120results about "Functional group formation/introduction" patented technology

The invention provides a method 100 for separating different polymeric spectacle lens materials in a mixture comprising at least two different polymeric spectacle lens materials by separating at least one polymeric spectacle lens material of the at least two different polymeric spectacle lens materials by using their different physical behavior and / or chemical behavior, wherein the at least two different polymeric spectacle lens materials are selected from the group consisting of polyallyl carbonate, polyurea, polyurethane, polyurethane / polyurea, polycarbonate, polyepisulfide and polythiourethane. The invention further provides a method for separating at least one polythiourethane from a mixture comprising at least two different polythiourethanes by thiolysis.

The invention belongs to the technical field of organic synthesis, and particularly relates to an alkyl pentafluorosulfenyl compound and a preparation method and application thereof.The preparation method comprises the following steps that in the protective gas atmosphere, in a solvent, SF5Cl serves as a pentafluorosulfenyl source, an olefin compound serves as a reaction substrate and a free radical trapping agent, a thiol compound serves as a hydrogen source, and the alkyl pentafluorosulfenyl compound is obtained through a one-step reaction; under the action of an olefin additive, the alkyl pentafluorothio compound is constructed by a one-step method through a visible light-induced free radical process, and the olefin additive is used for inhibiting generation of a pentafluorothio chloride byproduct from a pentafluorothio source and an olefin compound. According to the method disclosed by the invention, a series of alkyl pentafluorosulfenyl compounds can be prepared by only needing olefin double bonds in substrates and selecting more substrates through the reaction, the reaction is simple, the reaction condition is mild, the reaction can be completed under visible light, the reaction time is short, the implementation is easy, and the method is suitable for industrial production. And a method support is provided for further screening the alkyl pentafluorosulfenyl compound with excellent biological activity.

The objective of the present invention is to provide a method for producing a polycarbonate safely and efficiently even without using a base. The method for producing a carbonate derivative according to the present invention is characterized in comprising the step of irradiating a high energy light to a composition comprising the halogenated methane and the hydroxy group-containing compound in the presence of oxygen, wherein a molar ratio of a total usage amount of the hydroxy group-containing compound to 1 mole of the halogenated methane is 0.05 or more.

The invention discloses a method for synthesizing a sulfur-containing compound by using an amino sulfur trifluoride compound, which comprises the following two steps: S1, by taking the amino sulfur trifluoride compound and a compound A as reactants, stirring and reacting for 8-15 minutes or 10-15 hours at normal temperature in an organic solvent under an alkaline condition; the compound A is any one of an amide compound or a sulfanilamide compound, or water; and S2, adding a nucleophilic reagent into the solution after the reaction in the step S1, stirring at normal temperature to react for 8-15 minutes or 5-8 hours, and then purifying through a rapid chromatography to obtain a final product, namely, all-heteroatom substituted thioimine or all-heteroatom substituted sulfoxide, the nucleophilic reagent is an alcohol or an amine. According to the method disclosed by the invention, the amido sulfur trifluoride compound is used for synthesizing the asymmetric full heteroatom substituted thioimine and sulfoxide compound for the first time, the reaction steps are simple, the reaction conditions are mild, and expensive reagents are not needed.

The invention relates to a method for producing tetrahydrothiophene comprising the following consecutive steps: a) reaction of 1,4-butanediol in the presence of hydrogen sulfide (H2S), in the gas phase, in the presence of at least one catalyst in order to form a stream (A) comprising tetrahydrothiophene, water, and possibly unreacted hydrogen sulfide; b) condensation of the stream (A) in order to obtain a tetrahydrothiophene-rich stream (B) and gaseous effluents (C) containing the non-condensables possibly formed at the end of step a); c) at least one step of purifying, preferably by settling, the stream (B) with separation of the aqueous phase, of the organic phase constituting the stream (D) and of gaseous effluents (E); d) optionally at least one distillation of the stream (D) in order to isolate the tetrahydrothiophene from gaseous effluents (F); e) recovery of the tetrahydrothiophene isolated in step c) and optionally in step d), it being possible for steps b) and c) to be consecutive or simultaneous; f) gas-liquid extraction by means of a column supplied with one or more gas streams (G) comprising gaseous effluents (C) and / or gaseous effluents (E) and optionally gaseous effluents (F) and with a liquid stream of 1,4-butanediol, in order to form, at the column outlet, a gas stream (H) and an enriched liquid stream (I) comprising 1,4-butanediol; g) recirculation of all or part of stream (I) to reaction a).

The invention relates to an MOFs (Metal-Organic Frameworks) catalyst for oxidative coupling of aromatic amine as well as a preparation method and application of the MOFs catalyst. And the MOFs catalyst is an MOF-808 catalyst. The structure is simple and clear, and the catalyst has good catalytic activity and cycling stability; h2O2 can be effectively activated, and aromatic amine can be efficiently and selectively oxidized, so that the conversion rate of aromatic amine and the selectivity of products can be improved in a method for preparing azoic compounds by catalyzing aromatic amine oxidation.

The present invention concerns proteins having improved lipase activity, nucleic acid molecules encoding respective proteins having improved lipase activity and methods for stereo-selective synthesis of chiral amines or increasing of chiral amines isomers in enantiomer mixtures.

The invention relates to a method for purifying a thermoplastic material (22), such as polyethylene terephthalate (PET), comprising the steps of: - supplying pellets or shreds of the thermoplastic material into a melt processing device (20); and - melting the thermoplastic material to form a polymer melt; wherein the method further comprises a step of: - adding a pro-degradant into the pellets or shreds of the thermoplastic material, and / or into the polymer melt, to selectively degrade at least polyvinyl chloride (PVC) and benzene impurities, and / or any intermediate degradation product formed by or leading to the formation of such impurities, contained within said thermoplastic material and / or said polymer melt.

The invention provides an aryl alkyl ketoxime derivative as well as a preparation method and application thereof, and relates to the field of aryl oxime derivatives. The preparation method of the aryl alkyl ketoxime derivative comprises the following steps: by taking potassium formate as an additive, carrying out free radical reaction on a compound I and a compound II under ultraviolet irradiation in the presence of tert-butyl nitrite to obtain the aryl alkyl ketoxime derivative, the compound I is substituted iodobenzene or iodopyridine; the compound II is substituted styrene or thienyl ethylene; wherein a hydrogen atom transfer / single electron transfer relay sequence is utilized to activate a compound I, and tert-butyl nitrite is adopted as a bifunctional reagent, and is used as a hydrogen atom transfer reagent and an oxime source. According to the preparation method of the aryl alkyl ketoxime derivative, pre-functionalization is not needed, a reaction substrate is wide in universality and good in compatibility, reaction conditions are mild, operation is easy and convenient, a target product can be efficiently and rapidly prepared on the premise of high yield, and a new way is provided for oxime synthesis.

The present invention relates to a process for the production of tetrahydrothiophene, which comprises the following successive stages: a) reacting 1,4-butanediol in the gas phase, in the presence of at least one catalyst and in the presence of hydrogen sulfide (H2S) to form a stream (A) comprising tetrahydrothiophene, water and possibly unreacted hydrogen sulfide; b) condensing stream (A) to obtain a tetrahydrothiophene-rich stream (B) and a gaseous effluent (C) containing the condensables possibly formed at the end of stage a); c) at least one stage of purifying stream (B), preferably by sedimentation, in which an aqueous phase, an organic phase constituting stream (D) and a gaseous effluent (E) are separated; d) optionally distilling stream (D) at least once to isolate tetrahydrothiophene from a gaseous effluent (F); e) recovering the tetrahydrothiophene separated in stages c) and optionally d); stages b) and c) may be successive or simultaneous; f) gas-liquid extraction carried out in a column to which is supplied a gas stream (G) comprising one or more of gaseous effluent (C) and / or gaseous effluent (E) and optionally gaseous effluent (F) and a liquid stream of 1,4-butanediol, to form at the column outlet a gas stream (H) and an enriched liquid stream (I) containing 1,4-butanediol; g) recycling all or part of stream (I) to reaction a).

The invention discloses a multi-component preparation method of an N-sulfonyl fluoride compound, and relates to the field of organic synthesis. The preparation method comprises the following steps: reacting an amine compound with a chlorine source in a solvent to generate an intermediate, then continuously adding a sulfur dioxide source and a fluorine source for reaction, and purifying after one-pot reaction to obtain the N-sulfonyl fluoride compound, the structural general formula of the amine compound is shown in the specification, the structural general formula of the N-sulfonyl fluoride compound is shown in the specification. The reaction general formula is shown in the specification. The method has the advantages of cheap and easily available raw materials, simple operation, mild conditions, safety, environmental protection, short reaction time, good yield and wide substrate range, can be applied to various types of amine substrates, including primary (alkyl / aromatic) amine, secondary (alkyl / aromatic) amine, amide, nitrogen-containing heteroaromatic ring and the like, and has wide application prospects. Wide application prospects are realized in the fields of medicinal chemistry, synthetic chemistry, material science and the like.

The invention relates to ylide-functionalized phosphane ligands, the production of same and use in transition metal compounds, as well as the use of same as catalysts in organic reactions.

Efficient carbonylative synthesis of alkenes to form anhydrides using transition metal catalysts such as palladium-phosphine catalysts.

The present invention discloses a chiral nitrogen oxide compound, its preparation method, and application, belonging to the fields of organic synthesis technology and pesticide antibacterial activity research technology. The present invention discloses a method for preparing chiral nitrogen oxide compounds from nitrogen oxides and bromocinnamaldehyde, and synthesizes a series of compounds. The derivatives have good universality, excellent yields (up to 86%), enantioselectivity (up to 96%), and good biological activity, which is of great research significance for the further development and utilization of chiral nitrogen oxide compounds.

The present invention provides a thionizing solution having high stability that contains a compound represented by formula (3) as a thionizing agent and a method for producing a nucleic acid molecule by the amidite method using the thionizing solution. The present invention also provides a composition containing an aromatic heterocyclic compound represented by formula (1) [in the formula, X1 to X5 each independently are the same or different and represent a hydrogen atom, etc.], an aromatic hydrocarbon compound represented by formula (2) (in the formula, Y1 to Y6 each independently are the same or different and represent a hydrogen atom, a C1-C5 alkyl group, or a halogen atom.), and a thionizing agent represented by formula (3).

The invention relates to a method for purifying a thermoplastic material (22), such as polyethylene terephthalate (PET), comprising the steps of: - supplying pellets or shreds of the thermoplastic material into a melt processing device (20); and - melting the thermoplastic material to form a polymer melt; wherein the method further comprises a step of: - adding a pro-degradant into the pellets or shreds of the thermoplastic material, and / or into the polymer melt, to selectively degrade at least polyvinyl chloride (PVC) and benzene impurities, and / or any intermediate degradation product formed by or leading to the formation of such impurities, contained within said thermoplastic material and / or said polymer melt.

This invention discloses a method for preparing organic sulfates, comprising the following steps: using persulfate as the sulfate source, and achieving the functional group transformation of a free radical precursor compound through the free radical anion of the sulfate ion, thereby preparing the organic sulfate. This invention uses persulfate as the source and, through a free radical addition mechanism, acts on the free radical precursor substrate. Persulfate, as a sulfate free radical anion, participates in the functional group transformation of the organic compound, resulting in the efficient synthesis of organic sulfates.

The present invention belongs to the technical field of organic synthesis, and particularly relates to a method for synthesizing thiosemicarbazone compounds. The method for synthesizing thiosemicarbazone compounds uses (isocyanimino) triphenylphosphine and one of thiophenol substances, thiol substances, and disulfide substances as reactants, and uses methanol or a mixed solution of methanol and water as a solvent for reaction. After separation and purification, thiosemicarbazone compounds are obtained. The synthesis method of the present invention has mild conditions, does not require additional metals and additives, the product is easy to separate and has a high yield, and the reaction is green and efficient.

The application belongs to the technical field of organic synthesis, and particularly relates to a method for efficiently and greenly preparing allyl ketoxime in one step. The preparation method specifically comprises the following steps: cross-coupling reaction of enol, hydrazine and aldehyde under the action of a palladium catalyst to obtain an allyl ketoxime compound. The reaction raw materials used in the application are cheap and easy to obtain. The allyl ketoxime compound can be efficiently and greenly prepared in one step through the coupling reaction, the synthesis process is simple, and the synthesis cost is greatly reduced. The reaction condition is mild, the yield is high, the substrate applicability range is wide, the reaction conversion efficiency is high, the gram-scale experiment can be realized, and industrialization is easy to realize.

The invention belongs to the technical field of organic compound process synthesis and application, and discloses a thioamide derivative and a synthesis method thereof. According to the preparation method, the gem-difluoroolefin which is simple and convenient to prepare and the cheap and abundant amine compound are used as raw materials, the green and economical sulfur salt is used as the vulcanizing reagent, and the thioamide derivative can be obtained at a relatively high yield by reacting in the organic solvent at a proper temperature; the structural formula of the thioamide derivative is # imgabs0. The synthesis method has the characteristics of simplicity and convenience in operation, mild conditions, greenness, economy and wide substrate compatibility, and solves the technical problem that the synthesis conditions of the thioamide derivative are complex and harsh. On one hand, the method is short in reaction period, can be amplified to gram scale, is insensitive to water and air, and is expected to be used for industrial production; on the other hand, the synthesis method is good in selectivity, can be efficiently used for modification of medicine molecules, and has a good application prospect in the field of medicine.

The present invention relates to the technical field of organic synthesis, and in particular to a method for synthesizing dithiocarbamate derivatives. The method comprises the following steps: mixing a compound represented by Formula I, an alcohol reagent, carbon disulfide, and a compound represented by Formula II to obtain a mixture; and reacting the resulting mixture at a temperature of 20 to 30°C for 5 hours to obtain the dithiocarbamate derivative. The method for synthesizing the dithiocarbamate derivative does not require an oxidant or a metal catalyst, can react at room temperature, is environmentally friendly, has high reaction tolerance, and provides a good yield.

The invention discloses a preparation method of a trifluoromethyl substituted chroman-4-one compound, and relates to the technical field of organic matter synthesis. According to the method, a Togni's reagent is used as a trifluoromethyl source, various 2-allyloxy benzaldehyde compounds are used as substrates, and a nonmetal photosensitizer is used, so that synthesis of various trifluoromethyl substituted chroman-4-ones and derivatives thereof is realized. By optimizing the synergistic effect of the photosensitizer and the light source, substrate limitation is broken through, the reaction stability is improved, and the problems that in the prior art, substrate applicability is limited, light source dependency is high, and the substrate yield is unstable are solved.

This invention discloses a zinc carbonyl reagent, its preparation method, and its application. The general structural formula of the zinc carbonyl reagent is: where R... 1 R 2 The reagent is independently selected from chain alkyl, cyclic alkyl, substituted alkyl, aryl, or benzyl groups. This invention synthesizes and prepares a zinc carbonyl reagent, which is then applied to the synthesis of urea and thiocarbamate drugs. This provides a new reaction pathway for drug molecule synthesis, and is safe, reliable, and non-toxic. It solves the problem that the synthesis of urea and thiocarbamate drugs in existing technologies requires the use of toxic carbon monoxide, phosgene, and its derivative triphosgene, resulting in a high risk factor in the synthesis process. The synthesis method of this invention uses simple raw materials, has mild reaction conditions, and the synthesized zinc carbonyl reagent can be directly used in the reaction as a solid, making the operation simple.

An electrochemical reaction apparatus 10 comprises: a cathode 11 that comprises a first catalyst 16 that reduces carbon dioxide to carbon monoxide; an anode 12; an electrolytic solution 13 that contains a reactant and an electrolyte; and a second catalyst 17 that synthesizes an oxygen-containing organic material from the carbon monoxide and the reactant, in which the electrolytic solution 13 has a convection flow, and the direction of the convection flow F is formed so that the electrolytic solution comes into contact with the first catalyst 16 and the second catalyst 17 in this order.

A composition comprising a C2-C12 polyalphaolefin and a functionalized propylene-based elastomer comprising from about 4 to about 25 wt % units derived from one or more C2 or C4-C12 alpha-olefins; a triad tacticity greater than about 90%; a heat of fusion less than about 75 J / g; and a plurality of oxygen containing functional groups selected from carboxylic acids, anhydrides, ketones, carbonates, esters, ethers, lactones, and combinations thereof. Compositions containing the functionalized propylene-based elastomer and methods to produce the same are also disclosed.

A method for producing an α-acyloxycarboxylic acid ester of Formula (1) is described. The method involves reacting an α-hydroxycarboxylic acid ester compound with an acylating agent in the presence of a catalyst comprising an iron halide compound. R1 represents a hydrogen atom, a methyl group, an ethyl group, an n-propyl group, an isopropyl group, or a tert-butyl group, R2 and R3 each independently represent a methyl group or an ethyl group, and R4 represents a linear, branched, or cyclic alkyl group having from 1 to 6 carbon atoms.

The invention discloses a method for mechanically driving stainless steel to induce S-H bond activation to construct disulphide in the field of mechanochemistry, and particularly relates to a method for constructing disulphide through mechanical ball-milling high-energy activation in a mechanical driving mode by taking phenylmercaptan as a substrate and a grinding material as a catalyst. The synthesis method effectively avoids the use of a noble metal catalyst, a ligand, a toxic or flammable organic solvent, an exogenous oxidant, an auxiliary additive, light energy and electric energy, does not need to prepare a catalyst, greatly reduces the cost, simplifies the operation steps, and is suitable for industrial production. A series of disulfides containing different substituent groups can be obtained at the yield of 41-100% under mild conditions, and a target product can still be obtained at the yield of 91.4% after the concentration of a substrate is amplified to 40 mmol, so that more possibilities are provided for industrial application of the disulfides. The synthesis method provided by the invention provides a novel, simple, efficient and green way for synthesizing the symmetric disulfide.

The invention relates to the technical field of organic synthetic chemistry, in particular to a selenylation preparation method of aniline and an indole compound, which comprises the following steps: A1, reacting the indole compound or the aniline compound with potassium selenide and N-chloro-N-fluorobenzenesulfonamide in an organic solvent at the temperature of 0 DEG C to room temperature; and A2, after the reaction is finished, carrying out extraction, concentration and column chromatography purification to obtain the selenium cyanate indole or aniline derivative, wherein the reaction operation comprises the following steps: dissolving the indole or aniline compound and KSeCN in an organic solvent, slowly dropwise adding CFBSA while stirring at the temperature of 0 DEG C, heating to room temperature after dropwise adding, and continuously stirring for reaction. According to the method, the CFBSA reagent is taken as an oxidizing agent, relatively cheap potassium selenide is taken as a selenium cyano group source, selenylation of aniline, indole and part of aromatic rings is realized at room temperature under a mild oxidation condition, and corresponding products are obtained at medium to excellent yield.