4 results about "Anti hbv" patented technology

The application discloses a dehydrocostus lactone derivative, a preparation method and medical application thereof, and belongs to the technical field of chemical synthesis. The dehydrocostus lactone derivative is shown as a general formula I. The compound has certain inhibiting effect on HBsAg and HBeAg, can be used for preparing anti-HBV drugs, and provides more efficient and safe candidate drug molecules for clinical anti-HBV treatment.

The invention discloses a nano antibody targeting a hepatitis B core antigen as well as a coding gene and application thereof, and relates to the technical field of biological medicines. The nano antibody comprises an amino acid sequence as shown in any one of SEQ ID NO: 1 to SEQ ID NO: 5, and can be specifically combined with HBcAg. The invention also relates to a coding nucleic acid, an expression vector, a host cell and a preparation method of the nano antibody, and application of the nano antibody in preparation of anti-hepatitis B virus drugs and diagnostic reagents. Experiments show that the nano antibody has high affinity of targeting HBcAg, can combine and destroy hepatitis B virus nucleocapsid assembly and inhibit secretion of virus proteins such as HBsAg, HBeAg and the like, and thus has good anti-hepatitis B virus activity.

This invention provides an anti-S-HBs antibody and a method for using the same. [Solution] The present invention provides an antibody that binds to S-HBs, is cross-reactive to each of the HBV proteins of a specific sequence, and / or, when measured in vitro, has a neutralization IC50 value of ≤1 ng / ml against HBV genome D.

The invention discloses a novel N4-acyl substituted-2 '-deoxy-2'-fluoro-4 '-azido cytidine derivative and pharmaceutical application thereof, the novel N4-acyl substituted-2'-deoxy-2 '-fluoro-4'-azido cytidine derivative has a structure of a general formula (b): in the formula, R1 is H, F or CH3; r2 = H, N3 or C2H; and R3 is C0-C10 straight chain or branched chain saturated and unsaturated alkane, C6-C12 aromatic alkane or C3-C6 heterocyclic alkane. N4-acyl substituted-2 '-deoxy-2'-fluoro-4 '-azide cytidine derivatives are synthesized by modifying the 4-amino group of a compound a, and the compounds have anti-hepatitis B virus and anti-tumor activity; the preparation method is feasible; the compound has a good application prospect when being applied to drugs for treating viruses and tumors.