78results about "Functional group formation/introduction" patented technology

The invention provides a method 100 for separating different polymeric spectacle lens materials in a mixture comprising at least two different polymeric spectacle lens materials by separating at least one polymeric spectacle lens material of the at least two different polymeric spectacle lens materials by using their different physical behavior and / or chemical behavior, wherein the at least two different polymeric spectacle lens materials are selected from the group consisting of polyallyl carbonate, polyurea, polyurethane, polyurethane / polyurea, polycarbonate, polyepisulfide and polythiourethane. The invention further provides a method for separating at least one polythiourethane from a mixture comprising at least two different polythiourethanes by thiolysis.

The invention belongs to the technical field of organic synthesis, and particularly relates to an alkyl pentafluorosulfenyl compound and a preparation method and application thereof.The preparation method comprises the following steps that in the protective gas atmosphere, in a solvent, SF5Cl serves as a pentafluorosulfenyl source, an olefin compound serves as a reaction substrate and a free radical trapping agent, a thiol compound serves as a hydrogen source, and the alkyl pentafluorosulfenyl compound is obtained through a one-step reaction; under the action of an olefin additive, the alkyl pentafluorothio compound is constructed by a one-step method through a visible light-induced free radical process, and the olefin additive is used for inhibiting generation of a pentafluorothio chloride byproduct from a pentafluorothio source and an olefin compound. According to the method disclosed by the invention, a series of alkyl pentafluorosulfenyl compounds can be prepared by only needing olefin double bonds in substrates and selecting more substrates through the reaction, the reaction is simple, the reaction condition is mild, the reaction can be completed under visible light, the reaction time is short, the implementation is easy, and the method is suitable for industrial production. And a method support is provided for further screening the alkyl pentafluorosulfenyl compound with excellent biological activity.

The invention discloses a method for synthesizing a sulfur-containing compound by using an amino sulfur trifluoride compound, which comprises the following two steps: S1, by taking the amino sulfur trifluoride compound and a compound A as reactants, stirring and reacting for 8-15 minutes or 10-15 hours at normal temperature in an organic solvent under an alkaline condition; the compound A is any one of an amide compound or a sulfanilamide compound, or water; and S2, adding a nucleophilic reagent into the solution after the reaction in the step S1, stirring at normal temperature to react for 8-15 minutes or 5-8 hours, and then purifying through a rapid chromatography to obtain a final product, namely, all-heteroatom substituted thioimine or all-heteroatom substituted sulfoxide, the nucleophilic reagent is an alcohol or an amine. According to the method disclosed by the invention, the amido sulfur trifluoride compound is used for synthesizing the asymmetric full heteroatom substituted thioimine and sulfoxide compound for the first time, the reaction steps are simple, the reaction conditions are mild, and expensive reagents are not needed.

The invention relates to a method for producing tetrahydrothiophene comprising the following consecutive steps: a) reaction of 1,4-butanediol in the presence of hydrogen sulfide (H2S), in the gas phase, in the presence of at least one catalyst in order to form a stream (A) comprising tetrahydrothiophene, water, and possibly unreacted hydrogen sulfide; b) condensation of the stream (A) in order to obtain a tetrahydrothiophene-rich stream (B) and gaseous effluents (C) containing the non-condensables possibly formed at the end of step a); c) at least one step of purifying, preferably by settling, the stream (B) with separation of the aqueous phase, of the organic phase constituting the stream (D) and of gaseous effluents (E); d) optionally at least one distillation of the stream (D) in order to isolate the tetrahydrothiophene from gaseous effluents (F); e) recovery of the tetrahydrothiophene isolated in step c) and optionally in step d), it being possible for steps b) and c) to be consecutive or simultaneous; f) gas-liquid extraction by means of a column supplied with one or more gas streams (G) comprising gaseous effluents (C) and / or gaseous effluents (E) and optionally gaseous effluents (F) and with a liquid stream of 1,4-butanediol, in order to form, at the column outlet, a gas stream (H) and an enriched liquid stream (I) comprising 1,4-butanediol; g) recirculation of all or part of stream (I) to reaction a).

The invention relates to an MOFs (Metal-Organic Frameworks) catalyst for oxidative coupling of aromatic amine as well as a preparation method and application of the MOFs catalyst. And the MOFs catalyst is an MOF-808 catalyst. The structure is simple and clear, and the catalyst has good catalytic activity and cycling stability; h2O2 can be effectively activated, and aromatic amine can be efficiently and selectively oxidized, so that the conversion rate of aromatic amine and the selectivity of products can be improved in a method for preparing azoic compounds by catalyzing aromatic amine oxidation.

The invention relates to a method for purifying a thermoplastic material (22), such as polyethylene terephthalate (PET), comprising the steps of: - supplying pellets or shreds of the thermoplastic material into a melt processing device (20); and - melting the thermoplastic material to form a polymer melt; wherein the method further comprises a step of: - adding a pro-degradant into the pellets or shreds of the thermoplastic material, and / or into the polymer melt, to selectively degrade at least polyvinyl chloride (PVC) and benzene impurities, and / or any intermediate degradation product formed by or leading to the formation of such impurities, contained within said thermoplastic material and / or said polymer melt.

The invention provides an aryl alkyl ketoxime derivative as well as a preparation method and application thereof, and relates to the field of aryl oxime derivatives. The preparation method of the aryl alkyl ketoxime derivative comprises the following steps: by taking potassium formate as an additive, carrying out free radical reaction on a compound I and a compound II under ultraviolet irradiation in the presence of tert-butyl nitrite to obtain the aryl alkyl ketoxime derivative, the compound I is substituted iodobenzene or iodopyridine; the compound II is substituted styrene or thienyl ethylene; wherein a hydrogen atom transfer / single electron transfer relay sequence is utilized to activate a compound I, and tert-butyl nitrite is adopted as a bifunctional reagent, and is used as a hydrogen atom transfer reagent and an oxime source. According to the preparation method of the aryl alkyl ketoxime derivative, pre-functionalization is not needed, a reaction substrate is wide in universality and good in compatibility, reaction conditions are mild, operation is easy and convenient, a target product can be efficiently and rapidly prepared on the premise of high yield, and a new way is provided for oxime synthesis.

The invention discloses a multi-component preparation method of an N-sulfonyl fluoride compound, and relates to the field of organic synthesis. The preparation method comprises the following steps: reacting an amine compound with a chlorine source in a solvent to generate an intermediate, then continuously adding a sulfur dioxide source and a fluorine source for reaction, and purifying after one-pot reaction to obtain the N-sulfonyl fluoride compound, the structural general formula of the amine compound is shown in the specification, the structural general formula of the N-sulfonyl fluoride compound is shown in the specification. The reaction general formula is shown in the specification. The method has the advantages of cheap and easily available raw materials, simple operation, mild conditions, safety, environmental protection, short reaction time, good yield and wide substrate range, can be applied to various types of amine substrates, including primary (alkyl / aromatic) amine, secondary (alkyl / aromatic) amine, amide, nitrogen-containing heteroaromatic ring and the like, and has wide application prospects. Wide application prospects are realized in the fields of medicinal chemistry, synthetic chemistry, material science and the like.

The invention relates to ylide-functionalized phosphane ligands, the production of same and use in transition metal compounds, as well as the use of same as catalysts in organic reactions.

Efficient carbonylative synthesis of alkenes to form anhydrides using transition metal catalysts such as palladium-phosphine catalysts.

The present invention provides a thionizing solution having high stability that contains a compound represented by formula (3) as a thionizing agent and a method for producing a nucleic acid molecule by the amidite method using the thionizing solution. The present invention also provides a composition containing an aromatic heterocyclic compound represented by formula (1) [in the formula, X1 to X5 each independently are the same or different and represent a hydrogen atom, etc.], an aromatic hydrocarbon compound represented by formula (2) (in the formula, Y1 to Y6 each independently are the same or different and represent a hydrogen atom, a C1-C5 alkyl group, or a halogen atom.), and a thionizing agent represented by formula (3).

The invention relates to a method for purifying a thermoplastic material (22), such as polyethylene terephthalate (PET), comprising the steps of: - supplying pellets or shreds of the thermoplastic material into a melt processing device (20); and - melting the thermoplastic material to form a polymer melt; wherein the method further comprises a step of: - adding a pro-degradant into the pellets or shreds of the thermoplastic material, and / or into the polymer melt, to selectively degrade at least polyvinyl chloride (PVC) and benzene impurities, and / or any intermediate degradation product formed by or leading to the formation of such impurities, contained within said thermoplastic material and / or said polymer melt.

This invention discloses a method for preparing organic sulfates, comprising the following steps: using persulfate as the sulfate source, and achieving the functional group transformation of a free radical precursor compound through the free radical anion of the sulfate ion, thereby preparing the organic sulfate. This invention uses persulfate as the source and, through a free radical addition mechanism, acts on the free radical precursor substrate. Persulfate, as a sulfate free radical anion, participates in the functional group transformation of the organic compound, resulting in the efficient synthesis of organic sulfates.

The application belongs to the technical field of organic synthesis, and particularly relates to a method for efficiently and greenly preparing allyl ketoxime in one step. The preparation method specifically comprises the following steps: cross-coupling reaction of enol, hydrazine and aldehyde under the action of a palladium catalyst to obtain an allyl ketoxime compound. The reaction raw materials used in the application are cheap and easy to obtain. The allyl ketoxime compound can be efficiently and greenly prepared in one step through the coupling reaction, the synthesis process is simple, and the synthesis cost is greatly reduced. The reaction condition is mild, the yield is high, the substrate applicability range is wide, the reaction conversion efficiency is high, the gram-scale experiment can be realized, and industrialization is easy to realize.

This invention discloses a zinc carbonyl reagent, its preparation method, and its application. The general structural formula of the zinc carbonyl reagent is: where R... 1 R 2 The reagent is independently selected from chain alkyl, cyclic alkyl, substituted alkyl, aryl, or benzyl groups. This invention synthesizes and prepares a zinc carbonyl reagent, which is then applied to the synthesis of urea and thiocarbamate drugs. This provides a new reaction pathway for drug molecule synthesis, and is safe, reliable, and non-toxic. It solves the problem that the synthesis of urea and thiocarbamate drugs in existing technologies requires the use of toxic carbon monoxide, phosgene, and its derivative triphosgene, resulting in a high risk factor in the synthesis process. The synthesis method of this invention uses simple raw materials, has mild reaction conditions, and the synthesized zinc carbonyl reagent can be directly used in the reaction as a solid, making the operation simple.

An electrochemical reaction apparatus 10 comprises: a cathode 11 that comprises a first catalyst 16 that reduces carbon dioxide to carbon monoxide; an anode 12; an electrolytic solution 13 that contains a reactant and an electrolyte; and a second catalyst 17 that synthesizes an oxygen-containing organic material from the carbon monoxide and the reactant, in which the electrolytic solution 13 has a convection flow, and the direction of the convection flow F is formed so that the electrolytic solution comes into contact with the first catalyst 16 and the second catalyst 17 in this order.

A composition comprising a C2-C12 polyalphaolefin and a functionalized propylene-based elastomer comprising from about 4 to about 25 wt % units derived from one or more C2 or C4-C12 alpha-olefins; a triad tacticity greater than about 90%; a heat of fusion less than about 75 J / g; and a plurality of oxygen containing functional groups selected from carboxylic acids, anhydrides, ketones, carbonates, esters, ethers, lactones, and combinations thereof. Compositions containing the functionalized propylene-based elastomer and methods to produce the same are also disclosed.

The invention relates to the technical field of organic synthetic chemistry, in particular to a selenylation preparation method of aniline and an indole compound, which comprises the following steps: A1, reacting the indole compound or the aniline compound with potassium selenide and N-chloro-N-fluorobenzenesulfonamide in an organic solvent at the temperature of 0 DEG C to room temperature; and A2, after the reaction is finished, carrying out extraction, concentration and column chromatography purification to obtain the selenium cyanate indole or aniline derivative, wherein the reaction operation comprises the following steps: dissolving the indole or aniline compound and KSeCN in an organic solvent, slowly dropwise adding CFBSA while stirring at the temperature of 0 DEG C, heating to room temperature after dropwise adding, and continuously stirring for reaction. According to the method, the CFBSA reagent is taken as an oxidizing agent, relatively cheap potassium selenide is taken as a selenium cyano group source, selenylation of aniline, indole and part of aromatic rings is realized at room temperature under a mild oxidation condition, and corresponding products are obtained at medium to excellent yield.

The application belongs to the technical field of diboron compound synthesis, and particularly relates to a synthesis method of 1,3-diboron compound. The method comprises the following steps: taking an olefin compound, pinacol diboron and iodo-methylene boronic acid ester as raw materials, performing an olefin carbon boronation reaction in a reaction system composed of a Cu-based catalyst, sodium ethoxide and a solvent under a protective atmosphere to obtain the 1,3-diboron compound. The application provides a copper-catalyzed olefin boronation strategy, uses iodo-methylene boronic acid ester as an electrophilic reagent, constructs a series of racemic 1,3-diboron compounds through a Cu-catalyzed olefin carbon boronation reaction with an excellent yield, realizes an effective 1,3-diboron compound modular synthesis method, and the reaction has the characteristics of mild reaction condition, wide raw material source, simple reaction process and high yield.

The invention relates to a method for realizing chemical mutation from dehydroalanine to aspartic acid (Asp) through a Michael addition reaction of a photocatalytic dehydroalanine (Dha) compound and a carbon dioxide free radical anion (CO2 <.->) generated by ammonium formate. According to the invention, ammonium formate which is cheap and easy to operate and store is used as a carbon source, so that a noble metal catalyst and traditional carbon sources which are difficult to store and operate, such as carbon dioxide and carbon monoxide, are not used, and the method has the advantages of light regeneration and no pollution; according to the present invention, the method has advantages of mild reaction conditions, general room temperature, good selectivity, wide substrate application range and the like, can achieve the hydrocarboxylation modification of the dehydroalanine (Dha) and the short peptide containing the dehydroalanine (Dah), and can chemically mutate the dehydroalanine (Dha) into the aspartic acid (Asp), such that the green path is provided for the aspartic acid synthesis; the future work can focus on mechanism deepening, stereoselectivity improvement and complex biomolecule application, and is expected to become an important tool for precise modification of protein.

The invention discloses application of oxyalkyl isourea in introduction of methyl and isotope labeling of methyl. The oxygen alkyl isourea comprises two applications: 1, nucleophilic substitution reaction: heating and stirring oxygen alkyl isourea and a nucleophilic reagent under the condition of not adding any exogenous alkali at 50-130 DEG C to react, so as to obtain a methylated or isotope labeled methylated product; and 2, Suzuki-Miyaura coupling reaction: carrying out stirring reaction on oxygen alkyl isourea and aryl boride under the action of a palladium catalyst and alkali at 60-130 DEG C to obtain a methylated or isotope labeled methylated product. The methyl of the oxygen alkyl isourea is derived from a cheap methanol compound, the limitation that exogenous alkali must be used in an existing alkylation reagent is overcome through the nucleophilic substitution reaction, methyl and isotope labeling methyl can be efficiently introduced into medicine molecules, construction of C-O, C-S, C-N and C-C four types of chemical bonds is achieved, and large-scale and industrial application is easy.

The application discloses a synthesis method of a carbamic acid alkyl ester compound, which comprises the following steps: dispersing an alkynyl high-valence iodine compound, a palladium catalyst, an amine, formic acid and a base in a solvent, and then introducing carbon dioxide to perform a reaction, so as to obtain the carbamic acid alkyl ester compound. The synthesis method of the carbamic acid alkyl ester compound has the advantages of cheap and easily obtained raw materials, mild reaction conditions, simple operation, high economy of steps, wide applicable range of substrates, good region selectivity and good functional group tolerance, and is suitable for large-scale industrial application.

The invention discloses a preparation method of a chiral thioimine compound, and belongs to the technical field of visible light catalysis and organic synthesis.The preparation method comprises the steps that a compound containing inert carbon-hydrogen bonds and a sulfenamide compound serve as raw materials, N-[(9R)-6 '-methoxyl cinchonin-9-yl]-8-quinoline sulfonamide serves as a chiral ligand, fluorobenzene serves as a solvent, and the chiral thioimine compound is prepared through a one-step reaction; under the action of a copper salt and an oxidizing agent, the copper salt, a sulfenamide compound and N-[(9R)-6 '-methoxyoctann-9-yl]-8-quinoline sulfonamide form a copper complex under the irradiation of visible light at room temperature in a protective atmosphere, the copper complex enters an excited state under the irradiation of the visible light, and the oxidizing agent is cracked through an energy transfer or single electron transfer process, so that the copper complex is obtained. The free radicals activate inert carbon-hydrogen bonds to generate alkyl free radicals, the alkyl free radicals react with sulfenamide in the copper complex, asymmetric vulcanization of the inert carbon-hydrogen bonds is achieved, and the chiral thioimine compound is obtained.

The invention discloses a pentafluorothio sulfonium salt solid reagent as well as a preparation method and application thereof, the pentafluorothio sulfonium salt solid reagent is obtained by reacting a sulfur reagent as shown in a formula I and a compound as shown in a formula II in a protective atmosphere in the presence of an organic solvent, and can stably exist in air. The pentafluorothio sulfonium salt solid reagent can be used as a pentafluorothio reagent to be used for a bifunctional reaction of an alkene compound and pyrazole or alcohol, the reaction is simple to operate, the defects that an existing pentafluorothio reagent is unstable, toxic, high in inertia and the like are effectively overcome, and the pentafluorothio sulfonium salt solid reagent is good in substrate applicability and high in yield. Different types of pentafluorosulfenyl-containing functional molecules can be constructed, and the pentafluorosulfenyl-containing functional molecules have a good application prospect in the aspects of biological medicines, hydrophobic materials and the like.

The invention relates to ylide-functionalized phosphine ligands, their production and use in transition metal compounds, and their use as catalysts in organic reactions.

The invention discloses a method for preparing a trifluoromethyl pyrazolone compound through visible light induction. According to the method, the trifluoromethyl pyrazolone compound is prepared through a free radical addition / cyclization cascade reaction. Under the irradiation of a visible light source, CF3 free radicals are generated through an electron donor-acceptor (EDA) compound formed by a Togni reagent II and organic alkali, and an external photocatalyst is not needed. According to the method, various N-methacrylhydrazide can be converted into target products, and the yield is good to excellent. The method is simple and convenient to operate and easy to amplify, has high functional group tolerance, and provides a sustainable synthesis path for synthesis of the functionalized heterocyclic compound.

The application discloses a preparation method of an asymmetric ure compound and the asymmetric ure compound. The preparation method of the asymmetric ure compound provided by the application is one-pot reaction of a primary amine compound and a secondary amine compound with carbonyl sulfur (COS) under the condition of no catalyst, and selective synthesis of the asymmetric ure compound by using carbonyl sulfur as a carbonylation reagent. The application utilizes carbonyl sulfur as a kind of active carbonylation reagent, and can efficiently make aromatic primary amine compounds and fatty secondary amine compounds react with normal-pressure carbonyl sulfur to generate the asymmetric ure compound, and has strong industrial application value.

The invention discloses a method for synthesizing oxime under mild conditions and application thereof. The method comprises the following steps: carrying out physical contact combination on an electron donor and a catalyst, then putting the obtained product into a solution containing NOx <-> and a reaction substrate, and carrying out a reaction to obtain oxime, x being 2 or 3. Through the method, high-efficiency conversion from resource micromolecules to oxime is realized under the condition that external energy input is not needed.