272 results about "Enol" patented technology

The invention relates to the technical field of pigment synthesis, and particularly discloses a synthetic method of ornamental blue. According to the synthetic method, 5-hydroxy-3-iminopyridine-2, 6-diketone is adopted as a raw material, enol interconversion is performed on the raw material under the alkaline condition (under the action of an alkali catalyst), heating is performed, and chemical condensation reaction is performed to obtain the ornamental blue. The synthetic method of the ornamental blue provided by the invention is simple in process and high in reaction selectivity, the yield and purity of the product are high, the yield of the ornamental blue product is more than or equal to 80%, the purity of the ornamental blue product is more than 99%, the synthetic method has obvious advantages, no potential safety hazard exists in the process, and industrial production can be realized.

The invention belongs to the field of flexible piezoelectric polymer materials, and discloses a polyvinylidene fluoride based ferroelectric polymer and a preparation method thereof. The preparation method comprises the following steps: (1) adding an inorganic alkaline reagent into a polyvinylidene fluoride-trifluoroethylene ferroelectric polymer solution, carrying out dehydrofluorination and nucleophilic addition-elimination reaction to generate a polymer with an enol structure, and then washing, precipitating and purifying a reaction product; and (2) re-dissolving by using an organic solvent, then forming a film by using a tape casting method, and carrying out ketone-enol tautomerization reaction in the film forming process of the tape casting method to finally prepare the polyvinylidene fluoride based ferroelectric polymer film. According to the effective modification and preparation method disclosed by the invention, an enol structure is promoted to be converted into a more stable ketone structure through a ketone-enol tautomerization reaction by utilizing a high-temperature environment in a film forming process, so that C = O double bonds are introduced into a polymer chain, and the piezoelectric property of the polymer is remarkably enhanced.

The invention relates to a synthesis method of a diunsaturated ester compound catalyzed by N-heterocyclic carbene, and belongs to the field of organic synthesis. According to the preparation method, the synergistic effect of N-heterocyclic carbene and light is utilized, gamma-oxo unsaturated aldehyde and Katritzky salt are taken as starting raw materials, the Katritzky salt generates alpha-ester free radicals through a single electron transfer process under the illumination condition, the free radicals react with a nucleophilic trienol intermediate generated through catalysis of the N-heterocyclic carbene, and the alpha-ester free radicals react with the nucleophilic trienol intermediate to generate the gamma-oxo unsaturated aldehyde. Target products are obtained with good yield and high regioselectivity, so that a series of epsilon-alkylated diunsaturated ester compounds are efficiently synthesized. The method is simple and convenient to operate, green and efficient, has the advantages of no transition metal participation, wide substrate applicability and the like, provides a new way for synthesis of the diunsaturated ester compound, and has a wide application prospect.

The invention provides a 2-succinyl-5-enol acetonyl-6-hydroxy-3-cyclohexene-1-carboxylic acid (SEPHCHC) synthase mutant, which is characterized in that on the basis of a bacillus subtilis SEPHCHC synthase gene MenD, 12 SEPHCHC synthase mutants are obtained by virtue of a site-specific mutagenesis PCR (Polymerase Chain Reaction) technology, and the SEPHCHC synthase gene MenD is used as a base. Recombinant bacteria of bacillus subtilis or bacillus natto or bacillus licheniformis or bacillus amyloliquefaciens for expressing the mutant are respectively constructed, and the yield of heptaene menadione fermented by the recombinant bacteria is 74%-203% of the yield of heptaene menadione fermented by the recombinant bacteria of bacillus subtilis for expressing wild type SEPHCHC synthase MenD.

The invention discloses a hyperbranched polyether branching agent with an adjustable structure and a preparation method and application thereof.According to the branching agent, 3-butene-1-alcohol serves as an initiator, a hyperbranched skeleton is constructed through anion ring-opening polymerization reaction and diglycidyl ether, then esterification and end capping are conducted through anhydride, and the hyperbranched polyether branching agent with the adjustable structure is obtained. The tail end of the hyperbranched polyether contains vinyl double bonds, and the ester group structure of the hyperbranched polyether can be regulated and controlled. Different diepoxy compounds are selected to control a main chain structure, and different anhydrides are used for regulating and controlling the chemical composition of branched chains, so that accurate design of molecular weight, polarity and number of functional groups of the branching agent is realized. The branching agent has excellent dissolvability in common organic solvents, and solves the problem of poor dissolvability of the traditional polydiene branching agent. When the star-shaped branched butyl rubber is applied to the synthesis of star-shaped branched butyl rubber, the distribution and number of branched points can be accurately regulated and controlled, the weight-average molecular weight and molecular weight distribution index of the rubber are remarkably improved, and the side reaction of gel is avoided.

The application provides a catalyst for preparing an enol from an alkyne alcohol, a preparation method and a method for preparing the enol by using the catalyst. By precisely controlling the particle size, specific surface area and added toxicant of the Lindlar catalyst, the catalytic efficiency can be significantly improved, and the catalyst performance is quantified with each parameter, so that the catalyst can be widely applied in industrial production.

An antifungal composition including a first essential oil, and a second essential oil, where the composition is configured to reduce disease onset, pathogen spread, or a combination thereof. Further, an antifungal compound including one or more aroma compounds selected from 4-(4-hydroxyphenyl)-2-butanone, furaneol, ethyl methylphenylglycidate, ethyl hexanoate, ethyl butanoate, beta-ionone, alpha-ionone, (R)-(+)-limonene, (S)-(-)-limonene, cis-3-Hexen-1-ol, nerol, linalool, 2-heptanone, alpha-terpineol, beta-damascenone, β-caryophyllene, ethyl 2-methylbutanoate, β-myrcene, gamma-octalactone, alpha-humulene, nerolidol, (E,E)-2,4-decadienal, (E,E)-α-farnesene, vanillin, phenylethyl acetate, citral, 3-methylbutan-1-ol, or a combination thereof.

The invention belongs to the field of organic synthesis, and particularly relates to a method for constructing a high-crystallinity covalent organic framework material by melting a nucleophilic catalyst, which comprises the following steps of: mixing a construction monomer and a pyridine-containing nucleophilic catalyst under a solid-phase condition or grinding slurry, directly placing in a reaction container, and reacting for 1-2 hours to obtain a covalent organic framework material with high crystallinity; and raising the temperature to a melting temperature, and polymerizing the monomer to obtain the COFs material. According to the method, the existing synthesis method of a covalent organic framework material with vinyl connection, imide connection, imine bond connection or ketone-enol connection is optimized, reaction monomers are expanded, the material cost is reduced, the use of a high-toxicity catalyst and a solvent is avoided through solvent-free synthesis, the energy consumption is reduced, and the method is suitable for industrial production. The crystallinity and the specific surface area of the covalent organic framework are improved; and the method has excellent universality.

The invention discloses a chain dienol carboxylate compound and a preparation method thereof, alkynyl allyl ester is used as a substrate, in the presence of a nucleophilic catalyst, alkynyl allyl ester, a carboxylic acid compound and an active methylene compound are subjected to a biaddition reaction, and a product containing a chain dienol carboxylate structure is obtained with high double bond cis-trans selectivity. The compound with the chain diene carboxylic ester structure is a chain compound with alternating single and double bonds, and has obvious and important application value in the fields of medicinal chemistry, analytical chemistry, synthetic chemistry and the like. The compound containing the chain-like dialkenyl carboxylic ester structure is a dienol ester compound, and has extremely wide and important application value in many fields such as choline active drug development, fluorescence detection and diagnosis molecular research, natural product synthesis and the like; according to the invention, an efficient synthesis means and a series of candidate compounds for further development can be provided for the development of diene alcohol ester functional molecules with high similarity.

The invention relates to a water-soluble ultraviolet absorbent 4-disubstituted aminobenzyl subunit camphorsulfonic acid and a synthesis method and application thereof, and the synthesis method comprises the following steps: in a toluene-methanol mixed solvent, carrying out heating reflux reaction on camphorsulfonic acid and 2 equivalent weight of sodium methoxide, and after enolation conversion is completed, carrying out reduced pressure distillation to obtain the 4-disubstituted aminobenzyl subunit camphorsulfonic acid. Slowly dropwise adding a corresponding 4-disubstituted aminobenzaldehyde solution with the molar weight equal to that of camphorsulfonic acid, continuously heating and stirring to react for 6-12 hours, adding water to terminate the reaction, acidifying the reaction solution by using hydrochloric acid or sulfonic acid type cation exchange resin, separating to remove methylbenzene, adjusting the pH value of a water phase to about 6.5, performing rotary evaporation dehydration under reduced pressure, and extracting a crude product by using a conventional method; a target product can be obtained through column chromatography purification, and the target product not only has water solubility, but also has the characteristic of absorbing UVA and UVB ultraviolet light at the same time; the composition can be applied to sun-screening agent products, cosmetics or home care products, and also can be applied to various industrial products such as paint, varnish, plastics, textiles and rubber to improve the light resistance of the industrial products.

The invention discloses a preparation method and application of a high-purity cannabidiol heptyl derivative CBDP, and belongs to the technical field of organic synthesis compounds. In order to solve the technical problems of low purity, complex process and high cost of cannabidiol heptyl derivatives in the prior art, the invention provides a preparation method with high purity and simple preparation process. The key points of the technical scheme are as follows: (1) 5-heptylresorcinol and (1S, 4R)-1-methyl-4-(1-methylvinyl)-2-cyclohexene-1-alcohol are dissolved in a solvent and react under the action of a Lewis acid catalyst, and a cannabidiol heptyl derivative CBDP is obtained; (2) dissolving a cannabidiol heptyl derivative CBDP in a solvent, reacting with a derivatization reagent, and purifying to obtain an intermediate 7; and (3) dissolving the intermediate 7 in a solvent, and purifying through an enzyme hydrolysis reaction to obtain the high-purity cannabidiol heptyl derivative CBDP.

Disclosed is a method for preparing 3-chlorobicyclo[3.2.1]-3-octen-2-ol, which belongs to the field of pharmaceutical technology. The method for preparing 3-chlorobicyclo[3.2.1]-3-octen-2-ol can be achieved by any of the following reaction routes: Reaction route I: 3,4-dichlorobicyclo[3.2.1]-2-octene is esterified in the presence of a carboxylate, and hydrolyzed in a strong base to obtain 3-chlorobicyclo[3.2.1]-3-octen-2-ol; Reaction route II: in the presence of an inorganic salt of strong base and weak acid, 3,4-dichlorobicyclo[3.2.1]-2-octene is reacted in a solvent to obtain 3-chlorobicyclo[3.2.1]-3-octen-2-ol. The present application can result in decreased formation of polymers and impurities, more obvious layering, and improved purification efficiency.

The invention provides a preparation method of polar polyolefin, and belongs to the technical field of polyolefin. The preparation method comprises the following steps: in an inert atmosphere, under the action of a catalyst and a cocatalyst, copolymerizing C2-C6 olefin and an alkylated polar monomer in an organic solvent to prepare polar polyolefin, wherein the alkylated polar monomer is prepared by the following steps: dissolving an alkylating reagent in an organic solvent, adding a polar monomer, and mixing and stirring to obtain the alkylated polar monomer; the polar monomer comprises at least one of halogenated alpha-olefin, alpha-olefine acid, alpha-enol, alpha-olefine aldehyde, alpha-olefine ester and alpha-olefine ketone. The polar monomer is pre-protected by adding the alkylating reagent, so that effective copolymerization of C2-C6 olefin and the polar monomer is realized, and the performance of polyolefin is favorably improved.

The invention provides a ketone-enol tautomeric structure catalyst as well as a preparation method and application thereof in photosynthesis of hydrogen peroxide, and belongs to the technical field of catalysts. The preparation method comprises the following steps: mixing a first organic linker, a second organic linker, an acid catalyst and an organic solvent, and carrying out solvothermal reaction to obtain the ketone-enol tautomeric structure catalyst. According to the beta-keto-enamine COFs and the preparation method thereof, keto-enol tautomerism can be effectively adjusted through integration of different amounts of-OH groups in the beta-keto-enamine COFs, so that the visible light absorption capacity and the charge generation efficiency of the COFs are improved. When the keto-enol tautomeric structure catalyst provided by the invention is used for photosynthesis of hydrogen peroxide, water and oxygen can be effectively activated, so that the keto-enol tautomeric structure catalyst shows excellent hydrogen peroxide photosynthesis activity. The result of the embodiment shows that the H2O2 production rate of the ketone-enol tautomeric structure catalyst provided by the invention can reach 3474 mu mol / gcat <-1 > h <-1 >.

This invention belongs to the field of organic synthesis and discloses a method for preparing α-difluoroselenomethyl ketone derivatives using electrochemistry. The method involves preparing α-difluoroselenomethyl ketone derivatives under electrochemical conditions using 2,2-difluorovinyl alcohol trimethylsilyl ether compounds and dialkyl diselenoether. Specifically, the 2,2-difluorovinyl alcohol trimethylsilyl ether compound and the dialkyl diselenoether compound are dissolved in an organic solvent, mixed thoroughly, an electrolyte is added, an inert electrode is inserted, and the reaction is carried out under electrostatic stirring at room temperature to obtain the product α-difluoro(selenomethyl) ketone derivative. This invention eliminates the need for catalysts, bases, persulfates, persulfates, or iodobenzene acetates considered necessary in the prior art; it only requires electrolysis to obtain α-difluoroselenomethyl ketone derivatives in a mild and efficient manner.

The application provides a flexible water-stable coordination confined material as well as a preparation method and application thereof, and belongs to the technical field of metal organic coordination polymers. The flexible water-stable coordination confined material is obtained through a coordination reaction of metal ions and oxygen-based organic ligands; wherein the metal ions are selected from any one of V 4+ , Zr 4+ , Cu 2+ , Ti 4+ , Al 3+ , Cr 3+ , Fe 3+ ; and the oxygen-based organic ligands are selected from any one of nitrogen heterocyclic phosphonic acid organic ligands, alkyl phosphonic acid organic ligands, sugar organic ligands, phenolic hydroxyl organic ligands, alcoholic hydroxyl organic ligands, nitrogen heterocyclic hydroxyl organic ligands and enolic organic ligands.

The invention relates to the technical field of building energy conservation, heat preservation and heat insulation materials, and discloses a flame-retardant phase-change heat preservation and heat insulation building material and a preparation method thereof.The preparation method of the flame-retardant phase-change heat preservation and heat insulation building material comprises the following steps that paraffin is loaded in ZnO / CuO hollow microspheres to obtain phase-change microspheres; modifying the phase change microspheres with polydopamine and acryloyl chloride to obtain functionalized phase change microspheres; the preparation method comprises the following steps: carrying out graft polymerization on a phosphorus-containing eugenol compound and 1-amino-5-hexene-2-alcohol on the functionalized phase change microspheres to obtain multifunctional phase change microspheres; polyether polyol, functionalized polyol, myricetin, multifunctional phase-change microspheres and the like are used as raw materials, foaming is performed, and the flame-retardant phase-change heat-preservation and heat-insulation building material is obtained. The flame-retardant phase-change heat-preservation and heat-insulation building material is excellent in heat-preservation and heat-insulation performance, flame-retardant performance and mechanical performance, has anti-ultraviolet performance and antibacterial and mildew-proof performance, can reduce erosion damage caused by external conditions, and prolongs the service life.

The invention belongs to the technical field of chemical medicines, and particularly relates to a novel triterpene alcohol ferulate compound as well as a preparation method and medical application thereof. According to the invention, oryzanol is used as a raw material, and the new triterpene alcohol ferulate compound is obtained through reversed-phase preparative high performance liquid chromatography and SFC chiral separation and purification. A method and a tool of network pharmacology are used for researching the action mechanism of potential anti-inflammatory and anti-infection related treatment of the new compound. Hierarchical analysis from a global network to a core target reveals a possible action mechanism of the compound in anti-inflammatory and anti-infection, and highlights a regulation mode of a key acting protein. Wherein IGF1R, CTSS, MMP2, BCL2 and other proteins may be core regulatory factors of compound mediated host immune regulation and bacterial drug resistance inhibition, and an important theoretical basis is provided for further research on molecular mechanisms and potential therapeutic targets of compounds in anti-inflammatory and anti-infection related treatment.

The invention discloses a high-efficiency polycarboxylic acid polyether macromonomer preparation method, and belongs to the field of polycarboxylic acid polyether macromonomers, in the reaction, enol is added, nitrogen is used for replacement, then trimethylaluminum and anhydrous zinc chloride are added, stirring is carried out for dissolution, metallic sodium is added as a catalyst to obtain an initiator, the reaction time is 200-360 min, the addition amount of trimethylaluminum is 0.002-0.003%, the reaction time is 1-2 min, and the reaction time is 1-2 min. The addition amount of anhydrous zinc chloride is 0.005-0.006%, and the principle is that trimethylaluminum and anhydrous zinc chloride belong to Lewi acids, have a vacancy capable of accepting electron pairs to form coordinate bonds, react with Lewi alkali, and can be combined with alcohol to generate Lewi acid characteristics to react with metal sodium. In the prior art, a larger reactor is configured to increase the single-batch yield of an initiator, the input amount of single-batch alkali metal (such as metal sodium and sodium hydride) is increased sharply, and the production risk is greatly improved; and meanwhile, the prolonging of the storage time of the initiator can cause the increase of chromaticity and directly influence the stability of product indexes, and the method is mainly applied to the synthesis of polycarboxylic acid polyether macromonomers.

The present invention relates to a method for the preparation of 3-methyl-3-butene-1-ol (isoprenol), comprising the steps of preparing isobutylene (also: isobutene, 2-methylpropene) by contacting 3-methylbutan-1-ol (isoamyl alcohol) to a catalyst comprising at least one catalytically active metal and reacting at least one formaldehyde source and the isobutylene obtained in step a-i) to obtain isoprenol. Furthermore, the present invention refers to processes for the preparation of 3-methyl-2-butene-1-ol (prenol), of 3-methyl-3-butenal (isoprenal), of 3-methyl-2-butenal (prenal), and of 3,7-dimethy l-octa-2, 6-dienal (citral) and further downstream products comprising the use of isoprenol of the present invention and the resulting products and product streams.

The application belongs to the technical field of chemical synthesis, and particularly relates to a synthesis method of 2-aryl-2-cyclohexanedione enol ester compounds. The method uses a transition metal complex as a catalyst, and uses a phenyl boronic acid compound and an iodine onium compound as raw materials, first synthesizes a 3-hydroxy-2-aryl-2-cyclohexenone compound, and then synthesizes the 2-aryl-2-cyclohexanedione enol ester compound through acylation. The reaction condition is mild, no additional additives (such as alkali-sodium acetate, expensive silver salt-silver acetate, etc.) need to be added, the C-C bond can be efficiently and quickly constructed, the 2-aryl-2-cyclohexanedione cyclization derivative is obtained, the reaction operation is simple, the reaction time is short, the method has high efficiency and high safety, the substrate range is wide, the functional group tolerance is good, the method conforms to the concept of green chemistry and high atomic economy, and is very suitable for large-scale industrial production.

Derivatives of Sabinene (1-isopropyl-4-methylenebicyclo[3.1.0]hexane, CAS No. 3387-41-5), as well as their synthesis and use in organoleptic applications, are described herein. The Sabinene derivatives include a compound having a general Formula (I), wherein --- is a single or a double bond; wherein if --- is a single bond, then Y is selected from the group consisting of CH2R1, CH=C(R2)R3, and (CH2)xCHR3R4; and OR5; wherein if --- is a double bond, then Y is O, N-OMe, or N-OEt; R is selected from the group consisting of H, C(O)-R6, and CH(R6)-OR5; R1 is selected from the group consisting of 1,3-dioxepan, 5-methyl-1,3-dioxolan-4-one, (CH=CH)x(CH2)nOH, (CH=CH)x(CH2)nCHO, CH(CH3)CO2Et, and CH(CH3)OH; R2 = H or Me; R3 is selected from the group consisting of CHO, CO2Et, (CH2)nOH, (CH2)nCHO, (CH2)nCN, and (CH2)nCO2Bu; and R4 is CHO or CH2OH; or R3 and R4 in combination form a dihydropyran, a tetrahydropyran, a tetrahydropyranol, a tetrahydropyranone, a dimethylcyclohexenone, or a dimethylcyclohexenol; R5 is selected from the group consisting of CH(CH3), CH(CH2CH3), C(CH3)CH3, and C(CH3)CH2CH3; R6 is selected from the group consisting of OMe and Me; x is an integer selected from 0 or 1; and n is an integer selected from 2 to 7; with the proviso that when --- is a double bond and Y is O, then R and R6 are not H.

The invention discloses a synthesis method of 2-butyl-3-(4-hydroxybenzoyl) benzofuran, and relates to the technical field of amiodarone intermediates.The synthesis method comprises the following steps that 2-bromoanisole and 1-hexene-2-alcohol are dissolved in a first solvent, and a first catalyst is added for a reaction; cooling to 25 DEG C, adjusting the pH value to 9-10, adding a catalyst II for reaction, and removing impurities after the reaction is completed, so as to obtain 2-butylbenzofuran; 2-butylbenzofuran and a catalyst III are added into a solvent II, vacuumizing is performed after nitrogen replacement, carbon dioxide is introduced to 0.02-3 MPa for a reaction, impurity removal treatment is performed after the reaction is completed, and 2-butyl-3-(4-hydroxybenzoyl) benzofuran is obtained; compared with a synthetic route in the prior art, the synthetic method has the advantages that the reaction steps are shortened into two steps, the synthetic steps are simplified, the synthetic efficiency is improved, the process cost is reduced, meanwhile, the conversion efficiency is higher, the total yield reaches 70% or above, and the yield is improved by 15% or above compared with the yield in the prior art.

The present invention relates to halogenated alkenylalkoxymethyl ether compounds of the following general formula (1): R 1 CH2OCH2OCH2CH2CH=CH(CH2) a X 1 (1), wherein R 1 represents a hydrogen atom, a n-alkyl group having 1 to 9 carbon atoms, or a phenyl group, X 1 represents a halogen atom, and a represents an integer of 3 to 14. The present invention also relates to a method for producing terminal conjugated alkadien-1-yl acetate compounds of the following general formula (5): CH2=CHCH=CH(CH2) a OAc (5), wherein a is defined as above, and Ac represents an acetyl group, and a method for producing terminal conjugated alkadien-1-ol compounds of the following general formula (6): CH2=CHCH=CH(CH2) a OH (6), wherein a is defined as above.

The present invention belongs to the field of organic synthesis technology and specifically relates to genipin derivatives, preparation methods, and applications thereof. The genipin derivatives provided by the present invention are structurally modified using genipin as a lead compound, attaching an unsaturated enol or alkynol group, and replacing the H atom on the C-1 hydroxyl group of genipin with 3-butene-1-ol, 4-pentene-1-ol, 5-hexene-1-ol, or 3-butyn-1-ol. The resulting four genipin derivatives containing unsaturated groups have excellent anti-inflammatory activity and are more suitable for preparing drugs for treating central nervous system inflammation.

The invention belongs to the field of fine chemical engineering, and discloses an electrochemical method for preparing enol through hydrogenation of alkynol compounds. According to the method, 2-methyl-3-butyne-2-alcohol is selectively converted into 2-methyl-3-butene-2-alcohol through an electrochemical method by taking palladium and copper-containing metals as electrode materials and taking a catalyst PdCu / CC, and the selectivity is greater than 96% and is far better than that of a single metal palladium and copper catalyst. The electrochemical method provided by the invention has the advantages of environment-friendly process, no need of external hydrogen input, reaction at normal temperature and normal pressure, mild conditions, simple catalyst preparation process, recyclability and cost saving, conforms to the development direction of green chemical synthesis, and has good industrial application prospects.

Methods and compositions are disclosed for reducing neuropathy or ototoxicity associated with chemotherapeutic agents by administering one or more enol compounds to a subject.

Methods and compositions are disclosed for reducing neuropathy or ototoxicity associated with chemotherapeutic agents by administering one or more enol compounds to a subject.

The invention belongs to the technical field of synthesis of medicines and spices, and particularly relates to a synthesis method of trans-2-octenal. The synthesis method comprises the following steps: carrying out isomerization reaction on 1-octylene-3-alcohol under the catalytic action of 3, 4-dinitrobenzoic acid to obtain a trans-2-octylene-1-alcohol intermediate; the preparation method comprises the following steps: preparing trans-2-octenal from trans-2-octylene-1-alcohol under the oxidation action of m-chloroiodobenzene, 4-hydroxy-TEMPO (4-hydroxy-2, 2, 6, 6-tetramethylpiperidine nitroxide free radical) and peracetic acid, and further preparing the trans-2-octenal from the trans-2-octylene-1-alcohol. The preparation method is mild in reaction condition, simple to operate and free of expensive reagents or catalysts.

The present invention relates to the field of organic synthesis and more specifically to a process for preparing a compound of formula (I) from the compound of formula (II) catalyzed by a metal complex.