194results about How to "Maximum efficacy" patented technology

Peptide ligands having affinity for serum albumin are useful for tumor targeting. Conjugate molecules comprising a serum albumin binding peptide fused to a biologically active molecule demonstrate modified pharmacokinetic properties as compared with the biologically active molecule alone, including tissue (e.g., tumor) uptake, infiltration, and diffusion.

The present disclosure provides antibody-drug conjugates that are potent cytotoxins, wherein the drug is linked to the antibody through a linker. The disclosure is also directed to compositions containing the antibody-drug conjugates, and to methods of treatment using them.

The present disclosure provides drug-ligand conjugates and drug-cleavable substrate conjugates that are potent cytotoxins. The disclosure is also directed to compositions containing the drug-ligand conjugates, and to methods of treatment using them.

A system including a controlled agriculture environment containing one or more growing rooms, each containing one or more growing units is described. Each growing room is managed by an HVAC system under the control of an environmental control unit. Each growing room may have a specific temperature and humidity optimized for the type of plant or plants being room. The growing room may have a positive air pressure when compared to areas connected to it to ensure that no insects or contaminants can enter the growing room. The growing room may provide water feed, compressed air, CO2, and electricity to each of the growing units. The growing units are also connected wirelessly to an environmental control unit.

Peptide ligands having affinity for serum albumin are useful for tumor targeting. Conjugate molecules comprising a serum albumin binding peptide fused to a biologically active molecule demonstrate modified pharmacokinetic properties as compared with the biologically active molecule alone, including tissue (e.g., tumor) uptake, infiltration, and diffusion.

A therapeutic compression garment having an the inner layer of compression fabric and an outer layer of gradient compression fabric that also includes an area of zoned compression, wherein a pocket is defined between the outer and inner layers of fabric, is positioned under the area of zoned compression, and is accessible through a slit formed in the outer layer of fabric, wherein the pocket is strategically positioned within the garment overlying a respective body part of the wearer of the garment, and wherein the pocket receives an insertable thermal medium therein, whereby the insertable thermal medium is held securely in place and applies compressive thermal therapy to the respective underlying body part of the wearer as a function of the compression applied by the inner and outer layers of fabric.

The invention discloses a mitochondrion-targeting nano-drug delivery system, comprising polyethylene glycol connected with TPP and thioketal linker connected with a chemotherapeutic drug, the polyethylene glycol and the thioketal linker are connected with each other through amino and carboxyl condensation. This system also comprises DSPE-PEG and a photosensitizer; the chemotherapeutic drug forms a hydrophobic core inside, a hydrophilic shell layer is formed in the center of the polyethylene glycol, a mitochondrion-targeting crown is formed outside the TPP, and the photosensitizer is of hydrophobic structure distributed inside the core and / or around the core. TPP is selectively positioned to mitochondrion. This system is ROS responsive, the photosensitizer is laser excited to release ROS, and ROS cuts the thioketal linker to release the chemotherapeutic drug and can carry out photodynamic therapy at the same time, thus enabling synergic therapy of mitochondrion-targeting photodynamic therapy and chemotherapy. The invention also discloses a preparation method and application of the mitochondrion-targeting nano-drug delivery system.

Devices that include multi-reservoir infusion devices and systems for dispensing compositions for the treatment of subjects with an amylin agonist (e.g., the amylin agonist analog, pramlintide), wherein amylin agonists are administered in certain differential bolus and basal ratios to an administered insulin, as well as methods, compositions, and kits and articles of manufacture comprising said compositions for use in the treatment of responsive patients with an amylin and an insulin in ratios thereof that are distinct for bolus and basal administration.

A delivery capsule, designed to retain and protect its contents until an intended site of delivery or conditions of delivery are encountered, has at least two separate chambers (18, 20), the chambers usually containing different materials. The capsule is preferably internally divided by a dividing wall or septum (16), conveniently in the form of a median wall symmetrically arranged to form two chambers of similar size and shape. Also disclosed are a method of encapsulation and encapsulation apparatus.

Embodiments of the invention provide AC LED lighting apparatuses. The AC LED lighting apparatuses may increase luminous flux and provide optimal efficiency through novel arrangement of a plurality of light emitting blocks on a circuit board and a plurality of LEDs and drive ICs included in each of the light emitting blocks to be sequentially driven, and / or through efficient series-parallel connection between a limited number of LEDs.

A magnetic resonance method and system are provided for generating real-time motion-corrected perfusion images based on pulsed arterial spin labeling (PASL) with a readout sequence such as a 3D gradient and spin echo (GRASE) image data acquisition block. The real-time motion correction is achieved by using a volumetric 3D EPI navigator that is provided during an intrinsic delay in the PASL sequence, which corrects for motion prospectively and does not extend the image data acquisition time as compared to a similar non-motion-corrected imaging procedure.

The present invention provides a compound having a superior acid secretion inhibitory action, an antiulcer activity and the like.A proton pump inhibitor containing a compound represented by the formula (I)wherein ring A is a saturated or unsaturated 5- or 6-membered ring group optionally having, as a ring-constituting atom besides carbon atom, 1 to 4 hetero atoms selected from a nitrogen atom, an oxygen atom and a sulfur atom, ring-constituting atoms X1 and X2 are each a carbon atom or a nitrogen atom, a ring-constituting atom X3 is a carbon atom, a nitrogen atom, an oxygen atom or a sulfur atom, R1 is an optionally substituted aryl group or an optionally substituted heteroaryl group, R2 is an optionally substituted alkyl group, an optionally substituted aryl group or an optionally substituted heteroaryl group, R3 is an aminomethyl group optionally substituted by 1 or 2 lower alkyl groups, which is a substituent on a ring-constituting atom other than X1, X2 and X3, and ring A optionally further has substituent(s) selected from a lower alkyl group, a halogen atom, a cyano group and an oxo group, or a salt thereof or a prodrug thereof.

Provided is a compound having a superior acid secretion suppressive action, which shows an antiulcer activity and the like.A compound represented by the formula (I) or a salt thereof:wherein ring A is a saturated or unsaturated 5-membered heterocycle containing, as a ring-constituting atom besides carbon atoms, at least one heteroatom selected from a nitrogen atom, an oxygen atom and a sulfur atom, the ring-constituting atoms X1 and X2 are the same or different and each is C or N, the ring-constituting atoms X3 and X4 are the same or different and each is C, N, 0 or S (provided that a pyrrole ring wherein X1 is N is excluded from ring A), and when the ring-constituting atom X3 or X4 is C or N, each ring-constituting atom optionally has substituent(s) selected from an optionally substituted alkyl, an acyl, an optionally substituted hydroxy, an optionally substituted mercapto, an optionally substituted amino, a halogen, a cyano and a nitro;R1 and R2 are each a cyclic group optionally having substituent(s); R3 and R4 are each H or alkyl, or R3 and R4 form, together with the adjacent N, an nitrogen-containing heterocycle; and Y is a spacer.

The invention relates to a novel elliptical machine designed on orthopedic standards of body kinetics wherein the handles rotate 360 degrees and the foot pedals slide fore and aft and roll forwards and backwards as the user is exercising on the machine. This novel machine provides maximum efficacy and safety while a user is exercising, and does not limit the range of motion to the standard fixed elliptical motion of merely forward and backwards.

Provided are a fusion protein of Exendin-4 and its analog, the preparation method and use thereof. The fusion protein is obtained by fusing of Exendin-4 or its analog to Fc region of human IgG2 via a linking peptide, which has the better stability and prolonged serum half-life, and can be used for treating diabetes and obesity.

A product and apparatus for cleaning water or industrial and sewage waste water includes a mixture of diatomite that is heated and stirred to impart an enhanced negative electrical charge to the diatomite. A mixture of approximately 50% aluminium chloride (AlCl3) by volume is blended to provide a powder mixture for use as a flocculant in the system. According to a modification, the charged diatomite is instead blended with a mixture of approximately 50% ferric chloride (FeCl3) by volume and is stored in liquid form for later use as a flocculant in the system. From one to five percent, by volume, of polyacrylamide is preferably added to the mixture for use in sewage waste water treatment applications. An efficient system for reacting either the mixture or separately adding the diatomite and the metallic chloride to the water is described.

The invention provides binding molecules, including antibody molecules which selectively bind to a cell surface antigen of a target cell, and wherein the binding molecules, on binding the cell surface antigen, induce apoptosis of the target cell. There is also provided methods of and pharmaceutical compositions for apoptosis induction and uses thereof.

Systems and methods are provided for determining optimized settings for a closed-loop stimulation system based on analyzing a phase response curve measured from electrophysiological activity, such as electrical nerve activity or electrical muscle activity. The slope of the phase response curve is computed and used to determine a phase window during which phasic burst stimulation should be provided to achieve a desired effect on oscillations in the subject. When the slope of the phase response curve is positive, a phasic burst stimulation applied during the phase window will decrease synchrony of the oscillations. When the slope of the phase response curve is negative, a phasic burst stimulation applied during the phase window will increase synchrony of the oscillations.

The present invention provides 5-membered heterocycle compounds represented by the following general formula (I):The present compounds have a superior acid secretion inhibitory effect, and shows an antiulcer activity and the like.

A stabilized superoxide dismutase (SOD1) analogue, wherein the side chains of two amino acids on two different SOD1 monomers are connected is provided. A method of producing a stabilized superoxide disumutase (SOD1) analogue comprises reacting a first SOD1 monomer, a second SOD1 monomer, and a cross-linker.

A one-component prescription fluoride treatment composition having both fluoride efficacy and sensitivity relief is disclosed. The composition includes at least one metal fluoride and a nerve desensitizing agent such as potassium nitrate. The invention further includes a composition having at least one metal fluoride less than about 1.15% by weight of at least one metal fluoride; less than about 5 percent by weight of at least one alkali metal salt having desensitizing effect; at least one carrier; and at least one foaming agent that has thickening property. The composition may be formulated into a gel, a paste or any other convenient form, some of which contain abrasives.

A flash memory accessing apparatus is disclosed. The flash memory accessing apparatus includes a controller, a first channel memory set and a second channel memory set. The first channel memory set includes a first flash memory and at least one first memory expanding socket. The second channel memory set includes a second flash memory and at least one second memory expanding socket. The controller determines the accessing method to be implemented on the first memory and second flash memory according to whether there is any flash memory inserted into the first memory expanding socket and the second memory expanding socket.

The present invention relates to methods, pharmaceutical compositions and kits for treating osteoarthritis associated pain, inflammation and improving function in a patient comprising a first therapeutic agent which comprises bicifadine or a pharmaceutically acceptable salt, enantiomer, solvate, hydrate, polymorph or prodrug thereof and a second therapeutic agent which comprises a non-steroidal anti-inflammatory drug or derivative thereof.

A process for dispersing medicament from an inhalator device which contains medicament particles. The process involves (i) providing an inhalator which contains at least one dose of medicament particles comprising spherical hollow particulates of respirable particle size suitable for deposition in a human being's lungs, and (ii) removing the spherical hollow particulates from the inhalator.

A system and apparatus for treatment of cellular structure anomalies, principally in human patients, utilizes precisely controlled electromagnetic wave energy and electromagnetic field energy. The former energy is generated from a combination of coherent and incoherent light energy which is joined and focused on patients thru a unique arrangement of faceted coated reflectors and filters. The latter energy is generated in part by unique coils surrounding the light sources which include coils wound with bifilar wire. The disclosed apparatus also includes a platform, preferably segmented, that facilitates alignment of a patient's bodily area needing treatment. Additional coils are placed in the platform in strategic locations proximate the area of the patient to be treated. A digital control module can be programmed to regulate the frequency, duration, phase, duty cycle, pulse and amplitude of all energy sources in the claimed systems.

A method for skin improvement, comprising the application of a mask composed of two different fluid components, wherein the first component is adapted to be applied to contact skin, and second component is adapted to be applied to contact the first component, and whereby first and second components chemically react with each other to form a new gel-like component that adapts to the shape of skin as a continuous film, and which is removed from skin as a continuous gel-like film upon being pulled away from skin, and which also removes skin wrinkles, skin blemishes, and skin discoloration as the continuous film is pulled away from skin.