199 results about "Enol" patented technology

The invention relates to a synthesis method of a diunsaturated ester compound catalyzed by N-heterocyclic carbene, and belongs to the field of organic synthesis. According to the preparation method, the synergistic effect of N-heterocyclic carbene and light is utilized, gamma-oxo unsaturated aldehyde and Katritzky salt are taken as starting raw materials, the Katritzky salt generates alpha-ester free radicals through a single electron transfer process under the illumination condition, the free radicals react with a nucleophilic trienol intermediate generated through catalysis of the N-heterocyclic carbene, and the alpha-ester free radicals react with the nucleophilic trienol intermediate to generate the gamma-oxo unsaturated aldehyde. Target products are obtained with good yield and high regioselectivity, so that a series of epsilon-alkylated diunsaturated ester compounds are efficiently synthesized. The method is simple and convenient to operate, green and efficient, has the advantages of no transition metal participation, wide substrate applicability and the like, provides a new way for synthesis of the diunsaturated ester compound, and has a wide application prospect.

The invention provides a 2-succinyl-5-enol acetonyl-6-hydroxy-3-cyclohexene-1-carboxylic acid (SEPHCHC) synthase mutant, which is characterized in that on the basis of a bacillus subtilis SEPHCHC synthase gene MenD, 12 SEPHCHC synthase mutants are obtained by virtue of a site-specific mutagenesis PCR (Polymerase Chain Reaction) technology, and the SEPHCHC synthase gene MenD is used as a base. Recombinant bacteria of bacillus subtilis or bacillus natto or bacillus licheniformis or bacillus amyloliquefaciens for expressing the mutant are respectively constructed, and the yield of heptaene menadione fermented by the recombinant bacteria is 74%-203% of the yield of heptaene menadione fermented by the recombinant bacteria of bacillus subtilis for expressing wild type SEPHCHC synthase MenD.

The invention discloses a hyperbranched polyether branching agent with an adjustable structure and a preparation method and application thereof.According to the branching agent, 3-butene-1-alcohol serves as an initiator, a hyperbranched skeleton is constructed through anion ring-opening polymerization reaction and diglycidyl ether, then esterification and end capping are conducted through anhydride, and the hyperbranched polyether branching agent with the adjustable structure is obtained. The tail end of the hyperbranched polyether contains vinyl double bonds, and the ester group structure of the hyperbranched polyether can be regulated and controlled. Different diepoxy compounds are selected to control a main chain structure, and different anhydrides are used for regulating and controlling the chemical composition of branched chains, so that accurate design of molecular weight, polarity and number of functional groups of the branching agent is realized. The branching agent has excellent dissolvability in common organic solvents, and solves the problem of poor dissolvability of the traditional polydiene branching agent. When the star-shaped branched butyl rubber is applied to the synthesis of star-shaped branched butyl rubber, the distribution and number of branched points can be accurately regulated and controlled, the weight-average molecular weight and molecular weight distribution index of the rubber are remarkably improved, and the side reaction of gel is avoided.

The application provides a catalyst for preparing an enol from an alkyne alcohol, a preparation method and a method for preparing the enol by using the catalyst. By precisely controlling the particle size, specific surface area and added toxicant of the Lindlar catalyst, the catalytic efficiency can be significantly improved, and the catalyst performance is quantified with each parameter, so that the catalyst can be widely applied in industrial production.

An antifungal composition including a first essential oil, and a second essential oil, where the composition is configured to reduce disease onset, pathogen spread, or a combination thereof. Further, an antifungal compound including one or more aroma compounds selected from 4-(4-hydroxyphenyl)-2-butanone, furaneol, ethyl methylphenylglycidate, ethyl hexanoate, ethyl butanoate, beta-ionone, alpha-ionone, (R)-(+)-limonene, (S)-(-)-limonene, cis-3-Hexen-1-ol, nerol, linalool, 2-heptanone, alpha-terpineol, beta-damascenone, β-caryophyllene, ethyl 2-methylbutanoate, β-myrcene, gamma-octalactone, alpha-humulene, nerolidol, (E,E)-2,4-decadienal, (E,E)-α-farnesene, vanillin, phenylethyl acetate, citral, 3-methylbutan-1-ol, or a combination thereof.

The invention discloses a chain dienol carboxylate compound and a preparation method thereof, alkynyl allyl ester is used as a substrate, in the presence of a nucleophilic catalyst, alkynyl allyl ester, a carboxylic acid compound and an active methylene compound are subjected to a biaddition reaction, and a product containing a chain dienol carboxylate structure is obtained with high double bond cis-trans selectivity. The compound with the chain diene carboxylic ester structure is a chain compound with alternating single and double bonds, and has obvious and important application value in the fields of medicinal chemistry, analytical chemistry, synthetic chemistry and the like. The compound containing the chain-like dialkenyl carboxylic ester structure is a dienol ester compound, and has extremely wide and important application value in many fields such as choline active drug development, fluorescence detection and diagnosis molecular research, natural product synthesis and the like; according to the invention, an efficient synthesis means and a series of candidate compounds for further development can be provided for the development of diene alcohol ester functional molecules with high similarity.

The invention relates to a water-soluble ultraviolet absorbent 4-disubstituted aminobenzyl subunit camphorsulfonic acid and a synthesis method and application thereof, and the synthesis method comprises the following steps: in a toluene-methanol mixed solvent, carrying out heating reflux reaction on camphorsulfonic acid and 2 equivalent weight of sodium methoxide, and after enolation conversion is completed, carrying out reduced pressure distillation to obtain the 4-disubstituted aminobenzyl subunit camphorsulfonic acid. Slowly dropwise adding a corresponding 4-disubstituted aminobenzaldehyde solution with the molar weight equal to that of camphorsulfonic acid, continuously heating and stirring to react for 6-12 hours, adding water to terminate the reaction, acidifying the reaction solution by using hydrochloric acid or sulfonic acid type cation exchange resin, separating to remove methylbenzene, adjusting the pH value of a water phase to about 6.5, performing rotary evaporation dehydration under reduced pressure, and extracting a crude product by using a conventional method; a target product can be obtained through column chromatography purification, and the target product not only has water solubility, but also has the characteristic of absorbing UVA and UVB ultraviolet light at the same time; the composition can be applied to sun-screening agent products, cosmetics or home care products, and also can be applied to various industrial products such as paint, varnish, plastics, textiles and rubber to improve the light resistance of the industrial products.

The invention discloses a preparation method and application of a high-purity cannabidiol heptyl derivative CBDP, and belongs to the technical field of organic synthesis compounds. In order to solve the technical problems of low purity, complex process and high cost of cannabidiol heptyl derivatives in the prior art, the invention provides a preparation method with high purity and simple preparation process. The key points of the technical scheme are as follows: (1) 5-heptylresorcinol and (1S, 4R)-1-methyl-4-(1-methylvinyl)-2-cyclohexene-1-alcohol are dissolved in a solvent and react under the action of a Lewis acid catalyst, and a cannabidiol heptyl derivative CBDP is obtained; (2) dissolving a cannabidiol heptyl derivative CBDP in a solvent, reacting with a derivatization reagent, and purifying to obtain an intermediate 7; and (3) dissolving the intermediate 7 in a solvent, and purifying through an enzyme hydrolysis reaction to obtain the high-purity cannabidiol heptyl derivative CBDP.

The invention provides a preparation method of polar polyolefin, and belongs to the technical field of polyolefin. The preparation method comprises the following steps: in an inert atmosphere, under the action of a catalyst and a cocatalyst, copolymerizing C2-C6 olefin and an alkylated polar monomer in an organic solvent to prepare polar polyolefin, wherein the alkylated polar monomer is prepared by the following steps: dissolving an alkylating reagent in an organic solvent, adding a polar monomer, and mixing and stirring to obtain the alkylated polar monomer; the polar monomer comprises at least one of halogenated alpha-olefin, alpha-olefine acid, alpha-enol, alpha-olefine aldehyde, alpha-olefine ester and alpha-olefine ketone. The polar monomer is pre-protected by adding the alkylating reagent, so that effective copolymerization of C2-C6 olefin and the polar monomer is realized, and the performance of polyolefin is favorably improved.

The invention provides a ketone-enol tautomeric structure catalyst as well as a preparation method and application thereof in photosynthesis of hydrogen peroxide, and belongs to the technical field of catalysts. The preparation method comprises the following steps: mixing a first organic linker, a second organic linker, an acid catalyst and an organic solvent, and carrying out solvothermal reaction to obtain the ketone-enol tautomeric structure catalyst. According to the beta-keto-enamine COFs and the preparation method thereof, keto-enol tautomerism can be effectively adjusted through integration of different amounts of-OH groups in the beta-keto-enamine COFs, so that the visible light absorption capacity and the charge generation efficiency of the COFs are improved. When the keto-enol tautomeric structure catalyst provided by the invention is used for photosynthesis of hydrogen peroxide, water and oxygen can be effectively activated, so that the keto-enol tautomeric structure catalyst shows excellent hydrogen peroxide photosynthesis activity. The result of the embodiment shows that the H2O2 production rate of the ketone-enol tautomeric structure catalyst provided by the invention can reach 3474 mu mol / gcat <-1 > h <-1 >.

This invention belongs to the field of organic synthesis and discloses a method for preparing α-difluoroselenomethyl ketone derivatives using electrochemistry. The method involves preparing α-difluoroselenomethyl ketone derivatives under electrochemical conditions using 2,2-difluorovinyl alcohol trimethylsilyl ether compounds and dialkyl diselenoether. Specifically, the 2,2-difluorovinyl alcohol trimethylsilyl ether compound and the dialkyl diselenoether compound are dissolved in an organic solvent, mixed thoroughly, an electrolyte is added, an inert electrode is inserted, and the reaction is carried out under electrostatic stirring at room temperature to obtain the product α-difluoro(selenomethyl) ketone derivative. This invention eliminates the need for catalysts, bases, persulfates, persulfates, or iodobenzene acetates considered necessary in the prior art; it only requires electrolysis to obtain α-difluoroselenomethyl ketone derivatives in a mild and efficient manner.

The application provides a flexible water-stable coordination confined material as well as a preparation method and application thereof, and belongs to the technical field of metal organic coordination polymers. The flexible water-stable coordination confined material is obtained through a coordination reaction of metal ions and oxygen-based organic ligands; wherein the metal ions are selected from any one of V 4+ , Zr 4+ , Cu 2+ , Ti 4+ , Al 3+ , Cr 3+ , Fe 3+ ; and the oxygen-based organic ligands are selected from any one of nitrogen heterocyclic phosphonic acid organic ligands, alkyl phosphonic acid organic ligands, sugar organic ligands, phenolic hydroxyl organic ligands, alcoholic hydroxyl organic ligands, nitrogen heterocyclic hydroxyl organic ligands and enolic organic ligands.

The invention relates to the technical field of building energy conservation, heat preservation and heat insulation materials, and discloses a flame-retardant phase-change heat preservation and heat insulation building material and a preparation method thereof.The preparation method of the flame-retardant phase-change heat preservation and heat insulation building material comprises the following steps that paraffin is loaded in ZnO / CuO hollow microspheres to obtain phase-change microspheres; modifying the phase change microspheres with polydopamine and acryloyl chloride to obtain functionalized phase change microspheres; the preparation method comprises the following steps: carrying out graft polymerization on a phosphorus-containing eugenol compound and 1-amino-5-hexene-2-alcohol on the functionalized phase change microspheres to obtain multifunctional phase change microspheres; polyether polyol, functionalized polyol, myricetin, multifunctional phase-change microspheres and the like are used as raw materials, foaming is performed, and the flame-retardant phase-change heat-preservation and heat-insulation building material is obtained. The flame-retardant phase-change heat-preservation and heat-insulation building material is excellent in heat-preservation and heat-insulation performance, flame-retardant performance and mechanical performance, has anti-ultraviolet performance and antibacterial and mildew-proof performance, can reduce erosion damage caused by external conditions, and prolongs the service life.

The present invention relates to a method for the preparation of 3-methyl-3-butene-1-ol (isoprenol), comprising the steps of preparing isobutylene (also: isobutene, 2-methylpropene) by contacting 3-methylbutan-1-ol (isoamyl alcohol) to a catalyst comprising at least one catalytically active metal and reacting at least one formaldehyde source and the isobutylene obtained in step a-i) to obtain isoprenol. Furthermore, the present invention refers to processes for the preparation of 3-methyl-2-butene-1-ol (prenol), of 3-methyl-3-butenal (isoprenal), of 3-methyl-2-butenal (prenal), and of 3,7-dimethy l-octa-2, 6-dienal (citral) and further downstream products comprising the use of isoprenol of the present invention and the resulting products and product streams.

The application belongs to the technical field of chemical synthesis, and particularly relates to a synthesis method of 2-aryl-2-cyclohexanedione enol ester compounds. The method uses a transition metal complex as a catalyst, and uses a phenyl boronic acid compound and an iodine onium compound as raw materials, first synthesizes a 3-hydroxy-2-aryl-2-cyclohexenone compound, and then synthesizes the 2-aryl-2-cyclohexanedione enol ester compound through acylation. The reaction condition is mild, no additional additives (such as alkali-sodium acetate, expensive silver salt-silver acetate, etc.) need to be added, the C-C bond can be efficiently and quickly constructed, the 2-aryl-2-cyclohexanedione cyclization derivative is obtained, the reaction operation is simple, the reaction time is short, the method has high efficiency and high safety, the substrate range is wide, the functional group tolerance is good, the method conforms to the concept of green chemistry and high atomic economy, and is very suitable for large-scale industrial production.

Derivatives of Sabinene (1-isopropyl-4-methylenebicyclo[3.1.0]hexane, CAS No. 3387-41-5), as well as their synthesis and use in organoleptic applications, are described herein. The Sabinene derivatives include a compound having a general Formula (I), wherein --- is a single or a double bond; wherein if --- is a single bond, then Y is selected from the group consisting of CH2R1, CH=C(R2)R3, and (CH2)xCHR3R4; and OR5; wherein if --- is a double bond, then Y is O, N-OMe, or N-OEt; R is selected from the group consisting of H, C(O)-R6, and CH(R6)-OR5; R1 is selected from the group consisting of 1,3-dioxepan, 5-methyl-1,3-dioxolan-4-one, (CH=CH)x(CH2)nOH, (CH=CH)x(CH2)nCHO, CH(CH3)CO2Et, and CH(CH3)OH; R2 = H or Me; R3 is selected from the group consisting of CHO, CO2Et, (CH2)nOH, (CH2)nCHO, (CH2)nCN, and (CH2)nCO2Bu; and R4 is CHO or CH2OH; or R3 and R4 in combination form a dihydropyran, a tetrahydropyran, a tetrahydropyranol, a tetrahydropyranone, a dimethylcyclohexenone, or a dimethylcyclohexenol; R5 is selected from the group consisting of CH(CH3), CH(CH2CH3), C(CH3)CH3, and C(CH3)CH2CH3; R6 is selected from the group consisting of OMe and Me; x is an integer selected from 0 or 1; and n is an integer selected from 2 to 7; with the proviso that when --- is a double bond and Y is O, then R and R6 are not H.

The present invention relates to halogenated alkenylalkoxymethyl ether compounds of the following general formula (1): R 1 CH2OCH2OCH2CH2CH=CH(CH2) a X 1 (1), wherein R 1 represents a hydrogen atom, a n-alkyl group having 1 to 9 carbon atoms, or a phenyl group, X 1 represents a halogen atom, and a represents an integer of 3 to 14. The present invention also relates to a method for producing terminal conjugated alkadien-1-yl acetate compounds of the following general formula (5): CH2=CHCH=CH(CH2) a OAc (5), wherein a is defined as above, and Ac represents an acetyl group, and a method for producing terminal conjugated alkadien-1-ol compounds of the following general formula (6): CH2=CHCH=CH(CH2) a OH (6), wherein a is defined as above.

Methods and compositions are disclosed for reducing neuropathy or ototoxicity associated with chemotherapeutic agents by administering one or more enol compounds to a subject.

Methods and compositions are disclosed for reducing neuropathy or ototoxicity associated with chemotherapeutic agents by administering one or more enol compounds to a subject.

The invention belongs to the technical field of synthesis of medicines and spices, and particularly relates to a synthesis method of trans-2-octenal. The synthesis method comprises the following steps: carrying out isomerization reaction on 1-octylene-3-alcohol under the catalytic action of 3, 4-dinitrobenzoic acid to obtain a trans-2-octylene-1-alcohol intermediate; the preparation method comprises the following steps: preparing trans-2-octenal from trans-2-octylene-1-alcohol under the oxidation action of m-chloroiodobenzene, 4-hydroxy-TEMPO (4-hydroxy-2, 2, 6, 6-tetramethylpiperidine nitroxide free radical) and peracetic acid, and further preparing the trans-2-octenal from the trans-2-octylene-1-alcohol. The preparation method is mild in reaction condition, simple to operate and free of expensive reagents or catalysts.

The present invention relates to the field of organic synthesis and more specifically to a process for preparing a compound of formula (I) from the compound of formula (II) catalyzed by a metal complex.

The present application relates to a kind of targeting bacterial UDP-N-acetylglucosamine enolpyruvate transaminase antibacterial compound and its application, the antibacterial compound is S-(4-chlorobenzyl) chloro isothiourea, its chemical structure is as shown in formula I: I;Or its pharmaceutically acceptable salt, stereoisomer, solvate, crystal form, isotopically labeled or prodrug.The antibacterial compound of the present application can effectively inhibit the growth of klebsiella pneumoniae, including carbapenem-resistant klebsiella pneumoniae and high virulence klebsiella pneumoniae;It also has good bacteriostatic effect on escherichia coli and pseudomonas aeruginosa;It is expected to be applied to the clinical treatment of infection caused by drug-resistant klebsiella pneumoniae and high virulence klebsiella pneumoniae and other pathogenic bacteria, and has important clinical significance and social benefits.

The application provides a method for preparing 7-octene-1-ol polyoxyethylene ether and application thereof, and the method comprises the following steps: S1: adding sodium metal into 7-octene-1-ol to obtain a precursor solution; S2: adding a small molecule ligand into the precursor solution and then introducing ethylene oxide to obtain an oligomer intermediate; wherein the small molecule ligand comprises at least one of a β-diketone compound and an imidazole compound; S3: continuously introducing ethylene oxide into the oligomer intermediate to obtain 7-octene-1-ol polyoxyethylene ether. The method can effectively improve the double bond retention rate of 7-octene-1-ol polyoxyethylene ether, reduce the risk of side reactions such as addition, rupture or isomerization of unsaturated structures in the polymerization process, and improve the reaction efficiency and structural integrity of the target product in the subsequent copolymerization reaction.

The present invention addresses the problem of providing an alcohol-containing composition in which the irritation of alcohol is reduced. In a composition containing alcohol, linalool and / or geraniol is blended, and cis-3-hexene-1-ol is blended.

The application discloses a synthesis process of (-)-alpha-lycorane alkaloid and belongs to the technical field of organic synthesis chemistry. (2Z,4E)-7,7-diethoxy-3-hydroxyhepta-2,4-dienoic acid methyl ester and 3,4-methylenedioxy-beta-nitrostyrene are used as starting materials, and (-)-alpha-lycorane is obtained through catalytic asymmetric tandem Michael addition reaction, nitro reduction amination reaction, Boc amidation reaction, Bischler-Napieralski cyclization reaction, ketone enolization tandem esterification reaction, enol triflate reductive hydrogenolysis reaction and amide reduction reaction in sequence. (-)-Alpha-lycorane has a four-membered ring core skeleton of pyrrole-phenanthridine ring, has good in-vitro tumor inhibition activity and cell proliferation growth inhibition activity. The synthesis process can realize efficient, simple and full synthesis of (-)-alpha-lycorane.

The application relates to the technical field of polyolefins, and discloses a coordination precipitation polymerization method for olefin polymerization and a polyolefin, the method comprising mixing olefin monomers, a catalyst and an additive, and performing a polymerization reaction; the olefin monomers contain nonpolar monomers and polar monomers, the nonpolar monomers are selected from one or more than two of ethylene, alpha-olefins and internal olefins, and the polar monomers are selected from one or more than two of enol, unsaturated carboxylic acids and unsaturated carboxylic acid esters; and the catalyst is selected from a post-transition metal complex shown in formula (I). The application can eliminate the catalyst loading process, realize olefin homogeneous catalyst polymerization self-forming, and prepare polyolefins with good particle morphology.

The invention provides a method for catalytically synthesizing 7-amino-3-oxabicyclo [3.3. 1] nonyl-6-ene-1-ol by using rare earth, which comprises the following steps of: adding a catalyst and a catalyst, according to the preparation method, rare earth trifluoromethanesulfonate is taken as a catalyst, 6-alkoxy-2, 6-dihydropyran-3-ketone and enamine compounds are taken as raw materials, and the 7-amino-3-oxabicyclo [3.3. 1] nonyl-6-ene-1-ol is prepared by catalyzing (3 + 3) cyclization reaction. The synthesis method provided by the invention is simple in reaction raw material synthesis, low in rare earth salt price, easy in experimental operation and suitable for large-scale preparation. The obtained compound can be applied to the fields of organic synthesis, drug synthesis, organic materials and the like.

The application discloses a liquid-phase detection method for curcumin related substances and application thereof, characterized in that the method adopts high performance liquid chromatography, and the chromatographic conditions comprise that a mobile phase A is a 1% mass concentration phosphoric acid aqueous solution; a mobile phase B is acetonitrile; gradient elution is adopted, and the program of the gradient elution is as follows: 0-11 min, the volume percentage of the mobile phase A changes from 60% to 38%; 11-15 min, the volume percentage of the mobile phase A remains 38%; 15-20 min, the volume percentage of the mobile phase A changes from 38% to 30%; and 20-30 min, the volume percentage of the mobile phase A remains 30%. The application can effectively alleviate the problem of unstable baseline caused by curcuminone-enol tautomerism, and can simultaneously separate and detect multiple related substances including vanillin, acetylacetone and ketone isomers, and has the characteristics of high resolution, good specificity and high sensitivity.

A composition for enhanced bioavailability of curcumin comprising a curcuminoid mixture and an essential oil of turmeric, wherein the curcuminoid mixture comprises a curcumin-keto compound, a curcumin-enol compound, a bisdemethoxycurcumin, a demethoxycurcumin, wherein a weight ratio of the curcumin-keto compound to the curcumin-enol compound ranges from about 0.12 - 0.20 : 0.8 - 0.88. A composition for enhanced lymphatic bioavailability of curcumin comprising a curcuminoid mixture and an essential oil of turmeric, wherein the curcuminoid mixture comprises a curcumin-keto compound, a curcumin-enol compound, a bisdemethoxycurcumin, a demethoxycurcumin, wherein a weight ratio of the curcumin-keto compound to the curcumin-enol compound ranges from about 0.12 - 0.20 : 0.8 - 0.88. Methods for making the composition for enhanced bioavailability of curcumin. Methods for making the composition for enhanced lymphatic bioavailability of curcumin.

This invention relates to a method for preparing a bimetallic cyanide (DMC) catalyst, comprising a reaction of an aqueous solution of a cyanide-free metal salt, an aqueous solution of a basic metal cyanide salt, an organic complexing ligand, and optionally a component forming a complex, wherein the metal cyanide salt is one or more compounds selected from potassium hexacyanocobalt(III), potassium hexacyanoferrate(II), potassium hexacyanoferrate(III), calcium hexacyanocobalt(III), and lithium hexacyanocobalt(III), wherein the organic complexing ligand is one or more compounds selected from dimethoxyethane, tert-butanol, 2-methyl-3-buten-2-ol, 2-methyl-3-butyn-2-ol, ethylene glycol mono-tert-butyl ether, and 3-methyl-3-oxetane-methanol, and wherein the basic metal cyanide salt used has an alkalinity between 0.700 wt% and 3.000 wt% sodium hydroxide (NaOH) based on the total weight of the basic metal cyanide salt used, determined by titration as disclosed in the experimental section. Another subject of the invention includes a bimetallic cyanide catalyst (DMC) obtainable by the method according to the invention, and the use of said DMC catalyst in the preparation of polyoxyethylene polyols.