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Anti-hepatitis B virus composition taken from fresh dandelion and application of anti-hepatitis B virus composition in preparation of anti-hepatitis B virus drug

A dandelion, anti-hepatitis B technology, applied in the directions of antiviral agents, drug combinations, medical preparations containing active ingredients, etc., can solve problems such as the application of anti-hepatitis B virus drugs without anti-hepatitis B virus compositions, and achieve high development value and price. Inexpensive, easy-to-manufacture effects

Inactive Publication Date: 2013-05-15
苏州艾费堂医药科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] In recent years, the reports on the pharmacological activity of dandelion are mainly aimed at the dried medicinal material of dandelion, and there is no relevant research on the anti-hepatitis B virus composition of fresh dandelion and its application in the preparation of anti-hepatitis B virus drugs

Method used

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  • Anti-hepatitis B virus composition taken from fresh dandelion and application of anti-hepatitis B virus composition in preparation of anti-hepatitis B virus drug
  • Anti-hepatitis B virus composition taken from fresh dandelion and application of anti-hepatitis B virus composition in preparation of anti-hepatitis B virus drug
  • Anti-hepatitis B virus composition taken from fresh dandelion and application of anti-hepatitis B virus composition in preparation of anti-hepatitis B virus drug

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0033] Take 5kg of fresh dandelion whole plant, wash it and put it in a juicer to squeeze the juice, filter and centrifuge to separate the juice and medicine residue, soak the medicine residue with 2 times the amount of distilled water for 3h, continue to squeeze the juice 1-2 times, combine and filter, The squeezed juice after centrifugation is concentrated under reduced pressure at low temperature and freeze-dried to obtain freeze-dried powder. Reconstitute the lyophilized powder with distilled water and load the sample to the processed AB-8, HP20, D101, HPD600, HPD826 or NKA-9 large resin column at a certain concentration, and first elute with distilled water and collect The eluate is concentrated under reduced pressure at low temperature to obtain extract I, freeze-dried, reconstituted with an appropriate amount of distilled water, then added Savage reagent to remove protein, centrifuged to obtain the supernatant; then precipitated with 50% ethanol solution, and the obtained...

Embodiment 2

[0035] Take 5kg of fresh dandelion whole plant, wash it and put it in a juicer to squeeze the juice, filter and centrifuge to separate the juice and medicine residue, soak the medicine residue with 3 times the amount of distilled water for 6h, continue to squeeze the juice 1-2 times, combine and filter, The squeezed juice after centrifugation is concentrated under reduced pressure at low temperature and freeze-dried to obtain freeze-dried powder. Reconstitute the lyophilized powder with distilled water and load the sample to the processed AB-8, HP20, D101, HPD600, HPD826 or NKA-9 macroporous resin column at a certain concentration, and elution with distilled water first, and collect The eluate is concentrated under reduced pressure at low temperature to obtain extract I, freeze-dried, reconstituted with an appropriate amount of distilled water, then added Savage reagent to remove protein, centrifuged to obtain the supernatant; then precipitated with 60% ethanol solution, and the...

Embodiment 3

[0037] Take 5kg of fresh whole dandelion plant, wash it and put it into a juicer to squeeze the juice, filter and centrifuge to separate the juice and medicine residue, soak the medicine residue in 4 times the amount of distilled water for 8h, continue to squeeze the juice 1-2 times, combine and filter, The squeezed juice after centrifugation is concentrated under reduced pressure at low temperature and freeze-dried to obtain freeze-dried powder. Reconstitute the lyophilized powder with distilled water and load the sample to the processed AB-8, HP20, D101, HPD600, HPD826 or NKA-9 macroporous resin column at a certain concentration, and elution with distilled water first, and collect The eluate is concentrated under reduced pressure at low temperature to obtain extract I, freeze-dried, reconstituted with an appropriate amount of distilled water, then added Savage reagent to remove the protein, centrifuged to obtain the supernatant; then precipitated with 70% ethanol solution, and...

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Abstract

The invention relates to an anti-hepatitis B virus composition taken from fresh dandelion and an application of the anti-hepatitis B virus composition in preparation of an anti-hepatitis B virus drug and belongs to the field of traditional Chinese medicines. The anti-hepatitis B virus composition provided by the invention comprises a fresh dandelion polysaccharide component, a phenolic acid component and a flavone component and is characterized in that the weight ratio of the fresh dandelion polysaccharide component to the phenolic acid component to the flavone component is (2-40): (3-70): (2-50). According to an optimized scheme, the phenolic acid component takes caffeic acid, chlorogenic acid and isochlorogenic acid A as typical ingredients; the flavone component takes galuteolin, quercetin and luteolin as typical ingredients; and the weight ratio of the caffeic acid to the chlorogenic acid to the isochlorogenic acid A to the galuteolin to the quercetin to the luteolin is (0.25-10): (2-40): (0.25-20): (0.5-20): (0-10): (1.5-20). According to the invention, the fresh dandelion is taken as raw material, effective ingredients are separated, purified and enriched by macroporous resin, the effective ingredients are mixed to obtain the fresh dandelion anti-hepatitis B virus composition, a process is simple and convenient, related diseases caused by hepatitis B viruses can be effectively treated, cost is low, and mass production can be achieved.

Description

Technical field [0001] The invention relates to a pharmaceutical composition, in particular to an anti-hepatitis B virus pharmaceutical composition taken from fresh dandelion, and the application of the composition in the preparation of anti-hepatitis B virus drugs, belonging to the field of traditional Chinese medicine. Background technique [0002] Hepatitis B is an infectious disease caused by hepatitis B virus, mainly caused by inflammatory lesions of the liver and causing damage to multiple organs. The relative risk of cirrhosis and liver cancer in people infected with hepatitis B virus increases by at least 1,000 times, which will eventually lead to death. About 2 billion people in the world have been infected with HBV, and more than 350 million patients have chronic hepatitis. my country is a high-risk area for hepatitis B. According to statistics, there are about 130 million HBV carriers in my country. The treatment of hepatitis B has become a common concern of all count...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/288A61P1/16A61P31/20A61K31/715
Inventor 贾晓斌施亚琴成旭东
Owner 苏州艾费堂医药科技有限公司
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