6 results about "Acyl azide" patented technology

This invention discloses a method for preparing furanyl diisocyanate and its applications, relating to the field of organic polymer compounds. Under nitrogen atmosphere, furoic acid is added to concentrated sulfuric acid and mixed, followed by the addition of paraformaldehyde and a temperature-controlled reaction to obtain bis(5-formic acid-2-furan)methane. An organic base is added to a solvent containing bis(5-formic acid-2-furan)methane, and diphenyl azide phosphate is added dropwise to react and obtain bis(5-acyl azide-2-furan)methane. The bis(5-acyl azide-2-furan)methane is dissolved in an organic solvent and reacted to obtain furanyl diisocyanate. This invention provides a high-yield, high-selectivity one-step method for obtaining the intermediate bis(5-formic acid-2-furan)methane, shortening the synthetic route, improving synthetic efficiency, avoiding the use of sodium azide, increasing safety, and reducing production costs. The production of bio-based polyurethane is environmentally friendly, economical, and industrially applicable, and can be used to develop environmentally friendly coatings, adhesives, and sealants.

The present application relates to the technical field of pyrazole derivative compound synthesis, and particularly relates to a preparation method of an amino-formamido pyrazole derivative compound, which comprises the following steps: S1, synthesizing an intermediate 1 by using pyrazole amine and triphenyl chloromethane as raw materials; S2, synthesizing an intermediate 2 by means of a hydrazinolysis reaction of the intermediate 1; S3, oxidizing the intermediate 2 into an intermediate 3 by means of sodium nitrite; and S4, preparing a target product by condensing the intermediate 3 with Boc-ethylenediamine. The raw material in the present application is easy to obtain, and the reaction process is mild. The key intermediate acylhydrazine is synthesized by means of a hydrazinolysis reaction, and then the acylhydrazine is oxidized into the intermediate acyl azide by means of sodium nitrite, so that the use of an expensive reagent DPPA is avoided, and the material cost is greatly saved.

Disclosed are a semiconductor photoresist composition and a method of forming patterns using the same, the semiconductor photoresist composition including a compound including at least one structural unit including an acyl azide functional group; and a solvent.

The invention relates to the field of thioester peptide synthesis, in particular to a method for preparing thioester peptide with L-thiazolidine-4-carboxylic acid at the N end, which comprises the following steps: S1, dissolving polypeptide hydrazide in a mixed solvent consisting of hydrochloric acid, guanidine hydrochloride and sodium dihydrogen phosphate, and reacting with excessive sodium nitrite and L-thiazolidine-4-carboxylic acid at the temperature of 15 DEG C below zero to 5 DEG C below zero to obtain polypeptide hydrazide; generating an acyl-containing azide peptide system; s2, adding excessive methyl thioglycolate into the acyl-containing azide peptide system, then adding an ammonium bicarbonate solution to adjust the pH value to 5.5, and carrying out oscillation reaction at normal temperature to generate a sulfur-containing ester peptide system; and S3, adding diethyl ether which is precooled to 0 DEG C into the thioester peptide-containing system for washing, and removing an upper-layer solution to prepare the thioester peptide of which the N end is L-thiazolidine-4-carboxylic acid. According to the method, the L-thiazolidine-4-carboxylic acid is added in the sodium nitrite treatment process, conversion from the hydrazide peptide with the N end being the L-thiazolidine-4-carboxylic acid to the hydrazide peptide with the N end being the L-thiazolidine-4-carboxylic acid thioester peptide is achieved, the synthesis process is simple, and the synthesis efficiency is high.

The application provides a method for preparing an intermediate of abubinitin by using a micro-channel reactor, 3-oxocyclobutane acyl chloride and sodium azide are respectively dissolved and pumped into a micro-channel reactor I to perform an acyl azide reaction, and the intermediate reaction solution is continuously pumped into a micro-channel reactor II to perform a reaction with benzyl alcohol to obtain 3-oxocyclobutyl benzyl carbamate. The micro-channel reactor is used as a core reaction equipment, continuous acyl azide reaction and continuous Curtius rearrangement reaction are realized, the method has the advantages of high yield, good quality, reduced reaction risk, high mass and heat transfer efficiency, safe and simple operation and the like, and is beneficial to the large-scale production and application of the intermediate.

The invention relates to the technical field of high-molecular polymer synthesis, in particular to alpha / omega-acyl azide / hydroxyl-terminated polyether as well as a preparation method and application thereof. An acid-base pair obtained by mixing polynuclear organoboron Lewis acid and Lewis base can catalyze ring opening of an epoxy compound monomer and further react with a compound 1, and controllable preparation of alpha / omega-acyl azide / hydroxyl-terminated polyether is achieved. An acyl azide terminal group is used as latent curing isocyanate, and is subjected to thermal induction to generate Coutius rearrangement to generate isocyanate in situ, and then the isocyanate reacts with hydroxyl to form a carbamate bond; in addition, the alpha / omega-acyl azide / hydroxyl-terminated polyether forms polyurethane under heat treatment, compared with traditional gradual addition polymerization based on diisocyanate, polyurethane formation in the preparation method is derived from a pre-programmed macromolecular precursor, polyurethane synthesis is converted into a chain growth driven and terminal group triggered macromolecular assembly process, and the preparation method has the advantages that the preparation method is simple, the preparation cost is low, and the preparation efficiency is high. And the structural accuracy and the synthesis safety are obviously improved.