156 results about "Sodium azide" patented technology

The invention discloses a silver azide in-situ charging method based on ink-jet printing, and belongs to the technical field of energetic material charging. According to the ink-jet printing method, sodium azide printing ink and a silver salt solution are prepared respectively, the surface tension and viscosity of the sodium azide printing ink are adjusted through a binder and a surfactant, the surface tension and viscosity of the silver salt printing ink are adjusted through the mass ratio of ethylene glycol to water, sodium azide and silver salt are printed in sequence, and silver azide is obtained through an in-situ reaction. According to the method, the initiating explosive can be printed on the medium in situ, complete hand-free operation is achieved in the charging process, and danger in the manual silver azide charging process is avoided.

The invention relates to the technical field of protective films, in particular to a high-light-transmittance label protective film and a preparation method thereof.A multi-layer protective film formed by compounding a release film layer, an adhesive layer, a PET film and a protective layer is constructed; composite vinyl ester resin constructed by taking epoxy resin and acrylic acid as raw materials is subjected to toughening modification, and then a linear reactive diluent is compounded to construct a high-toughness protective layer which is resistant to high temperature and aging and can be photo-cured; long-chain alkane modified nano silicon dioxide is introduced into the protective coating, nano silicon dioxide is aminated by 3-aminopropyltriethoxysilane, and then 17-carbon monoisocyanate prepared by taking acetone, stearic acid, triphenylphosphine, sodium azide and N-chlorosuccinimide as raw materials is grafted to form the long-chain alkane modified nano silicon dioxide. Vinyl butadiene styrene rubber, composite vinyl ester resin, tackifying resin, a softening agent and a photoinitiator are mixed to prepare the adhesive layer.

The invention discloses a reagent for detecting the activity of isocitrate dehydrogenase. The reagent consists of a first reagent and a second reagent, the first reagent comprises an electron carrier, isocitric acid or isocitrate, divalent metal ions, a first reagent buffer solution, a first reagent additive, a first reagent preservative and a first reagent surfactant; the divalent metal ions comprise metal ions; the second reagent comprises a dye which comprises tetrazolium salt and has an oxidation state and a reduction state, a cofactor, a second reagent buffer solution, a second reagent additive, a coenzyme stabilizer, a second reagent surfactant and a second reagent preservative; the pH is buffered to 7-9.5 and 5-9 by the first buffer solution and the second buffer solution respectively; the first reagent additive and the second reagent additive comprise divalent metal salt, sugar, sugar alcohol, protein, chelating agent and basic amino acid; the first and second reagent surfactants comprise nonionic and anionic surfactants; the first reagent preservative and the second reagent preservative comprise sodium azide or isothiazolinones. The invention further discloses a corresponding detection method.

The invention provides a preparation method of (S)-oxetane-2-methylamine. The preparation method of (S)-oxetane-2-methylamine comprises the following steps: (1) carrying out ring closing reaction on a compound A under an alkaline condition to obtain a compound B; (2) reacting the compound B with dibenzylamine to obtain a compound C; (3) reacting the compound C with a reducing agent to obtain a compound D; (4) reacting the compound D with paratoluensulfonyl chloride to obtain a compound E; (5) reacting the compound E with alkali to obtain a compound F; and (6) carrying out a reaction on the compound F and palladium on carbon to obtain the (S)-oxetane-2-methylamine. According to the preparation method provided by the invention, ring expansion reaction using trimethylsulfoxide iodide in the prior art is avoided, the problem that residual sulfur elements cause poisoning of a palladium-carbon catalyst is solved, meanwhile, sodium azide is also avoided, and the preparation method is safe and reliable in process, high in chiral purity and yield and suitable for industrial large-scale production.

The invention discloses a water treatment filtering material and a preparation method thereof, and relates to the technical field of water treatment. When the water treatment filtering material is prepared, polyacrylonitrile reacts with sodium azide to prepare graft modified polyacrylonitrile; alkali lignin is subjected to chloroethylation, and chlorinated modified lignin is prepared; the preparation method comprises the following steps: hydrolyzing tetrabutyl titanate, doping nickel and iron elements, and growing on a graphene nanosheet in situ to prepare modified titanium dioxide loaded graphene; modifying the graphene loaded with the modified titanium dioxide by using a silane coupling agent to prepare modified graphene; reacting the casting membrane base solution with the modified graphene and potassium carbonate to prepare a casting membrane solution A; reacting the membrane casting base solution with chlorinated modified lignin and polyethyleneimine to prepare a membrane casting solution B; and mixing the membrane casting solution A and the membrane casting solution B, and scraping into a membrane to prepare the water treatment filtering material. The water treatment filtering material prepared by the invention has the advantages of hydrophilicity, oil stain resistance, self-cleaning property, antibacterial property and good filtering property.

The invention relates to the technical field of chemical equipment, and provides a tetrazoleacetic acid production system which comprises a glycine tank, a triethanol orthoformate tank, a glacial acetic acid tank, a regulating liquid tank, a pretreatment kettle, a refining reaction kettle and a nitrogen displacement device, a feeding mechanism for feeding sodium azide is arranged at the upper end of the refining reaction kettle, and a nitrogen replacement pipe of the nitrogen replacement device can be alternatively communicated with the feeding mechanism or the refining reaction kettle; when the sodium azide is fed, the nitrogen replacement pipe is communicated with the feeding mechanism, and the feeding mechanism can enable the sodium azide to enter the refining reaction kettle under the pushing of nitrogen; according to the invention, the feeding of sodium azide can be combined with the nitrogen replacement device through the feeding mechanism, the feeding work of sodium azide is driven by nitrogen, manual feeding is eliminated in the production system, and the convenience and safety are improved.

The invention discloses a chemical-enzymatic coupling synthesis method of oseltamivir phosphate, which comprises the following steps: by taking monasic acid OS-01 as a substrate, sequentially carrying out S1 esterification, S2 ketalation, S3 selective ring opening, S4 TEMPO oxidation, S5 primary transaminase reaction, S6 acetylation, S7 secondary transaminase reaction and S8 phosphorylation reaction to obtain the final product oseltamivir phosphate OS-09. According to the method, the step of sodium azide required by a traditional route is avoided, the production safety and the industrialization possibility are enhanced, two different transaminases are used for respectively constructing different chiral centers, the steps of protecting groups and deprotecting groups on the traditional route are not needed, the overall route is short, the used chemical reagents are few, the yield is high, and the method is suitable for industrial production. The industrial requirements of environmental protection and low cost are met.

Disclosed is a method for preparing oxetan-2-ylmethanamine, which belongs to the field of organic synthesis. [2-(1-ethoxyethoxy)methyl]propylene oxide is used as an initial raw material, and reacted in the presence of potassium tert-butoxide and trimethylsulfoxonium iodide; the resulting product is reacted with a sulfonyl compound and triethylamine; the resulting product is reacted with a compound of phthalimide; the resulting product is reacted with an amino group-containing compound, to obtain oxetan-2-ylmethanamine. The method according to the disclosure allows for an overall yield of not less than 30% in scale-up production (kilogram level), which is higher. Moreover, compared with the traditional method for preparing oxetan-2-ylmethanamine, a palladium-carbon catalytic hydrogenation step is not required, and dangerous chemical-sodium azide is not required in the method according to the disclosure. Thus, the method has high safety, low production cost, simple operations, and thereby is suitable for industrial production.

The invention discloses a synthesis method of an inner piroxostat key intermediate and a synthesis method of inner piroxostat. The invention provides a novel synthesis method of an inner piroxostat key intermediate 5, 7-difluoro-1, 2, 3, 4-tetrahydronaphthalene-2-amine, which comprises the following steps: taking 3, 5-difluorobenzyl bromide as a raw material, carrying out substitution reaction on the 3, 5-difluorobenzyl bromide and methane tricarboxylic acid triethyl ester, then carrying out hydrolysis decarboxylation, adding 1, 2, 3, 4-tetrahydronaphthalene-2-amine, and carrying out reaction to obtain the 5, 7-difluoro-1, 2, 3, 4-tetrahydronaphthalene-2-amine. The preparation method comprises the following steps: substituting 1, 2-diiodoethane, catalyzing carbon-hydrogen activation and ring closing by tetrakis (triphenylphosphine) palladium, hydrolyzing and decarboxylating, amidating, and carrying out Hofmann degradation reaction to obtain a target intermediate. The method has the advantages of cheap and easily available raw materials, simple synthesis and high yield, avoids the use of ethylene, sodium azide and other reagents, and is green and safe. The invention provides a method for further synthesizing the endopiroxostat based on the synthesis method, the method comprises a novel endopiroxostat hydrochloride chiral resolution method, the chiral pure endopiroxostat is conveniently prepared through a chiral preparative column, and the ee value is 100%.

The present application relates to a kind of preparation method and application of composite modified clay mineral adsorbent for adsorbing dioxin, and the preparation method includes the following steps: (1) clay mineral is crushed and sieved, sintering, obtain the clay mineral powder after sintering;(2) the clay mineral powder after sintering and cerium trichloride are mixed into deionized water, citric acid solution is added, obtain the cerium after clay mineral;(3) the cerium after clay mineral, sodium azide and alkali metal element are weighed and mixed uniformly, after temperature treatment, obtain cerium nitride & clay mineral compound;(4) the cerium nitride & clay mineral compound is dispersed into phosphate buffer solution, hafnium oxychloride solution is added, in situ photodeposition method is reacted, obtain composite modified clay mineral.Compared with traditional clay mineral, the composite modified clay mineral prepared in the present application not only has strong adsorption removal efficiency for dioxin, but also has better reusability.

The present invention relates to the technical field of organic synthesis, and in particular to a method for synthesizing an edoxaban intermediate, using N-[(1R, 2R, 5S)-5-(dimethylcarbamoyl)-2-hydroxycyclohexyl]-5-methyl-4,5,6,7-thiazolidine [5,4-c] and pyridine-2-formamide (compound 1) as a starting material, reacting with bis(tert-butyloxycarbonyl)amine under the conditions of the presence of an organophosphorus reagent and a condensing agent in a solvent by Mitsunobu reaction to generate compound 2, and removing the tert-butyloxycarbonyl group under acidic conditions to generate an edoxaban intermediate (compound 3). This route has low cost, and reaction conditions are easily industrialized and easy to achieve, without the characteristics of harsh reaction conditions. It is possible to avoid using expensive protective reagents, and easily explosive sodium azide. The resulting product has the characteristics of simple purification, reliable quality, and the intermediate produced by the method meets the relevant requirements for the production of edoxaban bulk drug.

The invention provides a triazole-containing compound as well as a synthesis method and application thereof, and belongs to the field of pesticides. The method comprises the following steps: taking heterocyclic molecules with carboxyl functional groups as raw materials, carrying out amidation reaction on the heterocyclic molecules and aminoacetylene to generate an intermediate as shown in a formula (I), and reacting the intermediate (I) with an azide to obtain the amide-containing triazole compound as shown in a formula (II), substituted benzaldehyde, sodium azide and 2-(benzenesulfonyl) acetonitrile are used as raw materials to react to generate the cyano-containing triazole compound as shown in a formula (III). The method disclosed by the invention is simple to operate, relatively mild in condition and high in functional group tolerance. The prepared intermediate and the final product have certain insecticidal and bactericidal activity, and have potential application prospects.

This invention provides a continuous process for producing ultrafine sodium azide, employing either System A or System B, including a nitrite ester synthesis section, a sodium azide synthesis section, and a gravity separation section. In the nitrite ester synthesis section of System A, the reaction temperature is -5℃ to 55℃, and the pressure is atmospheric pressure; the raw material alcohol includes methanol or ethanol. In the nitrite ester synthesis section of System B, the reaction temperature is -15℃ to 5℃, the pressure is atmospheric pressure, and the separation temperature is -5℃ to 55℃; the raw material alcohol includes methanol, ethanol, propanol, or isopropanol. This invention effectively enhances the mixing and transfer of materials under strong centrifugal force, thereby accelerating the reaction and separation speed. Even the azide reaction can proceed rapidly in the aqueous phase without a phase-transfer catalyst, reducing the reaction time from several hours to minutes. The residence time of materials in the equipment is extremely short, significantly shortening the production cycle.

This invention discloses a method for preparing furanyl diisocyanate and its applications, relating to the field of organic polymer compounds. Under nitrogen atmosphere, furoic acid is added to concentrated sulfuric acid and mixed, followed by the addition of paraformaldehyde and a temperature-controlled reaction to obtain bis(5-formic acid-2-furan)methane. An organic base is added to a solvent containing bis(5-formic acid-2-furan)methane, and diphenyl azide phosphate is added dropwise to react and obtain bis(5-acyl azide-2-furan)methane. The bis(5-acyl azide-2-furan)methane is dissolved in an organic solvent and reacted to obtain furanyl diisocyanate. This invention provides a high-yield, high-selectivity one-step method for obtaining the intermediate bis(5-formic acid-2-furan)methane, shortening the synthetic route, improving synthetic efficiency, avoiding the use of sodium azide, increasing safety, and reducing production costs. The production of bio-based polyurethane is environmentally friendly, economical, and industrially applicable, and can be used to develop environmentally friendly coatings, adhesives, and sealants.

The present application relates to the field of chemical and chemical technology, and in particular to a method for synthesizing sodium azide. It can solve the problems of long reaction time, low production efficiency, many by-products, large pollution emissions, and high safety hazards in the sodium azide preparation process in the related technology. A method for synthesizing sodium azide, comprising: using aromatic alcohol as a raw material to prepare nitrite ester of aromatic alcohol; under alkaline conditions, allowing nitrite ester to undergo a reduction reaction with hydrazine hydrate to prepare sodium azide; wherein the aromatic alcohol comprises: one or more compounds represented by the structural formula: #imgabs0#, wherein Ar is selected from the following substituted or unsubstituted C6~C 20 Aryl and substituted or unsubstituted C3~C 10 Any one of the heteroaryl groups, R is selected from #imgabs1#n is an integer of 1 to 3; wherein, in #imgabs2#, R1 and R2 are the same or different and are independently selected from any one of H and C1 to C3 alkyl groups; when Ar is selected from substituted C6 to C 20 Aryl or substituted C3~C 10 In the case of heteroaryl, the substituted substituent is selected from C1-C9 alkyl, and * indicates the attachment site.

The invention discloses a preparation method of a nano tungsten nitride powder material, and belongs to the technical field of preparation of transition metal nitride materials. The preparation method comprises the following steps: by taking tungsten powder as a tungsten source and sodium azide and melamine as nitrogen sources, grinding and mixing the tungsten powder and the sodium azide according to a mass ratio of 5: 1, and tabletting the mixture and the melamine by using a hydraulic machine respectively, so as to obtain the composite material. The method comprises the following steps: preparing a cylindrical shape by wrapping a cylindrical sheet formed by pressing a mixture of tungsten powder and sodium azide with two pieces of melamine according to the size of a synthesis cavity, putting the cylindrical raw material into a heating container, putting the heating container into the synthesis cavity, keeping the temperature and pressure for 10 minutes at the pressure of 3.0-5.0 GPa and the temperature of 1500-1800 DEG C, cooling and relieving the pressure, and finally putting a sample into diluted hydrochloric acid for cleaning, and preparing the nano tungsten nitride powdery material. The technological process is simple, and the preparation period and the sintering time are shortened; air pollution and resource waste are avoided; the prepared nano powdery material has the characteristics of high purity, easiness in impurity removal and the like.

The invention discloses a falling collision protection device, a task equipment module and an aerostat, and relates to the technical field of aerostats, the falling collision protection device comprises a mounting part, an air bag and a control unit, and the mounting part is provided with a containing cavity; the air bag can be contained in the containing cavity, and a gas generating agent is loaded in the air bag; the control unit is used for judging whether falling and collision protection is implemented or not, and when falling and collision protection is implemented, the gas generating agent is excited to generate protective gas, so that the air bag is unfolded under the action of pressure. According to the falling collision protection device, the solid sodium azide is instantaneously decomposed to generate nitrogen, so that the air bag is quickly unfolded before touching the ground, and the buffer failure caused by inflation delay of the compressed air cylinder is eliminated.

The application provides a method for continuously preparing iodine azide and application thereof, and comprises the following steps: sending an azide reagent and a quaternary ammonium salt phase transfer reagent into a continuous flow reactor to obtain a mixture A, then reacting the mixture A with an iodine reagent entering the continuous flow reactor to obtain iodine azide, and continuously discharging the iodine azide from the continuous flow reactor during the reaction to obtain the iodine azide. The application utilizes the continuous flow reactor to quickly and efficiently prepare the explosive iodine azide. Compared with the existing sodium azide / ICl technology, the application greatly solves the explosion risk caused by the storage and transfer of a large amount of sodium azide, and greatly improves the safety.

The present invention discloses a compound for treating methamphetamine addiction and cognitive impairment, its preparation method and application. The new compound NBU513-1 for treating methamphetamine addiction and cognitive impairment induced by the present invention can significantly improve the addictive behavior of mice for methamphetamine, has a therapeutic effect on the cognitive dysfunction caused by methamphetamine, and can be used to prepare a medicine for treating methamphetamine addiction and cognitive impairment induced by methamphetamine. The present invention provides a total synthesis route of compound NBU513-1. Compared with the preparation method of similar compounds in the prior art, the method of the present invention does not need to react with sodium azide, does not produce powerful explosives and highly toxic substances, has high stability and low reaction risk; the method has mild reaction conditions, simple scheme, safe and reliable production and can prepare target products with higher yields, and is suitable for industrial production.

The application discloses a kind of azole-based metal organic framework and its preparation method and application, preparation method includes: sodium azide, hydrazine hydrate, 4-imidazole formaldehyde, ferrous trifluoromethyl sulfonate are dissolved in methanol solution and are reacted;The reaction product is filtered, washed, dried, and azole-based organic ligand is obtained;Azole-based organic ligand and transition metal salt are reacted in the mixed solution of N, N-dimethylformamide and methanol or ethanol, and the reaction product is centrifuged, filtered, washed, and azole-based metal organic framework is obtained.In the application, azole-based metal organic framework has the characteristics of spontaneous generation of singlet oxygen, without active oxygen under light conditions, and the needle shape of azole-based metal organic framework material can produce physical puncture effect on bacteria, which can effectively cooperate with the singlet oxygen spontaneously generated to resist bacteria.

The invention discloses a synthesis method of 5-(5-azido-3-nitro-1H-1, 2, 4-triazole-1-yl)-1H-tetrazole sodium salt and an application of the 5-(5-azido-3-nitro-1H-1, 2, 4-triazole-1-yl)-1H-tetrazole sodium salt. A synthesis process of the 5-(5-azido-3-nitro-1H-1, 2, 4-triazole-1-yl)-1H-tetrazole derivative comprises the following steps: (1) carrying out a reaction on 5-azido-3-nitro-1, 2, 4-triazole, cyanogen bromide and sodium azide to generate 5-(5-azido-3-nitro-1H-1, 2, 4-triazole-1-yl)-1H-tetrazole; (2) carrying out a reaction on the 5-(5-azido-3-nitro-1H-1, 2, 4-triazole-1-yl)-1H-tetrazole and sodium hydroxide which is equal to the 5-(5-azido-3-nitro-1H-1, 2, 4-triazole-1-yl)-1H-tetrazole in mole to obtain a 5-(5-azido-3-nitro-1H-1, 2, 4-triazole-1-yl)-1H-tetrazole sodium salt; the-(5-azido-3-nitro-1H-1, 2, 4-triazole-1-yl)-1H-tetrazole sodium salt synthesized by the method is good in free-running property, does not contain heavy metal, is clean and pollution-free in explosive product, has excellent detonating capacity, and is a novel green and environment-friendly initiating explosive.

The invention discloses a synthetic method of 5-(5-azido-3-nitro-1H-1, 2, 4-triazole-1-yl)-1H-tetrazole and an energetic ionic salt of the 5-(5-azido-3-nitro-1H-1, 2, 4-triazole-1-yl)-1H-tetrazole. A synthesis process of the 5-(5-azido-3-nitro-1H-1, 2, 4-triazole-1-yl)-1H-tetrazole derivative comprises the following steps: (1) carrying out a reaction on 5-azido-3-nitro-1, 2, 4-triazole, cyanogen bromide and sodium azide to generate 5-(5-azido-3-nitro-1H-1, 2, 4-triazole-1-yl)-1H-tetrazole; (2) generating corresponding ammonium salt, hydrazinium salt or hydroxylamine salt from the 5-(5-azido-3-nitro-1H-1, 2, 4-triazole-1-yl)-1H-tetrazole and ammonia water, hydrazine hydrate or hydroxylamine solution which is equal to the 5-(5-azido-3-nitro-1H-1, 2, 4-triazole-1-yl)-1H-tetrazole in mole; the preparation method comprises the following steps: reacting 5-(5-azido-3-nitro-1H-1, 2, 4-triazole-1-yl)-1H-tetrazole with equimolar silver nitrate to generate 5-(5-azido-3-nitro-1H-1, 2, 4-triazole-1-yl)-1H-tetrazole silver salt, then reacting the silver salt with guanidine hydrochloride, aminoguanidine hydrochloride or diaminoguanidine hydrochloride, filtering to remove precipitate, concentrating filtrate, and drying to obtain the 5-(5-azido-3-nitro-1H-1, 2, 4-triazole-1-yl)-1H-tetrazole. The corresponding guanidine salt, aminoguanidine salt and diaminoguanidine salt are obtained. The 5-(5-azido-3-nitro-1H-1, 2, 4-triazole-1-yl)-1H-tetrazole synthesized by the method and the energetic ionic salt of the 5-(5-azido-3-nitro-1H-1, 2, 4-triazole-1-yl)-1H-tetrazole have excellent detonation performance and have an application prospect in the aspect of high-energy explosives.

The application belongs to the technical field of extraction separation, and particularly relates to a 3N-PTD ligand and a preparation method and application thereof. The preparation method provided by the application comprises the following steps: mixing 3-chloropropylamine hydrochloride, sodium azide and deionized water, and performing a reflux reaction to obtain 3-azidopropylamine; dissolving 2,6-diethynylpyridine, 3-azidopropylamine, sodium ascorbate and CuSO4.5H2O, and performing a click reaction to obtain the 3N-PTD ligand. The yield of the 3N-PTD ligand obtained by the preparation method is high.

The application discloses a high-ammonia-nitrogen wastewater simultaneous nitrification and denitrification and chromium remediation method based on a microorganism-promoter combination. 12 The combination is composed of simultaneous nitrification and denitrification bacteria and sodium azide (NaN3), alanine and dodecamolybdenum phosphate (PMo 12 ) and is used for detoxifying dissolved heavy metal chromium and improving denitrification efficiency. The method is to culture SND simultaneous short-cut nitrification and denitrification biological bacteria under aerobic conditions, inoculate the biological bacteria into a high-chromium solution, add biological promoters, promote the growth of microorganisms and the conversion of nitrogen, continuously receive and provide electrons in a reversible oxidation-reduction process, thereby reducing the total activation energy of the reaction and efficiently detoxifying heavy metal chromium. The microorganism-promoter combination technology obtained in this way can not only realize efficient simultaneous nitrification and denitrification in high-ammonia-nitrogen wastewater, but also maintain the biological activity of the SND bacteria in a high-chromium environment, thereby providing reliable technical support for efficient chromium removal and toxicity remediation of high-ammonia-nitrogen wastewater.

The application relates to a preparation method of diamond containing NV color centers and a quantum current sensor, and comprises the following steps: pretreating a diamond substrate; performing high-energy particle irradiation on the pretreated diamond substrate to introduce vacancies in a diamond lattice; placing the irradiated diamond substrate in a solution containing a nitrogen source to perform hydrothermal treatment; the solution containing the nitrogen source is a modified sodium azide solution to which sodium hydroxide is added; and performing annealing treatment on the hydrothermally treated diamond substrate in a protective atmosphere, so that the vacancies are combined with injected nitrogen atoms to form NV color centers, so as to obtain diamond containing NV color centers. The preparation method of diamond containing NV color centers and the quantum current sensor provided by the application have the advantages of high NV color center concentration and good uniformity.

The invention relates to the technical field of textile detection, in particular to a method for detecting enterococcus faecalis in textiles, which comprises the following steps: S1, sample preparation: selecting a weighing method, a multi-point sampling elution method or a cotton swab smearing method according to the types of the textiles to prepare a sample homogenate; step S2, dilution and inoculation: performing 10-time series dilution on the sample homogenate, selecting a sample with 2-3 continuous dilution degrees, inoculating the sample to a bile aesculin sodium azide agar culture medium, and culturing at 36 + / -1 DEG C for 24-48 hours. According to the method, the detection technology of enterococcus faecalis in the textile is innovatively adopted, and the pollution condition of enterococcus faecalis in the textile is effectively monitored; the method has the following remarkable advantages that operation is easy and convenient, cost is low, complex instruments and equipment are not needed, the method is suitable for conventional detection of a primary laboratory, and the technology has outstanding originality and practicability in the aspect of improving the biological safety prevention and control capacity of the textile.

The utility model discloses a protective barrier for road bridge and tunnel engineering, which relates to the technical field of protective barriers and comprises a vertical column, a second upper column is arranged on one side of the vertical column, a second lower column is arranged at the bottom end of one side of the vertical column, and a first upper column is arranged at one end of the second upper column. A first lower column is arranged at one end of the second lower column, and a plurality of mounting cylinders are arranged at the bottom of the second upper column and the bottom of the first upper column respectively. According to the protective barrier for the road, bridge and tunnel engineering, when one side of the mounting cylinder is impacted by an automobile, the impact rod impacts solid sodium azide in the protective cylinder, the solid sodium azide is subjected to decomposition reaction when being impacted violently, so that the solid sodium azide is quickly decomposed to generate a large amount of nitrogen, and the nitrogen is fully absorbed by the impact rod. The nitrogen is inflated into the air bag through the base, so that the air bag continues to expand outwards, the expanded air bag can buffer impact of the automobile and can protect pedestrians on the other side from being hurt, and the effect of protecting the pedestrians and the automobile is achieved.

The invention relates to the field of organic synthesis, in particular to a method for continuously preparing 5-(trifluoromethyl)-1H-tetrazole sodium salt. The method comprises the following steps: mixing trifluoroacetamide and 3-methylpyridine to obtain a mixture I; phosphorus oxychloride and 3-methylpyridine are mixed, and a second mixture is obtained; a continuous feeding mode is adopted, the first mixture and the second mixture are mixed, a steady-state reaction is maintained, and reaction liquid is continuously obtained; performing gas-liquid separation on the reaction liquid to obtain liquid and gas, quenching the liquid, performing gas washing on the gas through 3-methylpyridine, then introducing the gas into a mixed solution of sodium azide and acetone for absorption and filtration to obtain a filter cake, and performing drip washing to obtain the 5-(trifluoromethyl)-1H-tetrazole sodium salt. The purity of the product prepared by the method is greater than or equal to 99.3%, the yield is 84-91%, and the method is easy for industrial production.

The present invention discloses a method for synthesizing an edoxaban intermediate. First, the raw material (S)-(−)-3-cyclohexene carboxylic acid is oxidized by potassium permanganate to generate intermediate 2; intermediate 2 reacts with methanesulfonyl chloride to generate intermediate 3; intermediate 3 reacts with ammonia in ethanol to generate intermediate 4; intermediate 4 undergoes a self-cyclization reaction under the catalysis of EDCI and HOBt to generate intermediate 5; intermediate 5 reacts with benzyl chloride to generate intermediate 6; intermediate 6 is hydrolyzed under alkaline conditions and reacts with Boc2O simultaneously to generate intermediate 7; intermediate 7 undergoes a condensation reaction with dimethylamine to generate intermediate 8; intermediate 8 is hydrogenated to remove the benzyl group to generate the edoxaban intermediate. The synthesis method of the present invention has simple operation steps, high chiral selectivity, is beneficial to improving the product yield and reducing the production cost, and does not use the dangerous reagent sodium azide, reducing the production risk and ensuring the safety and operability of the reaction.

The invention provides a lipid index quality control product as well as a preparation method and application thereof. The lipid index quality control product comprises serum, a fat emulsion injection and a preservative; the serum, the fat emulsion injection and the preservative are mixed according to different preset proportions to obtain quality control products with different lipid indexes; the preset proportion is that the volume ratio of the serum to the fat emulsion injection to the preservative is 100: (2-10): (0.05-0.1); the preservative is 0.05% of sodium azide. By applying the provided lipid index quality control product, the accuracy and stability of a detection system on a lipid blood sample can be evaluated, and the reliability of a detection result in the presence of lipid interference is ensured.