84 results about "Paris polyphylla" patented technology

The invention belongs to the technical field of traditional Chinese medicines, and particularly relates to a blood-activating and detoxifying traditional Chinese medicine formula and a nanogel preparation method thereof. The invention provides a traditional Chinese medicine formula for promoting blood circulation and removing toxicity and a nanogel preparation method of the traditional Chinese medicine formula for promoting blood circulation and removing toxicity to solve the problem that in the prior art, a good external application traditional Chinese medicine formula capable of being used for skin with damp-heat toxin accumulation does not exist, and the traditional Chinese medicine formula for promoting blood circulation and removing toxicity and the nanogel preparation method of the traditional Chinese medicine formula for promoting blood circulation and removing toxicity comprise monarch drugs, ministerial drugs, adjuvant drugs and conductant drugs, the ministerial drugs comprise honeysuckle flowers, fructus forsythiae, paris polyphylla, cortex dictamni and fructus kochiae, the adjuvant drugs comprise radix salviae miltiorrhizae, flos carthami, garden balsam stems and centella asiatica, and the conductant drug comprises bletilla striata. The traditional Chinese medicine composition provided by the invention is precise and appropriate in compatibility and distinct in gradation, and can form a synergistic treatment chain of clearing heat, detoxifying, activating blood and promoting tissue regeneration, so that the wound healing speed of the skin surface is accelerated, and the traditional Chinese medicine composition has a relatively good curative effect on damp-heat and toxic stasis type skin diseases.

The invention provides an application of polyphyllin VII in preparation of an Akt signaling pathway inhibitor targeting GRB2, the invention reveals that PPVII is specifically combined with GRB2 protein and regulates and controls the function of the GRB2 protein for the first time, the Akt pathway inhibition effect is exerted, and the molecular mechanism of PPVII is specifically shown as follows: molecular docking and dynamic simulation confirms that PPVII and an SH3 structural domain of GRB2 form a stable compound, and the stable compound is used for inhibiting the Akt pathway of the GRB2. And the key amino acid binding sites are Ile65, Gln157, Tyr160 and Phe182. Cell thermal transfer experiments (CETSA) show that PPVII can significantly enhance the thermal stability of GRB2 protein, surface plasmon resonance (SPR) determines the direct binding affinity KD = 58.5 [mu] M, functional research proves that PPVII inhibits an Akt signal channel through a GRB2 dependency mode, the polyphyllin VII is used as a GRB2 targeted inhibitor, and by specifically binding with an SH3 structural domain of GRB2 and inhibiting a downstream Akt signal channel, the polyphyllin VII can be used for inhibiting the Akt signal channel in the GRB2 targeted inhibitor. And a new strategy and a candidate compound are provided for intervention of related diseases.

The invention belongs to the technical field of phytochemistry and medicines, and discloses a hemostatic active component from paris polyphylla Franch., an active ingredient, a composition and application of the hemostatic active component, the active ingredient and the composition. The active component mainly contains steroid saponin. The invention also relates to a compound with hemostatic activity, and the compound is 21-hydroxy polyphyllin VII. The active component, the active ingredient and the hemostatic active compound provided by the invention are obtained by extracting a paris polyphylla plant material. Experiments show that the active component and the active ingredient of the paris polyphylla pall have a remarkable hemostatic effect and can be used as a medicine for treating hemorrhagic diseases.

This invention provides a method for obtaining ingredients from Dulong Paris polyphylla (… Paris dulongensis A method for preparing parisyunnanoside G (PFE55) in H. Li & Kurita and its application in cosmetics and pharmaceuticals. This research belongs to the field of cosmetics and pharmaceutical technology. PFE55 is used at extremely low concentrations (0.1... μ At a concentration of g / mL, it exhibits activity in promoting collagen secretion in adult dermal fibroblasts (HDFa) and is non-cytotoxic at this concentration, making it suitable for the preparation of anti-aging drugs or skincare products.

The invention provides a traditional Chinese medicine composition for preventing hair loss, growing hair and removing dandruff as well as a preparation method and application thereof, and belongs to the technical field of traditional Chinese medicines. The invention discloses a traditional Chinese medicine composition for preventing hair loss, growing hair and removing dandruff. The traditional Chinese medicine composition is prepared from the following raw materials in parts by weight: 8-12 parts of lithospermum, 8-12 parts of paris polyphylla, 15-25 parts of duckweed, 8-12 parts of golden larch bark, 8-12 parts of lucid ganoderma, 15-25 parts of cocklebur fruit, 15-20 parts of gallnut, 8-12 parts of radix sophorae flavescentis, 5-10 parts of schizonepeta, 8-12 parts of radix saposhnikoviae, 4-8 parts of notopterygium root, 5-10 parts of schisandra chinensis, 5-10 parts of elecampane, 5-10 parts of eclipta, 5-10 parts of ginseng, 5-10 parts of angelica sinensis, 5-10 parts of saponin, 5-10 parts of soapberry and 5-10 parts of broadleaf holly leaf. , 8-12 parts of fructus ligustri lucidi, and 4-8 parts of herb of wiss mannii The invention provides a traditional Chinese medicine composition for preventing alopecia, growing hair and removing dandruff, aiming at improving the problems of alopecia, dandruff and scalp discomfort.

This invention provides a Panax notoginseng-Paris polyphylla supramolecular complex, its preparation method, cosmetic products, and applications. The Panax notoginseng-Paris polyphylla supramolecular complex is a complex formed by non-covalent bonding of Panax notoginseng extract (as the host molecule) and Paris polyphylla extract (as the guest molecule), with the host molecule encapsulating the guest molecule structure. The Panax notoginseng-Paris polyphylla supramolecular complex of this invention not only improves the water solubility of Paris polyphylla extract but also increases its skin permeability and reduces its cytotoxicity. The preparation method of this invention utilizes the synergistic effect of the active ingredients, resulting in strong compatibility and synergistic efficacy. It also slows down the release time of the active ingredients, extends their shelf life, and features a simple and easy-to-control process, stable granulation effect, and low production cost.

The invention relates to a saponin metabolic pathway, in particular to paris polyphylla glycosyl transferase PpUGT73YD1 and application of the paris polyphylla glycosyl transferase PpUGT73YD1 in synthesis of steroid saponin. The amino acid sequence of the glycosyl transferase is shown as SEQ ID NO: 2. The invention also provides a gene for coding the glycosyl transferase, an expression box, a vector or host bacteria containing the gene, and application of the glycosyl transferase in a glycosyl transfer reaction. The glycosyl transferase can catalyze the reaction of polyphyllin V and UDP-rhamnose to generate polyphyllin III, or catalyze the reaction of polyphyllin VI and UDP-rhamnose to generate pennogenin-3-O-rhamnosyl-(1-> 2)-[rhamnosyl-(1-> 4)]-glucoside, and lays a foundation for the biosynthesis and pharmacological research and development of polyphyllin.

The utility model provides a rhizoma paridis planting rhizome cutting device. The paris polyphylla planting rhizome cutting device comprises a hollow rod; the lifting cover is fixedly mounted at the top of the hollow rod; the protective shell is arranged on the hollow rod and the lifting cover in a sleeving manner; the fixed shaft is fixedly mounted on the protective shell; the two clamping pieces are both rotationally mounted on the fixed shaft; the two fixing rods are both fixedly installed on the protective shell, and the two fixing rods and the two clamping pieces are correspondingly arranged; and the two first springs are fixedly mounted on the two clamping pieces and the two fixing rods correspondingly. The paris polyphylla planting rhizome cutting device has the advantages that paris polyphylla planted in a scattered mode can be harvested conveniently, and time and labor are saved.

The utility model relates to the technical field of paris polyphylla planting, in particular to a seedling transplanting device for paris polyphylla planting, which comprises a transport case, a supporting block is fixedly connected to the inner surface of the transport case, a transplanting box is movably connected to the outer surface of the supporting block, and a partition plate is movably connected to the inner surface of the transplanting box. The outer surface of the partition plate is fixedly connected with a fixing ring, the interior of the fixing ring is movably connected with a pressing rod, and the side surface of the partition plate is fixedly connected with a fixing plate. Through the arrangement of the partition plate and the limiting block, after a planting pot is placed in the transplanting box, the distance between the partition plate and the planting pot is adjusted, the pressing rod is loosened, and the partition plate can be limited on the inner wall of the transplanting box, so that the planting pot is clamped and limited; and plant damage caused by shaking or bumping in the vehicle transportation process can be effectively prevented.

The invention discloses an application of a polyphyllin monomer drug in cancer treatment. The polyphyllin monomer drug comprises at least one of polyphyllin I, polyphyllin II, polyphyllin VI and polyphyllin VII. The polyphyllin monomer drug inhibits proliferation, migration and angiogenesis of cancer cells and inhibits up-regulation of EGFR (epidermal growth factor receptor) by regulating phosphorylation of FGFR2 and a downstream signal channel thereof, and a new application scheme is provided for cancer treatment.

The invention discloses traditional Chinese medicine combined powder for rapidly treating various burns and scalds, and relates to the technical field of traditional Chinese medicine formulas. Traditional Chinese medicine combined powder for rapidly treating various burns and scalds is characterized in that the active ingredients of the powder comprise 6-10 parts by weight of polygonum cuspidatum, 3-9 parts by weight of coptis chinensis, 4-10 parts by weight of paris polyphylla, 6-12 parts by weight of rhizoma bletillae, 15-30 parts by weight of calcined dens draconis, 3-9 parts by weight of spar and 0.1-0.3 part by weight of pearl. The combined medicine powder has the effects of clearing away heat and toxic materials, promoting tissue regeneration, relieving pain, promoting wound repair and enhancing local microcirculation of the wound, the medicine powder generally needs to be combined with sesame oil for use, the core components of the medicine powder, namely polygonum cuspidatum and coptis chinensis, synergistically exert broad-spectrum antibacterial and antioxidant effects, and paris polyphylla and rhizoma bletillae enhance the barrier function of the wound; the calcined dens draconis and the kyanite promote activation of a calcium ion channel, and the pearl can regulate and control ordered deposition of collagen and reduce scar hyperplasia.

The invention discloses preparation and application of paris-based nitrogen-doped fluorescence-enhanced carbon dots Pol-CDs, a dark brown crude Pol-CDs solution is obtained from polyphyllin and o-phenylenediamine according to the feeding ratio of 1: (1-20) through a hydrothermal method, DMF or ethyl alcohol or methyl alcohol or acetone or THF serves as a solvent, then purification is conducted through dialysis, thin-layer chromatography and a chromatographic column, and green fluorescent Pol-CDs are prepared. Due to the selectivity of Pol-CDs, only carbendazim can efficiently sensitize green fluorescence, other pesticide residue molecules do not interfere with one another, and the content of carbendazim in food is detected under the stable condition that the pH value is 8.0.

The invention discloses a Yao medicine composition with effects of regulating menstruation and stopping bleeding as well as a preparation method and application of the Yao medicine composition, and belongs to the technical field of ethnic medicines. The composition is prepared from paris polyphylla, radix zanthoxyli, giantleaf ardisia rhizome, ovateleaf holly bark, radix fici simplicissimae and callicarpa macrophylla. The preparation method comprises the following steps: carrying out secondary water extraction on the raw materials, concentrating to specified density, standing, precipitating, removing impurities, preparing and the like. The Yao medicine composition disclosed by the invention not only has a remarkable hemostatic effect, but also has an excellent endocrine regulation function. Pharmacodynamic experiments show that in a rat dysfunctional blood model induced by combination of mifepristone and misoprostol, the composition can significantly reduce the bleeding amount and shorten the bleeding time, the hemostatic effect is equivalent to that of a positive control drug, namely Gongxuening capsule and a pure paris polyphylla extract, and although a paris polyphylla preparation exists, the hemostatic effect of the composition is remarkably improved. However, the problem that a single paris polyphylla preparation is weak in FSH / LH regulation capacity is solved, and data prove that the compound is irreplaceable.

The utility model discloses an automatic heavy building breeding dish relates to medicinal material planting technical field, including base, the top fixedly connected with support frame of base, the outside of support frame is installed with a plurality of support rings, and the outside of support frame and be located the top of a plurality of support rings all are equipped with the slide sleeve of one side fixedly connected with the support frame of slide sleeve, and the inside of support frame is inserted with the breeding dish body. The utility model has the beneficial effect that: the automatic heavy building breeding dish, through the rotation type planting dish of multiple groups that set up in proper order on the support frame, adopts the mode of three -dimensional planting, is convenient to the breeding of multiple groups heavy building seed at the same time, can staggered development or retracted, reduces the occupation to space, and the flow guide pipe in support frame, cooperation swivel joint and bevel gear set, drive flow guide pipe rotation, make the nozzle of flow guide pipe one end automatic even to multiple breeding dish carry out sprinkling irrigation, is favorable to improve efficiency, reduce cost.

The application discloses a SNP site for identifying or assisting in identifying Parthenocissus henryana, a KASP primer group and application thereof. The SNP site is located at the 2688th position of SEQ ID No. 1. The KASP primer group is composed of single-stranded DNAs shown in SEQ ID No. 2, SEQ ID No. 3 and SEQ ID No. 4. The application performs second-generation sequencing and assembly on Parthenocissus henryana for the first time, forms an ultralong scaffold as a reference genome ultralong fragment, then performs simplified genome sequencing on 15 kinds of Parthenocissus plants and carries out alignment with the reference genome ultralong fragment, obtains a difference site, and finally develops a KASP molecular marker CA24547 based on the difference site and verifies the KASP molecular marker. The KASP molecular marker developed in the application can realize accurate identification of Parthenocissus henryana at a seedling stage, and has important significance for protecting Parthenocissus henryana.

The invention provides a Paris polyphylla (Takht.) H. Li] extract product PCT100, and an application of the Paris polyphylla (Takht.) H. Li] extract product PCT100 in the technical fields of cosmetics and medicines. Belongs to the technical field of cosmetics and medicines. The PCT100 (0.4 [mu] g / mL) provided by the invention can significantly improve the expression quantity of the human dermal fibroblast elastin gene Elastin under UVA radiation, and does not show obvious cytotoxicity to human fibroblasts in a concentration range of 3.2 [mu] g / mL. The PCT100 can be used for preparing medicines or cosmetics for resisting skin aging caused by UVA, repairing wounds, reducing scar formation, repairing skin injury and promoting elastin gene expression and synthesis.

The preparation method comprises the following steps: mixing and crushing the following components in parts by weight: 10-15 parts of astragalus membranaceus, 2-3 parts of paris polyphylla, 2-6 parts of liquorice, 3-5 parts of pseudo-ginseng, 1-2 parts of pericarpium citri reticulatae, 20-30 parts of American ginseng, 5-10 parts of angelica sinensis and 4-5 parts of fructus gardeniae, and then performing purification treatment to obtain a composition I; 0.02 to 0.05 part of bifidobacterium lactis, 0.02 to 0.05 part of bifidobacterium breve, 0.02 to 0.08 part of lactobacillus rhamnosus and 0.01 to 0.02 part of lactobacillus acidophilus are used for preparing microcapsule powder, and the microcapsule powder is used as a composition II; and mixing the composition I and the composition II according to a mass ratio of (8: 1)-(10: 1) to obtain the probiotic composition for enhancing immunity. The defects in the prior art can be overcome, and the immunity is effectively improved.

The invention relates to a paris polyphylla carbon quantum dot loaded antibacterial hydrogel preparation method, which comprises: accurately weighing 30-40 parts of paris polyphylla powder, and placing in a high pressure reaction kettle; discharging air therein, and then heating at 200-300 DEG C for 5-8 hours; cooling, taking out the solid in the reaction kettle, crushing, adding 100-110 parts of 50% ethanol, uniformly stirring, and filtering with a 0.22-0.28 [mu] m filter membrane; collecting liquid, freezing and drying to obtain the traditional Chinese medicine biomass carbon quantum dots. The paris polyphylla carbon quantum dot-loaded antibacterial hydrogel prepared by the preparation method has a good antibacterial effect, can delay the generation of drug-resistant bacteria, is biodegradable, small in environmental pollution, free of environmental protection pressure, good in skin repair effect and capable of effectively promoting skin repair, the paris polyphylla rhizome paris polyphylla is adopted to prepare carbon quantum dots, and the specific saponin carbonization product of the carbon quantum dots is used for production, so that the preparation method is simple, and the preparation cost is low. The porosity is improved to 82% by combining acetic acid pretreatment with PVA freeze-thaw crosslinking, carboxyl groups on the surfaces of the carbon quantum dots and PVA hydroxyl groups form a hydrogen bond network, the contradiction between antibiosis and mechanics is broken through, and the characteristic of sustainable release is achieved.

The invention relates to the field of repair product preparation, in particular to a novel nano-antibacterial skin repair product for preventing hpv viruses. The formula is prepared from the following raw materials by weight: 0.80 to 4.50 g of purified water, 0.008 to 0.150 g of carbomer, 0.01 to 0.80 g of fenugreek oil, 0.01 to 0.30 g of oat beta glucan, 0.003 to 0.400 g of folium artemisiae argyi extracting solution, 0.01 to 0.40 g of herba portulacae extracting solution, 0.006 to 0.420 g of herba violae extracting solution, 0.001 to 0.200 g of herba lophatheri extracting solution, 0.007 to 0.300 g of herba taraxaci extracting solution, 0.008 to 0.220 g of rhizoma paridis chinensis extracting solution, 0.01 to 0.40 g of herba leonuri extracting solution, 0.0005 to 0.0300 g of nano silver and 0.008 to 0.150 g of borneol. The adhesive comprises the following components by weight: 0.01 to 0.30 g of sodium carboxymethyl cellulose, 0.008 to 0.220 g of lubrajel, 0.007 to 0.300 g of benzoyl peroxide, and 0.0005 to 0.0300 g of a cross-linking agent. The invention has the following beneficial effects: the ointment comprises a plurality of plant extracts, has no irritation to vagina, is safe and has no side effect; the carried antiviral and antibacterial components can rapidly permeate into the skin to protect mucous membrane cells from being damaged by viruses; skin tissues can be quickly repaired, and wound healing and regeneration capacity is improved; various plant extracts in the gel can also improve the immunity of the organism and can achieve a good antiviral effect.

The utility model discloses a paris polyphylla flower and fruit supporting device which is characterized in that the paris polyphylla flower and fruit supporting device comprises four supporting cylinders and supporting mechanisms, the four supporting cylinders are located in four directions respectively, a pull rope is detachably installed among the supporting cylinders, the supporting mechanisms are detachably installed on the pull rope, each supporting mechanism comprises a hook hung on the pull rope, and the hooks are connected with the supporting cylinders. A pull wire is arranged below the hook and fixedly installed in storage wheels, the two storage wheels are rotatably installed on the two sides of the interior of the storage box, a worm is rotatably installed in the middle of the storage box, a lifting hook is arranged at the other end of the pull wire, and a fixing net is hung on the lifting hook. A fixing ring is fixedly mounted at the bottom of the fixing net; the paris polyphylla flowers and fruits can be supported by the fixing net in the flower and fruit growth stage through the supporting mechanism, and the length of the pull wire can be adjusted through the supporting mechanism, so that the paris polyphylla flowers and fruits in different growth periods can be supported.

The invention discloses a Tibetan medicine plaster formula for treating pain, and relates to the technical field of traditional Chinese medicines, and the Tibetan medicine plaster formula is prepared from the following active raw materials in parts by weight: 10-20 parts of lamiophlomis rotata, 5-10 parts of rhodiola rosea, 15-20 parts of paris polyphylla, 3-10 parts of lemonfragrant angelica root and 10-20 parts of aconitum pendulum. Through the synergistic effect of lamiophlomis rotata, aconitum pendulum and paris polyphylla in a specific ratio, the effects of promoting blood circulation to remove blood stasis and calming and relieving pain are remarkably enhanced, and meanwhile, the qi-tonifying and collateral-dredging component of rhodiola rosea can improve local microcirculation so as to promote medicine permeation and pain area repair; and the lemonfragrant angelica root is used as a channel guiding medicine to effectively improve the transdermal absorption rate of the medicinal components.

The invention discloses a latex agent containing rhizoma paridis total saponins as well as a preparation method and application of the latex agent. The latex agent is prepared from the following components in percentage by mass: 0.5 to 2 percent of rhizoma paridis total saponins, 0.5 to 2 percent of a film-forming agent, 8 to 12 percent of an emollient, 1 to 4 percent of an emulsifier, 1 to 5 percent of a co-emulsifier, 0.05 to 0.2 percent of a preservative, 0.05 to 0.2 percent of a metal chelating agent, a proper amount of a pH regulator and the balance of purified water. Wherein the mass ratio of the rhizoma paridis total saponins to the film-forming agent is 1: (0.8-1.2). During preparation, the active ingredients and the film-forming agent need to be premixed and then added into an emulsification system. The problems of gastrointestinal stimulation of an oral preparation and flowing property of a biscuit are solved, the stability is remarkably improved through a film-forming agent premixing process (layering is avoided after centrifugation is conducted for 3000 rpm / 20 min and 40 DEG C / 3 months), and the medicine effect is better than that of cream. The latex agent is safe and non-irritant (30 human body tests have no adverse reaction), and is suitable for treating inflammatory diseases such as furuncle and carbuncle swelling, snake and insect bites and the like.

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The invention belongs to the technical field of health care, and particularly relates to essential oil for releasing fascia through a stone needle and a preparation method and application of the essential oil. According to the essential oil, sunflower seed oil and peony seed oil serve as base oil, turmeric root oil, ginger root oil and wintergreen leaf oil are matched, active ingredients such as phellinus igniarius polysaccharide extract, polyphyllin extract, borneol and tocopherol are added, the formula is scientific, and the synergistic effect is obvious. The preparation method relates to the processes of multi-enzyme synergistic enzymolysis, supercritical CO2 extraction, molecular distillation, efficient extraction, purification and the like, and high-activity and high-purity key components can be obtained. The essential oil disclosed by the invention has good permeability, anti-inflammatory property, repairability and safety, can remarkably improve the smoothness and comfort of fascia release of the stone needle knife, and is suitable for multiple physiotherapy scenes such as fascia rehabilitation, soft tissue repair and pain relief.

The utility model discloses a paris polyphylla seedling straightening device which comprises a fixing mechanism and a lifting mechanism and is characterized in that the fixing mechanism comprises a fixing plate and an insertion rod arranged at the bottom end of the fixing plate, and the interior of the insertion rod is of a hollow structure; the lifting mechanism comprises a lifting rod slidably connected to the interior of the fixing plate and the interior of the insertion rod, a plurality of supporting blocks movably connected to the lifting rod, a supporting plate fixedly connected to the supporting blocks, and a fixing belt movably connected to the supporting plate. According to the paris polyphylla seedling straightening device, reliable supporting and effective straightening of paris polyphylla seedlings with different heights are achieved through height adjustment of the limiting rods and the supporting blocks and use of the fixing belts.

The invention provides a complex microbial inoculant for reducing continuous cropping obstacles of polygonatum kingianum and a use method of the complex microbial inoculant, and relates to the technical field of polygonatum kingianum planting. The composite microbial agent is prepared from a pea sprout fermentation material, a zanthoxylum bungeanum leaf fermentation material, first composite bacteria, second composite bacteria, carboxymethyl chitosan, sodium alginate, acid modified starch, silicon dioxide and bentonite. The pea sprout fermented material is prepared by fermenting pea sprouts by adopting trichosporon aryabhattai; the zanthoxylum bungeanum leaf fermented material is prepared by fermenting zanthoxylum bungeanum leaves with lactobacillus plantarum. According to the method, the defects in the prior art are overcome, the continuous cropping obstacle of the polygonatum kingianum can be effectively overcome, meanwhile, growth of newly-planted polygonatum kingianum is promoted, the quality and yield of the polygonatum kingianum are further guaranteed, and the economic benefits of planting are comprehensively improved.

This invention proposes a traditional Chinese medicine compound for treating ankylosing spondylitis of the kidney-deficiency and damp-heat type accompanied by gastrointestinal dysfunction, along with its preparation method, belonging to the field of traditional Chinese medicine technology. The compound consists of Smilax glabra, Bletilla striata, Paris polyphylla, Geranium wilfordii, Dioscorea hypoglauca, Patrinia scabiosaefolia, Dipsacus asper, Drynaria fortunei, Pyrola rotundifolia, Clematis chinensis, Pheretima aspergillum, Lycopodium clavatum, Corydalis yanhusuo, Paeonia lactiflora, Atractylodes macrocephala (fried), Coix lacryma-jobi (raw), Aucklandia lappa, and Glycyrrhiza uralensis. This invention combines these herbs to achieve a synergistic effect, collectively clearing heat and dampness, strengthening the spleen and kidneys, and unblocking the meridians. The overall formula addresses both strengthening the body's foundation and eliminating pathogenic factors, ensuring unobstructed meridian flow and relieving arthralgia. This compound has the functions of clearing heat and dampness, strengthening the spleen and kidneys, and unblocking the meridians. It offers a short treatment course, rapid efficacy, low recurrence rate after cure, few side effects, and is inexpensive and convenient to use for treating ankylosing spondylitis with gastrointestinal dysfunction.

The invention discloses a separation method of extracellular vesicles derived from non-medicinal parts of paris polyphylla and application of the extracellular vesicles in anti-inflammatory and whitening. According to the method, the extracellular vesicles are separated from stems, leaves and root hairs of non-medicinal parts of paris polyphylla by adopting double isoelectric precipitation combined with electrophoresis dialysis, and biological activity research is systematically performed on the extracellular vesicles sourced from the stems, leaves and root hairs. The cell and zebra fish model comprehensive evaluation proves that the extracellular vesicles from the two sources have obvious anti-inflammatory effects. However, in the melanin inhibition activity, the extracellular vesicles of the stems and leaves of the paris polyphylla are good in performance, and the inhibition effect of the extracellular vesicles on melanin generation in a zebra fish in-vivo model and the inhibition capacity of the extracellular vesicles on tyrosinase in vitro are obviously superior to those of a classic whitening agent arbutin. The limitation that only paris polyphylla tubers are utilized traditionally is broken through, development and efficacy verification of the paris polyphylla stem leaf and root hair extracellular vesicles are achieved for the first time, and the application prospect in the aspect of developing anti-inflammatory drugs and whitening cosmetics is wide.

The invention provides a hemostatic medicine and a preparation method thereof, and belongs to the technical field of medicines. Comprising the following steps that S1, 60% by weight of galium aparine, 30% by weight of paris polyphylla and 10% by weight of lysimachia christinae hance are pretreated, and pretreatment comprises cleaning, drying and processing; s2, carrying out superfine grinding on the pretreated raw materials, and sieving with a 200-mesh sieve; s3, carrying out segmented sterilization on the sieved powder, firstly drying at 80-90 DEG C for 1 hour, and then sterilizing at 120-130 DEG C for 1.5 hours; and S4, finally, performing vacuum packaging in a sterile environment to obtain the finished product. With galium aparine, paris polyphylla and lysimachia christinae hance as main raw materials, the medicine is good in hemostatic effect, high in safety, simple and feasible in preparation process and suitable for large-scale production.

The invention relates to a compound medicine for treating oral mucositis caused by luconobutuzumab and a preparation method of the compound medicine, and the compound medicine realizes the comprehensive curative effects of resisting inflammation, easing pain and promoting mucosal repair through combination of traditional Chinese medicines and western medicines and synergism of multi-ethnic medicines. The compound medicine is prepared from the following components in parts by weight: 0.1 to 0.5 part of recombinant human epidermal growth factor, 0.5 to 2.0 parts of lidocaine, 0.01 to 0.1 part of vitamin B12, 1.0 to 5.0 parts of astragalus polysaccharide, 0.5 to 3.0 parts of honeysuckle chlorogenic acid, 0.2 to 1.5 parts of glycyrrhizic acid, 0.1 to 1.0 part of crocin, 0.3 to 2.0 parts of saussurea involucrata flavone, 0.2 to 1.8 parts of paris polyphylla saponin and 0.4 to 2.5 parts of sculellaria barbata flavone. The compound provided by the invention is suitable for tumor patients receiving treatment of luconatobutuzumab, is especially suitable for patients suffering from I-III grade oral mucositis, can be used as a hospital preparation or new drug development, and has wide clinical application and market prospects.