45 results about "Sodium azide" patented technology

The invention discloses a chemical-enzymatic coupling synthesis method of oseltamivir phosphate, which comprises the following steps: by taking monasic acid OS-01 as a substrate, sequentially carrying out S1 esterification, S2 ketalation, S3 selective ring opening, S4 TEMPO oxidation, S5 primary transaminase reaction, S6 acetylation, S7 secondary transaminase reaction and S8 phosphorylation reaction to obtain the final product oseltamivir phosphate OS-09. According to the method, the step of sodium azide required by a traditional route is avoided, the production safety and the industrialization possibility are enhanced, two different transaminases are used for respectively constructing different chiral centers, the steps of protecting groups and deprotecting groups on the traditional route are not needed, the overall route is short, the used chemical reagents are few, the yield is high, and the method is suitable for industrial production. The industrial requirements of environmental protection and low cost are met.

Disclosed is a method for preparing oxetan-2-ylmethanamine, which belongs to the field of organic synthesis. [2-(1-ethoxyethoxy)methyl]propylene oxide is used as an initial raw material, and reacted in the presence of potassium tert-butoxide and trimethylsulfoxonium iodide; the resulting product is reacted with a sulfonyl compound and triethylamine; the resulting product is reacted with a compound of phthalimide; the resulting product is reacted with an amino group-containing compound, to obtain oxetan-2-ylmethanamine. The method according to the disclosure allows for an overall yield of not less than 30% in scale-up production (kilogram level), which is higher. Moreover, compared with the traditional method for preparing oxetan-2-ylmethanamine, a palladium-carbon catalytic hydrogenation step is not required, and dangerous chemical-sodium azide is not required in the method according to the disclosure. Thus, the method has high safety, low production cost, simple operations, and thereby is suitable for industrial production.

This invention discloses a method for preparing furanyl diisocyanate and its applications, relating to the field of organic polymer compounds. Under nitrogen atmosphere, furoic acid is added to concentrated sulfuric acid and mixed, followed by the addition of paraformaldehyde and a temperature-controlled reaction to obtain bis(5-formic acid-2-furan)methane. An organic base is added to a solvent containing bis(5-formic acid-2-furan)methane, and diphenyl azide phosphate is added dropwise to react and obtain bis(5-acyl azide-2-furan)methane. The bis(5-acyl azide-2-furan)methane is dissolved in an organic solvent and reacted to obtain furanyl diisocyanate. This invention provides a high-yield, high-selectivity one-step method for obtaining the intermediate bis(5-formic acid-2-furan)methane, shortening the synthetic route, improving synthetic efficiency, avoiding the use of sodium azide, increasing safety, and reducing production costs. The production of bio-based polyurethane is environmentally friendly, economical, and industrially applicable, and can be used to develop environmentally friendly coatings, adhesives, and sealants.

The invention discloses a falling collision protection device, a task equipment module and an aerostat, and relates to the technical field of aerostats, the falling collision protection device comprises a mounting part, an air bag and a control unit, and the mounting part is provided with a containing cavity; the air bag can be contained in the containing cavity, and a gas generating agent is loaded in the air bag; the control unit is used for judging whether falling and collision protection is implemented or not, and when falling and collision protection is implemented, the gas generating agent is excited to generate protective gas, so that the air bag is unfolded under the action of pressure. According to the falling collision protection device, the solid sodium azide is instantaneously decomposed to generate nitrogen, so that the air bag is quickly unfolded before touching the ground, and the buffer failure caused by inflation delay of the compressed air cylinder is eliminated.

The application belongs to the technical field of extraction separation, and particularly relates to a 3N-PTD ligand and a preparation method and application thereof. The preparation method provided by the application comprises the following steps: mixing 3-chloropropylamine hydrochloride, sodium azide and deionized water, and performing a reflux reaction to obtain 3-azidopropylamine; dissolving 2,6-diethynylpyridine, 3-azidopropylamine, sodium ascorbate and CuSO4.5H2O, and performing a click reaction to obtain the 3N-PTD ligand. The yield of the 3N-PTD ligand obtained by the preparation method is high.

The application discloses a high-ammonia-nitrogen wastewater simultaneous nitrification and denitrification and chromium remediation method based on a microorganism-promoter combination. 12 The combination is composed of simultaneous nitrification and denitrification bacteria and sodium azide (NaN3), alanine and dodecamolybdenum phosphate (PMo 12 ) and is used for detoxifying dissolved heavy metal chromium and improving denitrification efficiency. The method is to culture SND simultaneous short-cut nitrification and denitrification biological bacteria under aerobic conditions, inoculate the biological bacteria into a high-chromium solution, add biological promoters, promote the growth of microorganisms and the conversion of nitrogen, continuously receive and provide electrons in a reversible oxidation-reduction process, thereby reducing the total activation energy of the reaction and efficiently detoxifying heavy metal chromium. The microorganism-promoter combination technology obtained in this way can not only realize efficient simultaneous nitrification and denitrification in high-ammonia-nitrogen wastewater, but also maintain the biological activity of the SND bacteria in a high-chromium environment, thereby providing reliable technical support for efficient chromium removal and toxicity remediation of high-ammonia-nitrogen wastewater.

The application relates to a preparation method of diamond containing NV color centers and a quantum current sensor, and comprises the following steps: pretreating a diamond substrate; performing high-energy particle irradiation on the pretreated diamond substrate to introduce vacancies in a diamond lattice; placing the irradiated diamond substrate in a solution containing a nitrogen source to perform hydrothermal treatment; the solution containing the nitrogen source is a modified sodium azide solution to which sodium hydroxide is added; and performing annealing treatment on the hydrothermally treated diamond substrate in a protective atmosphere, so that the vacancies are combined with injected nitrogen atoms to form NV color centers, so as to obtain diamond containing NV color centers. The preparation method of diamond containing NV color centers and the quantum current sensor provided by the application have the advantages of high NV color center concentration and good uniformity.

The invention relates to the field of organic synthesis, in particular to a method for continuously preparing 5-(trifluoromethyl)-1H-tetrazole sodium salt. The method comprises the following steps: mixing trifluoroacetamide and 3-methylpyridine to obtain a mixture I; phosphorus oxychloride and 3-methylpyridine are mixed, and a second mixture is obtained; a continuous feeding mode is adopted, the first mixture and the second mixture are mixed, a steady-state reaction is maintained, and reaction liquid is continuously obtained; performing gas-liquid separation on the reaction liquid to obtain liquid and gas, quenching the liquid, performing gas washing on the gas through 3-methylpyridine, then introducing the gas into a mixed solution of sodium azide and acetone for absorption and filtration to obtain a filter cake, and performing drip washing to obtain the 5-(trifluoromethyl)-1H-tetrazole sodium salt. The purity of the product prepared by the method is greater than or equal to 99.3%, the yield is 84-91%, and the method is easy for industrial production.

The invention discloses a composite plugging material with a core-shell structure, a preparation method and a water-based drilling fluid, and relates to the technical field of oilfield chemistry, and the preparation method of the composite plugging material comprises the following steps: reacting a polyhydroxy aromatic compound with epichlorohydrin to prepare an aromatic compound, the preparation method comprises the following steps: mixing epoxy resin with an aromatic compound prepared by reacting a multi-primary alcohol aromatic compound with triphenylphosphine, bromotrichloromethane, sodium azide and triethyl phosphite in sequence, melting, casting and crushing to obtain epoxy resin particles, and coating a polymer with the epoxy resin particles to obtain the composite plugging material which is used for preparing a water-based drilling fluid. Compared with a common rigid particle material, the core-shell structure plugging material prepared in the invention has the advantages that the pressure resistance is higher, after the core-shell structure plugging material reaches a softening point in a high-temperature and high-pressure stratum, a glass state is converted into a high-elastic state, the core-shell structure plugging material has elastic deformation capacity, the slippage effect among particles can be reduced, a more compact plugging layer is formed, and the pressure bearing capacity is higher.

Disclosed is a thickener dispersion including a thickener including at least one among carboxymethyl cellulose and metal salt of the carboxymethyl cellulose, a change-over-time inhibitor, and an aqueous solvent. The change-over-time inhibitor includes at least one selected from the group consisting of phenoxyethanol, sodium azide, paraben, formaldehyde, 5-chloro-2-methyl-4-isothiazolin-3-one, sodium benzoate, ethylhexylglycerin, and 1,2-hexanediol. The thickener is included in an amount of 0.05 wt % to 3.5 wt % in the thickener dispersion, and the change-over-time inhibitor is included in an amount of 0.05 wt % to 3.0 wt % in the thickener dispersion.

Disclosed is a method for stabilizing a fructosyl peptide oxidase in the presence of methylene blue or a chromogen that produces methylene blue, the method comprising a step for preparing an aqueous solution containing a fructosyl peptide oxidase, methylene blue or a chromogen that produces methylene blue, and at least one compound selected from the group consisting of sodium azide and tryptophan.

This utility model relates to biotechnology and microbiology, specifically to the production of anthrax erythrocyte antigen diagnostic solution for the indirect hemagglutination assay (IHA). The technical result achieved by this utility model is increased specificity, sensitivity, and standardization of the erythrocyte antigen diagnostic solution, and reduced conjugating agent content, all while maintaining a long shelf life. A method for obtaining an anthrax erythrocyte antigen diagnosticum, including obtaining an antigen from the culture filtrate of the vaccine strain Bacillus anthracis 55, treating formalized ram erythrocytes with a conjugating preparation, followed by sensitization of the erythrocytes with anthrax antigen, to 100.0 mg of acetone-dried bacterial mass of the anthrax vaccine strain Bacillus anthracis STI-1 add 10.0 ml of a 70% phenol solution, shake and leave in the cold at 4°C for 3 hours, then the mixture is centrifuged at 6000 rpm for 90 minutes, the supernatant liquid is drained and neutralized by adding a saturated solution of sodium carbonate until a pH of 7.1±0.1 is obtained, and to remove insoluble particles the mixture is centrifuged at 6000 rpm for 30 minutes, the resulting yellowish opalescent supernatant is placed in a laboratory dialysis bag and dialyzed against running water for 2 days and then for 24 hours against distilled water, changing the water 4-5 times; the lipopolysaccharide antigen is extracted from the dialyzed solution by adding 5 volumes of 96° ethyl alcohol and acetone 1:1; the resulting mixture is shaken and left at a temperature of 4°C for 18-20 hours, After the specified period, the mixture is centrifuged at 5000 rpm for 90 min, then the supernatant is drained, and the sediment is washed twice with 3 volumes of 96° ethyl alcohol by centrifugation at 5000 rpm for 30 min, then the sediment is dissolved in distilled water, the resulting liquid lipopolysaccharide antigen in a volume of 3.0 ml is poured into glass vials with a capacity of 20.0 ml, after which the frozen antigen in the vials is transferred to a drying chamber, pre-cooled to a temperature of minus 30°C, hermetically close the lid and turn on the vacuum pump, after creating a vacuum in the chamber, after 2 hours turn on the heating of all the plates, while the temperature of the plates after 1 hour is raised to + 28°C, this heating temperature is maintained until the end of lyophilization, while the temperature in the vial with the antigen after 13 hours is also brought to a temperature of + 28°C, when this temperature is reached, lyophilization is completed after 6 hours, then the sensitized erythrocytes are washed and preserved, the residue of atkisencitin that has not bound to the erythrocyte receptors is removed, they are washed four times for 10 minutes at 3000 rpm with a solution of Tween-80 in a dilution of 1:5000 at the rate of 25-fold volume to the erythrocyte sediment, the sediment of sensitized erythrocytes after washing is diluted with a 0.9% solution of sodium chloride pH (6.8 ± 0.1) and sodium azide to a 10% concentration of erythrocytes.

The invention discloses a C-reactive protein rapid detection method, and belongs to the technical field of C-reactive protein detection.The C-reactive protein rapid detection device comprises a disc provided with a first liquid storage bin, a second liquid storage bin and a reaction bin, and the first liquid storage bin and the second liquid storage bin are communicated with the reaction bin through corresponding microfluidic channels; a mixed solution of polystyrene microspheres, Tween20, sodium azide, a phosphate buffer and a C reactive protein polyclonal antibody is added into the first liquid storage bin; a mixed solution of a phosphate buffer solution with the pH value of 7.4, Tween 20, polyethylene glycol, sodium chloride and sodium azide is added into the second liquid storage bin; adding a to-be-detected sample into the second liquid storage bin; the disc is driven to rotate; the flow (such as starting, stopping and path switching) of the solution in the micro-channel can be accurately controlled by driving the disc to rotate without externally connecting a pump, a valve and other complex mechanical devices and adjusting the rotating speed of the disc, uniform mixing of a sample and a solution reagent is promoted, the mixing efficiency is remarkably improved compared with passive diffusion, and the reaction is sufficient.

The invention discloses a method for synthesizing a benzyl azide compound in a tubular reactor, and belongs to the technical field of azide compounds. According to the technical scheme, the method comprises the following steps: 1) dissolving sodium azide in a solvent I to prepare a sodium azide solution; dissolving benzyl halide in a solvent II to prepare a benzyl halide solution; (2) continuously pumping the sodium azide solution and the benzyl halide solution into a tubular reactor respectively, and reacting under a control condition to generate a reaction solution; according to the method, benzyl halide / substituted benzyl halide and sodium azide are used as raw materials, the characteristics of efficient mass transfer and heat transfer of the tubular reactor are brought into full play, and the reaction efficiency and the product yield are greatly improved.

The invention relates to a thermal insulation material and a finished product crystallization reaction kettle applied to intermediate synthesis, and belongs to the technical field of thermal insulation materials. The preparation method comprises the following steps: carrying out ring opening on vinyl ethylene oxide through diluted hydrochloric acid to obtain 4-chloro-1-butene-3-alcohol, reacting with paratoluensulfonyl chloride to obtain a sulfonate derivative, reacting with magnesium chips to generate a Grignard reagent, and reacting with tetraethoxysilane to obtain sulfonate silane; then, sulfonate silane and sodium azide are subjected to an azido reaction to obtain azido silane, and azido silane and triphenylphosphine are subjected to a reaction and purification to obtain an amino co-precursor; mixing and reacting the amino co-precursor with tetraethoxysilane, absolute ethyl alcohol and deionized water, and aging and drying to obtain hydrophobic amino silicon dioxide aerogel; and finally, taking polyether polyol as a base material, adding the hydrophobic amino silicon dioxide aerogel, and reacting with diphenylmethane diisocyanate to obtain the thermal insulation material.

The synthesis method comprises the following steps: by taking bronopol as a raw material and toluene as a solvent, carrying out esterification on micromolecular fatty acid to obtain an intermediate, and then carrying out azidation reaction on the intermediate and sodium azide in an acetone / aqueous solution at 20-50 DEG C to obtain the energetic compound containing nitryl and azido. And after the reaction is finished, extracting, distilling and concentrating to obtain a liquid product 2-bromo-2-nitro-1, 3-diazido propane. According to the route, the intermediate is synthesized through esterification of low-cost and low-pollution micromolecular fatty acid, the subsequent azidation reaction conditions are mild, the method is simple, the reaction time is short, and the method can be popularized and applied to design of synthetic routes of energetic plasticizers of other similar structures and has good application prospects in solid propellants.

The invention discloses a multi-parameter monitoring transformer based on the Internet of Things, and relates to the technical field of transformers, the two sides of a pulse tube are connected with pulse cylinders through three gas distribution pipes, the outer sides of the pulse cylinders are provided with a plurality of pressure relief holes, the top of a wiring terminal and the bottom of an outer joint are connected with a lifting frame through electric connection rods, and the two sides of the lifting frame are connected with limiting rods. A tightening frame is slidably connected between every two adjacent limiting rods, a tightening spring is connected between the lifting frame and the adjacent tightening frame, embedded rods are connected to the opposite faces of every two adjacent tightening frames, and a connecting box is connected between every two adjacent embedded rods. Rapid power-off of the outer connector and the wiring terminal is achieved, power-off of the transformer body and the outside can be achieved in time in the early stage of a fire, economic losses are reduced, generated nitrogen can dilute the oxygen concentration in the box body, and fire extinguishing is achieved.

The invention discloses a functional cyclodextrin polyether macromonomer as well as a preparation method and application thereof, the functional cyclodextrin polyether macromonomer is prepared by condensing cyclodextrin and alkynyl polyethylene glycol siloxane to prepare alkynyl cyclodextrin, and then the alkynyl cyclodextrin and an azido compound are subjected to click chemistry to obtain the functional cyclodextrin polyether macromonomer. The azido compound is prepared from allyl chloride or methyl allyl chloride and sodium azide, and the polycarboxylic acid admixture is prepared based on the polyether macromonomer. The functional cyclodextrin polyether macromonomer with a novel structure is efficiently prepared on the basis of click chemistry for the first time, the polycarboxylic acid additive is prepared on the basis of the polyether macromonomer, the polycarboxylic acid additive effectively improves the workability of concrete under a current concrete raw material system, and the concrete with a high water-binder ratio or a large volume has a good application prospect. The hydration heat release can be effectively controlled, the hydration heat release temperature peak is inhibited, the internal temperature rise of the concrete is reduced, and the generation of temperature cracks is reduced.

The invention provides a biosynthesis method of an esdoxaban tosylate chiral intermediate. According to the preparation method, 3-cyclohexene-1-carboxylic acid methyl ester is taken as a starting raw material, and a target intermediate is finally obtained through carboxylesterase resolution, hydrolysis, hydroxylation, dehydrogenation oxidation, transamination reaction, amidation and Boc2O reaction in sequence. According to the method, high-selectivity carboxylesterase is used for realizing chiral resolution; p450 oxidase with excellent regioselectivity and stereoselectivity is utilized to realize specific hydroxylation of a C-H bond under a mild condition, and a traditional process depending on a highly toxic chemical oxidant is overturned; then, clean oxidation is realized through alcohol dehydrogenase, and a way is laid for subsequent reaction; most importantly, the transaminase is adopted to directly construct the chiral amine, so that the use of a high-risk reagent sodium azide is thoroughly avoided, and major potential safety hazards are eliminated from the source; and finally, green amidation is realized by virtue of lipase, and an acyl chloride method for generating corrosive wastewater is replaced.

The invention provides a method for detecting the molecular weight of sodium hyaluronate, which specifically adopts a molecular exclusion chromatography method for determination, and the chromatographic conditions are as follows: a chromatographic column is formed by connecting at least two water-phase gel chromatographic columns with different filler apertures in series, the filler apertures of the water-phase gel chromatographic columns are as follows: the mobile phase is a phosphate buffer solution, the concentration is 3-20mmol / L, and the pH value is 6.5-7.5. According to the method, the molecular weight of sodium hyaluronate is measured in a double-column series connection mode, the separation effect is better, the accuracy is higher, and the repeatability is better; sodium azide (which is highly toxic and easy to explode) added into the mobile phase is also avoided, and the phosphate buffer solution is used as the mobile phase, so that the toxicity is low, the pollution is basically avoided, and the operation safety is improved.

The utility model relates to the field of wastewater treatment, and discloses a sodium azide wastewater treatment system which comprises a two-stage denitrification unit, an advanced oxidation pond, a PH (Potential of Hydrogen) regulating pond, a flocculation treatment unit, a hydrolysis acidification pond, an A / O (Anaerobic / Oxic) reaction unit, an activated carbon adsorption pond, a treatment system water outlet unit and a sludge treatment unit for treating sludge which are sequentially communicated, the two-stage denitrification unit and the advanced oxidation pond are used for removing sodium azide and potassium cyanide in the wastewater; the A / O reaction unit is used for reducing the chemical oxidation amount and the total amount of total nitrogen and phosphorus in the wastewater; the flocculation treatment unit and the A / O reaction unit are both communicated with the sludge treatment unit. According to the embodiment of the invention, sodium azide and potassium cyanide can be efficiently decomposed through a combined process of the two-stage denitrification unit and the advanced oxidation pond.

The invention relates to the technical field of protein detection, in particular to non-protein confining liquid based on poloxamer and application of the non-protein confining liquid in protein detection. The confining liquid for protein detection provided by the invention does not contain protein, and comprises 2-10g / L of a polyether compound; a nonionic surfactant with a volume fraction of 0.1%-0.2%; the volume fraction of the antibacterial preservative is 0.2%-0.5%; the balance is a buffer solution; the confining liquid has the advantages of being short in confining time, stable in confining effect, low in background signal, high in signal-to-noise ratio, simple to prepare, good in compatibility with detected antibodies and antigens, wide in applicable detection platform, simple and convenient to prepare, low in cost and the like, does not contain toxic components such as sodium azide and the like, and is suitable for large-scale production. And the method is suitable for the closing step of the solid-phase carrier in various protein detection experiments such as Western blot and ELISA (Enzyme-Linked Immunosorbent Assay).

The application discloses a clinical biochemical composite quality control product, which comprises detection item raw materials, a matrix liquid and a protective agent; the detection item raw materials are alkaline phosphatase, amylase, sodium glycocholate, cholinesterase, creatinine, leucine aminopeptidase, lactate dehydrogenase, lipase, triglyceride, cholesterol, uric acid, urea, alanine aminotransferase, aspartate aminotransferase, gamma-glutamyl transferase, glucose, alpha-hydroxybutyric acid dehydrogenase, sodium hydrogen phosphate, magnesium chloride, calcium chloride, ferrous chloride, bilirubin, pancreatic amylase and sodium bicarbonate; the matrix liquid is bovine serum albumin and human serum albumin; and the protective agent is dithiothreitol (DTT), mannitol, trehalose, sodium chloride, a composite enzyme stabilizer AES and sodium azide. The quality control product can realize the detection of 27 clinical biochemical items, and the freeze-drying process is adopted, so that the freeze-dried composite quality control product has low viscosity, is easy to be re-dissolved and mixed, has high stability and has small matrix effect.

The invention discloses an electrochromic material based on pillararene and triphenylamine as well as a preparation method and application of the electrochromic material. The preparation method comprises the following steps: carrying out Suzuki reaction through a boric acid ester reagent of triphenylamine to obtain a triphenylamine alkynyl compound 2 substituted by three 3, 4-ethylenedioxythiophene; then reacting with NBS (N-bromosuccinimide) to obtain a bromo-pillararene polymer monomer compound 4; reacting the compound 4 with sodium nitrite and sodium azide to generate a pillararene compound 5 with azide groups; the compound 2 and a compound 5 are subjected to a click reaction in the presence of cuprous, and the pillararene electrochromic molecule TPA-Th-P5 based on triphenylamine is obtained. According to the electrochromic material, the color can be changed from light yellow to light blue under low voltage, the color can be reversibly recovered, and the electrochromic material is rapid in response, high in contrast ratio and high and good in reversibility. The electrochromic device made of the electrochromic material has more prominent color changing performance, higher transmissivity and longer service life.

The invention relates to a method for quantifying biological activated carbon adsorption and biodegradation contribution in removal of pollutants by biological activated carbon, and belongs to the technical field of water treatment. The method comprises the following steps: constructing two groups of quick small-scale biological activated carbon carbon column devices which run in parallel, adding NaN3 into inlet water of one group of carbon columns to inhibit the activity of microorganisms on biological activated carbon, measuring the concentration of pollutants in the inlet water and outlet water of the two groups of carbon columns, and calculating to obtain the contribution rate of adsorption and biodegradation of the biological activated carbon to removal of the pollutants. Experimental results show that the microbial activity can be effectively inhibited under the condition that 300mg / L of sodium azide is added into the inlet water, so that the contribution rate of adsorption and biodegradation of the biological activated carbon in the process of removing pollutants by the biological activated carbon is calculated, and the efficiency of the biological activated carbon with the carbon age of 3.5-15 years is obviously distinguished. The method provided by the invention can enhance the control efficiency of a biological activated carbon process on pollutant removal, improve the utilization rate of biological activated carbon with different carbon ages, and contribute to cost reduction and benefit improvement of a water plant.

This invention relates to the field of crop breeding technology, and in particular to a method for inducing mutagenesis in wheat breeding. The invention involves sequentially soaking wheat seeds in a sodium azide solution, an N-nitroso-N-methylurea solution, and an ethyl methanesulfonate solution to obtain new wheat germplasm with phenotypic variations. This invention, by combining sodium azide, N-nitroso-N-methylurea, and ethyl methanesulfonate for mutagenesis, can obtain dwarf wheat plants and improve ear length and yield.

The invention relates to the technical field of cellulose nanofibrils, and discloses a reed stem cellulose nanofibril as well as a preparation method and application thereof, specifically, a bromine functional group grafted on the reed stem cellulose nanofibril is taken as an initiator, and under the action of cuprous halide, the reed stem cellulose nanofibril is grafted on the bromine functional group to prepare the reed stem cellulose nanofibril. Carrying out atom transfer radical polymerization reaction on the alkenyl compatibilization monomer on the surface of the reed stem cellulose nanofibril, and then carrying out substitution reaction on the ethyl sulfonate of the monomer and sodium azide to prepare the azide reed stem cellulose nanofibril; polylactic acid and azide groups on the surfaces of the nanofibrils are subjected to a click reaction for generating triazole groups through alkynyl functional groups, covalent connection of polylactic acid and the nanofibrils is achieved, silver ions are loaded through the strong coordination effect of the triazole groups and the silver ions, and finally, the silver-loaded polylactic acid / silver-loaded nanofibrils are obtained through a film scraping method. The reed stem cellulose nanofibril modified polylactic acid membrane has the beneficial technical effects that the antibacterial property and the mechanical property of the membrane are remarkably improved.

The synthesis method comprises the following steps: by taking nitroethane, formaldehyde and liquid bromine as reaction raw materials, continuously synthesizing 2-bromo-2-nitropropanol (BNPOH) in an alkaline aqueous solution in two steps under an ice bath condition; the method comprises the following steps: by taking concentrated sulfuric acid as a catalyst, carrying out condensation on BNPOH and trioxymethylene to synthesize bis (2-bromo-2-nitropropanol) formal (BBNPF); then sodium azide is used as an azidation reagent, and heating and stirring reaction are carried out in the mixed system; and after the reaction is finished, extracting with dichloromethane, washing with water, distilling and concentrating to obtain a light yellow liquid product, and carrying out column chromatography separation to obtain a high-purity product bis (2, 2-diazido propyl alcohol) formal (BDAPF). The product disclosed by the invention is a novel gem-diazido acetal energetic molecule, has proper density and viscosity and lower glass transition temperature compared with an A3 plasticizer molecule, can be used as an A3 plasticizer substitute for a solid propellant, and has a better application prospect.

The efficient preparation method of a tedizolid intermediate includes the following steps: 1) subjecting 2-fluoro-4-substituted phenylacetic acid to a reaction with a Vilsmeier reagent, and adding a resulting reaction solution to an MX aqueous solution for quenching to obtain an intermediate shown in formula (II); and 2) subjecting the intermediate shown in formula (II) obtained in step 1) and 1-(2-methyl-2H-tetrazol-5-yl)ethanone to one-pot synthesis in the presence of an alkali and an ammonia source to obtain the intermediate shown in formula (I). In this method, a pyridine ring of the key intermediate shown in formula (I) is obtained through a ring-closing reaction of the 1-(2-methyl-2H-tetrazol-5-yl)ethanone and a Vinamidinium salt, and a key methyltetrazolyl group is introduced into the structure, which successfully avoids the use of highly-toxic sodium cyanide and sodium azide, the use of expensive palladium catalyst, and the use of methylation with low selectivity.