Laser-induce self-assembly method for preparing high-sensitivity optical fiber SERS probe

Abstract

The invention discloses a laser-induce self-assembly method for preparing a high-sensitivity optical fiber SERS probe. The method comprises the steps of conducting fusion welding on one end of an optical fiber and an output tail fiber of a laser device, and inserting the other end of the optical fiber into precious metal nano-particle sol; slowly lifting the optical fiber from the sol to be higher than the liquid level by a certain height by means of a one-dimensional precise displacement platform, so that a specific meniscus structure is formed; switching on a laser light source to enable precious metal nano-particles at the position of the meniscus to be self-assembled at the end face of the optical fiber under laser radiation, so that the optical fiber SERS probe is formed. The laser-induce self-assembly method has the advantages of being low in cost, easy to operate, short in preparation cycle, high in preparation repeatability and the like. The prepared optical fiber SERS probe has high detection sensitivity and high spectrum repeatability and has important application prospects in remote / field detection of environment pollutants, in-vivo analysis in biomedicine, real-time detection of chemical reaction process and other fields.

Description

technical field [0001] The invention relates to the technical field of surface-enhanced Raman spectroscopy molecular detection, in particular to a method for preparing a high-sensitivity optical fiber SERS probe by a laser-induced self-assembly method. Background technique [0002] Raman spectroscopy has "fingerprint" characteristics and can be used for the detection and identification of various molecules. However, the Raman scattering interface of molecules is usually very small, making it difficult to achieve high-sensitivity measurement. Surface Enhanced Raman Scattering (SERS) spectroscopy utilizes the local field enhancement properties of noble metal nanostructures, which can greatly enhance the intensity of Raman signals (typical enhancement factors are 10 4 -10 10 magnitude), and has important applications in the fields of pollutant detection, analytical chemistry, biomedicine, and environmental science. [0003] The SERS substrate is the key to realize high-sensi...

AI Technical Summary

Problems solved by technology

Generally, the chemical preparation method is simple to operate and low in cost, but most of the prepared nanostructures are noble metal nanoparticle island films, and the SERS enhancement factor is weak (about 10 4 order of magnitude); while the physical preparation method can get a larger SERS enhancement factor (10 6 -10 8 magnitude), but usually rely on expensive instruments and equipment, the preparation process is complex, time-consuming and difficult to meet the practical needs of high-throughput preparation

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