Process for simultaneously abstracting essential oil, chromocor and triterpenes components from agastache

A technology of triterpenes and essential oils, applied in the field of processing and utilization of Chinese herbal medicine resources

Inactive Publication Date: 2008-10-15
JIANGNAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

The process of simultaneously extracting essential oils, flavonoids an

Method used

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  • Process for simultaneously abstracting essential oil, chromocor and triterpenes components from agastache
  • Process for simultaneously abstracting essential oil, chromocor and triterpenes components from agastache
  • Process for simultaneously abstracting essential oil, chromocor and triterpenes components from agastache

Examples

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example 1

[0016] Take 100g of patchouli stems, put it on the steam distillation device, connect the steam generating device, carry out steam distillation, condense with tap water at 20°C, collect the distillate, and distill until the distillate reaches 300ml. The residue was left to dry at room temperature; the distillate was rectified to obtain 2.5 g of essential oil. After the residue was aired until the moisture content was lower than 15%, it was extracted with ethanol with a concentration of 95% v / v according to a solid-liquid ratio of 1:4 at reflux temperature (78.5°C) for 3 times, each time for 30 minutes, to obtain an ethanol extract. The solvent was recovered from the ethanol extract to obtain 13.05 g of a tan to tan paste. The paste was extracted 3 times with acetone at reflux temperature (56.5° C.) according to the solid-liquid ratio of 1:4, each time for 30 minutes, and the paste was divided into two parts: acetone extract and acetone-insoluble solid powder. Acetone was reco...

example 2

[0018] Take 20kg of fresh patchouli leaves, put them into a 1000L still after rinsing, feed steam for steam distillation, condense with water at 4°C, collect the distillate, and distill until the distillate reaches 100kg to stop. Collect the residue in the distillation still, dry it in a vacuum oven at 60°C until the water content is less than 10%, put the distillate in a fractionation still for fractional distillation, collect the first 0.5% fraction, and obtain 0.5kg of essential oil. After the moisture content reaches the requirement, according to the solid-liquid ratio of 1:4, soak and extract with 95% v / v ethanol at 75° C. for 3 times, each time for 30 minutes, to obtain an ethanol extract. The extract was placed on an evaporating and concentrating device to recover ethanol to obtain 2.5 kg of brownish-yellow to tan paste. The paste was added with acetone according to the solid-liquid ratio of 1:4, and extracted three times at the reflux temperature (56.5° C.) to obtain a...

example 3

[0020] The composition of an essential oil sample obtained by steam distillation of fresh Ageratum leaves was determined, and the results are shown in Table 1. The measurement results showed that the main components of the essential oil obtained from fresh Ageratum leaves were cis-isomenthone and trans-isomenthone, the contents of which were 34.11% and 15.42%, respectively. The rest are 40 ingredients such as piperonone, hexenal, δ-juniperne terpene, juniper alcohol, α-ylangene, limonene, pulegone, etc. Among them, piperonone has an antiasthmatic effect and is allergic to guinea pigs Shock has a protective effect, and with the increase of dose, there is a quantitative-effect relationship, which can be used for the treatment of asthma. Pulegone has antihistamine effect, hexenal has effective antibacterial activity, D-limonene has antitumor effect, antibacterial activity, expectorant, cough relieving effect, and gallstone dissolution effect, indicating that the essential oil obt...

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Abstract

The invention belongs to natural products separating and extracting technical field, particularly relating to a process for simultaneously extracting essential oil, flavone and triterpene out of wrinkled giant hyssop. The invention provides a novel separating and extracting process, which can simultaneously separate and extract essential oil, flavone and triterpene by taking wrinkled giant hyssop as raw materials; the used raw materials can be wrinkled giant hyssop as well as cablin pacholi, fresh or dried herbs as well as fresh or dried leaves, stems or other parts. When fresh wrinkled giant hyssop leaves are used as the raw materials, the essential oil thereof comprises more than 40 volatile components such as cis form - isomenthone, anti form - isomenthone piperitone, hexenoic aldehyde, delta-cadinene, cadinol, alpha-muurolene, limonene and pulegone, wherein main volatile components are the cis form - isomenthone and the anti form- isomenthone, contents of which are 34.11 percent and 15.42 percent respectively; the total flavone comprises flavonoids such as acacia substance, tilianin, linarin, agastachoside, isoagastachoside, agastachin, apigenin, apigenin-7- glucoside, 6-methoxyl group apigenin, luteolin and luteolin-7- glucoside, etc., wherein main flavone components are the agastachoside and the isoagastachoside , contents of which are 25.8 percent and 8.21 percent respectively; the triterpene materials comprises triterpene compounds such as cralaegolic acid, oleanolic acid, 3-acetyl oleanolic aldehvde, 3- acetyl oleanolic acid, alpha-amyrin, beta- amyrin, campesterol, campestanol, ursolic acid, erythrodiol, erythrodiol-3-acetic ester, wherein the main triterpene component is the cralaegolic acid , the content of which is 34.6 percent. The components have wide biological activities and a plurality of effects such as liver protection, anti-tumor, anti-HIV-1, anti-proteinase activity of HIV-1, anti-herpes zoster virus and immunity improvement, etc.

Description

technical field [0001] The invention relates to a process for simultaneously extracting essential oil, flavonoids and triterpenes from Huoxiang, belonging to the technical field of processing and utilization of Chinese herbal medicine resources. Background technique [0002] Patchouli (Herba Pogostemosis, also known as geranium mint, patchouli), is an annual herb, and it is also a well-known common herbal medicine in Southeast Asia. It is native to subtropical regions such as the Philippines in Asia. It is mainly produced in Guangdong and Hainan in my country; it is cultivated. Patchouli is a commonly used aromatizing dampness medicine in clinic. It has a pungent taste and slightly warm nature, and it returns to the spleen, stomach, and lung meridians. Clinically, it is mainly used for the treatment of dampness and turbidity, nausea and vomiting, summer-dampness fatigue, chest tightness and discomfort, cold-dampness blocking heat, abdominal pain and diarrhea, nasal sinusiti...

Claims

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Application Information

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IPC IPC(8): C11B9/00C07D311/30C07J63/00
Inventor 汤鲁宏葛海锋姜瑞霞邓超陈伟
Owner JIANGNAN UNIV
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