16 results about "Maslinic acid" patented technology

The invention discloses a feed additive for synergistically improving oxidative stress resistance of broiler chickens based on oleuropein-luteoloside-maslinic acid ternary combination and application of the feed additive, the feed additive is the olea europaea leaf extract, the total polyphenol content of the feed additive is about 52%, the total flavone content is 7%, and the total flavone content is 5%. The feed is mainly composed of oleuropein, luteolin-7-beta-glucoside and maslinic acid, the oleuropein, the luteolin-7-beta-glucoside and the maslinic acid are sequentially added in a molar ratio of 6: 1: 1 to generate a synergistic anti-oxidative stress effect, and when the feed is applied to breeding on the basis of corn-soybean daily ration of broilers, the daily gain of the broilers can be obviously increased, the feed conversion ratio is reduced, and the feed conversion rate is increased. The intestinal micro-ecological health, the anti-oxidative stress effect and the organism immunity are improved, and the infection rate and the death rate of intestinal diseases such as diarrhea of broilers are reduced. The product has the advantages of being simple and convenient to prepare and use, free of toxic and side effects, beneficial to broiler chicken growth and human health, free of the problems of drug resistance, drug residues and the like, and capable of promoting chicken meat quality improvement and the like.

This invention discloses a separation and purification device for extracting hawthorn acid from olive pomace. The device includes a base plate, a magnetic pump fixed to the top of the base plate, a support fixed to the top of the base plate, an adsorption cylinder installed on the inner wall of the support, and the magnetic pump and the adsorption cylinder connected via a pipe. An adsorption mechanism is installed on the top of the adsorption cylinder, and a side cover is detachably installed on the cylinder wall. A base is fixed to the top of the base plate, and a hawthorn acid enrichment structure is provided on the top of the base. A valve is connected to the bottom of the adsorption cylinder. This invention can separate ethanol solution from hawthorn acid at room temperature. Compared with the method of multiple concentration and drying and ethanol reconstitution for hawthorn acid separation and purification, it consumes less energy. Furthermore, the device integrates separation and purification functions with target enrichment, eliminating the need to transfer olive pomace extract between different operating devices for further processing, simplifying the hawthorn acid separation and purification process and making it more convenient.

The invention provides maslinic acid PROTACs as well as a preparation method and application thereof, and belongs to the technical field of drug development. According to the invention, maslinic acid is taken as a POI ligand, lenalidomide and fluoro-thalidomide are taken as E3 ligands, and linker selects a PEG chain or an aliphatic chain, so that the anti-cancer activity of the compound is superior to that of maslinic acid, and the compound has a good potential application prospect in the aspect of anti-tumor treatment.

The present invention provides an animal feed additive with anti-inflammatory and antioxidant functions, namely, a traditional Chinese medicine-type feed additive with anti-biotic efficacy. The preparation method comprises the following steps: mixing a dried olive pomace powder sample with a subcritical extractant, performing subcritical extraction, and obtaining an extraction system; removing the subcritical extractant from the extraction system to obtain a pomace powder system from which pomace oil has been removed; mixing the pomace powder system with ethanol, performing leaching, and subjecting the obtained extract to vacuum distillation to obtain an extract; mixing the extract system with petroleum ether, allowing the petroleum ether phase to stand for stratification, and filtering the obtained petroleum ether phase to obtain an extract. The maslinic acid and oleanolic acid extracted by the present invention have anti-inflammatory and antioxidant effects, and animal experiments have confirmed that they can enhance intestinal health in a short period of time. The addition of a polypeptide improves the side effects of the maslinic acid and oleanolic acid caused by their long-term use. The present invention can be promoted and used as a new animal feed additive.

The invention relates to a system or composition to topically deliver and / or release a pentacyclic triterpene or an Olea europaea fruit extract titrated in maslinic and / or oleanolic acid. The delivery and release system may be contained in a cosmetic composition to be applied to skin, scalp, eyelashes, eyebrows, and nails.

The application relates to the technical field of biological medicine, and discloses application of maslinic acid or a derivative thereof in preparation of a product for treating Clostridium perfringens infection. The application verifies that the maslinic acid has a good inhibiting effect on Clostridium perfringens through in-vitro experiments and in-vivo infection models, and has a good treatment effect on intestinal infection of Clostridium perfringens in mammals and avian necrotic enteritis, thereby providing a new approach and thought for treatment of Clostridium perfringens infection, and having important clinical significance and application value.

The invention relates to the technical field of preparation of olive leaf extracts, in particular to an olive leaf extract and a preparation process and application thereof, and the process comprises the following steps: crushing dried olive leaves, mixing the crushed olive leaves with an ethanol aqueous solution, and carrying out multi-stage temperature control hot reflux extraction and solid-liquid separation to obtain a supernatant and a precipitate; loading the supernate to a resin column, washing with water and then eluting with ethanol, and drying the eluent to obtain an oleuropein crude product; blending the oleuropein crude product and the sample stirring silica gel, drying, filling into a chromatographic column, eluting by using an ethyl acetate-ethanol mixed solvent, and collecting a high-purity oleuropein fine product; sequentially carrying out ultrasonic dissolution, concentration, standing crystallization and filtration on the precipitate through medium-concentration and high-concentration ethanol to obtain a maslinic acid crude product and an oleanolic acid crude product; and respectively heating and dissolving with ethanol, cooling and crystallizing, and circularly recrystallizing to obtain a corresponding refined product. The invention aims to guarantee the extraction yield and quality of oleuropein by controlling the multi-stage temperature of heating reflux extraction of olive leaves.

The invention belongs to the field of biological pharmacy, and particularly relates to application of maslinic acid as a cis-platinum toxicity protective agent. The maslinic acid disclosed by the invention can be used for preventing ototoxicity induced by cis-platinum by recovering the activity of mouse cochlear hair cells SLC7A11, and can be used for repairing mouse hearing impairment induced by cis-platinum. Experimental results show that maslinic acid can recover activity reduction of SLC7A11 caused by cis-platinum, so that the level of LPO in cells is reduced, the survival rate of HEI-OC1 cells is increased, and the anti-cancer effect of cis-platinum is not affected; animal experiments also show that maslinic acid can inhibit mouse hearing impairment induced by cis-platinum. Therefore, maslinic acid can reduce the ear toxicity of cis-platinum and exert an inner ear protection effect.

The application belongs to the field of biological medicine, and particularly relates to a Bama pig model for preclinical research of a weight loss drug COST and application. Healthy Bama pigs are first adaptively fed with ordinary feed, and then fed with high-fat feed to model, and the Bama pigs are detected for obesity-related indexes at a fixed time period every week; the high-fat feed comprises ordinary feed, beef tallow, artificial butter, sucrose, casein, experimental animal premix, microcrystalline cellulose, calcium bicarbonate, gypenoside, peppermint leaf, maslinic acid, ursolic acid, atractylodes, nutmeg. The application can quickly construct a Bama pig model with stable phenotype, and provides a reliable model for preclinical research of a new drug for treating obesity, and provides guarantee for research on the mechanism of obesity, screening, development and mechanism research of a new drug for treating obesity and the like.

The application relates to the technical field of composite piezoelectric materials, and particularly discloses a composite nano piezoelectric material loaded with maslinic acid, a preparation method and application thereof, which comprises the following steps: adding barium titanate nano powder and maslinic acid into a solvent in sequence, performing ultrasonic treatment, then stirring and treating at 50-70 DEG C for 1.5-3h to obtain a mixture; adding PVDF powder into the mixture, stirring and treating at 50-70 DEG C for 4-6h to obtain a final mixed solution; meanwhile, washing and drying a glass slide to obtain a treated glass slide substrate; coating the mixed solution on the glass slide to form a film, drying to obtain a precursor film; and performing polarization treatment on the film to obtain the composite nano piezoelectric material loaded with maslinic acid. By introducing the barium titanate and the maslinic acid, the application effectively induces the PVDF to form a high-content polar beta crystal phase, thereby significantly improving the piezoelectric performance of the PVDF, and meanwhile, the flexibility of the PVDF film is also enhanced, the wearable patch substrate is suitable, and the application exhibits good drug controlled release potential.

The application belongs to the field of biological pharmacy, and particularly relates to application of maslinic acid as a cisplatin ototoxicity protective agent. The application discloses that maslinic acid can prevent cisplatin-induced ototoxicity by restoring the activity of mouse cochlea hair cells SLC7A11, and can repair cisplatin-induced hearing impairment in mice. Experimental results show that maslinic acid can restore the reduced activity of SLC7A11 caused by cisplatin, thereby reducing the intracellular LPO level, increasing the HEI-OC1 cell survival rate, and not affecting the anticancer effect of cisplatin; animal experiments also show that maslinic acid can inhibit cisplatin-induced hearing impairment in mice. Therefore, maslinic acid can reduce the ototoxicity of cisplatin and play an inner ear protection role.

The invention relates to the technical field of composite piezoelectric materials, and particularly discloses a maslinic acid-loaded composite nano piezoelectric material external application patch as well as a preparation method and application thereof.The preparation method comprises the following steps: sequentially adding barium titanate nano powder and maslinic acid into a solvent, performing ultrasonic treatment, and then performing stirring treatment at 50-70 DEG C for 1.5-3 h to obtain a mixture; pVDF powder is added into the mixture, stirring treatment is conducted for 4-6 h at the temperature of 50-70 DEG C, and a final mixed solution is obtained; meanwhile, cleaning and drying the glass slide to obtain a treated glass slide substrate; coating the mixed solution on a glass slide to form a film, and drying to obtain a precursor film; and carrying out polarization treatment on the membrane to obtain the maslinic acid-loaded composite nano piezoelectric material. By introducing barium titanate and maslinic acid, PVDF is effectively induced to form a high-content polar beta crystal phase, so that the piezoelectric property of PVDF is remarkably improved, the flexibility of the PVDF film is enhanced, and the PVDF film is suitable for a wearable patch substrate and shows good drug controlled release potential.

The invention relates to the technical field of biological medicine, and discloses application of maslinic acid or a derivative thereof in preparation of a product for treating clostridium perfringens infection. In-vitro experiments and in-vivo infection models verify that maslinic acid has a good inhibition effect on clostridium perfringens and has a good treatment effect on mammal clostridium perfringens intestinal infection and poultry necrotic enteritis, and a new way and thought are provided for treatment of clostridium perfringens infection; important clinical significance and application value are realized.

Present invention relates to the use of hydroxytyrosol (HT), maslinic acid (MA) and oleanolic acid (OA) as additive in feed for a domesticated animal at very early days of life or from birth. The invention provides an additive with particular amounts of these three ingredients and an additivated feedstuff ready to use comprising said additive.

The invention relates to a traditional Chinese medicine composition containing thermosensitive components and a preparation method and application thereof.According to the preparation method of the traditional Chinese medicine composition containing the thermosensitive components, a large amount of absolute ethyl alcohol is not used for alcohol precipitation, polysaccharide effective components are prevented from being precipitated and lost, high-temperature extraction at the temperature higher than 80 DEG C is not used either, and the extraction time is shortened; the loss of thermosensitive components such as maslinic acid and hesperidin is avoided. The preparation method integrates enzyme engineering, countercurrent kinetics, supercritical fluid and other technologies, while the extraction efficiency is guaranteed, the loss of thermosensitive components such as maslinic acid and hesperidin and effective components of saccharides is reduced, the extraction efficiency is improved, the energy consumption cost is reduced, the dosage of absolute ethyl alcohol is reduced by 70% or above, and the GMP clean production standard is met.

The invention relates to the technical field of medicines for treating non-alcoholic fatty liver diseases, in particular to an application of a compound and a composition thereof in preparation of medicines for treating non-alcoholic fatty liver diseases. The compound used for preparing the medicine for treating the non-alcoholic fatty liver disease or having the body weight reducing effect or the weight losing effect comprises podocarpus macrophyllus flavone A and pharmaceutically acceptable salt thereof, hevea brasiliensis biflavone and pharmaceutically acceptable salt thereof, 3 beta-O-trans-p-coumaroyl maslinic acid and pharmaceutically acceptable salt thereof, 1, 3, 4-trimethyl-1, 3, 4-trimethyl-1, 3, 4-trimethyl-1, 3, 4-trimethyl-1, 3-trimethyl-1, 3-trimethyl-1, 3-trimethyl-1, 3-trimethyl-1, 3-trimethyl-1 The compound is selected from at least one of 3, 6-di-O-caffeoyl-beta-D-glucopyranoside and a pharmaceutically acceptable salt thereof, and 3, beta-O-trans-p-coumaroyl-2alpha-hydroxy-ursoene-12-ene-28-acid and a pharmaceutically acceptable salt thereof. The compound is selected from at least one of 3, 6-di-O-caffeoyl-beta-D-glucopyranoside and a pharmaceutically acceptable salt thereof. According to the technical scheme, the technical problem that drugs for comprehensively adjusting lipid metabolism, improving liver functions and effectively preventing NAFLD development are lacked in the prior art can be solved, and the pharmaceutical composition has ideal application prospects.