7 results about "Maslinic acid" patented technology

This invention discloses a separation and purification device for extracting hawthorn acid from olive pomace. The device includes a base plate, a magnetic pump fixed to the top of the base plate, a support fixed to the top of the base plate, an adsorption cylinder installed on the inner wall of the support, and the magnetic pump and the adsorption cylinder connected via a pipe. An adsorption mechanism is installed on the top of the adsorption cylinder, and a side cover is detachably installed on the cylinder wall. A base is fixed to the top of the base plate, and a hawthorn acid enrichment structure is provided on the top of the base. A valve is connected to the bottom of the adsorption cylinder. This invention can separate ethanol solution from hawthorn acid at room temperature. Compared with the method of multiple concentration and drying and ethanol reconstitution for hawthorn acid separation and purification, it consumes less energy. Furthermore, the device integrates separation and purification functions with target enrichment, eliminating the need to transfer olive pomace extract between different operating devices for further processing, simplifying the hawthorn acid separation and purification process and making it more convenient.

The invention relates to the technical field of preparation of olive leaf extracts, in particular to an olive leaf extract and a preparation process and application thereof, and the process comprises the following steps: crushing dried olive leaves, mixing the crushed olive leaves with an ethanol aqueous solution, and carrying out multi-stage temperature control hot reflux extraction and solid-liquid separation to obtain a supernatant and a precipitate; loading the supernate to a resin column, washing with water and then eluting with ethanol, and drying the eluent to obtain an oleuropein crude product; blending the oleuropein crude product and the sample stirring silica gel, drying, filling into a chromatographic column, eluting by using an ethyl acetate-ethanol mixed solvent, and collecting a high-purity oleuropein fine product; sequentially carrying out ultrasonic dissolution, concentration, standing crystallization and filtration on the precipitate through medium-concentration and high-concentration ethanol to obtain a maslinic acid crude product and an oleanolic acid crude product; and respectively heating and dissolving with ethanol, cooling and crystallizing, and circularly recrystallizing to obtain a corresponding refined product. The invention aims to guarantee the extraction yield and quality of oleuropein by controlling the multi-stage temperature of heating reflux extraction of olive leaves.

The application belongs to the field of biological medicine, and particularly relates to a Bama pig model for preclinical research of a weight loss drug COST and application. Healthy Bama pigs are first adaptively fed with ordinary feed, and then fed with high-fat feed to model, and the Bama pigs are detected for obesity-related indexes at a fixed time period every week; the high-fat feed comprises ordinary feed, beef tallow, artificial butter, sucrose, casein, experimental animal premix, microcrystalline cellulose, calcium bicarbonate, gypenoside, peppermint leaf, maslinic acid, ursolic acid, atractylodes, nutmeg. The application can quickly construct a Bama pig model with stable phenotype, and provides a reliable model for preclinical research of a new drug for treating obesity, and provides guarantee for research on the mechanism of obesity, screening, development and mechanism research of a new drug for treating obesity and the like.

The application relates to the technical field of composite piezoelectric materials, and particularly discloses a composite nano piezoelectric material loaded with maslinic acid, a preparation method and application thereof, which comprises the following steps: adding barium titanate nano powder and maslinic acid into a solvent in sequence, performing ultrasonic treatment, then stirring and treating at 50-70 DEG C for 1.5-3h to obtain a mixture; adding PVDF powder into the mixture, stirring and treating at 50-70 DEG C for 4-6h to obtain a final mixed solution; meanwhile, washing and drying a glass slide to obtain a treated glass slide substrate; coating the mixed solution on the glass slide to form a film, drying to obtain a precursor film; and performing polarization treatment on the film to obtain the composite nano piezoelectric material loaded with maslinic acid. By introducing the barium titanate and the maslinic acid, the application effectively induces the PVDF to form a high-content polar beta crystal phase, thereby significantly improving the piezoelectric performance of the PVDF, and meanwhile, the flexibility of the PVDF film is also enhanced, the wearable patch substrate is suitable, and the application exhibits good drug controlled release potential.

The application belongs to the field of biological pharmacy, and particularly relates to application of maslinic acid as a cisplatin ototoxicity protective agent. The application discloses that maslinic acid can prevent cisplatin-induced ototoxicity by restoring the activity of mouse cochlea hair cells SLC7A11, and can repair cisplatin-induced hearing impairment in mice. Experimental results show that maslinic acid can restore the reduced activity of SLC7A11 caused by cisplatin, thereby reducing the intracellular LPO level, increasing the HEI-OC1 cell survival rate, and not affecting the anticancer effect of cisplatin; animal experiments also show that maslinic acid can inhibit cisplatin-induced hearing impairment in mice. Therefore, maslinic acid can reduce the ototoxicity of cisplatin and play an inner ear protection role.

The invention relates to the technical field of composite piezoelectric materials, and particularly discloses a maslinic acid-loaded composite nano piezoelectric material external application patch as well as a preparation method and application thereof.The preparation method comprises the following steps: sequentially adding barium titanate nano powder and maslinic acid into a solvent, performing ultrasonic treatment, and then performing stirring treatment at 50-70 DEG C for 1.5-3 h to obtain a mixture; pVDF powder is added into the mixture, stirring treatment is conducted for 4-6 h at the temperature of 50-70 DEG C, and a final mixed solution is obtained; meanwhile, cleaning and drying the glass slide to obtain a treated glass slide substrate; coating the mixed solution on a glass slide to form a film, and drying to obtain a precursor film; and carrying out polarization treatment on the membrane to obtain the maslinic acid-loaded composite nano piezoelectric material. By introducing barium titanate and maslinic acid, PVDF is effectively induced to form a high-content polar beta crystal phase, so that the piezoelectric property of PVDF is remarkably improved, the flexibility of the PVDF film is enhanced, and the PVDF film is suitable for a wearable patch substrate and shows good drug controlled release potential.

Present invention relates to the use of hydroxytyrosol (HT), maslinic acid (MA) and oleanolic acid (OA) as additive in feed for a domesticated animal at very early days of life or from birth. The invention provides an additive with particular amounts of these three ingredients and an additivated feedstuff ready to use comprising said additive.