25 results about "In vivo analysis" patented technology

The present disclosure refers to an in vivo analyte sensor, comprising: a substrate (20); a conductive layer (21) disposed over at least a portion of the substrate (20); a sensing layer (24) disposed formed on the conductive layer (21), wherein the sensin\g layer (24) forms a sensing area configured to generate one or more signals identifying a monitored analyte level after insertion of the analyte sensor and when maintained in fluid contact with interstitial fluid; and a membrane layer (25) formed at least on the sensing layer (24). The sensing layer (24) is formed with an area sensitivity of 0,2 to 1,5 nA / (mqx / dL) mm2 within the sensing area. Further, a method of manufacturing an in vivo analyte sensor is provided.

Electrochemical aptamer (EAB)-based sensors support high frequency real-time monitoring of analytes in vivo. Methods of reducing sensor drift during in vivo placement are described. EAB sensors with non-natural nucleic acids can be used to reduce sensor signal drift. The EAB sensor improves the stability and reduces the signal loss.

A sensor (e.g., an optical sensor) that may be implanted within a living animal (e.g., a human) and may be used to measure an analyte (e.g., glucose or oxygen) in a medium (e.g., interstitial fluid, blood, or intraperitoneal fluid) within the animal. The sensor may include a sensor housing, an analyte indicator covering at least a portion of the sensor housing, and one or more compounds containing boronate or boronic acid moieties that reduce degradation of the analyte indicator.

The present disclosure discloses devices and systems that use a combined sensor and cannula mounted to a body. The combination provides electrical coupling of the sensor to a signal processing device and fluidic coupling of the cannula to a drug delivery source for combined subcutaneous liquid drug delivery and amperometric analyte sensing without the need for multiple skin-piercing elements.SOLUTION: The present disclosure provides systems and devices for combining analyte monitoring with fluid delivery, including devices having a sensor and a cannula in a single component and adapted for use with a combined sensor and cannula. These systems and devices may be used for a variety of applications involving simultaneous in vivo monitoring of analyte concentration and drug delivery.SELECTED DRAWING: Figure 1A

A monitor for determining analyte concentrations in vivo includes a housing configured to adhere to a patient's skin, and a sensor member configured to extend from the housing into the patient's skin. The sensor member includes at least a first working electrode and a separate second working electrode that are independently connected to electronics in the housing via separate electrical connections and that function independently from one another.

According to the display interface interaction method and system, target user data of a target user are obtained, and the target user data comprise user related data and / or sensor related data; the terminal equipment comprises a display interface, and the display interface displays content related to the target user; the display interface is provided with at least one dynamic display area, and dynamic information is displayed in the dynamic display area; based on the target user data, generating at least one dynamic content through an artificial intelligence model; and displaying dynamic information containing dynamic content in the dynamic display area in response to a user behavior. Information on the display interface can be dynamically displayed, user interaction can be supported, and corresponding content can also be dynamically changed, so that a user is attracted to interact on the display interface, and the utilization rate of the in-vivo analyte monitoring system is improved.

Systems, devices and methods are provided for inserting at least a portion of an in vivo analyte sensor, such as a dermal sensor, for sensing an analyte level in a bodily fluid of a subject. An applicator is positioned against a skin surface and a force is applied to the applicator causing at least a portion of a sharp and an in vivo analyte sensor to be positioned in the body of the subject. In particular, disclosed herein are embodiments of applicators designed to prevent premature sharp withdrawal and / or reduce the likelihood of improper sensor insertion. Also disclosed are embodiments of applicators including sharp modules having an angled sharp which can be configured to create an insertion path for a sensor.

An apparatus for in vivo profiling a region of biological tissue to determine its state of mutation is provided. The apparatus includes a light source configured to generate at least one light beam, an optical arrangement configured to form the light beam into an optical probe beam for illuminating the region of biological tissue and receiving a Raman backscattered optical signal from the region of biological tissue, wherein the optical arrangement is further configured to filter the Raman backscattered optical signal to generate a filtered optical signal. The apparatus further comprises an optical detector configured to receive the filtered optical signal to generate a corresponding detector signal including one or more components indicative of one or more molecular species present in the region of biological tissue; and a data processing arrangement configured to process the detector signal to determine from the one or more components a concentration of the one or more molecular species to compute the state of mutation of the biological tissue.

A system, device, and method are provided for inserting at least a portion of an in vivo analyte sensor to sense an analyte level in a bodily fluid of a subject. In particular, various embodiments of sensor control devices and components thereof are disclosed herein that are designed to reduce the size and number of internal components of the sensor control device. In addition, embodiments of the sensor control devices and related sensor features disclosed herein are designed to increase the comfort and convenience of a subject.

A monitor for determining analyte concentrations in vivo includes a housing configured to adhere to the skin of a subject, a sensor body configured to extend from the housing into a patient's skin, the sensor body being elongate and extending along a longitudinal axis in a length direction, and further having a width and a thickness each measured perpendicular to the length, and an analyte sensing region formed on the sensor body. The analyte sensing region has opposite ends in the length direction, where a maximum length of the analyte sensing region measured between the opposite ends is 80 μm or less.

A sensor (e.g., an optical sensor) that can be implanted within a living animal (e.g., a human) and used to measure an analyte (e.g., glucose or oxygen) in a medium (e.g., interstitial fluid, blood, or intraperitoneal fluid) within the animal, the sensor including a sensor housing, an analyte indicator covering at least a portion of the sensor housing, and a multi-metal protection system including multiple metals incorporated within and / or proximate to a surface of the analyte indicator that reduces deterioration of the analyte indicator.

The invention provides a rich media content generation method for an in-vivo analyte monitoring system and the in-vivo analyte monitoring system. The method comprises the steps of calling target user data and / or a knowledge base to generate target content in response to user behavior operation and / or triggering of a content generation condition; determining a target format corresponding to the target content; generating target rich media content based on the target content and the target format; and displaying the target rich media content on a target interface of the terminal device.

A monitor for determining analyte concentrations in vivo includes a housing configured to adhere to a patient's skin, and a sensor member configured to extend from the housing into the patient's skin. The sensor member includes at least a first working electrode and a separate second working electrode that are configured to be activated at different times upon implantation of the sensor member into the patient's skin.

A reader device for displaying analyte data includes a housing, a charging port configured to engage with a connector of a charging device, and a power source configured to be charged by the charging device. The reader devices includes communication circuitry for receiving analyte data from a sensor control device having an in vivo analyte sensor, and a display for displaying analyte data. The reader device includes a first temperature sensor configured to measure a first temperature of the charging port, and a second temperature sensor configured to measure an internal temperature within the housing. A processing device of the reader device receives the first and second temperatures, determines a difference between the first and second temperatures, and outputs an alert when the difference exceeds a temperature difference threshold.

The present invention, among other things, provides technologies for detecting and / or quantifying nucleic acids in cells, tissues, organs, or organisms. Pre-designed barcodes are associated with specific molecular targets through sequential hybridization experiments. A pseudo-color based barcoding scheme is described that overcomes the limitations in the previous generation of the technology. The current method can be applied to both in vitro and in situ analysis.

Methods and devices to monitor an analyte in body fluid are provided. Embodiments include continuous or discrete acquisition of analyte related data from a transcutaneously positioned in vivo analyte sensor automatically or upon request from a user. The in vivo analyte sensor is coupled to an electronics unit holding a memory with instruction to cause processing circuitry to initiate a predetermined time period that is longer than a predetermined life of the sensor, during the predetermined time period, convert signals from the sensor related to glucose to respective corresponding glucose levels, without relying on any post-manufacture independent analyte measurements from a reference device, and at the expiration of the predetermined time period, disable, deactivate, or cease use of one or more feature.

Systems, devices and methods are provided that allow for enhanced performance, power efficiency, interoperability, data security and user privacy for in vivo analyte monitoring systems that utilize wireless communications. The in vivo analyte monitoring systems can include a Bluetooth or Bluetooth Low Energy enabled handheld relay device for wirelessly relaying analyte data between a sensor unit device and one or more reader devices. The in vivo analyte monitoring systems can employ advertisement and encryption schemes for wirelessly transmitting data in a manner that allows for improved security, efficiency and privacy.

Systems, devices, and methods are provided for the assembly and subsequent delivery of an in vivo analyte sensor. An applicator with sensor electronics is inserted into a tray containing an assembly that includes a sharp and an analyte sensor. The insertion causes the assembly to couple with the sensor electronics and form a deliverable sensor control device retained within the applicator, which can then be placed in position on a body of a user to monitor that user's analyte levels.

A monitor for determining analyte concentrations in vivo includes a housing configured to adhere to a patient's skin, and a sensor member configured to extend from the housing into the patient's skin. The sensor member includes at least a first working electrode and a separate second working electrode that are independently connected to electronics in the housing via separate electrical connections and that function independently from one another.

This invention discloses the application of an oligopeptide derived from *Sipunculus nudus* and 5-FU in the preparation of drugs for treating colorectal cancer, belonging to the field of biomedical technology. This invention isolates an oligopeptide from *Sipunculus nudus*. Experimental verification shows that this small-molecule oligopeptide, when combined with 5-FU at high concentrations, significantly inhibits the proliferation of colon cancer cells, exhibiting a dose-dependent synergistic effect. Oligopeptide 659 and 5-FU synergistically activate the mitochondrial apoptosis pathway; combined administration enhances γ-H2AX focal point formation and exacerbates DNA double-strand breaks, thereby synergistically inhibiting CRC cell proliferation. In vivo analysis of the antitumor effect of peptide 659 using NOD-SCID female mice inoculated with DLD-1 cells further demonstrates the anti-colorectal tumor effect of oligopeptide 659. Analysis of mouse autopsies showed that, compared to the control group, oligopeptide 659 inhibited tumor growth in mice.

According to the data processing method and system, target user data of a target user are obtained, the target user data comprise user-related data and / or sensor-related data, and an analyte monitoring curve is generated based on the sensor-related data; determining at least one recommendation topic at least based on the target user data; generating a brief review recommendation topic through an artificial intelligence model at least based on the target user data; and outputting the analyte monitoring curve, the brief comment and the at least one recommended topic on a display interface. The change of analyte data is displayed through an analyte monitoring curve, the attention of a user is quickly attracted through a brief evaluation extremely simple language, meanwhile, the conversation of the user is guided through a recommended topic, and the three parts adopt different forms to jointly describe the analyte condition of a target user to form resultant force, so that the target user is attracted to interact, and the interaction efficiency is improved. And the utilization rate of the in-vivo analyte monitoring system is improved.

Compositions and methods of capturing one or more nucleic acid molecules of a cell or subcellular compartment are described. In certain aspects, the compositions comprise a caged molecule comprising one or more photolinkers and an antisense oligonucleotide, which when uncaged hybridizes to a target nucleic acid molecule.

A monitor for determining analyte concentrations in vivo includes a housing configured to adhere to the skin of a subject, a sensor body configured to extend from the housing into a patient's skin, the sensor body being elongate and extending along a longitudinal axis in a length direction, and further having a width and a thickness each measured perpendicular to the length, and an analyte sensing region formed on the sensor body. The analyte sensing region has opposite ends in the length direction, where a maximum length of the analyte sensing region measured between the opposite ends is 80 pm or less.

Systems, devices and methods are provided for inserting at least a portion of an in vivo analyte sensor for sensing an analyte level in a bodily fluid of a subject. In various embodiments, applicators and components thereof are designed to reduce trauma to tissue of a sensor insertion site and to increase the likelihood of a successful sensor insertion. Some embodiments ensure structural integrity of a sensor.

According to the data processing method and system, target user data of a target user are obtained, the target user data comprise user-related data and / or sensor-related data, and the sensor-related data comprise analyte source data used for indicating the analyte level of the target user; based on the target user data, generating a brief review through an artificial intelligence model to generate a brief review and at least one recommended topic; and displaying the brief comment and the at least one recommended topic on a display interface to attract a user, thereby improving the utilization rate of the in vivo analyte monitoring system.