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Preparing method and application of coptidis-rhizoma shangqing tablets

A technology of Coptidis supernatant tablets and Coptis chinensis, applied to medical preparations containing active ingredients, pharmaceutical formulas, active ingredients of aluminum/calcium/magnesium, etc., can solve problems such as many impurities, rough and complicated processes, etc.

Inactive Publication Date: 2016-07-20
NANJING ZHENGLIANG MEDICAL TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] In the prior art, there is no report about the use of supercritical technology in the extraction and preparation of Huanglian Shangqing Tablets. However, methods such as powdering are used. The process is rough, complicated, backward, and there are many impurities, which leads to excessive dosage for patients, which is inconvenient to take and seriously affects This product has been applied clinically

Method used

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  • Preparing method and application of coptidis-rhizoma shangqing tablets

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0015] Example 1: Take 5g of Coptis chinensis, 40g of forsythia, 20g of Fangfeng, 40g of Angelica dahurica, 80g of chrysanthemum, 160g of rhubarb, 40g of bellflower, 20g of gypsum, 20g of licorice, 40g of gardenia, 40g of fried vitex, 40g of nepeta, and 40g of skullcap , Peppermint 20g, Phellodendron Phellodendri 20g, Rhizoma Chuanxiong 20g, Inula 10g, join in CO2 supercritical extractor, ethanol is as entrainer, and entrainer accounts for 4% by volume of total extraction solvent, extraction pressure 30MPa, temperature 30 ℃, The CO2 flow rate is 1m1 / g crude drug·min, and the extraction time is 180min to obtain a supercritical extract, which is crushed into fine powder, granulated, and compressed into tablets, each weighing 0.3g.

Embodiment 2

[0016] Example 2: Take 5g of Coptis chinensis, 40g of forsythia, 20g of Fangfeng, 40g of Angelica dahurica, 80g of chrysanthemum, 160g of rhubarb, 40g of bellflower, 20g of gypsum, 20g of licorice, 40g of gardenia, 40g of fried vitex, 40g of nepeta, and 40g of scutellaria . The CO2 flow rate is 1m1 / g crude drug·min, and the extraction time is 180min to obtain a supercritical extract, which is crushed into fine powder, granulated, and compressed into tablets, each weighing 0.3g.

Embodiment 3

[0017] Example 3: Take 5g Coptidis, 40g Forsythia, 20g Fangfeng, 40g Angelica dahurica, 80g Chrysanthemum, 160g Rhubarb, 40g Campanulaceae, 20g Gypsum, 20g Licorice, 40g Gardenia, 40g Stir-fried Vitex, 40g Nepeta, and 40g Scutellaria , Peppermint 20g, Phellodendron Phellodendron 20g, Rhizoma Chuanxiong 20g, Inula Inula 10g, join in CO2 supercritical extractor, ethanol is as entrainer, and entrainer accounts for 5% by volume of total extraction solvent, extraction pressure 20MPa, temperature 40 ℃, The CO2 flow rate is 2m1 / g crude drug·min, and the extraction time is 160min to obtain a supercritical extract, which is crushed into fine powder, granulated, and compressed into tablets, each weighing 0.3g.

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PUM

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Abstract

The invention belongs to the field of traditional Chinese medicine preparations, and particularly provides a preparing method of coptidis-rhizoma shangqing tablets.The coptidis-rhizoma shangqing tablets are prepared from 5 g of coptidis rhizome, 40 g of phillyrin, 20 g of radix saposhnikoviae, 40 g of radix angelicae, 80 g of chrysanthemums, 160 g of rheum officinale, 40 g of platycodon grandiflorum, 20 g of gypsum, 20 g of liquorice roots, 40 g of cape jasmine, 40 g of fried fructus viticis, 40 g of schizonepetaspike, 40 g of radix scutellariae, 20 g of mint, 20 g of cortex phellodendri, 20 g of rhizoma chuanxiong and 10 g of inula flowers through supercritical fluid extraction.The content is greatly increased, and the use quantity is reduced.The invention further provides an application of coptidis-rhizoma shangqing tablets to preparing of medicine for inhibiting proliferation of mouse macrophage tumors RAW-26407.

Description

technical field [0001] The invention relates to the technical field of traditional Chinese medicine preparations, in particular to a preparation method and application of Huanglian Shangqing Tablets. Background technique [0002] Coptis shangqing tablets are recorded in the Pharmacopoeia Standards, the prescription is Coptidis 5g, Forsythia 40g, Fangfeng 20g, Angelica dahurica 40g, Chrysanthemum 80g, Rhubarb 160g, Bellflower 40g, Gypsum 20g, Licorice 20g, Gardenia 40g, Stir-fried Vitex 40g, Vitex Mustard ear 40g, Scutellaria baicalensis 40g, Mint 20g, Phellodendron 20g, Ligusticum chuanxiong 20g, Inula inula 10g, the above seventeen herbs, rhubarb, Angelica dahurica, Coptis chinensis, and gypsum are crushed into powder; forsythia, Nepeta ear, mint extract volatile oil, medicine dregs Add water to decoct twice, every hour, filter, combine the filtrate and concentrate into a clear ointment; the rest of Inula inula and other ten flavors are heated and refluxed with 70% ethanol ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/85A61K9/20A61P35/00A61K33/06
CPCA61K36/85A61K9/2004A61K33/06A61K36/232A61K36/236A61K36/238A61K36/28A61K36/287A61K36/346A61K36/484A61K36/534A61K36/538A61K36/539A61K36/634A61K36/708A61K36/718A61K36/744A61K36/756A61K2236/37A61K2300/00
Inventor 赵明亮
Owner NANJING ZHENGLIANG MEDICAL TECH
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