8 results about "Isochlorogenic acid" patented technology

The application relates to the field of traditional Chinese medicine quality control, and particularly discloses a quality control method for Shuanghuanglian inhalation solution. The method can simultaneously determine the fingerprint spectrum and ingredient content of the Shuanghuanglian inhalation solution. The fingerprint spectrum detection method disclosed by the application adopts UPLC determination, has 17 characteristic peaks, and attributes 8 characteristic peaks. The contents of neochlorogenic acid, chlorogenic acid, cryptochlorogenic acid, isochlorogenic acid B, isochlorogenic acid A, isochlorogenic acid C and forsythoside are simultaneously determined. Compared with the prior art, the method for determining the fingerprint spectrum and content of the Shuanghuanglian inhalation solution is improved, and the quality of the Shuanghuanglian inhalation solution can be comprehensively monitored conveniently, quickly and accurately.

This invention discloses a method for extracting chlorogenic acids from stevia waste and its applications, including: extracting chlorogenic acids from stevia powder using an alkaline extraction method; and determining whether the chlorogenic acids contain chlorogenic acid, isochlorogenic acid A, and cryptochlorogenic acid. Using stevia waste as raw material, this invention involves solvent extraction, centrifugal filtration, reflux extraction, and chromatographic separation to obtain a fat-soluble extract. This extract is then dissolved and filtered with ethanol, evaporated and concentrated, and freeze-dried to obtain the chlorogenic acid product. This invention extracts and develops chlorogenic acids from stevia waste, solving the problems of environmental pollution and resource waste. The extracted chlorogenic acids contain chlorogenic acid, cryptochlorogenic acid, and isochlorogenic acid A, and have low sugar content. They possess antioxidant, anti-inflammatory, and blood pressure-lowering functions, and can be widely used in food, pharmaceuticals, and health products, demonstrating high application value and realizing the comprehensive utilization of stevia.

The present application relates to the technical field of pharmaceutical compositions, and provides a composition for improving immune function, a preparation and a preparation method and application thereof, comprising: 25-40% of chlorogenic acid, 5-12% of luteolin, 10-20% of isochlorogenic acid A, 3-8% of caffeic acid, 0.5-1% of a targeting ligand, 2-5% of a microecological component, and 5-8% of a nano-carrier, and application of the composition in preparation of medicines, health products and functional foods for improving immune function, and a preparation method of the above-mentioned medicine preparation, comprising the following steps: preparing a core particle; coating the core particle with a sustained-release enteric coating to obtain a microcapsule particle; filling the microcapsule particle into a capsule shell to obtain an enteric capsule; coating the enteric capsule with a stomach-dissolving coating liquid to obtain a capsule preparation; and achieving the effect of improving the whole gastrointestinal immune function by rapidly targeting anti-inflammation in the stomach and continuously targeting regulation in the intestinal tract, and greatly improving the action efficiency and immune regulation effect of the preparation.

The application relates to the field of biological medicine, and discloses self-assembled nanoparticles and a preparation method and application thereof. The self-assembled nanoparticles are formed by self-assembly of isoeuropetin and isochlorogenic acid C through non-covalent bond interaction to form supramolecules, and the particle size of the self-assembled nanoparticles is 50-200 nm, and the Zeta potential is-14.8 mV to-35.2 mV. Based on the self-assembly characteristics of active small molecules of traditional Chinese medicine, it is found and confirmed that EUP and IAC can be self-assembled to form stable nano drugs (EUP-IACs) through various technical means. The nano drugs significantly enhance the inhibiting effect on MRSA USA 300 through the synergistic effect of EUP and IAC, and the application provides a new idea and strategy for optimizing the preparation of traditional Chinese medicine carrier-free self-assembled nano and expanding the application of the traditional Chinese medicine in the antibacterial field.

The present application relates to the technical field of pharmaceutical chemistry, in particular to a preparation method and application of a berberine and isovitexin nanomedicine. The application is used in the preparation of a drug for treating diseases related to inflammation mediated by neutrophils. The berberine and isovitexin or the structural analogues of berberine and isovitexin form nanoparticles in a carrier-free form through self-assembly. The berberine and isovitexin nanomedicine has a synergistic anti-inflammatory and antioxidant effect, can efficiently inhibit key inflammatory mediators, realize high-efficiency anti-inflammatory and antioxidant synergy, and significantly improve the effect of preventing and treating acute inflammation.

This invention belongs to the field of traditional Chinese medicine processing and natural product chemistry, specifically relating to a method for the targeted enrichment of chlorogenic acid components in honeysuckle. The method involves placing honeysuckle powder under constant temperature heating conditions for dry heat treatment. Different dry heat treatment conditions are set according to different target concentrators to achieve the targeted enrichment of various chlorogenic acid components, including neochlorogenic acid, chlorogenic acid, isochlorogenic acid B, and isochlorogenic acid C. This method achieves the targeted and efficient enrichment of effective components during the processing of honeysuckle tablets, and the process is simple, convenient to operate, and easy to scale up for industrial production.

Disclosed is an industrial method for simultaneously preparingStevia rebaudiana chlorogenic acid and stevioside. The industrial method includes carrying out alcohol extraction on Stevia rebaudiana which is used as a raw material, and then adjusting the feed liquid state to allow chlorogenic acid to be in a free molecular state; carrying out extraction separation by a water-insoluble moderate-polarity organic solvent; enriching the Stevia rebaudiana chlorogenic acid in an organic layer; and enriching the stevioside in a water layer. Compared with a traditional water extraction process, the method has the advantages that chlorogenic acid ingredient in the Stevia rebaudiana can be prevented from being hydrolyzed, such that the contents and effects of effective ingredients in Stevia rebaudiana chlorogenic acid products can be guaranteed; effective separation can be carried out on the premise that the quality and the production efficiency of stevioside products are unaffected, the production efficiency can be improved, and the ratio of isochlorogenic acid to total chlorogenic acid in the resulting products is close to that in the raw material; production water consumption can be reduced, and discharge of sewage and flocculation residues can be decreased; and accordingly, the method is a green production process with high benefits.

The application provides a pharmaceutical composition for alleviating myocardial ischemia-reperfusion injury related oxidative stress and application thereof, and active ingredients of the composition comprise ilexin A, isochlorogenic acid C and isohyperoside, the active ingredients jointly act to achieve inhibition of myocardial ischemia-reperfusion injury related oxidative stress, alleviation of myocardial cell damage and improvement of mitochondrial function.