95 results about "Phillyrin" patented technology

The invention relates to a traditional Chinese medicine white wine medicament for effectively curing dermatopathy, which has the advantages of reasonable and scientific composing prescriptions, evident effect, convenient and hygienic employment, and is natural without hormones and chemical auxiliary agent, and is safe and reliable, and does not have side effect. The invention is made from raw material with the following part by weight, anoelica sinensis 8-10 parts by weight ( the following unit is the same), red peony root 6-10, chuanxiong rhizome 3-5, schizonepeta tenuifolia 3-5, coralbean bark 6, astragalus root 6-8, Chinese dittany bark 10-15, phillyrin 12-15, flavescent sophora root 15, honeysuckle flower 8-12, borneo camphor 3-5, radix salvia miltiorrhiza 9, frank incense 5, myrrh 5, and white wine 1.5-2, and the following operating procedures are concluded, the raw material except the borneo camphor, the frank incense, and the myrrh are positioned in a vessel and are filled with the white wine with the amount of 3-5cm higher than the medicine surface, and are sealed, and are opened and churned once a weak, and are immersed for three months in spring and two months in summer, and are filled with the frank incense and the myrrh one week before the employment, and can be employed when the medicine is filtered and is added with the borneo camphor.

The invention discloses preparation and quality detection method of compound prescription cortex phellodendri chinensis fluid. The quality detection method comprises the identification of forsythia fruit, cortex phellodendri, honeysuckle and dandehon herb, the checking of lonicerae flos, and the content determination of forsythin and berberine hydrochloride. According to the determination method, spots with the same colors are formed in a qualified test article thin-layer chromatogram and in corresponding positions of a reference substance thin-layer chromatogram, and negative control is interference-free, and the method is good in selectivity, simple and accurate. The checking method of lonicerae flos adopts a high performance liquid chromatography, is good in specificity, and can distinguish the situation that lonicerae flos is adopted in the compound prescription cortex phellodendri chinensis fluid to pretend honeysuckle flower to charge material. The content determination of forsythin and berberine hydrochloride is good in linear relation and high in recovery test accurancy, has good repeatability and stability, can accurately and strictly detect the quality of the compound prescription cortex phellodendri chinensis fluid, and guarantees a high quality standard level of the compound prescription cortex phellodendri chinensis fluid.

The invention relates to a method for rapidly and simultaneously detecting multiple indexes of a fructus forsythia medicinal material. The method comprises the following steps: collecting the fructus forsythia medicinal material; determining the content of rutin, forsythiaside A and forsythin by a high performance liquid chromatography; collecting near infrared spectrum data of fructus forsythia medicinal material powder, pretreating, building rapid detection models for the content of moisture, extractum, rutin, forsythiaside A and forsythin in the fructus forsythia medicinal material, wherein the built models are used for rapidly and simultaneously determining the content of various quality control indexes of the fructus forsythia medicinal material; and building a real-time release quantification standard. The method can be used for rapidly determining the content of the moisture, the extractum, the rutin, the forsythiaside A and the forsythin in the fructus forsythia medicinal material. Compared with a traditional method, the built analysis method and real-time release quantification standard are capable of relatively rapidly judging whether the quality of the medicinal material is qualified or not, and determining whether the medicinal material can enter the subsequent production process links or not, so that the rapid and high-efficiency scene requirements in practical production are met; and the method has an application prospect in producing medicinal material screening and comprehensive quality evaluation.

The invention provides a preparation method of Fructus Forsythiae extract, and belongs to the field of preparative technique of Chinese traditional medicine. The inventive method comprises decocting Fructus Forsythiae with water for extraction, preliminary purifying through alcohol precipitation, and refining through water satured n-butanol extraction method. Compared with present technology, the invention obtains efficient extract with phillyrin as main ingredient, avoids the loss of phillyrin in each operation, especially guarantee extraction rate of phillyrin, completely transfers effective ingredient, improves purity, thus, the invention has simple operation, and can provide technological conditions in favor of industrial production.

The invention provides a Shuanghuanglian medicinal composition. A method for preparing the Shuanghuanglian medicinal composition comprises the following steps of: mixing and extracting honeysuckle and fructus forsythiae to obtain a honeysuckle and fructus forsythiae extract; extracting scutellaria baicalensis to obtain a scutellaria baicalensis extract; and mixing the honeysuckle and fructus forsythiae extract and the scutellaria baicalensis extract to obtain the Shuanghuanglian medicinal composition, wherein the weight ratio of the honeysuckle to the fructus forsythiae to the scutellaria baicalensis is 1:2:1; and the medicinal composition comprises the following components in percentage by weight: 20 to 40 percent of total flavone, 5 to 20 percent of total saponins, 20 to 30 percent of total organic acid, 8 to 18 percent of saccharides, 0.2 to 2 percent of total amino acid and 0.35 to 1.0 percent of phillyrin. In the Shuanghuanglian medicinal composition, active ingredients are extracted and separated from the honeysuckle, the fructus forsythiae and the scutellaria baicalensis, the impurities and the inactive ingredients are removed, each active ingredient is proportioned reasonably, and the content of chlorogenic acid and caffeic acid is strictly limited, so that curative effect is ensured and safety is improved.

The invention relates to an antivirulent drug composition, and a preparation and a preparation method thereof. The drug composition comprises scutelloside, chlorogenic acid and caffeic acid, and phillyrin, wherein the weight ratio of scutelloside to chlorogenic acid to caffeic acid to phillyrin is (10-18):(0.6-2):(0.3-1). The drug composition and the preparation provided by the invention have a better inhibition effect on avian influenza virus and influenza A H1N1, with the effect being superior to that in the prior art.

The invention provides the application of phillyrin in preparing medicine that prevents and treats acute or chronic liver injury and liver fibrosis. It can be produced into oral preparation or injection preparation. The dose for injection is 25-800mg, and for oral is 50 -1500mg.

The present invention discloses a bulk drug phillyrin quality detection method, which comprises: 1) identifying phillyrin, 2) determining the phillyrin content, and 3) detecting the related substance. According to the present invention, the method is mainly used for the quality control of the bulk drug phillyrin and the preparation thereof, and has characteristics of simpleness, stability, good repeatability, testing efficiency improving, and bulk drug phillyrin and preparation treatment effect ensuring.

The invention discloses a medical polylactic acid (PLA) suture line. The medical polylactic acid (PLA) suture line is mainly prepared from, by weight, 9-13 parts of bidens tripartite, 10-16 parts of andrographis paniculata, 7-11 parts of phillyrin, 5-9 parts of folium isatidis, 6-8 parts of saposhnicovia divaricata, 3-7 parts of peanut coats, 6-10 parts of cape jasmine, 8-13 parts of patience dock roots, 4-9 parts of carbonized rubia cordifolia, 6-9 parts of humifuse euphorbia herb, 5-10 parts of panax notoginseng, 3-6 parts of resina draconis, 8-11 parts of agrimonla pilosa ledeb, 20-34 parts of PLA, 15-25 parts of chitin, an appropriate amount of crosslinking agents, an appropriate amount of stabilizer and an appropriate amount of antibacterial agents. The medical polylactic acid (PLA) suture line has the advantages that the suture line has the effects of resisting bacteria, eliminating inflammation, stopping blood and alleviating pain, can effectively restrain growth of pathogenic bacteria, prevent postoperation wound infection and accelerate wound healing, and is safe, effective and free of any toxic and side effects.

The invention relates to an antivirus extract, which comprises the following preparation medicinal materials in part by weight: 4.5 parts of mint, 4.5 parts of weeping forsythiae, 3 parts of unripe licorice, 4.5 parts of black gardenia husk, 9 parts of platycodon root, and 6 parts of mung bean seed-coat. The antivirus extract is prepared by a method through the following steps: 1) drying the medicinal materials, wherein the drying temperature is 50+/-10 DEG C and the drying time is 3 to 4 hours; 2) crushing the medicinal materials into coarse powder; 3) putting the medicinal materials into a supercritical extraction tank, and adding an entrainer ethanol or methanol, wherein the extraction condition comprises: a first-stage decompression separation under a condition with a pressure of 5 to 10 MPa, a temperature of 40 to 60 DEG C and a flow of 15 to 20 L/h to perform extraction for 3 to 4 hours, and a second-stage decompression separation under a condition with a pressure 5 to 10 MPa and a temperature of 35 to 50 DEG C; and 4) dehydrating and drying the extract. Through the supercritical preparation process, total flavone, total saponin and total terpenoid components can be enriched effectively. The antivirus extract comprises the following components in characteristic percentage by weight over 6 percent of the total flavone, over 15 percent of the saponin, over 0.3 percent of phillyrin, and over 2 percent of total volatile oil. The antivirus extract has the characteristics of more significant anti-inflammatory and anti-influenza virus functions, simple preparation process, high extraction yield, low cost and the like.

The invention discloses new application of phillyrin, phillyrin derivatives, and a phillyrin-phillygenin composition in preparation of drugs or health care products for relief or/and treatment of vomiting. Tests prove that the phillyrin, phillyrin derivatives, and phillyrin-phillygenin composition have the characteristics of significant vomiting relief or treatment effect, quick effect and small toxic and side effect, are a safe, efficient and stable vomiting treatment drug with a simple preparation process, and are suitable for industrial production and easy for popularization. The invention provides a new drug source for prevention and treatment of vomiting and its complications.

The invention discloses new application of phillyrin, phillyrin derivatives, and a phillyrin-phillygenin composition in preparation of anti-aging drugs. Tests prove that the phillyrin, phillyrin derivatives, and phillyrin-phillygenin composition have the characteristics of significant anti-aging effect, quick effect and small toxic and side effect, are a safe, efficient and stable anti-aging drug with a simple preparation process, and are suitable for industrial production and easy for popularization. The invention provides a new drug source for age defying and aging induced complications.

The invention provides a preparation method for an antivirus compound which adopts a supercritical carbon dioxide extraction method to extract a lipophilic active ingredient of patchouli and grass-leaved sweetflag, which is characterized in that the lipophilic active ingredient is volatile oil, the extracting efficiency is more than two times of the efficiency of steam distillation, no solvent toxicity remains, heat sensitive ingredient in natural active ingredient is not easy to de-compound and damage, and the natural characteristic of the extraction can be furthest maintained. Furthermore, active parts in antivirus compound are obtained by respectively exacting with water and alcohol, the extraction process is simple, scientific and reasonable, and active ingredient in medicinal materials can be furthest extracted. After impurities are removed, the active ingredient contents of mangiferin and phillyrin in medicine are respectively 16 time and 2 times higher than the same extracted with a prior method.

The invention provides a method for detecting a traditional Chinese medicine composition. According to the method, seven components of chlorogenic acid, caffeic acid, rutin, isochlorogenic acid B, isochlorogenic acid C, forsythiaside A and phillyrin in the traditional Chinese medicine composition are detected through an ultra-high performance liquid chromatography, and the quality of the traditional Chinese medicine composition can be represented more comprehensively.

The invention relates to a quantitative fingerprint quality monitoring technology for Shuanghuanglian oral liquid, and belongs to the technical field of compound quality analysis. A dual-wavelength quantitative fingerprint spectrum quality control method is established on the basis of a high performance liquid chromatography-ultraviolet detection technology, fingerprint spectrum monitoring of the Shuanghuanglian oral liquid is achieved through one-time analysis, content determination of three index components of chlorogenic acid, baicalin and forsythin is achieved at the same time, and one-standard multi-determination amount of neochlorogenic acid and cryptochlorogenic acid is achieved. According to the method, fingerprint spectrum and quantitative detection are simultaneously realized in one-time analysis, the quality of the Shuanghuanglian oral liquid can be more comprehensively and accurately evaluated, the Shuanghuanglian oral liquid of different manufacturers can be distinguished, meanwhile, the detection time is shortened to the greatest extent, and the resource consumption is reduced.

The invention belongs to the field of traditional Chinese medicine preparations, and particularly provides a preparing method of coptidis-rhizoma shangqing tablets.The coptidis-rhizoma shangqing tablets are prepared from 5 g of coptidis rhizome, 40 g of phillyrin, 20 g of radix saposhnikoviae, 40 g of radix angelicae, 80 g of chrysanthemums, 160 g of rheum officinale, 40 g of platycodon grandiflorum, 20 g of gypsum, 20 g of liquorice roots, 40 g of cape jasmine, 40 g of fried fructus viticis, 40 g of schizonepetaspike, 40 g of radix scutellariae, 20 g of mint, 20 g of cortex phellodendri, 20 g of rhizoma chuanxiong and 10 g of inula flowers through supercritical fluid extraction.The content is greatly increased, and the use quantity is reduced.The invention further provides an application of coptidis-rhizoma shangqing tablets to preparing of medicine for inhibiting proliferation of mouse macrophage tumors RAW-26407.

The invention discloses a miraculous pill of ledebouriella and a preparation method of the pill. The miraculous pill of ledebouriella is characterized in that 57g of radix clematidis, 38g of tabasheer, 38g of chinaberry fruits, 50g of mint, 50g of ephedra, 50g of rheum officinale, 50g of mirabilite, 27g of jasmine, 300g of talcum, 100g of balloon flower, 114g of plaster, 57g of chuanxiong rhizome, 50g of angelica, 114g of radix scutellariae, 57g of phillyrin and 228g of liquorice are crushed into crude powder and placed in a circulating ultrasonic extractor, water, germanium powder and tween 60 are added, ultrasonic extraction and jet spray drying are performed to prepare nano extraction powder, and honey is refined and coats the pill to prepare the miraculous pill of ledebouriella. The miraculous pill of ledebouriella is used for treating external cold, internal heat, internal-external sthenia, aversion to cold, strong fever, headache, dry throat, scanty dark urine, constipation, first symptoms of scrofula and rubella eczema, remarkable in curative effect and superior to commercially available miraculous pills of ledebouriella, and achieves fine effects.

The present invention discloses a piglet drug-resistant colibacillosis treating traditional Chinese medicine composition, which comprises 5-40% of cortex phellodendri, 5-40% of scutellaria baicalensis georgi, 5-40% of hypericum perforatum l, 5-40% of valeriana jatamansi jones, 5-40% milkvetch root, and 5-40% of acorus tatarinowii. According to the present invention, the product can treat piglet infectious diseases caused by drug-resistant Escherichia coli, infectious gastroenteritis viruses or epidemic diarrhea viruses, and does not have adverse reactions, drug residues and drug resistance during the use process; the product adopts berberine, phillyrin and hyperoside as the quantitative indexes and adopts the control substances of berberine, phillyrin, hypericum perforatum l, valeriana jatamansi jones, milkvetch root and acorus tatarinowii as the identification indexes so as to control the quality; and the safety test results and the clinical trial results prove that the granular dosage form of the product is safe and effective.

The invention relates to a Chinese herbal medicine combination drug treating livestock respiratory diseases and a preparation method thereof. The Chinese herbal medicine combination drug comprises, by weight, 95-105 parts of white mulberry root bark, 75-85 parts of rhizoma anemarrhenae, 75-85 parts of apricot kernels, 110-130 parts of gypsum, 55-65 parts of phillyrin, 55-65 parts of radix glycyrrhizae, 95-105 parts of radix scutellariae, 55-65 parts of platycodon grandiflorum and 55-65 parts of bupleurum. The combination drug is prepared on the basis of the traditional Chinese medicine theory in the principle of drug matching, and modern pharmacological research results are taken as reference. The combination drug has the effects of dispelling wind and heat, clearing the lung and calming panting, relieving sore-throat and diminishing swelling, resolving superficies syndrome with pungent and cool natured drugs and clearing heat and detoxifying. The combination drug is mainly used for treating the livestock respiratory diseases caused by single pathogens or various pathogens, and is an innovation of veterinary drugs treating the livestock respiratory diseases. The combination drug has the advantages of being rich in raw material, low in price, safe in drug use, free of toxic and side effects and good in use effect.

The invention provides a preparation method and application of fufang huangbaiye tuji. The fufang huangbaiye tuji is prepared from the following components in parts by weight: 0.5 to 1.5 parts of a volatile oil inclusion, 15 to 50 parts of a vegetation medicinal material extract and 0.5 to 10 parts of a centipede polypeptide extract, wherein based on a dry product, the vegetation medicinal material extract contains the following materials: not less than 1.05 percent of phillyrin, not less than 0.8 percent of berberine hydrochloride, not less than 4.17 percent of chlorogenic acid and not less than 3 percent of polysaccharide; based on the dry product, the centipede polypeptide extract contains not less than 10 percent of N. The problem that precipitations are formed in the existing fufang huangbaiye when the fufang huangbaiye is stored for a long time is solved; the prepared fufang huangbaiye tuji achieves a more ideal effect on treatment of sore and ulcer diseases and skin injury infection, and has a better effect of promoting migration of fibroblast.

The invention relates to vitamin C honeysuckle-phillyrin tablets and a preparation method thereof. The vitamin C honeysuckle-phillyrin tablets have the advantages that each table is above 0.25g, and the tablets are high in active ingredient content, capable of inhibiting bacteria and common cold viruses, capable of fast relieving corresponding common cold symptoms, low in gastrointestinal stimulation, low in side effects and good in effect.

The invention relates to a drug for treating chronic renal failure and preparation method thereof. The preparation method comprises the steps: adding water to radix astragali, white atractylodes rhizome, poria cocos, fructus psoraleae, angelica sylvestris, radix sileris, radix platycodi, polygala tenuifolia, gypsum, phillyrin, herba artemisiae scopariae, agastache rugosa, salviae miltiorrhizae, radix paeoniae rubra, radix glycyrrhizae, rheum officinale, semen cannabidis and the like, decocting to obtain decoction, concentrating and then adding conventional auxiliary materials, adding purified water till the content of crude drug is 1g/ml, encapsulating and disinfecting to obtain the oral liquid preparation. The drug can tonify spleen and warm the kidney, diffuse the lung to dispel wind and eliminate dampness, clear heat and remove toxicity, dampness and turbidity, activate blood and remove blood stasis, and expel toxin and relax the bowels. Proved by clinical observation, the effective rate is 66 percent. The drug is natural and clean, safe and non-toxic without dependency.

The invention relates to a preparation method of a medicine preparation for treating the common cold in children. The granule for treating the common cold in children is prepared from fifteen herbal medicine materials including honeysuckle, phillyrin, fructus arctii, mint, schizonepetaspike, radix scutellariae, cape jasmine (fried), semen armeniacae amarum, radix platycodi, radix peucedani, radix angelicae dahuricae, hawthorn (burnt), medicated leaven (burnt), malt (burnt), rhizoma phragmitis and the like. The preparation is formed through cyclodextrin wrapping, granulating, granule finishing and subpackaging by means of the modern extraction separation technology of supercritical fluid extraction, ultrasonic extraction, micro-aperture filter membrane filtering and the like. The method is good in extraction separation effect, high in extraction efficiency, and capable of saving energy and cost; the wrapper preparation technology is adopted for the product, the volatilization of volatile oil type functional components is avoided, the bad smell of the product is covered, and the product quality and child patient medicine taking compliance are further improved.

The invention relates to a topical health cream and a preparation method thereof, and belongs to the technical field of traditional Chinese medicine. The health cream is prepared from the following materials: notopterygium, radix angelicae dahuricae, herba schizonepeta, radices sileris, angelica pubescens, radix aconiti kusnezoffii, dandelion, radix sophorae tonkinensis, rhizoma dryopteris crassirhizomae, phillyrin, euphorbia humifusa, radix scutellariae, cortex phellodendri, coptidis rhizoma, sophora flavescens, radix phytolaccae, caulis akebiae and a variety of drugs to achieve divergent cold, warm menstruation pain-relieving, eruption-promoting and sore-eliminating, wind-heat dispelling, heat-clearing and detoxification, swelling and stasis-removing, heat-clearing and damp-drying, purging fire for removing toxin, rash-eliminating and itching-relieving, edema-relieving and swelling, secretion-smoothening, and the topical health cream can be used for treating cut, gunshot wound, osteomyelitis, hurricane, purpura, conjunctivitis, rhinitis, drug dermatitis, seborrheic dermatitis, diaper dermatitis, paronychia, subcutaneous tumors, subcutaneous cancer, mastitis, breast cancer, vaginitis, burns, open fractures, closed fractures, soft tissue injuries, hemorrhoids, frostbite, hemorrhoids, psoriasis, flat warts, nameless swollen, corns, dingoffingercondyle, porta hepatis erosion, oldwounds, rheumatism and the like and is easy to promote and apply.