The present invention is a method for improving
atopic dermatitis, comprising administering to a subject in need thereof a composition comprising a low-molecular-weight
fucoidan (LMF), wherein the weight-average molecular weight of the LMF is less than 3,000 Daltons. The composition of the present invention can effectively improve the area and severity of the
lesion in patients with AD, as well as the
itching symptoms (including
insomnia symptoms caused by
itching), and can significantly improve the SCORAD index of patients with AD. In addition, the composition of the present invention can reduce the patient's dependence on topical
steroid ointments and / or oral antihistamines and reduce the AD-related immune parameters without increasing the biochemical indices of
liver and kidney. Therefore, the composition of the present invention can be both effective and safe in the treatment of AD.