101 results about "Maslinic acid" patented technology

Disclosed are preparing processes for industrialized application of Corosolic acid with blood sugar lowering, weight reducing, anti-tumor and anti-inflammatory actions and maslinic acid with anti-tumor, anti-virus and cardiovascular diseases resistant actions. The processes include respectively preparing Corosolic acid and maslinic acid using 3-carbonyl ursolic acid ester and 3-carbonyl oleanolic acid ester by acid catalysed enolization esterification reaction, hydroboration oxidation reaction, catalytic hydrogenolysis reaction and haloidlysis reaction.

The invention belongs to the technical field of microbial fermentation and particularly relates to a preparation method of piglet feed fermented by tomato, hawthorn and fish meal. The preparation method includes: mixing the tomato, the hawthorn and the fish meal with water to obtain concentrated slurry, heating for soaking, sterilizing, cooling, inoculating bacillus subtilis producing protease, brewer's yeast and lactic acid bacteria, fermenting, proportionally adding puffed corn flour, corn flour, broken rice, puffed soybean meal powder, puffed soybean flour, protein whey powder, cane sugar, glucose, citric acid, and premix, fermenting, and drying to obtain the piglet feed fermented by the tomato, the hawthorn and the fish meal. The piglet feed is rich in activated small peptide, lycopene, maslinic acid and lactic acid, is high in nutrients, easily digestible, fine in palatability, low in antinutritional factor content, fine in growth promoting performance and the like. In addition, by the piglet feed, feed intake is improved, feed digestibility is improved evidently, antinutritional factors in the feed can be eliminated, and diarrhea of piglets can be reduced.

PCT No. PCT/ES97/00190 Sec. 371 Date Mar. 20, 1998 Sec. 102(e) Date Mar. 20, 1998 PCT Filed Jul. 24, 1997 PCT Pub. No. WO98/04331 PCT Pub. Date Feb. 5, 1998Process for the recovery of oleanolic and maslinic acids contained in the subproducts resulting from the milling and processing of olives or parts thereof, either proceeding from three-phase or two-phase presses. This process enables to obtain, by separation and with purities higher than 80%, of both acids with yields comprised between 0.2 and 1.5%, as a function of the product and prime material processed. Fundamentally, it comprises selective extractions and fractionation of resulting mixtures with the use of solvents.

A process for increasing lean body mass in a mammalian subject is provided that includes administering to the subject a purified quantity of maslinic acid, oleanolic acid, or a combination thereof. The administration can be orally and benefits from ingestion of an amino acid source such as dietary protein, oligopeptides, or amino acids. Administration within 2 hours of muscle-degrading exercise or on a daily basis for a period of time increases lean body mass.

The invention discloses a method for extracting a maslinic acid and oleanolic acid containing mixture from olea europaea L. pomace. The method comprises the following steps of: extracting an extract from the olea europaea L. pomace in an 80-95wt% (weight percent) ethanol aqueous solution, concentrating the extract, redissolving the extract in a 20-70wt% ethanol aqueous solution, adsorbing by using a macroporous adsorption resin, removing water-soluble impurities by using a water-washing resin column, desorbing by using a desorbing solution, mixing the desorbing solution, recovering the desorbing solution, and drying to obtain a maslinic acid and oleanolic acid containing extract. The mixture extracted from the olea europaea L. pomace contains more than 30% of maslinic acid and more than 23% of oleanolic acid.

A process for producing oleanolic acid and/or maslinic acid and physiologically acceptable salts thereof characterized by comprising extracting with water and/or an organic solvent olive plant and/or products formed in the course of the production of olive oil and then concentrating and/or fractionating and purifying.

The present invention provides a method of producing a triterpene composition wherein callus induced from banaba, loquat, perilla or guava is cultured with indoleacetic acid and another plant hormone, and a triterpene composition containing at least one selected from the group consisting of corosolic acid, tormentic acid, 2α,19α-dihydroxy-3-oxo-urs-12-en-28-oic acid and maslinic acid is obtained from the cultured callus.

The invention relates to red raspberry and hawthorn fruit compound juice and a preparation method thereof. The red raspberry and hawthorn fruit compound juice is prepared from red raspberry juice, hawthorn fruit juice and auxiliary materials. The red raspberry and hawthorn fruit compound juice is characterized in that the mass ratio of the red raspberry juice to the hawthorn fruit juice is 15% to 10%; the auxiliary materials include white granulated sugar the mass of which accounts for 12% of total mass, and a proper amount of citric acid and malic acid. According to sensory indexes, the red raspberry and hawthorn fruit compound juice disclosed by the invention looks like a uniform emulsion which is red or light red, can have a small quantity of pulp precipitates without suspension and layering, has specific smoky fragrance of red raspberry fruits and light sourness and fragrance of hawthorn fruits, is mellow in taste, and is sour and sweet and palatable without abnormal taste; according to physical and chemical indexes, the red raspberry and hawthorn fruit compound juice contains more than or equal to 15% of soluble solids, less than or equal to 0.26% of total acids, and more than or equal to 25% of original juice.

The invention discloses a method for preparing bean curd by a jujube and sour bean curd coagulating agent through curdling, relates to a method for preparing the bean curd, and aims to solve the problem that the bean curd prepared by a maslinic acid extracting solution through curdling is poor in uniformity. The method comprises the steps as follows: firstly, soaking, and obtaining soaked soybeans; secondly, obtaining cooked soybean milk through pulp grinding, filtering and pulp boiling; thirdly, obtaining soybean milk to be coagulated through filtering and cooling; fourth, obtaining solidified soybean milk through standing and coagulating; and fifth, obtaining finished bean curd through coagulating, compression and packaging. The method has the advantages that firstly, the uniformity of the bean curd is good; and secondly, the gel strength of the bean curd is higher than 43.KPa, the water-retention rate is higher than 50% and the bean curd yield is higher than 270%. The method disclosed by the invention is mainly used for preparing the bean curd by the wild jujube and sour bean curd coagulating agent through curdling.

The invention relates to a method for preparing dry hawthorn white spirit, which comprises the following steps: taking dry hawthorn slices as a raw material, adding sugar, doping with natural dry yeast and an additive, putting into a container containing hot water, fermenting for 5-50 days under a condition of the temperature of 10-30 DEG C and then carrying out cold storage for 5-30 days under a condition of the temperature of -5-8 DEG C after ageing and fermenting for 13-90 days; in the brewing process of the dry hawthorn white spirit, the fermentation process of transforming the sugar into alcohol and the extracting process of the nutritional components of amino acid, maslinic acid, flavone, vitamin C, trace elements and the like in hawthorns are simultaneously carried out, the hawthorn slices are transformed into the dry hawthorn white spirit, organic acid, vitamins, flavonoid substances, the trace elements, lipolytic enzymes and the like in hawthorn fruits are transferred into the dry hawthorn white spirit, and the dry hawthorn white spirit which has the sugar degree below 4 degrees and has the alcoholic strength of 12-15 degrees, has very good mouth feel, is sourish, sweet (slightly sweet), bitter (slightly bitter), acerb, clear, transparent, slightly yellow and amber, and is prepared by clarification, filtration, freezing, sterilization, inspection and encapsulation.

The invention belongs to natural products separating and extracting technical field, particularly relating to a process for simultaneously extracting essential oil, flavone and triterpene out of wrinkled giant hyssop. The invention provides a novel separating and extracting process, which can simultaneously separate and extract essential oil, flavone and triterpene by taking wrinkled giant hyssop as raw materials; the used raw materials can be wrinkled giant hyssop as well as cablin pacholi, fresh or dried herbs as well as fresh or dried leaves, stems or other parts. When fresh wrinkled giant hyssop leaves are used as the raw materials, the essential oil thereof comprises more than 40 volatile components such as cis form - isomenthone, anti form - isomenthone piperitone, hexenoic aldehyde, delta-cadinene, cadinol, alpha-muurolene, limonene and pulegone, wherein main volatile components are the cis form - isomenthone and the anti form- isomenthone, contents of which are 34.11 percent and 15.42 percent respectively; the total flavone comprises flavonoids such as acacia substance, tilianin, linarin, agastachoside, isoagastachoside, agastachin, apigenin, apigenin-7- glucoside, 6-methoxyl group apigenin, luteolin and luteolin-7- glucoside, etc., wherein main flavone components are the agastachoside and the isoagastachoside , contents of which are 25.8 percent and 8.21 percent respectively; the triterpene materials comprises triterpene compounds such as cralaegolic acid, oleanolic acid, 3-acetyl oleanolic aldehvde, 3- acetyl oleanolic acid, alpha-amyrin, beta- amyrin, campesterol, campestanol, ursolic acid, erythrodiol, erythrodiol-3-acetic ester, wherein the main triterpene component is the cralaegolic acid , the content of which is 34.6 percent. The components have wide biological activities and a plurality of effects such as liver protection, anti-tumor, anti-HIV-1, anti-proteinase activity of HIV-1, anti-herpes zoster virus and immunity improvement, etc.

The invention relates to a method for preparing spleen strengthening and appetite promoting fructus crataegi and snow pear juice. The method includes uniformly mixing 50-60 parts of fructus crataegi juice and 100-120 parts of snow pear juice with each other and then carrying out homogenization, degassing, sterilization and filling and packaging. The method has the advantages that the fructus crataegi juice is prepared by the aid of operation such as salicylic acid soaking and preliminary storage, baking and roast smoking heating softening, primary enzymatic hydrolysis deacidification and secondary enzymatic hydrolysis fructus crataegi flavone glycosylation, accordingly, spleen strengthening and appetite promoting active components such as polyphenol and flavone in fructus crataegi can be accumulated, the antioxidant activity and the stability can be enhanced, flavor substances can be released, the mouth feel can be improved by means of maslinic acid content adjustment and the like, andflavor and nutrition of the fructus crataegi juice can be reserved to the greatest extent; the snow pear juice is prepared by the aid of pulse type ultrasonic synergistic high-oxygen pretreatment, ultrasonic catalytic micro-nano ozone bubbly water cleaning, ultrahigh-pressure water jet cutting and crushing and low-temperature modified atmosphere type juicing technologies, accordingly, purification, sterilization and browning prevention can be efficiently carried out, the problem of browning during the traditional snow pear juice preparation and the difficult problem of severe loss of nutrients such as vitamin and carotene can be solved, and flavor and nutrition of the snow pear juice can be reserved to the greatest extent.

The invention discloses a full process for preparing hawthorn and walnut milk drink by taking hawthorns and walnuts as raw materials, adding white granulated sugar, polyglycerol fatty acid ester, xanthan gum, sodium bicarbonate, an antioxidant, sodium cyclamate and a softening agent and performing husking, selecting, cleaning, peeling, soaking, grinding, mixing, homogenizing, filling and sterilization, the natural nutritional components and the effects of the hawthorns and the walnuts are retained, and the hawthorn and walnut milk drink is plant protein drink which tastes sweet and sour, is fresh and cool in mouthfeel, is rich in unsaturated fatty acid, flavonoids, various vitamins and various organic acids such as tartaric acid, citric acid, maslinic acid and malic acid, can assist in digestion, tonify spleen and stomach, has obvious effects of expanding blood vessels and reducing pressure, has the functions of enhancing myocardium, resisting arrhythmia and adjusting blood fat and cholesterol content, and is beneficial for patients suffering from hyperlipidemia and hypertension, thereby being certainly popular among people.

The present invention belongs to the technical field of feed and microbial fermentation, and particularly relates to a preparation method of an immune-type Chinese herbal medicine fermented feed. Astragalus membranaceus powder, haw powder, eucommia ulmoides leaf powder, tomato pulp, glucose, yeast extract and water are mixed and blended into a thick seriflux, and the seriflux is heated, soaked, sterilized, and cooled, and inoculated with bacillus licheniformis, aspergillus niger and bacillus coagulans, fermented, and then mixed in proportion with corn flour, soybean meal, puffed soybean flour, whey powder, plasma protein powder, sucrose and premix, fermented, and dried to obtain the immune-type Chinese herbal medicine fermented feed. The feed is rich in active small peptides, astragalus membranaceus polysaccharides, eucommia ulmoides chlorogenic acid, tomatine, maslinic acid and lactic acid, and has the characteristics that the feed is high in nutrition, easy in digestion, good in palatability, low in anti-nutritional factor contents, and strong in immunity promoting effects, etc. At the same time, the feed can increase feed intake, significantly enhance feed digestibility, eliminate anti-nutritional factors in feed, and reduce diarrhea of sucking piglets.

The invention belongs to the field of chemical synthesis, and relates to a chemical synthesis method for crataegolic acid with low content in plants, which is suitable for industrialized production. The method comprises the following steps of: performing oxidation reaction on oleanolic acid serving as a raw material and Jones reagent to form 3-carbonyl oleanolic acid; then reacting the 3-carbonyloleanolic acid and potassium hydrogen persulfate to form 2alpha-hydroxy-3-carbonyl oleanolic acid; and finally, performing reduction reaction on the 2alpha-hydroxy-3-carbonyl oleanolic acid and sodium borohydride to obtain a crataegolic acid product. The method for preparing the crataegolic acid has the advantages of simple reaction step, simplified process route and low loss; the reaction conditions are easy to meet and control; and the reaction is environment-friendly, and the method is suitable for industrialized production.

The invention relates to a preparation method for triterpene acid of loquat leaf and the function of lowering the blood glucose. The preparation method comprises that dry loquat leaves are firstly extracted by ethanol or methanol with certain concentration, reclaimed in ethanol with low condensation for sedimentation, and centrifuged, precipitated and refluxing-decolorized with diatomite or done with chromatography with siliceous earth column, and then eluted with ethanol and reclaimed in condition of decompression and dried to obtain the triterpene acid of loquat leaf. Total content of ursolic acid, oleanolic acid, maslinic acid, corosolic acid and tormentic acid in the triterpene acid reaches more than 50 percent (by weight), wherein, the content of the tormentic acid is to be 10-30 percent, the maslinic acid 4-20 percent, the corosolic acid 5-20 percent, the oleanolic acid 1-10 percent and the ursolic acid 5-20 percent. The triterpene acid of loquat leaf prepared by the invention can be used for curing diabetes mellitus or preparing pharmaceutic preparations used for treating diabetes mellitus and diabetic complication.

The invention relates to a light affinity labelling small molecular probe based on maslinic acid and preparation method thereof, belonging to the technical field of organic compound and preparation thereof. Natural product maslinic acid is taken as initial raw material, compound I is obtained under the protection of acetyl, the compound I reacts with oxalyl chloride to obtain compound II, the compound II reacts with ethane diamine under single protection of Boc to obtain compound III, the compound III firstly strips Boc protecting group in HCl ethyl acetate solution and then reacts with segment IV with light affinity labelling group to obtain compound V, the compound V strips acetyl protecting group by hydrolysis with presence of alkali, so as to obtain light affinity labelling small molecular probe VI. The probe molecule can be used for researching and discovering active compound maslinic acid in vivo action target, action mode of target spot and structural information of active site and provides important information for research and development of related medicine.

The invention provides application of a triterpene compound and a Parkinson's disease treatment medicine. The application comprises blocking of mutual combination between autophagy skeleton protein Beclin1 and an autophagy inhibiting factor Bcl-2 so as to induce nerve cell autophagy, and preparation of a Parkinson's disease treatment medicine. The triterpene compound is any one or a mixture of two of maslinic acid and tormentic acid. The Parkinson's disease treatment medicine provided by the invention comprises a pharmaceutically acceptable auxiliary material as well as an effective dosage of any one or a mixture of two of the maslinic acid and the tormentic acid. The triterpene compounds, namely the maslinic acid and the tormentic acid, are capable of directly blocking mutual combination between the autophagy skeleton protein Beclin1 and the autophagy inhibiting factor Bcl-2, so that the triterpene compounds have the function of promoting autophagy in nerve cells, and have a nerve protection function on Parkinson's disease cells. Therefore, the maslinic acid and the tormentic acid can be directly adopted to prepare the Parkinson's disease treatment medicine, and the Parkinson's disease treatment medicine is endowed with good medicinal effect.

The invention discloses a hawthorn old ginger tea and a preparation method thereof. The hawthorn old ginger tea includes the following raw materials by weight: 10-20 parts of old ginger, 20-30 parts of hawthorn, 15-20 parts of tea, 3-8 parts of dried tangerine peel, 3-8 parts of Chinese wolfberry, 6-12 parts of dark plum, 0.5-4 parts of astragalus, 1-5 parts of salvia miltiorrhiza, 3-7 parts of panax notoginseng, 0.5-3 parts of dalbergia odorifera, 0.5-3 parts of dark brown sugar, 3-8 parts of dried longan, and 3-8 parts of honey. According to the hawthorn old ginger tea, the hawthorn component contains a variety of vitamins, maslinic acid, tartaric acid, citric acid, malic acid and the like, also contains flavonoid, lipoid, saccharide, protein, fat, calcium, phosphorus, iron and other minerals, has very high nutritional value and medical value, and has the effects of increasing appetite, improving sleep, keeping constant calcium in bone and blood and preventing atherosclerosis on the elderly by frequent eating, not only can effectively prevent cardiovascular disease, at the same time can play the role of invigorating stomach and promoting appetite, and preventing wind-cold type common cold, and the hawthorn ginger tea is added with honey, dark plum, Chinese wolfberry, dried longan and the like, thus effectively improving the taste of hawthorn tea.

An external preparation for the skin containing one or more members selected from the group consisting of maslinic acid, erythrodiol, uvaol, betulinic acid, betulin, and physiologically acceptable salts and derivatives of these compounds.

The invention provides a preparation method of maslinic acid and an application of maslinic acid in preparation of an antibacterial agent. According to the preparation method, powerful antibacterial agents (medicines) extracted and separated from akebia medicinal plants widely distributed in China are adopted, the preparation process is simple and has low cost and low contamination, the plant source is rich, the extraction is convenient, and when the fruits of the plants are extracted, the plants are not damaged and can be used for long term, so that the preparation method is environment-friendly and has good economic benefit. The monomeric compound product is stable and easy to store. Maslinic acid has wide antibacterial spectrum and high bacteriostatic activity, is much more likely to be developed into effective and safe food or vegetable and fruit antibacterial agents or new antibacterial agents capable of preventing and treating diseases caused by bacterial infection, and has a better market prospect.

A cosmetic composition and its use as an antioxidant and bleaching agent is described. In particular, said composition comprises different active ingredients, among them a botanical extract, and cosmetically acceptable excipients. The active compounds are selected from ferulic acid, olive leaves extract, maslinic acid, Octadecyl Di-t-butyl-4-hydroxyhydrocinnamate and BHT.

Formulations and methods for transdermal drug delivery compositions that include anastrozole are disclosed. Transdermal anastrozole compositions of the present disclosure may be indicated for treating testosterone deficiency. Disclosed transdermal anastrozole compositions may include permeation enhancers that may improve penetration of anastrozole in human skin. Permeation enhancers within transdermal anastrozole compositions may include oils from Amazon rainforest such as Pracaxi oil, Plukenetia volubilis seed oil, Inaja oil, and Patauá oil, which includes behenic and oleic fatty acids that may provide penetration power. Transdermal anastrozole may include organic solvents as transdermal penetration enhancers. Additionally, transdermal anastrozole compositions may include physiological lipids, phospholipids, and one or more butters rich in linoleic acid and linolenic acid that may also provide penetration power with restorative benefits to the skin.

The invention provides a composition for coronary heart disease and a medical application of the composition. The composition includes the following components in parts by weight: 1-5 parts by weightof puerarinoid D, 5-15 parts by weight of 3'-methoxydaidzin, 1-5 parts by weight of ononin, 10-30 parts by weight of 3'--methyoxy-puerarin, 25-45 parts by weight of puerarin, 10-30 parts by weight of3'-hydroxypuerarin, 0.2-1.0 part by weight of maslinic acid, 0.2-1.0 part by weight of hyperoside, 1.0-2.0 parts by weight of gypenoside A, 0.5-1.5 parts by weight of gypenoside LXXV and 1.0-2.0 partsby weight of gypenoside XLIX. The composition provided by the invention can significantly improve the pathological state of the coronary heart disease by normalizing disordered sphingolipid metabolism and glycerophospholipid metabolism of the coronary heart disease.