26 results about "Nitrene" patented technology

The wisdom utilization of nuclear energy occupies a core and irreplaceable position in consolidating national defense security and transforming an energy system to greenization. While the nuclear energy technology is vigorously developed, how to properly manage and efficiently recycle depleted uranium (especially 238U, although the depleted uranium does not cause direct radioactive hazards to human bodies) generated in the nuclear energy application process becomes a critical technical challenge faced by the field of environmental protection and sustainable development. Particularly, U3O8 prepared by depleting UF6 is used as a raw material, UO4. 2H2O prepared by a simple dissolution and re-precipitation method is used as a catalyst, and aniline is catalyzed and oxidized to synthesize diphenyl diazene or derivatives thereof. According to the invention, on one hand, a mode of recycling the depleted uranium waste is created, a brand new conversion way is found for the waste which is traditionally considered as a difficult problem, and on the other hand, a bridge from aniline and derivatives thereof to a high value-added chemical, namely diphenyl diazene or derivatives thereof, is skillfully erected. Potential threats of the depleted uranium waste to the environment can be effectively reduced, green transformation and resource utilization of the waste are achieved, meanwhile, the chemical industry can be promoted to proceed towards the more efficient and environment-friendly direction, and economic benefits are remarkably improved for the chemical industry.

This invention relates to the field of organic synthesis technology, specifically to a method for preparing aryltriazene; comprising the following steps: (1) preparing an aromatic nitroso compound Ar 1 NO is dissolved in the first solvent in the first ratio to obtain solution A; (2) unsymmetrical disubstituted hydrazine R 1 R 2 NNH2 is dissolved in the second solvent in the second ratio to obtain solution B; (3) under stirring, solution A and solution B are mixed and subjected to dehydration condensation reaction for 1-4 hours, and the reaction temperature of dehydration condensation is 10-40℃; after the reaction is completed, aromatic triazine is obtained by separation and purification; the first solvent and the second solvent are aprotic solvents; Ar 1 It is any of the substituted or unsubstituted phenyl, heterocyclic aryl, and fused-ring aryl groups, and the substituents on the ring do not react with hydrazine; R 1 R 2 It is at least one of alkyl and aryl groups. This preparation method is simple to synthesize, produces no unstable diazonium salt intermediates, has mild reaction conditions, and a relatively fast reaction rate.

The invention discloses a wound repair material and a preparation method thereof, and relates to the technical field of medical materials. The wound repair material is prepared from the following raw materials in parts by weight: 50 to 60 parts of bioactive glass, 15 to 30 parts of chitosan, 10 to 20 parts of functional materials and 300 to 450 parts of deionized water. The preparation method comprises the following steps: reacting oleamide propyl dimethylamine with 4-chlorobutanol to generate an intermediate 1, reacting the intermediate 1 with 5, 10, 15, 20-tetra (4-carboxyl phenyl) porphyrin to generate an intermediate 2, and reacting the intermediate 2 with 4, 4 '-{[6-((1-carboxyl-2-mercaptoethyl) amino)-1, 3, 5-triazine-2, 4-diyl] bis (nitrounit)} bis [4-(2-carboxyethyl) pimelic acid] under the action of a photoinitiator to generate the functional material. The wound repair material prepared by the invention has excellent antibacterial property and hemostatic property.

The present invention provides an organic photocatalytic synthesis method of a phenanthridine heterocyclic carbonyl compound. The organic photocatalyst is a nitrene, belonging to the technical field of organic synthesis. The organic photocatalyst and the compounds shown in Formula II and Formula III are dissolved in a solvent to obtain a reaction solution to be reacted; the obtained reaction solution to be reacted is subjected to an addition reaction under blue light to obtain the phenanthridine heterocyclic carbonyl compound. The organic photocatalyst provided by the present invention is economical and green. Compared with the prior art, the organic photocatalytic synthesis method described in the present invention has the characteristics of easily available raw materials, metal-free catalysis, economical and green reaction conditions, etc.

The invention provides a trifluoromethyl-initiated acrylic ester monomer reversible addition-fragmentation chain transfer free radical polymerization method, and belongs to the technical field of high polymer chemistry. The method comprises the following steps: mixing an acrylate monomer, trifluoromethylsulfonyl chloride, bis (dodecyl sulfur alkyl thiocarbonyl) disulfide and a nitrogen-based catalyst, and reacting in a nitrogen atmosphere and blue light to obtain the polymer. According to the method, the trifluoromethylsulfonyl chloride is directly used as a trifluoromethyl source to directly initiate polymerization, so that pre-synthesis of an initiator or a chain transfer agent is avoided, and controllable free radical polymerization is realized. Nitrogen-bene is selected as a catalyst, so that the method has the advantages of high stability, easiness in synthesis, low toxicity, low cost and the like. A catalytic optical activity strategy of RAFT polymerization is further introduced, trifluoromethyl free radicals are directly used for light-operated RAFT polymerization from widely available and stable trifluoromethylsulfonyl chloride for the first time, and synthesis of the polymer is simplified.

The invention relates to a polymer for treating a surface, which polymer comprises: n reactive intermediate precursor groups, wherein n is an integer equal to or greater than 3; and m groups which comprise an atom-transfer radical polymerization (ATRP) initiator, wherein m is an integer equal to or greater than 3, wherein the reactive intermediate precursor groups are selected from carbene precursor groups and nitrene precursor groups, wherein the carbene precursor groups are selected from hydrazone groups of formula (A), diazo groups of formula (B) and diazirine groups of formula (C), and the nitrene precursor groups are azide groups of formula (D), wherein R1 is H or -S(O)2R2, and R2 is an unsubstituted or substituted C1-6 alkyl group or an unsubstituted or substituted aryl group. The invention also relates to a process for producing a treated substrate, which treated substrate has a surface suitable for surface -initiated atom-transfer radical polymerization (SIATRP). The invention also relates to a treated substrate having a surface suitable for SIATRP, and to treated substrates obtainable by the aforementioned process of the invention. The invention also relates to a treated substrate which comprises: a substrate, a reacted polymer disposed on a surface of the substrate, and a further polymer, grown by SIATRP, bonded to the reacted polymer.

The invention discloses an azide modified platinum radiotherapy sensitizer as well as a preparation method and application thereof. The azide modified platinum radiotherapy sensitizer is an azide modified platinum complex, comprises a cis platinum complex and a trans platinum complex, and is characterized in that the structure of the azide modified platinum radiotherapy sensitizer is shown in the specification; in the formula I, R1 is cyclohexylamine or 2-methylpyridine; in the formula II, R2 is ammonia molecules or pyridine. The azide modified platinum radiotherapy sensitizer can generate a platinum-nitrogen-bin free radical under the irradiation of X rays, and by utilizing a nitrogen transfer reaction in organic chemistry, the platinum-nitrogen-bin free radical generated after the compound is irradiated by rays can be covalently coupled with some DNA (Deoxyribose Nucleic Acid) or protein, so that the sensitivity of the radiotherapy sensitizer is improved. The radiotherapy sensitization effect in tumor radiotherapy is achieved by directly damaging DNA and hindering DNA repair.

The present invention discloses a method for synthesizing an asymmetric azoxybenzene compound. Under light irradiation conditions, iminoiodobenzene and a nitroso compound are reacted in dichloromethane. First, iminoiodobenzene generates nitrene under light irradiation conditions, and then it is captured by the nitroso compound to generate an asymmetric azoxybenzene compound. This method is driven by visible light as a green energy source, without the addition of a catalyst, and the target product can be obtained by reacting for 2 h at room temperature. The reaction conditions are mild and rapid, and at the same time, it is insensitive to air and water and is easy to operate.

The present disclosure describes non-classical (e.g., quantum) computing systems and methods that utilize dopant molecules contained in host materials as qubits. The dopant molecules generally comprise ground-state triplet (GST) molecules, such as carbenes or nitrenes. The host materials generally comprise organic molecules. Precursors to the dopant molecules can be embedded in the host materials and then subjected to ultraviolet (UV) or visible light to form dilute molecular crystals comprising the dopant molecules embedded in the host materials. The triplet sub-levels of the dopant molecules may be manipulated using electromagnetic (EM) radiation such as optical, radiofrequency (RF), and / or microwave (MW) radiation to conduct non-classical computing operations.

The present invention relates to a process for the functionalization of a rubber polymer comprising reacting the rubber polymer with at least one source of nitrene or carbene, in the presence of a catalyst of formula TpxAg, wherein Tpx represents a hydrotris(pyrazolyl)borate ligand. This process leads to selective rubber functionalization without secondary reactions such as chain scission or cross linking and produces functionalized rubbers with improved compatibilization properties. The invention also refers to the polymer produced therefrom and to uses of said polymer.

The application discloses a wound repairing material and a preparation method thereof, and relates to the technical field of medical materials. The wound repairing material comprises the following raw materials in parts by weight: 50-60 parts of bioactive glass, 15-30 parts of chitosan, 10-20 parts of functional material, and 300-450 parts of deionized water. The intermediate 1 is generated by the reaction of oleamide propyl dimethylamine and 4-chlorobutanol, the intermediate 2 is generated by the reaction of the intermediate 1 and 5,10,15,20-tetra(4-carboxyphenyl)porphyrin, and the functional material is generated by the reaction of the intermediate 2 and 4,4'-{[6-((1-carboxyl-2-mercaptoethyl)amino)-1,3,5-triazine-2,4-diyl]bis(nitrene)}bis[4-(2-carboxyethyl)heptanedioic acid] under the action of a photoinitiator. The wound repairing material prepared by the application has excellent antibacterial performance and hemostatic performance.

Disclosed are a polyolefin graft copolymer produced using an initiator containing an azidoformate group and a production method therefor. Specifically, the present invention provides a polyolefin graft copolymer represented by structural formula 1, comprising: a polyolefin-based main chain; and a graft chain grafted to the polyolefin-based main chain and containing a polar polymer. Through the use of a polar polymer containing an azidoformate group as a terminal, the azidoformate group at the terminal is decomposed by photochemical or thermal energy to allow nitrogen gas to escape, forming a nitrene, and the formed nitrene reacts with a C-H bond of the polymer main chain, thereby achieve efficient grafting.

The invention discloses an organic electro-optical material capable of being used for waveguide interface functionalization and a preparation method and application thereof.A 4-azido-2, 3, 5, 6-tetrafluorobenzene structural unit is introduced into the material, nitrogen-guene generated by the structure under ultraviolet irradiation can be subjected to an insertion reaction with C-H bonds in material molecules or on an interface, and the material can be used as a functional material for waveguide interface functionalization. A solid three-dimensional cross-linked network is formed, meanwhile, a plurality of polar groups and fluorine atoms are provided, interface wettability and physical and chemical bonding force between the material and common waveguide materials such as Si, Si3N4 and SiO2 can be improved, interlayer adhesive force and interface stability in a waveguide structure are remarkably improved, and the performance of the material is improved. And the failure problems of delamination, thermal warping and the like in preparation and long-term operation of the device are reduced.

Described herein are markers, conjugates, compositions and methods for hypoxia imaging, mapping, and therapy. A compound comprising bio-reductively activated (BA) arm, linker arm and a mapping click wherein BA contains one for more of substituted or unsubstituted 2 / 4 / 5-substituted nitroimidazoles, or substituted benzotriazene-1,4-dioxides, or substituted 1,2,3 / 1,2,4-triazoles, or substituted 1,4-benzoquinones, or a combination of two homo-or hetero BA moieties, wherein linker arm contains C1-16 alkane, alkene, alkyne, alicyclic or aromatic linkers with or without hetero atoms as in ethers, amine, esters, acid, amides, 5 and 6 membered sugar sings with the substitution as described above, both monosaccharides and disaccharides, wherein mapping click contains one of substituted or unsubstituted —N3-, CN, SCN, substituted alkynes for click chemistry. Said compound undergoes in situ click reaction after its distribution in cells or tissues to link to a reporting group which may be unchelated or chelated with a metal-radioactive or non-radioactive-, or a radiohalogen for PET / SPECT, or a dye for fluorescent / optical reporting group, thus accomplishing hypoxia imaging.

The invention relates to a polymer for treating a surface, which polymer comprises n reactive intermediate precursor groups, wherein n is an integer equal to or greater than 3; and m groups for controlling surface-initiated reversible-deactivation radical polymerization (SIRDRP), wherein m is an integer equal to or greater than 3. The groups for controlling SIRDRP are selected from groups which comprise an initiator and groups which comprise a chain transfer agent (CTA). The reactive intermediate precursor groups are selected from carbene precursor groups and nitrene precursor groups. The carbene precursor groups are selected from hydrazone groups of formula (A), diazo groups of formula (B) and diazirine groups of formula (C), and the nitrene precursor groups are azide groups of formula (D): wherein R1 is H or –S(O)2R2, and R2 is an unsubstituted or substituted C1-6 alkyl group or an unsubstituted or substituted aryl group. The invention also relates to a process for producing a treated substrate, which treated substrate has a surface suitable for SIRDRP. The invention also relates to a treated substrate having a surface suitable for SIRDRP, and to treated substrates obtainable by the aforementioned process of the invention. The invention also relates to a treated substrate which comprises: a substrate, a reacted polymer disposed on a surface of the substrate, and a further polymer, grown by SIRDRP, bonded to the reacted polymer.

The invention provides a novel amination coupling strategy, and discloses a triazene oxide and a preparation method thereof. The method for preparing the triazene oxide comprises the following steps: taking an amine substance, an iso-head amide reagent and a nitroso aromatic hydrocarbon substance as raw materials, and reacting in an optional solvent under the action of an optional alkali additive to generate the triazene oxide. According to the synthesis strategy of the invention, isoamide is used as a linking reagent, and the nitrogen terminals of secondary aliphatic amine and nitroso aromatic hydrocarbon are efficiently crosslinked in the form of N-N = N + (O-) fragments, so that the triazene oxides with novel and diversified structures are efficiently prepared through one-pot reaction, and the use of toxic high-valence metal oxidants in traditional methods is avoided.

The present disclosure describes non-classical (e.g., quantum) computing systems and methods that utilize dopant molecules contained in a host material as qubits. The dopant molecules generally include triplet ground state (GST) molecules such as carbenes or nitrenes. The host material generally includes organic molecules. Precursors to the dopant molecules are embedded in the host material and then subjected to ultraviolet (UV) or visible light to form a dilute molecular crystal containing the dopant molecules embedded in the host material. The triplet sub-levels of the dopant molecules can be manipulated using electromagnetic (EM) radiation such as optical, radio frequency (RF), and / or microwave (MW) radiation to perform non-classical computing operations.

To provide a method and a compound useful for depositing a metal and a metal-containing layer in a gas phase.SOLUTION: The invention relates to the use of a metal complex, which has at least one ligand of the formula R1-N3-R2, wherein R1 and R2 are hydrocarbon moieties, for depositing the metal or a compound of the metal from the gas phase. The invention further relates to methods for depositing metals from the metal complexes, and to metal complexes, substituted triazene compounds and methods for the production thereof.SELECTED DRAWING: Figure 14

The present invention belongs to the technical field of organic synthesis, and provides a method for preparing benzamide and its derivatives, comprising the following steps: under photochemical catalysis, reacting 3-phenyl-1,4,2-dioxazol-5-one or its derivatives with pinacol borane to obtain benzamide and its derivatives. In the present invention, aryl dioxazolone is photochemically activated to remove CO2 to form a free radical, and a metal nitrene is constructed with the free radical through Fe(III) catalysis, and directly and selectively combines with the proton in pinacol borane to form an N-H bond, thereby obtaining benzamide or its derivatives. The raw materials are cheap and easily available, the synthesis is simple, the production cost can be effectively reduced, the yield and chemical selectivity can be improved, and it can be conveniently applied to the preparation of benzamide and its derivatives, having potential industrial application value.

The present invention relates to a process for the functionalization of a rubber polymer comprising reacting the rubber polymer with at least one source of nitrene or carbene, in the presence of a catalyst of formula TpxAg, wherein Tpx represents a hydrotris(pyrazolyl)borate ligand. This process leads to selective rubber functionalization without secondary reactions such as chain scission or cross linking and produces functionalized rubbers with improved compatibilization properties. The invention also refers to the polymer produced therefrom and to uses of said polymer.

The invention discloses an N-substituted benzisoxazole-3-ketone compound as well as a preparation method and application thereof, and the preparation method of the N-substituted benzisoxazole-3-ketone compound comprises the following steps: mixing thioimine, a catalyst and an organic solvent to obtain a mixture; replacing the mixture with an inert atmosphere, and carrying out light irradiation stirring reaction for a preset time at a preset temperature to obtain a reactant; and carrying out separation and purification treatment on a reactant, so as to obtain the N-substituted benzisoxazole-3-ketone compound. According to the preparation method, thioimine is used as a nitrogen alkene precursor for intramolecular C-O insertion, C-N bonds and N-O bonds are constructed at the same time, the N-substituted benzisoxazole-3-ketone compound is synthesized, and the preparation method has the advantages of being high in target product yield, good in substrate universality, high in atom economy, simple in reaction condition, convenient in aftertreatment, green and safe.

The invention discloses a 1, 2-bis (4-azido-3, 5-dinitro pyrazole) diazene compound, and the structure of the 1, 2-bis (4-azido-3, 5-dinitro pyrazole) diazene compound is as shown in a figure I. A synthesis process of the compound comprises the following steps: (1) carrying out a diazotization reaction on 4-amino-3, 5-dinitropyrazole to obtain 4-azido-3, 5-dinitropyrazole; (2) enabling the 4-azido-3, 5-dinitropyrazole to react with sodium hydroxide and O-2, 4, 6-trinitrobenzene hydroxylamine in sequence to generate 4-azido-3, 5-dinitropyrazole-1-amine, and enabling the 4-azido-3, 5-dinitropyrazole-1-amine to react with the sodium hydroxide and the O-2, 4, 6-trinitrobenzene hydroxylamine in sequence; and (3) carrying out a coupling reaction on the 4-azido-3, 5-dinitropyrazole-1-amine under the action of tert-butyl hypochlorite to generate the 1, 2-bis (4-azido-3, 5-dinitropyrazole) diazene. The 1, 2-bis (4-azido-3, 5-dinitropyrazole) diazene synthesized by the method has excellent detonation performance, and has the potential to be used as a high-energy single-compound explosive. # imgabs0 #

The application discloses a green and environment-friendly reaction of visible light-induced alpha, beta-unsaturated amide and aryl triazene in air without any additive or cosolvent, so that bifunctionalization is realized, and when the condition is changed and when there is a protective group on N, a cyclization reaction can also be realized. The metal-free reaction has high chemical selectivity, and corresponding beta-hydroxyl compounds and competitive cyclization products can be synthesized. The reaction has considerable advantages, including high selectivity, mild reaction condition, cleanness, no need of transition metal catalyst, high atom economy and good functional group compatibility.

The present invention discloses a photoactive nitrene-based organic small molecule photocatalyst, its preparation method, and application. The present invention utilizes nitrene compounds as organic photocatalysts to achieve free radical addition reactions between alkyl chlorides and organic selenium ether compounds under the action of visible light, resulting in highly selective synthesis of a series of organoselenium compounds with potential pharmaceutical activity. This method provides a simple, efficient, and highly selective synthesis pathway for organoselenium compounds. The method catalyzes Giese-type (cyclo)addition reactions, Heck-type coupling reactions, and Minisci-type aromatic ring reactions of unsaturated carbon-carbon double bonds. This method does not require the involvement of transition metals and utilizes readily available nitrene salts as photocatalysts, resulting in a novel method.

The invention discloses a method for synthesizing an aryl dithiocarbamate compound through light induction. Under purple light irradiation, aryl triazene is used as an aryl and amido bifunctional reagent, and green and efficient synthesis of the aryl dithiocarbamate compound is realized through nitrogen removal of the aryl triazene and insertion of carbon disulfide. The method has the advantages that raw materials are stable and easy to obtain, conditions are mild, operation is simple, reaction time is short, and any metal, photosensitizer and other additives do not need to be used.