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Transcriptome In Vivo Analysis (TIVA) and Transcriptome In Situ Analysis (TISA)
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US12662501B2
Ruthenium organic compounds
Sugar derivatives
Caged molecule
Organic chemistry
Compositions and methods of capturing one or more
nucleic acid
molecules of a
cell
or subcellular compartment are described. In certain aspects, the compositions comprise a caged molecule comprising one or more photolinkers and an antisense
oligonucleotide
, which when uncaged hybridizes to a target
nucleic acid
molecule.
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THE TRUSTEES OF THE UNIV OF PENNSYLVANIA
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