104 results about "Superoxide" patented technology

The invention provides lactobacillus plantarum XZFMCC101.23155, a probiotic agent and application of the lactobacillus plantarum XZFMCC101.23155 and belongs to the technical field of microorganisms. The invention provides lactobacillus plantarum XZFMCC101.23155, and the preservation number of the lactobacillus plantarum XZFMCC101.23155 is GDMCC No: 65783. The lactobacillus plantarum XZFMCC101.23155 can tolerate hydrogen peroxide, a fermentation product of the lactobacillus plantarum XZFMCC101.23155 has the capacity of removing DPPH, hydroxyl free radicals and superoxide anions, and the total antioxidant activity is high. The fermentation product can also significantly reduce the MDA content in mouse serum, significantly improve the SOD level in mouse serum, improve the GSH content in mouse serum and the like. The lactobacillus plantarum XZFMCC101.23155 and commercial zymophyte are jointly used as a leavening agent to prepare the cheese, and the antioxidant activity of the cheese can be remarkably improved.

The invention provides a coordination nano assembly of chiral cyclopeptide and manganese ions as well as a preparation method and application of the coordination nano assembly. According to the method, a manganese superoxide dismutase protein structural domain and a unique tumor microenvironment of melanoma high tyrosinase are combined, and polypeptide sequences L-YD-hL-DD-h, L-YL-HL-DL-H and D-yD-hD-dD-h with different chirality are designed for the first time; the chirality of the polypeptide is regulated and controlled, the in-vivo circulation stability and the cell entry efficiency of the nano assembly are improved, the coordination self-assembly of manganese and different chiral cyclopeptides is realized, and the in-situ oxidation of an in-vivo tumor microenvironment is simulated for photo-thermal therapy and cell membrane coating. The method disclosed by the invention is simple, mild in experimental condition and easy to operate, the prepared cell membrane coated nano assembly not only has long circulation stability and high cell entry efficiency, but also can realize mild photo-thermal therapy through in-situ oxidation, releases manganese ions to activate a CGAS-STING pathway for immunotherapy of tumors, and has a wide application prospect. The potential application value is realized in the field of combined treatment of tumors.

A lithium oxygen electrochemical cell includes an anode that includes lithium metal, a porous oxygen cathode that includes a conductive carbon and aluminum, and an electrolyte.

The invention provides an aza-BODIPY molecule with NIR-II fluorescence emission and I-type photodynamic activity and a preparation method thereof. The aza-BODIPY molecule has good light absorption in a near-infrared (NIR) region, the emission peak of the aza-BODIPY molecule is prolonged to a near-infrared second region (NIR-II), and the aza-BODIPY molecule shows an ultrahigh NIR-II fluorescence quantum yield of 13%. Meanwhile, the photosensitizer prepared by adopting aza-BODIPY molecules can effectively generate I-type active oxygen species, namely superoxide anion free radicals, under the excitation of 808nm laser. On the basis, high-resolution tumor fluorescence imaging can be realized by utilizing NIR-II fluorescence of the aza-fluorine boron fluorescent sensitizer, and the aza-fluorine boron fluorescent sensitizer is used for accurate and efficient NIR-II fluorescence imaging mediated I-type photodynamic therapy of deep tumor tissues.

The invention belongs to the technical field of organic dye synthesis and application, and discloses a conjugated compound containing a benzothiophenazine structure as well as a preparation method and application thereof, and the conjugated compound containing the benzothiophenazine structure has excellent photophysical properties, singlet oxygen yield and superoxide anion generation capacity. The novel conjugated compounds ENBO-NI and ENBS-NI containing benzothiophenazine structures are successfully prepared by replacing a benzene ring of Nile blue with a cycloalkane structure and adjusting the electron donating ability of an R1 group. The two compounds have near infrared fluorescence emission, good solubility and relatively high ROS yield. Compared with a classical photosensitizer NB, the singlet oxygen yield of ENBO-NI is increased by about 117.65%, and the singlet oxygen yield of ENBS-NI is as high as 70%. The absorption wavelength of the conjugated compound is in a red light wave band. The preparation process is simple and efficient, large-scale production is easy, and the preparation method has a wide clinical application prospect.

The invention discloses a banana drought-enduring functional gene MaPUB21 and application of the banana drought-enduring functional gene MaPUB21 in improvement of plant drought-enduring capability. A nucleotide sequence of the gene is shown as SEQ ID NO.2. The invention further discloses a method for preparing the banana drought-enduring functional gene MaPUB21. According to the invention, a silence vector (MaPUB21-pTRV) aiming at the MaPUB21 gene is constructed, and an agrobacterium-mediated method is utilized to carry out instantaneous silence in the Musa communis. Drought tolerance analysis shows that after drought stress treatment, compared with a wild type, the content of malonaldehyde, superoxide anions and hydrogen peroxide of the MaPUB21 silent strain is remarkably reduced, and the content of proline and the activity of peroxidase are remarkably improved. The result shows that the drought tolerance of the plant can be effectively improved by silencing the MaPUB21 gene. The gene provided by the invention provides a new resource for plant stress-resistant molecular breeding, and is of great significance for cultivating drought-resistant plants and improving the utilization rate of drought land.

The invention provides a grain boundary defect-enriched cerium dioxide nano catalyst and a preparation method thereof, and the preparation method comprises the following steps: preparing a cerium salt solution with nitrate radicals, reacting to obtain cerium formate and basic cerium carbonate precursor products, and washing, drying and roasting to obtain the grain boundary defect-enriched cerium dioxide nano catalyst. The cerium dioxide nano-catalyst prepared by the method can form an oxygen vacancy defect, promote the adsorption and activation of O2, form peroxy, superoxide and other active oxygen species, and improve the catalytic oxidation activity. According to the method, the covalence of Ce-O bonds is effectively reduced by destroying the periodicity of CeO2 crystal lattices. The reduction of covalence can weaken the constraint strength that surface lattice oxygen atoms are surrounded by Ce atoms and enhance the release reactivity of the surface lattice oxygen atoms essentially, so that the formation of oxygen deficiency is further promoted, the CeO2 adsorption is enhanced, the activity of activating O2 to form active oxygen for oxidation reaction is enhanced, and the oxidation reaction efficiency is improved. Furthermore, the catalyst has good catalytic performance on toxic and harmful substances such as chlorobenzene, sarin toxic agent simulation agents, CO and the like.

The invention belongs to the technical field of fermentation and metagen preparations, and particularly relates to application of bifidobacterium breve metagen in the aspects of scavenging free radicals and relieving oxidative aging. According to the present invention, the oxidative free radical scavenging experiment results show that the bifidobacterium breve NKU BB 1-2 metagen has good oxidative free radical scavenging ability, and has good scavenging ability on hydroxyl free radicals, superoxide anions and DPPH free radicals; meanwhile, through component analysis, it is found that the bifidobacterium breve NKU BB 1-2 metagen contains various antioxidant and anti-aging bioactive substances such as flavonoids, indoles, amino acids, bile acids and ceramides; a cell model experiment verifies that the bifidobacterium breve NKU BB 1-2 metagen can obviously relieve oxidative damage to the cells and improve the oxidation resistance of the cells, so that oxidative aging is relieved.

The invention relates to an application of a phosphorus vacancy mediated transition metal-based cathode material in electro-Fenton-like selective degradation of metronidazole antibiotics. The phosphorus vacancy-mediated transition metal-based cathode material is NiCoP-Vp, foamed nickel is used as a substrate, and a phosphorus vacancy-containing NiCoP catalyst is loaded on the surface of the substrate; the NiCoP catalyst containing the phosphorus vacancy is in a nanoneedle shape, and a large number of holes are formed in the surface of the NiCoP catalyst. The transition metal-based catalyst containing the phosphorus vacancy has higher electron transmission efficiency and relatively larger electrochemical active area, more active sites can be exposed, and 100% removal of metronidazole can be selectively realized. The fully exposed active sites provide more sites for the adsorption and activation of H2O2 and O2, the improved charge transfer can accelerate the redox cycle of transition metals, the two can cooperatively regulate and control to generate superoxide free radicals O2 <.-> and high-valence metal oxygen, and finally the selective efficient degradation of metronidazole antibiotics is realized.

The invention relates to the technical field of nano-materials, and discloses a heterogeneous diatomic nano-enzyme as well as a preparation method and application thereof. The invention provides a space confinement regulation and control strategy which is used for constructing a heterodiatomic catalytic center on a nitrogen-doped carbon skeleton and preparing nano-enzyme with structural stability and synergistic catalytic performance. According to the method, a confinement framework formed by self-assembly of first metal ions such as cobalt ions and second metal ions such as zinc ions and organic ligands is used as a template, third metal ions such as iron ions are introduced, and then carbonization heat treatment is performed in a protective gas atmosphere, so that bimetal sites with stable bridging configuration are formed in situ. The obtained nano-enzyme has the catalytic activity of various antioxidant enzymes, including catalase and remarkable superoxide dismutase activity, and has more excellent free radical scavenging capacity compared with a single-metal or non-bridging system.

The invention discloses a photochromic TiO2-PEG200 (Polyethylene Glycol 200) nano particle and an application of the photochromic TiO2-PEG200 nano particle in photocatalytic oxidation of a C-H bond. The catalyst is synthesized through a solvothermal method, PEG200 is used as a solvent and a modifier, and self-doped Ti < 3 + > and surface oxygen vacancies are introduced into TiO2. Under the irradiation of blue light (405nm), the catalyst generates a photochromic effect, Ti < 4 + > is reduced into high-concentration Ti < 3 + > in situ, and meanwhile, a large amount of superoxide free radicals (O < 2 + >) are generated. A photo-generated hole directly activates an ethylbenzene alpha-C-H bond to generate a benzyl free radical, and the benzyl free radical reacts with a superoxide free radical (O2.) and is finally converted into acetophenone. The catalyst has excellent visible light response and charge separation efficiency, and the acetophenone yield is up to 56 mmol.g <-1 >. H <-1 > and is 10 times that of traditional TiO2. The reversible circulation of Ti < 3 + > / Ti < 4 + > enables the catalyst to maintain good stability, and the activity is still maintained at 95% or above after five times of circulation. The operation conditions are mild (room temperature and normal pressure), a strong oxidant is not needed, an efficient, stable and environment-friendly photocatalysis solution is provided for C-H bond activation, and the method has important application value in the field of fine chemical synthesis.

This invention relates to a vehicle air conditioner, and the object of this invention is to improve the assemblability, maintenance, and repairability of a photocatalyst module by improving the intake housing structure, and to reduce air vortices generated at the air intake port side during air intake by the blower and the rumbling noise caused by these air vortices. To achieve this object, the vehicle air conditioner of this invention includes: an intake section that draws in internal and external air to blow them into the interior space of the vehicle; and a photocatalyst module that releases superoxide radicals into the air blown from the intake section into the interior space of the vehicle to purify the air, wherein the photocatalyst module is disposed on the outer surface portion of the downstream side of the blower housing of the intake section, and interference-avoidance recesses are formed on the outer surface portion of the intake housing corresponding to the periphery of the photocatalyst module disposed in the blower housing.

The invention belongs to the technical field of biological medicines, and discloses a carbazole / benzo [cd] indole compound as well as a preparation method and application thereof. The carbazole / benzo [cd] indole compound has a structure as shown in a general formula I: # imgabs0 #, wherein R is one of NO2, NH2, Br and N (Ph) 2. The carbazole / benzo [cd] indole compound can generate active oxygen molecules after illumination, including superoxide anions and hydroxyl radicals, and can be applied to preparation of drugs for photodynamic therapy.

This invention discloses the application of a porcine-derived Bacillus in antioxidant activity, wherein the porcine-derived Bacillus is used to prepare antioxidant products. The porcine-derived Bacillus is Bacillus subtilis YB-X-721, classified as Bacillus subtilis, and was deposited at the China General Microbiological Culture Collection Center on November 10, 2023, with accession number CGMCC No. 28942. The fermentation supernatant, bacterial suspension, and cell-free extract of the porcine-derived Bacillus subtilis YB-X-721 of this invention all possess certain DPPH free radical, superoxide anion free radical, and hydroxyl free radical scavenging abilities, as well as a certain reducing ability, and can be used to prepare antioxidant products. Furthermore, when the porcine-derived Bacillus subtilis YB-X-721 of this invention is added to piglet feed as an animal feed additive, it can improve the growth performance of weaned piglets, significantly increasing average daily weight gain, and significantly reducing average daily feed intake, feed conversion ratio, and diarrhea rate.

The invention relates to a substance with a Prussian blue structure, which can generate hydroxyl radicals, superoxide anions and singlet oxygen in parallel under ultrasonic irradiation, and in the presence of ultrasonic irradiation and H2O2, the substance with the Prussian blue is used as a sonodynamic therapy (SDT) means to kill focus cells by generating sonotoxic and cytotoxic free radicals, so as to achieve the purpose of improving the therapeutic effect of the substance with the Prussian blue structure. Therefore, diseases are effectively treated.

The use of a cell-permeant molecular probe to assay the presence, and monitor the production, of the reactive oxygen species, superoxide, in red blood cells (RBCs) is described. The assay is performed using electron paramagnetic resonance (EPR) spectroscopy and a cell-permeant hydroxylamine spin trap. The cell-permeant molecular probe is not detected or quantifiable by EPR in its reduced form. However, upon entering the RBCs, the probe is oxidized by reacting with superoxide to yield a stable nitroxide radical that is detected and quantified using EPR. Our studies indicate that superoxide production is consistent with RBC metabolism that predicts lipid oxidation, membrane injury and poor post-transfusion performance. Therefore, measurement of reactive oxygen species can be used as an indicator of RBC quality at the time of donation and after storage.

The present invention belongs to the field of pharmaceutical chemistry technology, and specifically relates to a binuclear ruthenium photocatalyst, its preparation method, and application. The present invention discloses a novel tridentate Ru(II) complex for antibacterial purposes. The present invention discloses a binuclear ruthenium complex (see the structural formula below) that has a photocatalytic therapeutic effect against Staphylococcus aureus (S. aureus) and exhibits proliferation inhibition (MIC) against Staphylococcus aureus under light conditions. 90 6.25μM), and can generate superoxide anions and singlet oxygen under light conditions, and has photocatalytic oxidation ability on NADH / NADPH in bacteria. This is of great significance for the research of binuclear ruthenium complex antibacterial drugs and provides new ideas for the clinical development of binuclear ruthenium complex antibacterial photocatalytic drugs or antibacterial metal photosensitizers. #imgabs0#

The invention discloses a preparation method of a thermophilic thermophilic bacteria fermentation lysate, which comprises the following steps: inoculating a seed culture medium with thermophilic thermophilic bacteria for culturing to prepare a seed bacteria solution; inoculating the seed bacterial liquid into an initial culture medium for culturing, adding a supplementary culture medium when residual sugar reaches 4-6g / L, maintaining the residual sugar at 4-6g / L, and fermenting for 30-40 hours to obtain fermentation liquor; and filtering the obtained fermentation liquor by using a ceramic membrane, cleaning by using 7 times of water volume until the conductivity of the supernate is 100 [mu] s / cm, diluting the bacterial suspension to OD = 20, and homogenizing at high pressure for 1-3 times to obtain the Thermus thermophilus lysate. According to the method, the activity of superoxide dismutase in the thermophilic thermophilic bacteria lysate is improved, and the stability of nucleic acid in the thermophilic thermophilic bacteria lysate at normal temperature is improved.

This invention discloses a method for enhancing the high-temperature resistance of citrus through exogenous spraying of naringin, belonging to the field of agricultural technology. The method involves preparing naringin into a formulation and spraying it exogenously onto the leaves of citrus plants. Experiments show that after treatment with naringin, phenotypic damage such as wilting and curling of citrus seedling leaves under high-temperature stress is significantly alleviated; the maximum photochemical efficiency of photosystem II (Fv / Fm) is significantly increased; electrolyte leakage rate and malondialdehyde content are significantly reduced; and the accumulation of hydrogen peroxide and superoxide anions is effectively inhibited. This invention utilizes naturally sourced naringin to significantly enhance the tolerance of citrus to high-temperature stress through multiple mechanisms, including maintaining photosynthetic system function, protecting cell membrane integrity, inhibiting membrane lipid peroxidation, and scavenging reactive oxygen species. Furthermore, the method is simple to operate, environmentally friendly, and low-cost, making it suitable for stress-resistant citrus cultivation.

The invention relates to the technical field of catalyst preparation, and particularly discloses a non-stoichiometric selenium-doped Cu7.2 S4 photocatalyst based on carbon coating and a preparation method and application thereof, and the preparation method comprises the following steps: preparing copper-based metal organic framework precursor powder, then mixing the copper-based metal organic framework precursor powder with a selenium source and a sulfur source, and carrying out high-temperature post-vulcanization, selenylation and carbonization processes to prepare the photocatalyst. The photocatalyst prepared by the invention comprises selenium-doped Cu7. 2S4 and a carbon matrix material, wherein the carbon matrix material is coated on the surfaces of selenium-doped Cu7. 2S4 particles. The prepared photocatalyst has good visible light response, excellent carrier transport performance and good stability, can generate superoxide free radicals and hydroxyl free radicals under visible light irradiation, further shows excellent water pollutant photocatalytic degradation capacity and has good application prospects.

The invention relates to the field of photocatalyst preparation, in particular to a preparation method, a product and application of a photocatalyst. The preparation method of the photocatalyst comprises the following steps: uniformly mixing a ferric salt solution and a perylenetetracarboxylic dianhydride solution, and then adding an H2O2 solution to obtain a mixed solution; and carrying out a hydrothermal reaction on the mixed solution, centrifuging, and washing and drying the obtained precipitate to obtain the photocatalyst. The photocatalyst FeOOH (at) PTCDA is prepared by adopting a hydrothermal method, a heterojunction formed between FeOOH and PTCDA remarkably blocks compounding of photo-generated electrons and photo-generated holes, the photocatalytic electron transfer capacity is improved, a large number of hydroxyl free radicals and superoxide anion free radicals are generated, and the photocatalytic activity of the photocatalyst is improved. Therefore, the strong degradation and reduction capability on oxytetracycline and heavy metal ions in sewage is brought.

The present disclosure relates to methods of treating a range of diseases or conditions. The methods involve administration of a superoxide dismutase mimetic.

The invention discloses a preparation method of melt-blown polypropylene melt spinning. The preparation method comprises the following steps: S1, preparing raw materials of a compound antibacterial agent; taking out quaternary phosphonium salt, mixed crystal type nano titanium dioxide and nano zinc oxide for later use, and preparing a dispersing agent and a silane coupling agent when the antibacterial agent is mixed; s2, mixing the compound antibacterial agent; s3, melting and mixing; s4, preparing an antibacterial master batch; s5, melt-blowing spinning; s6, subsequent preparation; nano-zinc oxide and nano-titanium dioxide have different energy band structures, and can broaden the light response range after compounding, so that the material absorbs light energy in a wider wavelength range, thereby generating more electron-hole pairs, generating hydroxyl free radicals and superoxide anion free radicals with strong oxidizing property, improving the photocatalytic efficiency, and reducing the energy consumption. The surface of the quaternary phosphonium salt is positively charged, the quaternary phosphonium salt can be adsorbed on the surface of bacteria with negative electricity through coulomb force, and after the three components are compounded, cell membranes of the bacteria can be more comprehensively destroyed, and the metabolic process of the bacteria is inhibited.

The invention relates to the technical field of active polysaccharide preparation, in particular to a hemerocallis fulva polysaccharide DLP-N as well as a preparation method and application of the hemerocallis fulva polysaccharide DLP-N. Grinding the dried day lily into powder, degreasing, desugaring and air-drying; preparing a deep eutectic solvent; using an extraction deep eutectic solvent; performing alcohol precipitation; performing freeze-drying; removing protein by a Sevage method; depigmentation is performed; carrying out DEAE-52 cellulose anion exchange chromatography; and carrying out sephadex SephacrylS-400 chromatography to obtain the white flocculent refined polysaccharide. The day lily polysaccharide component with remarkable antioxidant and cancer-inhibiting double activities is prepared by taking day lily as a raw material, the yield of the day lily polysaccharide component is as high as 25.6%, high-value utilization of resources is effectively realized, and the day lily polysaccharide component has excellent scavenging performance on DPPH free radicals, ABTS free radicals, hydroxyl free radicals and superoxide anion free radicals. Meanwhile, cancer cell proliferation can be effectively inhibited, and a definite structure-function relationship and functional gradient are shown.

The application provides a method for improving the biological manganese oxidation performance of manganese-oxidizing bacteria and application, and belongs to the technical field of wastewater treatment.The method improves the biological manganese oxidation performance of the manganese-oxidizing bacteria by adding biochar, and after the biochar is added into the manganese-oxidizing bacteria, the addition of divalent manganese can obviously improve the oxidation rate of the divalent manganese and the removal efficiency of heavy metals in wastewater.The biochar can be used as an electron shuttle, can improve the electron transfer capacity and accelerate the oxidation rate of the divalent manganese, and the biochar also improves the gene abundance and expression capacity of the manganese-oxidizing bacteria and the extracellular superoxide concentration, improves the biological activity of the manganese-oxidizing bacteria and accelerates the oxidation of the divalent manganese.Further, the biochar is widely available and low in cost, can realize the reuse of resources and reduce the treatment cost, is easy to prepare and put into use and is convenient for use in practical application.

The invention discloses a photosensitizer for inducing tumor cell copper death under illumination as well as a preparation method and application of the photosensitizer. The structure of the photosensitizer is as shown in a formula I, the core of the photosensitizer is bivalent copper ions, and a ligand is prepared by adopting Nile blue as a parent, adopting HATU / DIPEA catalytic amidation collaborative design with 8-hydroxyquinoline carboxylic acid and adopting a copper salt complexing process; under the triggering of 660nm near-infrared light (20mW / cm < 2 >), the photosensitizer can release GSH complexed copper ions (58%) by generating superoxide anions, specifically down-regulate FDX1 protein (less than 64%) and induce DLAT aggregation, so that the photodynamic-copper death synergistic treatment is realized, the median inhibitory concentration (IC50) on a breast cancer 4T1 model reaches 226nM and is reduced by 50% compared with that of a traditional photosensitizer, the liver accumulation is less than or equal to 0.5 mu M, and the photosensitizer has high efficiency and safety.

The present invention relates to a method of evaluating neutrophil activity, which includes: evaluating neutrophil activity based on an index derived from measurement results of myeloperoxidase (MPO) activity or superoxide production of a biological sample to which a neutrophil stimulant is added, in which the index is a time from addition of the neutrophil stimulant to rise of a peak of the MPO activity or the superoxide production.

The present disclosure provides for imaging agents and methods of making and using the same. The imaging agent comprises a luminol component comprising a luminol moiety or functional analogue thereof; a chelator; a linker group bonding or complexing the luminol component to the chelator; and a radiolabel component bound to the chelator. The imaging agent described herein is capable of monitoring, targeting, or imaging oxidative stress, reactive oxygen species (ROS), superoxide generation, or hydrogen peroxide generation, mediating pathophysiology of different disease states.

The invention relates to the technical field of catalyst preparation and biological hydrogen storage material synthesis, and discloses a preparation method of a monatomic iron catalyst, which comprises the following steps: firstly adding melamine into a ball milling tank, then adding L-alanine, finally adding 100mg of iron acetate, and carrying out ball milling treatment; the preparation method comprises the following steps: adding a hydrochloric acid ethanol solution into a nitrogen-doped carbon carrier, grinding, drying, pyrolyzing in an N2 atmosphere, pickling to obtain a monatomic iron catalyst FeN4, carrying out dehydrogenation reaction in the nitrogen-heterocyclic biological hydrogen storage material by using the monatomic iron catalyst FeN4, and representing that iron is dispersed in the nitrogen-doped carbon carrier in a monatomic form by using the monatomic iron catalyst to form FeN4 active sites. The catalyst is prepared by pyrolyzing an iron precursor and a nitrogen-carbon carrier and has high-dispersion monatomic iron active sites, in the presence of oxygen, FeN4 can activate oxygen molecules to form superoxide free radicals, dehydrogenation reaction energy barriers are remarkably reduced, efficient catalysis at room temperature is achieved, the catalysis cost is low, and the catalyst is environmentally friendly and has good application prospects. The catalyst is suitable for dehydrogenation reaction of nitrogen heterocyclic biological hydrogen storage materials.

This invention belongs to the field of pharmaceutical chemistry technology, specifically relating to a near-infrared II luminescent iridium(III) complex photosensitizer, its preparation method, and its application. The near-infrared II luminescent iridium(III) complex photosensitizer disclosed in this invention generates singlet oxygen (…) under 550 nm illumination. 1 O2), hydroxyl radicals (•OH), superoxide anions (O2) •‑ We evaluated the antitumor activity of near-infrared luminescent iridium complexes using mouse breast cancer cells (4T1). Under unilluminated conditions, the near-infrared II luminescent iridium(III) complex photosensitizers showed no significant cytotoxicity to 4T1 cells, while under illumination, they exhibited good phototoxicity to 4T1 cells, with an IC50 value of [missing value]. 50 The concentration is 15.92 μM. We have invented a near-infrared II luminescent iridium(III) complex photosensitizer, which has excellent photoimmunodynamic therapeutic effects and will have important application prospects in the treatment of hypoxic tumors.