring system that contains 0, 1, or 2 hetero ring atoms that are independently nitrogen, oxygen or sulfur. This treatment method is typically repeated a plurality of times or until the subject no longer needs it.

The present invention relates to a method for in vitro diagnosis of Long COVID in a subject, wherein the method comprises the following steps: a) providing a biological sample obtained from the subject; b) measuring the levels of at least one protein in said sample, wherein the at least one protein is selected from Autophagy Related 4B Cysteine Peptidase (ATG4B), Mitofusin 2 (MFN2), Dynamin-related Protein 1 (DRP1), and / or Superoxide dismutase 1 (SOD1); and c) comparing the levels of the at least one protein measured in step b) with a respective reference, wherein an increase in the levels of the at least one protein in said sample relative to the reference is indicative of Long COVID diagnosis.

It relates to a method for the treatment of famyotrophic lateral sclerosis (ALS) by an oligonucleotide agent, comprising the step of administering the subject a treatment effective amount of the oligonucleotide agent, wherein the oligonucleotide agent comprises a double-stranded targeting oligonucleotide (siRNA) and a non-targeting single-stranded accessory oligonucleotide (ACO). The method can be used in the treatment of ALS with and without SOD1 mutation. It also provides a safety therapeutic window and an effective dosing regimen for the treatment of ALS using the oligonucleotide agent.

The present disclosure provides oligonucleotides, pharmaceutical compositions, kits, and methods of using the oligonucleotide. The oligonucleotides comprise a central nervous system (CNS) ligand. A strand of the oligonucleotides may be a therapeutic or prophylactic agent. The oligonucleotides may be able to deliver the therapeutic or prophylactic agent to a subject. The oligonucleotides may be useful in modulate (e.g., inhibiting) the expression or activity of superoxide dismutase 1 (SOD1) and in treating or preventing diseases, e.g., central nervous system (CNS) diseases, in the subject.

The present disclosure provides oligonucleotides, pharmaceutical compositions, kits, and methods of using the oligonucleotide. The oligonucleotides comprise a central nervous system (CNS) ligand. A strand of the oligonucleotides may be a therapeutic or prophylactic agent. The oligonucleotides may be able to deliver the therapeutic or prophylactic agent to a subject. The oligonucleotides may be useful in modulate (e.g., inhibiting) the expression or activity of superoxide dismutase 1 (SOD1) and in treating or preventing diseases, e.g., central nervous system (CNS) diseases, in the subject.

The present invention relates to antisense oligonucleotides that are complimentary to SOD1, leading to decreased expression of SOD1. Reduced expression of SOD1 is beneficial in medical disorders such as Amyotrophic Lateral Sclerosis.

The invention discloses application of an antioxidant in preparation of a medicine for treating fat infiltration and fibrosis related diseases after rotator cuff injury, and belongs to the technical field of medicines. SD rat rotator cuff injury model research finds that vitamin C and N-acetylcysteine have dual core effects after rotator cuff injury: 1, muscle fiber atrophy, fibrosis hyperplasia and local inflammatory response of skeletal muscle after injury are improved, and muscle fat infiltration is remarkably inhibited; 2, the anti-oxidation defense capability of the body is enhanced, the expression of antioxidant genes such as superoxide dismutase (SOD1, SOD2 and SOD3) and peroxide reductase (PRDX5) is promoted, the activity of antioxidant enzyme is improved, and the oxidative stress level is effectively relieved. The antioxidant provided by the invention can simultaneously improve fat infiltration, fibrosis, muscle atrophy and local chronic inflammation after rotator cuff injury and regulate oxidative stress, is expected to reduce the risk of postoperative retearing and promote functional recovery, and has a wide application prospect.