42 results about "In vivo analysis" patented technology

The present disclosure refers to an in vivo analyte sensor, comprising: a substrate (20); a conductive layer (21) disposed over at least a portion of the substrate (20); a sensing layer (24) disposed formed on the conductive layer (21), wherein the sensin\g layer (24) forms a sensing area configured to generate one or more signals identifying a monitored analyte level after insertion of the analyte sensor and when maintained in fluid contact with interstitial fluid; and a membrane layer (25) formed at least on the sensing layer (24). The sensing layer (24) is formed with an area sensitivity of 0,2 to 1,5 nA / (mqx / dL) mm2 within the sensing area. Further, a method of manufacturing an in vivo analyte sensor is provided.

Electrochemical aptamer (EAB)-based sensors support high frequency real-time monitoring of analytes in vivo. Methods of reducing sensor drift during in vivo placement are described. EAB sensors with non-natural nucleic acids can be used to reduce sensor signal drift. The EAB sensor improves the stability and reduces the signal loss.

A sensor (e.g., an optical sensor) that may be implanted within a living animal (e.g., a human) and may be used to measure an analyte (e.g., glucose or oxygen) in a medium (e.g., interstitial fluid, blood, or intraperitoneal fluid) within the animal. The sensor may include a sensor housing, an analyte indicator covering at least a portion of the sensor housing, and one or more compounds containing boronate or boronic acid moieties that reduce degradation of the analyte indicator.

The present disclosure discloses devices and systems that use a combined sensor and cannula mounted to a body. The combination provides electrical coupling of the sensor to a signal processing device and fluidic coupling of the cannula to a drug delivery source for combined subcutaneous liquid drug delivery and amperometric analyte sensing without the need for multiple skin-piercing elements.SOLUTION: The present disclosure provides systems and devices for combining analyte monitoring with fluid delivery, including devices having a sensor and a cannula in a single component and adapted for use with a combined sensor and cannula. These systems and devices may be used for a variety of applications involving simultaneous in vivo monitoring of analyte concentration and drug delivery.SELECTED DRAWING: Figure 1A

A monitor for determining analyte concentrations in vivo includes a housing configured to adhere to a patient's skin, and a sensor member configured to extend from the housing into the patient's skin. The sensor member includes at least a first working electrode and a separate second working electrode that are independently connected to electronics in the housing via separate electrical connections and that function independently from one another.

Methods comprising applying a first analyte point measurement filter comprising: receiving, from an in vivo analyte sensor, at least a first, second, and third uncompensated analyte measurement at a first, second and third reference time; determining a first scaled rate-of-change by multiplying a first weighting coefficient and a first rate-of-change, the first rate-of-change computed between the first uncompensated analyte measurement at the first initial reference time to the second uncompensated analyte measurement at the first prior reference time; determining a second scaled rate-of-change by multiplying a second weighting coefficient and a second rate-of-change, the second rate-of-change computed between the first uncompensated analyte measurement at the first initial reference time to the third uncompensated analyte measurement at the second prior reference time; and calculating a first filter lag-compensated point measurement based on the sum of the first uncompensated analyte measurement, the first scaled rate-of-change, and the second scaled rate-of-change.

According to the display interface interaction method and system, target user data of a target user are obtained, and the target user data comprise user related data and / or sensor related data; the terminal equipment comprises a display interface, and the display interface displays content related to the target user; the display interface is provided with at least one dynamic display area, and dynamic information is displayed in the dynamic display area; based on the target user data, generating at least one dynamic content through an artificial intelligence model; and displaying dynamic information containing dynamic content in the dynamic display area in response to a user behavior. Information on the display interface can be dynamically displayed, user interaction can be supported, and corresponding content can also be dynamically changed, so that a user is attracted to interact on the display interface, and the utilization rate of the in-vivo analyte monitoring system is improved.

Systems, devices and methods are provided for inserting at least a portion of an in vivo analyte sensor, such as a dermal sensor, for sensing an analyte level in a bodily fluid of a subject. An applicator is positioned against a skin surface and a force is applied to the applicator causing at least a portion of a sharp and an in vivo analyte sensor to be positioned in the body of the subject. In particular, disclosed herein are embodiments of applicators designed to prevent premature sharp withdrawal and / or reduce the likelihood of improper sensor insertion. Also disclosed are embodiments of applicators including sharp modules having an angled sharp which can be configured to create an insertion path for a sensor.

Systems, methods and apparatus are provided for rejecting noise from sparsely sampled analyte sensor data. Embodiments of the present disclosure include receiving a raw set of sensor data from an on-body device including an in vivo analyte sensor, determining an interpolation-based estimate of an analyte level over time based on the raw set of sensor data, determining an extrapolation-based estimate of the analyte level over time based on the raw set of sensor data, determining a combined estimate of the analyte level over time based on the interpolation-based estimate and the extrapolation-based estimate, and displaying a representation of the combined estimate of the analyte level over time on an output device. Numerous additional aspects are disclosed.

The present specification provides an interaction content generation method and an in vivo analyte monitoring system. The generation method comprises the following steps: obtaining target user data of a target user, wherein the target user data comprises user-related data and / or analyte-related data; and providing the target user data to an artificial intelligence model in response to detecting that the generation condition is triggered, and guiding the artificial intelligence model to generate interaction content.

An apparatus for in vivo profiling a region of biological tissue to determine its state of mutation is provided. The apparatus includes a light source configured to generate at least one light beam, an optical arrangement configured to form the light beam into an optical probe beam for illuminating the region of biological tissue and receiving a Raman backscattered optical signal from the region of biological tissue, wherein the optical arrangement is further configured to filter the Raman backscattered optical signal to generate a filtered optical signal. The apparatus further comprises an optical detector configured to receive the filtered optical signal to generate a corresponding detector signal including one or more components indicative of one or more molecular species present in the region of biological tissue; and a data processing arrangement configured to process the detector signal to determine from the one or more components a concentration of the one or more molecular species to compute the state of mutation of the biological tissue.

The present invention relates to the field of biological immunity, and discloses a method and system for analyzing and evaluating immunotoxicity, the method comprising: culturing immune cells and non-immune cells, constructing an immune microenvironment of immune cell tissue, and constructing an in vitro immune system model of the human body; inputting exogenous substances into the in vitro immune system model, and detecting the cellular immune parameters of the experimental in vitro immune system model; extracting the mouse genome of mice, constructing the gRNA-Cas9 complex of the target immune gene, implanting the gRNA-Cas9 complex into a preset mouse fertilized egg, cultivating the target gene fertilized egg into a target gene mouse, inputting exogenous substances into the body of the target gene mouse, and analyzing the humoral immune parameters of the blood sample; detecting the organ parameters of the immune organ, calculating the organ coefficient of the immune organ, and analyzing the immune organ status of the immune organ; analyzing the immunotoxicity evaluation report of the exogenous substance on the human immune system. The present invention can improve the accuracy of immunotoxicity analysis.

Methods and devices to monitor an analyte in body fluid are provided. Embodiments include continuous or discrete acquisition of analyte related data from a transcutaneously positioned in vivo analyte sensor automatically or upon request from a user.

A system, device, and method are provided for inserting at least a portion of an in vivo analyte sensor to sense an analyte level in a bodily fluid of a subject. In particular, various embodiments of sensor control devices and components thereof are disclosed herein that are designed to reduce the size and number of internal components of the sensor control device. In addition, embodiments of the sensor control devices and related sensor features disclosed herein are designed to increase the comfort and convenience of a subject.

A monitor for determining analyte concentrations in vivo includes a housing configured to adhere to the skin of a subject, a sensor body configured to extend from the housing into a patient's skin, the sensor body being elongate and extending along a longitudinal axis in a length direction, and further having a width and a thickness each measured perpendicular to the length, and an analyte sensing region formed on the sensor body. The analyte sensing region has opposite ends in the length direction, where a maximum length of the analyte sensing region measured between the opposite ends is 80 μm or less.

A sensor (e.g., an optical sensor) that can be implanted within a living animal (e.g., a human) and used to measure an analyte (e.g., glucose or oxygen) in a medium (e.g., interstitial fluid, blood, or intraperitoneal fluid) within the animal, the sensor including a sensor housing, an analyte indicator covering at least a portion of the sensor housing, and a multi-metal protection system including multiple metals incorporated within and / or proximate to a surface of the analyte indicator that reduces deterioration of the analyte indicator.

The invention provides a rich media content generation method for an in-vivo analyte monitoring system and the in-vivo analyte monitoring system. The method comprises the steps of calling target user data and / or a knowledge base to generate target content in response to user behavior operation and / or triggering of a content generation condition; determining a target format corresponding to the target content; generating target rich media content based on the target content and the target format; and displaying the target rich media content on a target interface of the terminal device.

A monitor for determining analyte concentrations in vivo includes a housing configured to adhere to a patient's skin, and a sensor member configured to extend from the housing into the patient's skin. The sensor member includes at least a first working electrode and a separate second working electrode that are configured to be activated at different times upon implantation of the sensor member into the patient's skin.

A reader device for displaying analyte data includes a housing, a charging port configured to engage with a connector of a charging device, and a power source configured to be charged by the charging device. The reader devices includes communication circuitry for receiving analyte data from a sensor control device having an in vivo analyte sensor, and a display for displaying analyte data. The reader device includes a first temperature sensor configured to measure a first temperature of the charging port, and a second temperature sensor configured to measure an internal temperature within the housing. A processing device of the reader device receives the first and second temperatures, determines a difference between the first and second temperatures, and outputs an alert when the difference exceeds a temperature difference threshold.

The invention provides a rich media content generation method for an in-vivo analyte monitoring system and the in-vivo analyte monitoring system. The method comprises the steps of obtaining a content generation instruction, and guiding an artificial intelligence model to generate target rich media content meeting a target requirement at least based on the content generation instruction under the condition of determining that the content generation instruction has the target requirement; and outputting the target rich media content. Wherein the target demand is a demand for generating rich media content, and the content generation instruction is used for indicating to generate target content meeting the target demand.

The invention discloses application of phascolosoma esculenta-sourced oligopeptide and 5-FU in preparation of a medicine for resisting colorectal cancer, and belongs to the technical field of biological medicine. The oligopeptide is separated from a phascolosoma esculenta body, and tests prove that when the small-molecule oligopeptide and 5-FU are jointly applied at high concentration, colon cancer cell proliferation can be remarkably inhibited, and a dose-dependent synergistic effect is achieved. Oligopeptide 659 and 5-FU synergistically activate a mitochondrial apoptosis pathway, and combined medication can enhance gamma-H2AX focus formation and aggravate DNA double-chain breakage, so that CRC cell proliferation is synergistically inhibited. DLD-1 cells are inoculated to NOD-SCID female mice for modeling, then in-vivo analysis is carried out on the anti-tumor effect of the peptide 659, and the effect of the oligopeptide 659 on resisting colorectal tumors is proved again. An analysis result after mouse dissection shows that compared with a control group, the oligopeptide 659 inhibits growth of mouse tumors.

The present specification provides an interaction method and system for an in vivo analyte monitoring system. The method comprises: displaying at least one content item on a display interface of a terminal device, the content item being related to a target state in an analyte monitoring process, the target state being a state corresponding to a target user or a state corresponding to an analyte sensor device; and displaying a dialogue interface in response to a detected input operation of a user for a target content item in the at least one content item.

Methods, devices, and systems are provided. A method includes receiving sensor data from the glucose sensor, the sensor data being associated with a time window, determining a rate of change distribution of the sensor data, determining a first slope that corresponds to a line of the rate of change distribution, comparing a first slope with a first reference slope, generating, based on comparing the first slope with the first reference slope, an output; and, transmitting the output to a display or a transmitter. Numerous additional features are disclosed.

The method for generating the brief evaluation for the in-vivo analyte monitoring system is applied to terminal equipment in the in-vivo analyte monitoring system, the system further comprises analyte sensor equipment, and the analyte sensor equipment is in communication connection with the terminal equipment. The method comprises: obtaining target user data of a target user, the target user data comprising user-related data and / or sensor-related data, the sensor-related data comprising analyte source data for indicating an analyte level of the target user, and the user-related data comprising user information and behavior data; and based on the target user data, generating the brief review through an artificial intelligence model, and outputting the brief review on the terminal equipment, so that user interaction is attracted, and the utilization rate of the in-vivo analyte monitoring system is improved.

The present invention, among other things, provides technologies for detecting and / or quantifying nucleic acids in cells, tissues, organs, or organisms. Pre-designed barcodes are associated with specific molecular targets through sequential hybridization experiments. A pseudo-color based barcoding scheme is described that overcomes the limitations in the previous generation of the technology. The current method can be applied to both in vitro and in situ analysis.

Methods and devices to monitor an analyte in body fluid are provided. Embodiments include continuous or discrete acquisition of analyte related data from a transcutaneously positioned in vivo analyte sensor automatically or upon request from a user. The in vivo analyte sensor is coupled to an electronics unit holding a memory with instruction to cause processing circuitry to initiate a predetermined time period that is longer than a predetermined life of the sensor, during the predetermined time period, convert signals from the sensor related to glucose to respective corresponding glucose levels, without relying on any post-manufacture independent analyte measurements from a reference device, and at the expiration of the predetermined time period, disable, deactivate, or cease use of one or more feature.

A reader device for displaying analyte data includes a housing, a charging port configured to engage with a connector of a charging device, and a power source configured to be charged by the charging device. The reader devices includes communication circuitry for receiving analyte data from a sensor control device having an in vivo analyte sensor, and a display for displaying analyte data. The reader device includes a first temperature sensor configured to measure a first temperature of the charging port, and a second temperature sensor configured to measure an internal temperature within the housing. A processing device of the reader device receives the first and second temperatures, determines a difference between the first and second temperatures, and outputs an alert when the difference exceeds a temperature difference threshold.

Methods and devices to monitor an analyte in body fluid are provided. Embodiments include continuous or discrete acquisition of analyte related data from a transcutaneously positioned in vivo analyte sensor automatically or upon request from a user.

Systems, devices and methods are provided that allow for enhanced performance, power efficiency, interoperability, data security and user privacy for in vivo analyte monitoring systems that utilize wireless communications. The in vivo analyte monitoring systems can include a Bluetooth or Bluetooth Low Energy enabled handheld relay device for wirelessly relaying analyte data between a sensor unit device and one or more reader devices. The in vivo analyte monitoring systems can employ advertisement and encryption schemes for wirelessly transmitting data in a manner that allows for improved security, efficiency and privacy.

Systems, devices and methods are provided for inserting at least a portion of an in vivo analyte sensor, such as a dermal sensor, for sensing an analyte level in a bodily fluid of a subject. An applicator is positioned against a skin surface and a force is applied to the applicator causing at least a portion of a sharp and an in vivo analyte sensor to be positioned in the body of the subject. In particular, disclosed herein are embodiments of applicators designed to prevent premature sharp withdrawal and / or reduce the likelihood of improper sensor insertion. Also disclosed are embodiments of applicators including sharp modules having an angled sharp which can be configured to create an insertion path for a sensor.