29 results about "Enol" patented technology

This invention belongs to the field of organic synthesis and discloses a method for preparing α-difluoroselenomethyl ketone derivatives using electrochemistry. The method involves preparing α-difluoroselenomethyl ketone derivatives under electrochemical conditions using 2,2-difluorovinyl alcohol trimethylsilyl ether compounds and dialkyl diselenoether. Specifically, the 2,2-difluorovinyl alcohol trimethylsilyl ether compound and the dialkyl diselenoether compound are dissolved in an organic solvent, mixed thoroughly, an electrolyte is added, an inert electrode is inserted, and the reaction is carried out under electrostatic stirring at room temperature to obtain the product α-difluoro(selenomethyl) ketone derivative. This invention eliminates the need for catalysts, bases, persulfates, persulfates, or iodobenzene acetates considered necessary in the prior art; it only requires electrolysis to obtain α-difluoroselenomethyl ketone derivatives in a mild and efficient manner.

The application provides a flexible water-stable coordination confined material as well as a preparation method and application thereof, and belongs to the technical field of metal organic coordination polymers. The flexible water-stable coordination confined material is obtained through a coordination reaction of metal ions and oxygen-based organic ligands; wherein the metal ions are selected from any one of V 4+ , Zr 4+ , Cu 2+ , Ti 4+ , Al 3+ , Cr 3+ , Fe 3+ ; and the oxygen-based organic ligands are selected from any one of nitrogen heterocyclic phosphonic acid organic ligands, alkyl phosphonic acid organic ligands, sugar organic ligands, phenolic hydroxyl organic ligands, alcoholic hydroxyl organic ligands, nitrogen heterocyclic hydroxyl organic ligands and enolic organic ligands.

The present application relates to a kind of targeting bacterial UDP-N-acetylglucosamine enolpyruvate transaminase antibacterial compound and its application, the antibacterial compound is S-(4-chlorobenzyl) chloro isothiourea, its chemical structure is as shown in formula I: I;Or its pharmaceutically acceptable salt, stereoisomer, solvate, crystal form, isotopically labeled or prodrug.The antibacterial compound of the present application can effectively inhibit the growth of klebsiella pneumoniae, including carbapenem-resistant klebsiella pneumoniae and high virulence klebsiella pneumoniae;It also has good bacteriostatic effect on escherichia coli and pseudomonas aeruginosa;It is expected to be applied to the clinical treatment of infection caused by drug-resistant klebsiella pneumoniae and high virulence klebsiella pneumoniae and other pathogenic bacteria, and has important clinical significance and social benefits.

The application discloses a synthesis method of 7-dehydrocholesterol and 25-hydroxy-7-dehydrocholesterol, which comprises the following steps: taking cholesterols as raw materials, and synthesizing the 7-dehydrocholesterol through oxidation, enol esterification and reduction reaction; or taking 25-hydroxycholesterols as raw materials, and synthesizing the 25-hydroxy-7-dehydrocholesterol through oxidation, enol esterification, reduction and hydrolysis reaction. The synthesis route is short, the yield is high, the industrial production is facilitated, and the method has a wide application prospect.

This invention relates to a method for solution copolymerization to obtain hydroxyl-functionalized polyolefins, comprising at least the following steps: a) a contacting step for obtaining a mixture of oligomeric dialkyl aluminum alkoxides, wherein the alkoxide anion is a mixture of enol anions and alkanolate anions; b) a polymerization step of at least one olefin monomer with at least the mixture obtained in step a); and c) a deprotection step, wherein the product obtained in step b) is treated with an aliphatic alcohol and / or water and / or Brønsted acid or alkaline solution to obtain the hydroxyl-functionalized polyolefin.

The present invention relates to a method of converting 3-keto-DON into 3-epi-DON, reducing the content of DON in a composition comprising DON or of reducing the toxicity of a composition comprising DON as well as a method for converting a trichothecene comprising a 3-oxo group into a trichothecene comprising a 3-hydroxy group using one or more polypeptide(s) comprising or consisting of SEQ ID NO. 1 or a sequence having a sequence identity of at least 72.0% to SEQ ID NO. 1. Also envisioned are feed or food additives or feed or food as well as pharmaceutical compositions comprising one or more polypeptide(s) comprising or consisting of a sequence of SEQ ID NO. 1 or a sequence having a sequence identity of at least 72.0% to SEQ ID NO. 1 as well as the manufacture thereof. Encompassed are further polypeptide(s) comprising or consisting of a sequence of SEQ ID NO. 1 or a sequence having a sequence identity of at least 88.5% to SEQ ID NO. 1. Also envisioned are host cells or plants.

The application discloses a preparation method of long-chain alkyl green silane coupling agent, comprising the following steps: step one, 10-undecene-1-ol is reacted with chlorosulfoxide under the conditions of low-temperature dropwise adding and medium-temperature preservation, and 11-chloro-1-undecene is obtained through vacuum rectification purification; step two, under the action of a platinum catalyst, 11-chloro-1-undecene is subjected to addition reaction with trichlorosilane, excessive raw materials are removed, and 11-chloro undecyl trichlorosilane is obtained through rectification; step three, 11-chloro undecyl trichlorosilane is subjected to alkoxylation reaction with biological methanol or biological ethanol, by-products and excessive biological alcohol are removed, and high-purity long-chain alkyl green silane coupling agent is obtained through rectification. The carbon sources of raw materials are all biological, the method is green and low-carbon, the product has a long-chain structure, and the product has flexibility, fatigue resistance and aging resistance, and can be further derived into functional silane such as amino, mercapto and thiocyanogen; the long-chain alkyl green silane coupling agent can be widely applied to high-end flexible composite materials such as flexible electronics and robot joints, and effectively improves the service life and safety of the materials.

This invention discloses a palladium-based catalyst for the semi-hydrogenation of alkynols to enols and its preparation method. Specifically, a metal salt is added to deionized water and ultrasonically dispersed to obtain a uniformly dispersed metal salt solution. A support powder is uniformly spread on a polytetrafluoroethylene plate. The metal salt solution is loaded into a syringe pump and slowly added dropwise onto the support. The solution is allowed to stand and age to obtain a wet support. The wet support is transferred to an oven for calcination. The calcined sample is transferred to a tube furnace for reduction to obtain the palladium-based catalyst. The palladium-based catalyst of this invention can be applied to the selective hydrogenation reaction of alkynols. By controlling the impregnation rate, the active precursor solution is ensured to be absorbed instantaneously and completely, and the enrichment of the active component at the edges is effectively suppressed. High-temperature reduction achieves partial encapsulation of palladium nanoparticles with indium oxide, thereby altering their electronic structure and improving the selectivity for the semi-hydrogenation of alkynols to enols.

The present invention relates to a process for preparing (Z)-7-tetradecen-2-one of the following formula (5), the process comprising the steps of converting a (Z)-1-halo-4-undecene compound (1) of the following general formula (1), wherein X1 represents a halogen atom, into a nucleophilic reagent, (Z)-4-undecenyl compound, of the following general formula (2), wherein M1 represents Li or MgZ1, and Z1 represents a halogen atom or a (4Z)-4-undecenyl group, subjecting the nucleophilic reagent, (Z)-4-undecenyl compound (2), to an addition reaction with propylene oxide of the following formula (3) to obtain (Z)-7-tetradecen-2-ol of the following formula (4) and oxidizing (Z)-7-tetradecen-2-ol (4) thus obtained to form (Z)-7-tetradecen-2-one (5).

The present application provides a hydroxyl functionalized phenyl silicone oil and a preparation method thereof, a low-density foamed silicone rubber and a preparation method thereof, and an electronic instrument. The hydroxyl functionalized phenyl silicone oil comprises -(CH2) a OH groups, the preparation method comprising: condensation reaction of an enol compound with a silazane to obtain a compound X; addition reaction of the compound X with a double-end hydrogen-containing phenyl silicone oil to obtain a compound Y; alcoholysis reaction of the compound Y with an alcohol substance to obtain the hydroxyl functionalized phenyl silicone oil. The present application also provides a low-density foamed silicone rubber, the raw material of which comprises the above hydroxyl functionalized phenyl silicone oil and is prepared by using a two-component preparation method. The present application improves the surface tension and reaction speed of the foamed silicone rubber system by using the hydroxyl functionalized phenyl silicone oil, and thus a uniform and fine low-density high-foaming ratio foam can be formed.

The application relates to the technical field of polyolefins, and discloses a coordination precipitation polymerization method for olefin polymerization and a polyolefin, the method comprising mixing olefin monomers, a catalyst and an additive, and performing a polymerization reaction; the olefin monomers contain nonpolar monomers and polar monomers; the nonpolar monomers are selected from one or more than two of ethylene, alpha-olefins and internal olefins; the polar monomers are selected from one or more than two of enol, unsaturated carboxylic acids and unsaturated carboxylic acid esters; and the catalyst is selected from a single-metallocene pre-transition metal complex shown in formula (I). The application can eliminate the catalyst loading process, realize olefin homogeneous catalyst polymerization self-forming, and prepare polyolefins with good particle morphology.

The present application belongs to the field of organic chemical synthesis, and particularly relates to a thiepany spiroindolone compound and a synthesis method thereof. The present application takes MBH ester derived from oxidized indole and alpha-alkenol dithioester as starting materials, and prepares the target compound through a two-step one-pot reaction at room temperature in a specific base and solvent system. The synthesis strategy is novel, the reaction condition is mild, the operation is simple, efficient, and easy to operate, the raw materials and solvents are easy to obtain and controllable in cost, the reaction selectivity is high, the product yield is considerable, the substrate application range is wide, and the functional group tolerance is strong. The target product has clear in-vitro anti-tumor activity, definite application prospect, and outstanding industrialization potential, provides a new scheme for the preparation of thiepany spiroindolone compounds, and has strong popularization value.

This invention relates to the field of glucose preparation technology and relates to an unsaturated glucosamine with retained amino groups, its preparation method, and its applications. It solves the problems of low polymer drug loading, severe drug burst release, and poor biocompatibility caused by the blocking of amino groups in existing polymerizable monomers of glucosamine, as well as the cumbersome, low-yield, and poor-purity problems of existing methods for retaining amino groups. The preparation method includes: adding acetyl chloride to 3-buten-1-ol, stirring evenly at 0-5°C, then adding D-glucosamine hydrochloride in batches, heating to 60-80°C, and reacting for 2-4 hours. After the reaction is complete, post-treatment is performed to obtain an intermediate compound; dissolving the intermediate compound in deionized water, adding barium hydroxide hydrate, heating to 90-110°C, and stirring for 12-20 hours, after which post-treatment is performed to obtain unsaturated glucosamine with retained free amino groups. This invention can be applied to the preparation of drug carriers and has broad application prospects in the biomedical field.

The application discloses a preparation method and product of 1-octene-3-ol gas-sensitive material and application thereof, and improves the response of ternary metal oxide to 1-octene-3-ol through rare earth element doping. The preparation method comprises the following steps: taking a mixed solution of isopropyl alcohol and glycerol as a solvent, taking cadmium nitrate tetrahydrate and hydrated indium nitrate as cadmium sources and indium sources, and taking appropriate nitrate erbia hexahydrate to realize rare earth element Er doping; after water bath assisted dissolution, the mixed solution is transferred into a stainless steel high-pressure reaction kettle for sealing reaction; after the reaction is completed, the precursor material is obtained through washing and drying, and the gas-sensitive material is obtained through calcination. The gas-sensitive material prepared by the application has good response sensitivity to 1-octene-3-ol, and the electron mobility is further improved through rare earth element doping, so that the detection accuracy of the material under low VOC concentration is improved. The preparation method is simple and practical, and can be used for monitoring the aging phenomenon in the storage process of rice, so as to provide protection for food safety and fair trade of grain.

The present application relates to the technical field of asiatic acid, and particularly relates to an asiatic acid derivative and a preparation method. The asiatic acid derivative provided by the present application has R which is an alkyl group formed by removing a hydroxyl group from a saturated or unsaturated monohydric alcohol, and the saturated or unsaturated monohydric alcohol includes one of ethanol, octanol, hexadecanol, stearyl alcohol, 2-hexyl-1-decanol, decyltetradecin, oleyl alcohol, cis,cis-9,12-octadecadienol and bisabolol. The asiatic acid derivative of the present application has higher water solubility and oil solubility, especially oil solubility, so that the asiatic acid derivative has obviously enhanced liposolubility, is easily soluble in natural oil, alkane and other ester solvents, and has a significant inhibitory effect on EDNRA and TRPV1 and obviously enhanced bioactivity. The asiatic acid derivative of the present application has high availability, and the asiatic acid derivative has no safety risk.

This invention discloses a method for preparing benzyl 3-methyl-5-oxopiperidin-1-carboxylic acid ester and its intermediates. The method uses ethyl acetoacetate as a starting material, proceeding through trifluoromethanesulfonation to generate an enol trifluoromethanesulfonate intermediate, palladium-catalyzed cyanation, catalytic hydrogenation, reduction-cyclization transformation under a borohydride / transition metal salt system, nitrogen carbonyl protection, and sulfonium ylide-mediated transformation to obtain the intermediate. The intermediate is further rearranged / cyclized to obtain the target compound. Compared with existing routes, this invention avoids the use of malodorous / high-risk thiol reagents and highly corrosive acids, thus enabling the preparation of the target compound.

The present application relates to a photosensitive compound for G / I line photoresist, which is composed of polycarbonyl enol compound and diazonaphthoquinone sulfonyl group. The present application also provides a synthesis method of the photosensitive compound, by which a diazonaphthoquinone sulfonate photosensitive compound with excellent performance can be prepared, and the component ratio of the photosensitive compound can be adjusted arbitrarily. The present application also provides the application of the photosensitive compound in photoresist configuration, and the configured photoresist has good performance.

The application discloses a kind of metal modified covalent organic framework composite catalytic materials and preparation method thereof, the method is first prepared by solvent thermal method through Schiff base condensation reaction and enol-keto tautomerism β-ketoenamine type DAAQ-TP-COF;With β-ketoenamine type DAAQ-TP-COF and soluble copper salt as raw material, with aliphatic alcohol as solvent, copper ion functionalization Cu-DAAQ-TP-COF catalytic material is prepared by post-modification method.The preparation process of the application is simple, the production cost is low, the obtained Cu-DAAQ-TP-COF catalytic material has the advantages of structural stability, large specific surface area, strong visible light response ability, high carrier separation efficiency and rich catalytic active site.

The application discloses an environmentally-friendly anti-interference marine cable and a preparation method thereof, and relates to the technical field of power cables. The aldehyde group of 4-mercapto benzaldehyde is subjected to condensation reaction with the amino group of 2-isopropenyl aniline to generate an unsaturated antioxidant monomer; the carboxyl group of 3-(3,5-di-tert-butyl-4-hydroxyphenyl) propionic acid is subjected to esterification reaction with the hydroxyl group of 9-octadecene-1-ol to generate a hydrophobic modified hindered phenol monomer; then, the mercapto group of the unsaturated antioxidant monomer is subjected to click reaction with the double bond of the hydrophobic modified hindered phenol monomer to generate an antioxidant stabilizer, so that the synergistic antioxidant effect is achieved, and the hydrophobic structure makes the surface of the insulating layer hydrophobic, so that the performance decline caused by the penetration of seawater salt mist during use is prevented; finally, the antioxidant stabilizer, a crosslinking agent, a flame retardant, polyethylene and a heat-conducting filler are combined to melt and extrude an insulating layer composite conductor, a filling layer, a shielding layer and a protective layer to prepare the cable, so that the high insulation and anti-interference effects are achieved.

This invention relates to the field of olefin polymerization and discloses an ethylene-enol copolymer and its preparation method. The preparation method of the ethylene-enol copolymer provided by this invention includes: using a catalyst composition to copolymerize ethylene and an enol, wherein the catalyst composition includes a) a monometallic compound and b) a cocatalyst component. According to the preparation method of the ethylene-enol copolymer of this invention, it exhibits excellent copolymerization catalytic activity and good copolymerization performance even at high temperatures, and has a high comonomer content, resulting in a high molecular weight ethylene-enol copolymer.

The embodiment of the invention provides a nickel plating solution and a surface treatment method of an aluminum-based material. The nickel plating solution comprises soluble nickel salt, a complexing agent, a styrene polymer and ammonia water. The complexing agent comprises a compound as shown in a formula (I), and in the formula (I), X is an ether bond-containing alkyl chain, a phenyl-containing alkyl chain or a polyenol chain; r1 and R2 are respectively and independently selected from hydrogen, substituted or non-substituted alkyl, substituted or non-substituted cycloalkyl, substituted or non-substituted alkenyl, substituted or non-substituted alkynyl, substituted or non-substituted ester, substituted or non-substituted aryl, substituted or non-substituted heteroaryl or substituted or non-substituted alicyclic group, and R1 and R2 are independently selected from hydrogen, substituted or non-substituted alkyl, substituted or non-substituted cycloalkyl, substituted or non-substituted alkenyl, substituted or non-substituted alkynyl, substituted or non-substituted ester, substituted or non-substituted aryl, substituted or non-substituted heteroaryl or substituted or non-substituted alicyclic group; r1 and R2 are not heteroaryl containing sulfur atoms at the same time. The nickel plating solution is high in stability, does not need to add a reducing agent additionally, can be used for surface treatment of the aluminum-based material, enables the surface of the aluminum-based material to form a nickel film layer which is single in component, flat and uniform at room temperature, and further facilitates proceeding of a subsequent plating process.

The application relates to the technical field of film materials, and particularly provides a high-barrier high-residual anti-adhesion film and a preparation method and application thereof. The high-barrier high-residual anti-adhesion film comprises a seven-layer co-extrusion film structure, and from top to bottom, the seven-layer co-extrusion film structure comprises A and B layers mainly composed of polypropylene and polyolefin, a C layer mainly composed of an olefin-olefin alcohol copolymer, a D layer mainly composed of nylon, an E layer mainly composed of polypropylene and polyolefin, and F and G layers mainly composed of polypropylene, polyolefin and color masterbatch; and the other side of the A layer of the anti-adhesion film is further coated with a silicon oil layer. By optimizing the component types and the use amount of each layer structure of the anti-adhesion film, the anti-adhesion film has excellent barrier properties, high-temperature resistance and very low silicon transfer amount; when the anti-adhesion film is used as a release film or a face film of a waterproof roll material, the anti-adhesion film can prevent the yellowing problem of the waterproof roll material modified bitumen glue after storage and packaging, and can keep the adhesion of the waterproof modified bitumen glue, thereby prolonging the storage period of the roll material to 1 year, and the product appearance is more flat, and there is no wrinkling or deformation phenomenon.

The application discloses a kind of high-efficiency defoaming agent and its preparation method and application, it is related to fine chemical technology field.The high-efficiency defoaming agent contains higher alcohol, the carbon number of above-mentioned higher alcohol is 31~45;And, modified organosilicon, above-mentioned modified organosilicon is prepared by chemical modification to low hydrogen-containing silicone oil by silane addition reaction to cypressene alcohol;The conversion rate of above-mentioned silane addition reaction is >93.5%.The high-efficiency defoaming agent provided by the application has better defoaming and bubble inhibition capacity, and the defoaming, bubble inhibition active effect time is longer, and the defoaming agent stability is higher, while more obvious inhibition wastewater aerobic activated sludge tank's foaming trend, with wide application range.

The present application relates to a kind of heat-insulating materials and its application in intermediate synthesis finished product crystallization reactor, belong to heat-insulating material technical field;The present application is obtained 4-chloro-1-butene-3-al by the ring opening of ethylene oxide with dilute hydrochloric acid, then with p-toluenesulfonyl chloride to obtain sulfonate derivative, then with magnesium scrap to generate grignard reagent, then with tetraethyl orthosilicate to obtain sulfonate silane;Then sulfonate silane and sodium azide carry out azide reaction to obtain azidosilane, and azidosilane and triphenylphosphine are reacted to obtain amino co precursor;Amino co precursor is mixed with tetraethyl orthosilicate, anhydrous ethanol and deionized water, and hydrophobic aminosilica aerogel is prepared by aging and drying;Finally, with polyether polyol as base material, add hydrophobic aminosilica aerogel, then with diphenylmethane diisocyanate to obtain heat-insulating material.

This invention provides a coffee flavoring and its preparation method, comprising 0.1 parts of furanone, 2-acetylpyrazine, vanillin, ethanol, 3-methylthiopropional, 2-methoxy-4-vinylphenol, 2-ethyl-3-methylpyrazine, 2-ethyl-3,5-dimethylpyrazine, furfuryl mercaptan, β-damascone, p-cresol, hexanoic acid, 2-methylbutyric acid, 2,3-pentanedione, methyl furfuryl disulfide, 3-mercapto-3-methylbutyl formate, terpineol, 1-octen-3-ol, isobutyraldehyde, furfural, 5-methylfurfural, isovaleraldehyde, linalool, 2-methoxy-3-isobutylpyrazine, phenylacetaldehyde, eugenol, 2,3,5-trimethylpyridinium, guaiacol, 4-ethylguaiacol, an amino acid composition, glycerol, water, and coffee extract. The coffee flavoring of this invention has a strong three-dimensional aroma, rich layers, and high overall aroma realism and harmony.

This invention belongs to the field of biopharmaceutical carrier materials, specifically relating to a preparation process and composition of a medium-chain triglyceride composition. The composition comprises basic medium-chain and medium-to-long-chain triglycerides, two types of inorganic modified silica, an interface stabilizer, an antioxidant, and a flow modifier. The core of the process involves first preparing two types of modified silica: one is the grafting of ethylenediaminetetraacetic acid (EDTA) onto the surface of mesoporous silica via silanization and subsequent amidation; the other is the hydrolysis of glycidyl etheroxypropyltrimethoxysilane under acetic acid catalysis, followed by a ring-opening reaction with decenol, while the silane portion condenses with the surface of fumed silica. Finally, the two modified materials are mixed with lipids and other components, and the final product is obtained through dispersion and grinding processes. This invention significantly improves the physical stability and functional applicability of the composition by introducing inorganic modified components with specific structures, making it suitable for the food, pharmaceutical, or cosmetic fields.

The application discloses a biosynthesis gene cluster of marine fungus pyrenophorol compounds and application thereof. The nucleotide sequence of the biosynthesis gene cluster is shown in the 1-18549th of SEQ ID NO. 1, and the biosynthesis gene cluster comprises six genes, i.e. a gene responsible for synthesis of a pyl skeleton structure, namely pylA and pylB; a gene responsible for hydroxylation of carbon 4 and 4' in the pyl, namely pylC; a gene responsible for ketone-enol tautomerism, namely pylE; a gene responsible for reduction of ketone groups at carbon 4 and 4' into hydroxyl groups, namely pylD; and a gene responsible for compound efflux, namely pylF. All the gene information related to pyl biosynthesis provided by the application can help understand the biosynthesis mechanism of the sixteen-membered ring dilactone family natural products, and provide materials and knowledge for further structural modification of the compounds.

This invention provides a method for synthesizing aliphatic olefin metathesis products with high Z-isomer purity from olefin starting materials with low Z-isomer purity. [Solution] This method includes contacting an internal olefin with an olefin metathesis reaction partner, such as an acylated alkenol or alkenal acetal, in the presence of a Z-selective metathesis catalyst to form an aliphatic olefin metathesis product. In various embodiments, the aliphatic olefin metathesis product is an insect pheromone. Pheromone compositions and methods of use thereof are also described.

The application relates to the field of organic synthesis, in particular to a preparation method and application of a tetrahydrofuran ring styrene compound. The method comprises the following steps: under the condition of a first solvent, an alpha-aryl-2-methyl butene alcohol compound is contacted with an optional cyclization reagent to react; the tetrahydrofuran ring styrene compound has a structure as shown in formula (1); in formula (1), R1 is selected from hydrogen, a saturated alkane, a saturated alkoxy, a cyclic hydrocarbon and an aromatic hydrocarbon; and R2 is selected from hydrogen, a saturated alkane, a saturated alkoxy, a cyclic hydrocarbon and an aromatic hydrocarbon. The tetrahydrofuran ring styrene compound prepared by the method has the advantages of simple flow and high synthesis efficiency.