The invention discloses multi-item composite quality control liquor for urine analysis. The multi-item composite quality control liquor comprises a buffering solution, a surface active agent, 2-pyridinethiol 1-oxide sodium salt, MgC12, urea, sodium chloride, poloxamer, anhydrous dextrose, bovine serum albumin, esterase, a ketone body substitute, a bilirubin substitute, nitrite, creatinine, a urobilinogen substitute, anhydrous calcium chloride, red blood cell particles, white blood cell particles and crystals. Compared with existing quality control liquor, the multi-term composite quality control liquor can carry out quality control over urine dry chemistry and formal ingredients, and is good in real-time stability, small in toxicity, high in sensitiveness, accurate in detection result, low in production cost and capable of being applied to external quality assessment.