12results about How to "Significant clinical effect" patented technology

This invention provides an ophthalmic gel composition comprising (1) ropinirole or a pharmaceutically acceptable salt thereof, (2) one or more thickeners, and other pharmaceutically acceptable excipients, wherein the viscosity of the ophthalmic gel composition is ≥100 mPa·s. The ophthalmic gel composition increases the viscosity of the product, prolonging the adhesion time of ropinirole to the eye. Compared with other dosage forms, it achieves both rapid onset of action and convenient administration, greatly enhancing its clinical value as an emergency medication.

This invention discloses a topical Chinese medicine preparation for treating erosive tinea pedis and its preparation method, belonging to the technical field of topical Chinese medicine preparations. The preparation consists of 15-25 parts clove, 10-20 parts alum, 20-30 parts Polygonum cuspidatum, and 10-18 parts Psoralea corylifolia, and is prepared into a spray using a 45% low-alcohol countercurrent extraction process. This invention achieves synergistic effects through a three-stage targeting mechanism: eugenol inhibits fungal CYP51A1 enzyme, blocking ergosterol synthesis (targeted enrichment rate 62.1%), resveratrol inhibits the NF-κB pathway, reducing inflammatory response, and psoralen activates the PI3K / AKT pathway, promoting epidermal repair (repair rate 69.2%). The alcohol concentration of the preparation is reduced to 45%, eliminating irritation to broken wounds. A single application takes only 1 minute, and a 7-day treatment course has a clinical efficacy rate of 84.7%, saving 320 yuan per person compared to traditional methods. This invention overcomes the shortcomings of existing drugs for treating erosive tinea pedis, such as strong irritation, cumbersome operation, and limited efficacy, and fills the gap in the category of specialized preparations, with significant social benefits and market prospects.

The application belongs to the technical field of traditional Chinese medicine compositions, and particularly relates to a traditional Chinese medicine compound preparation for treating anal eczema as well as a preparation method and application thereof. The traditional Chinese medicine compound preparation is prepared from the following raw medicinal materials in parts by weight: 35-45 parts of Sophora flavescens, 35-45 parts of Cnidium monnieri, 18-22 parts of Semen Astragali Complanati, 18-22 parts of Cortex Dictamni, 18-22 parts of Scutellaria baicalensis, 118-22 parts of Phellodendri, 10-14 parts of Chuanxiong Rhizoma, 16-20 parts of Angelica sinensis, 10-14 parts of Radix Paeoniae Alba, 16-20 parts of Saposhnikovia divaricata, and 10-14 parts of Gleditsia sinensis. The application provides a traditional Chinese medicine compound preparation and a Chinese medicine treatment method for treating acute and chronic anal eczema caused by 'damp-heat invasion'. The traditional Chinese medicine compound preparation can not only significantly relieve the perianal pruritus and exudation of the patients with anal eczema, but also effectively reduce the skin lesion area and improve the skin lesion state, and the clinical curative effect is obvious. In addition, the raw materials of the traditional Chinese medicine compound preparation are widely sourced and low in price, the pure traditional Chinese medicine raw materials are used for processing, and the preparation process is simple.

This invention provides a traditional Chinese medicine composition for clearing the lungs and relieving asthma, its granules, and their applications, relating to the field of traditional Chinese medicine technology. The traditional Chinese medicine composition for clearing the lungs and relieving asthma of this invention is prepared from the following raw materials in the indicated weight proportions: Ephedra 8-12g, Earthworm 8-12g, Bitter Apricot Kernel 8-12g, Mulberry Bark 8-12g, Coltsfoot Flower 13-18g, Stemona 13-18g, Platycodon Root 8-12g, Prepared Pinellia Rhizome 8-12g, Tangerine Peel 8-12g, Ginkgo Root 8-12g, Scutellaria Root 13-18g, Perilla Seed 13-18g, Trichosanthes Peel 25-35g, Peucedanum Root 8-12g, and Belamcanda Rhizome 8-12g. The traditional Chinese medicine formula provided by this invention has good clinical efficacy in treating chronic obstructive pulmonary disease, with high clinical control and efficacy rates, and a high overall effective rate.

Provided in the present invention are an anti-human thymic stromal lymphopoietin (TSLP) monoclonal antibody and the use thereof. The monoclonal antibody has high affinity for human TSLP, has a neutralizing activity, and can be used for preventing or treating TSLP-mediated diseases.

The present application relates to the technical field of medical materials, in particular to a premixed calcium silicate-niobium compound composite root canal filling agent, a preparation method and application. The composite root canal filling agent comprises: (a) a calcium silicate compound, (b) a phosphate compound, (c) a calcium compound, (d) a niobium compound, (e) a barrier material, (f) a non-aqueous phase solvent miscible with water, and (g) an organic substance, wherein the total amount of components (a), (b), (c), (d), (e) and (g) accounts for 60-95% of the total mass of the filling agent, and the component (f) accounts for 5-40% of the total mass of the filling agent. The filling agent has the advantages of fast solidification, good biological activity, excellent antibacterial performance and easy popularization and application.

The application discloses a kind of external use traditional Chinese medicine compound compositions for reducing sensitivity of glans penis and penis and prolonging intravaginal ejaculation latency, and the pharmaceutical composition includes the following weight fractions of components: 30-70 parts of gallnut, 0.2-3 parts of toad venom, 9-35 parts of pomegranate peel, 6-14 parts of cnidium, 9-35 parts of dandelion, 6-14 parts of sophora, 2-10 parts of mint, 0.5-4 parts of pepper.The traditional Chinese medicine compound composition provided by the application uses scientific proportioning, mutually coordinates and mutually promotes between components, and plays the role of synergistic effect.The external use traditional Chinese medicine compound of the application can significantly reduce the sensitivity of glans penis and penis, prolong intravaginal ejaculation latency, has definite clinical curative effect, is convenient to use, has good patient tolerance and compliance, is safe and has no side effect, long-term use is not found adverse reaction, and after being made into standard preparation, can promote the standardization treatment of external treatment of traditional Chinese medicine.

Provided in the present invention are an anti-human thymic stromal lymphopoietin (TSLP) monoclonal antibody and the use thereof. The monoclonal antibody has high affinity for human TSLP, has a neutralizing activity, and can be used for preventing or treating TSLP-mediated diseases.

The application discloses a sawtooth piece, a sawtooth balloon and a sawtooth piece manufacturing method, and belongs to the technical field of medical devices.The sawtooth piece comprises a strip capable of being bonded to the outer surface of the balloon through a glue layer, the strip is provided with sawteeth arranged at intervals along the length direction of the strip, the end side area of the strip is provided with a bonding reinforced end head, and the bonding reinforced end head is provided with an embedding groove for embedding the glue layer.The sawtooth balloon comprises a balloon and a sawtooth piece, the length direction of the strip of the sawtooth piece is arranged along the axial direction of the balloon, the strip is connected with the balloon through a connecting structure, and the connecting structure at least comprises a glue layer.The sawtooth piece manufacturing method comprises the following steps: performing plastic processing on the end side area of the strip with sawteeth to form a bonding reinforced end head with an embedding groove, and the embedding groove is used for embedding the glue layer on the outer surface of the balloon.The main failure mode of the sawtooth piece, i.e., end lifting, can be effectively avoided, thereby avoiding the problem of the overall falling of the whole sawtooth piece.

The application discloses a double-camera visual flushing double-lumen bronchial intubation device and a collaborative control method, belongs to the technical field of medical devices, and aims to solve the problems of single data acquisition, lagging abnormal identification and easy distraction of doctors by double video streams of the existing device. The method comprises the following steps: capturing the positioning depth of the tube core through the positioner, triggering the double-camera to collect the cuff and lumen video streams and to construct a collaborative data set, triggering the lumen video stream sampling analysis through the tube core stable state judgment, regulating the sampling interval and screening the redundant frames to construct a key frame set, identifying the abnormal frames through the benchmark correction and multi-feature difference calculation, and adaptively switching the display terminal video source based on the abnormal degree. The application realizes accurate identification and efficient monitoring of the airway, takes into account the clinical operation concentration and response timeliness, and significantly improves the safety and operation efficiency of the intubation operation.

This invention relates to an odor combination for improving non-motor symptoms of Parkinson's disease. Its active ingredients consist of phenylethanol, eucalyptol, citronellol, and eugenol in a mass ratio of 0.5-2:0.5-2:0.5-2:0.5-2, with menthol microcapsules as the functional adjuvant. Each active ingredient is mixed with the menthol microcapsules in a mass ratio of 2-4:1, and the active ingredients are layered on a hydrogel material. The odor combination can be used alone or in conjunction with a breathing guide to form a multi-layered controlled-release olfactory training component. The odor combination and olfactory training component can generate a more progressive and hierarchical odor stimulation pattern that conforms to the laws of neural information processing, inducing stronger neural plasticity; it can also improve the experience and enjoyment of the training process, thereby increasing the long-term training compliance of Parkinson's disease patients; and the added adjuvant, without interfering with the main olfactory training, helps to regulate the patient's emotions and attention, thus producing a synergistic therapeutic effect.