1148results about How to "Achieve therapeutic effect" patented technology

A robot aided surgical system for the bone setting operation with the locking intramedullary nail is composed of multifunctional automatic operation bed, robot, bone setting regulator on said robot, bone fixing mechanism, high-accuracy full-automatic X-ray machine with C-shaped arm, navigation robot, robot controller, master hand control station, and slave hand control station.

The invention discloses a lower limbs rehabilitation training robot, which comprises an exoskeletal mechanical structure and a control system independent of the mechanical structure, wherein the exoskeletal mechanical structure comprises thigh mechanisms and shank mechanisms, which are bilaterally symmetrical and connected with a waist mechanism in turn; imitation human hip joints are arranged at the connection part of the waist mechanism and the thigh mechanisms; imitation knee joints are arranged between the connection parts of the thigh mechanisms and the shank mechanisms; the waist mechanism comprises a waist part connecting plate and flexible connecting plates which are connected with the waist part connecting plate in a bilateral symmetrical manner; the waist mechanism, the left and right thigh mechanisms and the left and right shank mechanisms are provided with flexible connecting bands for connecting the corresponding parts of a human body with the robot; the control system is independent of the mechanism of the robot and is connected with the robot body through data wires for controlling rehabilitation training; and the control system comprises hardware and software, the soft ware comprises a user module, a real-time control module and a rehabilitation effect evaluation module.

A composite medicine for preventing and treating primary liver cancer, lung cancer, rectum cancer, lymph cancer, gynecologic cancers, etc is proportionally prepared from gynostemma pentaphyllum or its extract, American ginseng or its extract, and astragalus root or its extract. Its preparing process is also disclosed.

The invention provides a construction method of a human papilloma virus resistant HPV polyvalent vaccine and application thereof.

The invention belongs to the field of genetic engineering, and discloses a target sequence, recognized by a streptococcus thermophilus CRISPR-Cas9 system, of a human CCR5 gene, sgRNA and an application of the CRISPR-Cas9 system. The target sequence is shown as any one of the nth bit to the 30th bit of the SEQ ID NO:1-30, and n is equal to 1-12. The invention further relates to the sgRNA of the sequence -3' with the sequence of 5'-recognition sequence-recruiting Cas9 protein and a coded DNA molecule thereof. The DNA sequence corresponding to the recognition sequence is identical to the target sequence. The invention further relates to the CRISPR-Cas9 system. The system comprises Cas9 protein, the sgRNA and / or the coded sequence carrying the Cas9 protein and a carrier of the coded sequence of the sgRNA. The invention further relates to the application of the CRISPR-Cas9 system in editing the CCR5 gene and preparing medicine for HIV infection. Editing of the human CCR5 gene can be achieved, and therefore Aids is prevented and treated.

The invention belongs to the field of genetic engineering, discloses a streptococcus thermophilus derived target sequence recognizable by a CRISPR (clustered regularly interspaced short palindromic repeat)-Cas9 (CRISPR associated 9) system and further discloses a sgRNA (single guide ribonucleic acid) and a coding DNA (deoxyribonucleic acid) molecule thereof. The target sequence is shown as n-30th of any one of SEQ ID NO:1-248, wherein n=1-12. A sequence of the sgRNA is 5'-recognition sequence- Cas9 protein recruitment sequence-3', and a DNA sequence corresponding to the recognition sequence is identical to the target sequence. The invention also discloses the CRISPR-Cas9 system, and the CRISPR-Cas9 system comprises Cas9 proteins and sgRNA and / or comprises carriers carrying a Cas9 protein coding sequence and a sgRNA coding sequence. The invention further discloses application of the CRISPR-Cas9 system to CXCR4 gene editing and preparation of medicines for treating HIV (human immunodeficiency virus) infection. CXCR4 gene editing can be realized to protect cells from HIV infection.

This invention discloses a medical image transmission and 3-D visual system and a realizing method, which develops an iconography diagnosis system operated by stand-alones and single persons to expand the image data process function of a radiation section or an image working station to computer terminals of hospitals, so that, doctors in hospitals can get the image data of patients directly from the terminals in their offices to carry out 3-D display interaction operations.

The invention relates to a heptamethine indocyanine dye containing N-fatty esters or N-fatty amide side chains, a synthetic method thereof and applications thereof in tumor targeting imaging and treatment. The heptamethine indocyanine dye which possesses or individually possesses near infrared absorption, fluorography and antineoplastic activity allows present research and development ideas and treatment levels of tumor targeting treatment medicaments to be greatly improved, and has great significances to aspects of early discovery, control and the like of various tumors.

The invention relates to a photosensitive PRP (platelet-rich plasma) gel and a preparation method and application thereof. The preparation method comprises the following steps of mixing a biocompatible medium solution of a macromolecule modified by an o-nitrobenzyl photo response group and an extracted PRP according to a certain ratio, so as to form a gel precursor solution; then, radiating the gel precursor solution by light, and enabling the o-nitrobenzyl group in the macromolecule modified by the o-nitrobenzyl photo response group to generate photochemical reaction under the excitation action of a light source, so as to produce an aldehyde functional group; generating coupling reaction with amino distributed at the surface of the protein in the PRP to form an imine bond, so as to realize the preparation of the photosensitive PRP gel. Compared with the prior art, the photosensitive PRP gel prepared by the method has the advantages that the internal cell factors can be slowly released, and the tight and seamless bonding between the PRP gel and wounds is realized.

The invention relates to the technical field of medicine, which is a preparation of a taxane drug for intravenous drug delivery, consisting of two parts of drug solution and an emulsion. The drug solution is composed of paclitaxel or docetaxel, a pH regulator and a solvent for injection, wherein, the solvent for injection is an organic solvent; the emulsion comprises a fat emulsion and is composed of oil for injection, an emulsifier, an antioxidant, an isotonic regulator, a stabilizer, a pH regulator and water for injection. When in use, the drug solution can be added and evenly mixed in the emulsion for direct intravenous drip according to the clinical drug dosage and can also be firstly added in the emulsion with the volume that is not less than 5 times of the volume of the drug solution according to the clinical drug dosage and then added with a certain amount of physiological saline or glucose injection for intravenous drip. The preparation of the invention does not contain solubilizer and has the advantages of little toxicity, safety, effectivity, stability and economy. The fat emulsion can also be taken as a nutrition replenisher for a patient, thus achieving better treatment effects. The physiological saline or the glucose injection can also replace a certain amount of the emulsion, so the storage and the transportation are convenient, and the preparation is more economical.

The invention discloses a cancer pain-relieving plaster prepared by a preparation A and a preparation B, wherein the preparation A is prepared by five branches, five skins, one brick, one stone, five cores, and the like; the preparation B is prepared by poria cocos, pinellia ternate, jackinthepulpit tuber rhizome, trichosanthes kirilowii maxim, centipede, zaocys dhumnade, and the like. When the cancer pain-relieving plaster is prepared, the preparation B is added into the preparation A to be decocted for 4.5-5.5 hours, red lead is added to be mixed to pasty fluid, then cold water is added for steeping to releasing fire-toxin, water is changed once one day, and the plaster is obtained after steeping for 7 days. When the plaster is used, the plaster is coated on cotton cloth or plaster paster. The cancer pain-relieving plaster mainly aims at tumour cancers of lung cancer, gastric cancer, liver cancer, pancreatic cancer, colon caner, rectal caner, kidney cancer, bladder caner, breast cancer, cervical cancer, ovarian cancer, esophagus cancer, laryngeal cancer, and the like and is obvious in pain-relieving effect.

The invention discloses a composite nano-drug for integrated tumor diagnosis and treatment and a preparation method thereof. A chemotherapeutic drug, a photodynamic drug and shRNA plasmids capable of reversing multidrug-resistant MDR1 genes of tumor cells are located through a nano-carrier, a magnetic nano-sphere with precious metal nano-particles arranged on the surface serves as a kernel of the nano-carrier, mesoporous silica with the surface modified with amino groups serves as a shell of the nano-carrier, and a polyelectrolyte thin film layer structure with pH response is formed on the surface of the kernel-shell structure through a layer-by-layer self-assembly technology. The composite nano-drug integrates targeted drug delivery, multimode imaging, chemotherapy, photodynamic therapy and gene therapy, can be applied to early diagnosis of tumors, image mediation and real-time monitoring treatment at the same time and overcomes the defect that tumor diagnosis and treatment are separate in the prior art; besides, the composite nano-drug is simple in preparation process, high in operability and suitable for industrial production.

The invention discloses a magnetic resonance imaging nanometer drug carrier, and a nanometer drug loading system and a preparation method thereof. The magnetic resonance imaging nanometer drug carrieris a triblock polymer nanoparticle, wherein the triblock polymer is PLGA-PEI-PEG, and has active groups on the surface, and the active groups comprise amino, hydroxyl and carboxyl. According to the present invention, the drug carrier can efficiently load a nuclear magnetic resonance imaging drug and an antitumor drug to make the antitumor drug specifically reach the tumor lesion site, such that the nuclear magnetic resonance positioning of the superparamagnetic ferroferric oxide nanoparticle at the tumor region can be achieved while the high-selectivity and low-toxicity treatment effect can be achieved, and the disadvantages of poor selectivity, strong toxic-side effect, easy drug-resistance generation and the like of the traditional cytotoxic drugs can be overcome; and the preparation method is simple and is easy to perform, the prepared triblock polymer nanoparticle can be stably stored in the aqueous solution so as to be easily stored, and various functional groups exist on the surface of the particle, such that the prepared triblock polymer nanoparticle can be easily subjected to surface modification or surface functionalization.

The invention discloses a system and method for separating and removing circulating tumor cell and blood platelet in blood, relates to the technical field of separation and removal of tumor cells, and aims at designing to solve the problems of poor effect on separating of circulating tumor cell, failure on blood platelet separation, failure on recycling of blood in the existing separating system. The system for separating and removing the circulating tumor cell and the blood platelet in the blood comprises a blood collecting device, a first micro-fluidic separating unit which is communicated with the blood collecting device through a pipeline, and a second micro-fluidic separating unit which is communicated with the first micro-fluidic separating unit through another pipeline; the first micro-fluidic separating unit is used for separating the circulating tumor cell in the blood; the second micro-fluidic separating unit is used for separating the blood platelet in the blood. The invention also provides a method for separating and removing the tumor cell and the blood platelet in the blood. With the adoption of the separating system, the circulating tumor cell and blood platelet in the blood of a patient with cancer can be effectively removed; the operation is simple and convenient; the separation effect is great; the spreading and metastasizing of cancer cells can be effectively controlled.

The invention provides a method and device for building diagnosis inquiring channels. The method includes the steps of receiving diagnosis inquiring questions input by patients through preset communication tools, decomposing diagnosis inquiring keywords in the diagnosis inquiring questions, finding diagnosis inquiring doctors matched with the diagnosis inquiring keywords, obtaining contact information of communication tools of the diagnosis inquiring doctors, and building the diagnosis inquiring channels between the doctors and the patients through the communication tools according to the contact information. The diagnosis inquiring keywords in the diagnosis inquiring questions asked by the patients are decomposed with the data extracting technology, the diagnosis inquiring doctors matched with the diagnosis inquiring keywords are found with the data retrieval technology, the diagnosis inquiring channels between the patients and the diagnosis inquiring doctors are rapidly built in time, the patients do not need to have medical science knowledge and also do not need to wait for registration for a long time, the diagnosis inquiring doctors can be automatically distributed for the patients only through simple disease descriptions, the patients can be in communication with the diagnosis inquiring doctors through the communication tools in time, and primary diagnosis and treatment on diseases can be achieved.

The invention relates to an artificial trachea cannula made of nano materials in the technical field of medical appliance and a preparation method thereof; the artificial trachea cannula comprises a respirator joint, an air supply tube, an inflation tube, an inflation gasbag, a drain pipe and a lubricant coating, wherein, the inflation tube is in the air supply tube, the output end of the air supply tube is connected with the respirator joint; an inserting section of the air supply tube is cuniform; the external wall of the air supply tube is provided with inflation gasbags; the position where the inflation tube is correspondingly arranged is provided with holes; the drain pipe is embedded on the external wall of the air supply tube and is adjacent to the inflation gasbag; the side of the drain pipe close to the inflation gasbag is provided with a liquid outlet, the other side thereof is connected with an injector; the lubricant coating is arranged on the external wall of the inflation gasbag and the air supply tube, the air supply tube and the inflation gasbag are made of modified plastics. With the method of the invention adopted, damage to lumen tissue when the tube is inserted is reduced, pain is reduced, complicating disease is prevented from occurring; in addition, the preparation process is easy and controllable, the cost is low, as a result, the method is applicable to batch production.

The invention relates to preparation and application of medicine-carrying polydopamine / dendrimer-gold nanoparticles. The preparation comprises the steps of modifying dendrimer-gold nanoparticles to the surfaces of polydopamine nanoparticles, and performing polyethylene glycol modification and anticancer medicine adriamycin loading. Obtained composite nanoparticles having a core-satellite structurecan be subjected to acid response to release minisize satellites, medicine delivery in deep tumors is realized, and medicine tolerance generated by tumor hypoxia is relieved; and adriamycin is released at a fixedpoint under internal (acid and hydrogen peroxide) and external (near infrared light) stimulation. The obtained composite nanoparticles have favorable biocompatibility, can realize optoacoustic diagnosis and photothermal treatment on tumor locations, and what's more, can realize remarkable restraining effects on tumor growth. Through the adoption of the method disclosed by the invention, the treatment effects of traditional chemical medicines can be notably improved, more comprehensive three-dimensional tumor treatment is realized, and a new thinking is provided for diagnosis and treatment of malignant tumors.

The invention provides a composite nano-grade novel material based on cancer early-stage integrated detection, diagnoses, and treatment, and a preparation method thereof. According to the invention, gold nano-cage (gold nano-box) and nano-grade iron oxide are assembled, such that gold nano-cage (box) / nano-grade iron oxide composite particles are synthesized. With an assembling method from the inside to the outside, the gold nano-cage (box) is first prepared; iron oxide is nucleated and grown in the gold nano-cage (box); with a surfactant (such as glucan or the like), mono-dispersed iron oxide is obtained; the iron oxide is packaged by using biological molecules, such that the gold nano-cage (box) / nano-grade iron oxide composite particles are obtained; surface modification is carried out by using biological targeting molecules (antibodies or DNA molecules). The material is used in tumor magnetic resonance imaging, fluorescence imaging, dark field imaging, specific targeting multifunctional diagnosis, and photothermal therapy. The material can also be used as a targeting medicine carrier.

The present invention provides methods of preventing, treating, managing or ameliorating disorders utilizing an integrin αvβ3 antagonist in combination with an HMG-CoA reductase inhibitor and / or a bisphosphonate. The present invention also encompasses methods of preventing, treating, managing or ameliorating disorders utilizing an integrin αvβ3 antagonist in combination with an HMG-CoA reductase inhibitor and / or a bisphophonate, in further combination with another therapy (e.g., another prophylactic or therapeutic agent or treatment) which is not an integrin αvβ3 antagonist, an HMG-CoA reductase inhibitor, or a bisphosphonate. In particular, the present invention provides methods of preventing, treating, managing or ameliorating inflammatory diseases, autoimmune disorders, disorders associated with aberrant expression and / or activity of integrin αvβ3, disorders associated with abnormal bone metabolism, disorders associated with aberrant angiogenesis and cancers, or conditions associated therewith, utilizing an antibody that immunospecifically binds to integrin αvβ3 (e.g., VITAXIN®) in combination with an HMG-CoA reductase inhibitor and / or bisphosphonate, and optionally in combination with another therapy (e.g., another prophylactic or therapeutic agent or treatment) which is not an integrin αvβ3 antagonist, an HMG-CoA reductase inhibitor, or a bisphosphonate. The present also invention encompasses compositions and articles of manufacture for use in preventing, treating, managing or ameliorating inflammatory diseases, autoimmune disorders, disorders associated with aberrant expression and / or activity of integrin αvβ3, disorders associated with abnormal bone metabolism, disorders associated with aberrant angiogenesis and cancers, or conditions associated therewith.

The invention relates to a traditional Chinese medicine composition for treating eczema. The traditional Chinese medicine composition is prepared from the following traditional Chinese raw medicines in parts by weight: 1-8 parts of wild chrysanthemum flower, 1-8 parts of senecio, 1-6 parts of encalyptus robusta, 1-8 parts of dandelion, 1-6 parts of radix sophorae flavescentis, 1-5 parts of mint, 1-6 parts of cortex dictamni, 1-8 parts of fructus kochiae, 1-8 parts of fructus cnidii and 1-2 parts of borneol. The composition is prepared into external powder or a washing lotion by a general medicine preparation method, or prepared into dosage forms for external application, such as emulsion and cream by being added with corresponding auxiliary materials. The traditional Chinese medicine composition has the main functions of clearing heat and toxic materials, dispelling wind, removing dampness and killing parasites to relieve itching, and can be used for effectively treating skin diseases such as dermatitis, eczema, furuncle, malignant boil, insect bite, scabies and skin infection.

A pharmaceutical composition of the present invention is used for improving health, cure abnormalities and degenerative disease; achieve anti-aging effect of therapy and therapeutic effect on mammals. The pharmaceutical composition includes a pharmaceutical carrier and an isotope selective ingredient including at least one of a chemical element and a chemical compound containing the chemical element whereby isotope distribution in the at least one of the chemical element and the chemical compound containing the chemical element is different from natural distribution of at least one of isotopes wherein the part of selected isotope of the chemical element ranges from 0 to 100%. A method of the present invention uses the inventive pharmaceutical composition to improve health, cure abnormalities and degenerative disease and achieve therapeutic effect on mammals.

The invention discloses an Endoglin antibody coupled liposome as well as a preparation method and an application thereof, and relates to an Endoglin antibody coupled liposome. The Endoglin antibody coupled liposome comprises nano liposome particles, Endoglin antibody molecules, a coupling agent and a plasmid DNA (deoxyribonucleic acid) / antineoplastic drug / imaging material, wherein the coupling agent is used for coupling the Endoglin antibody onto the nano liposome particles, and the plasmid DNA / antineoplastic drug / imaging material is carried by the nano liposome particles. The preparation method comprises the following steps: preparing a PEG (polyethylene glycol)-modified phospholipid lamina, filling the plasmid / drug / imaging material to prepare the nano liposome particles, homogenizing and purifying the nano liposome particles, thiolating the Endoglin antibody, and coupling the Endoglin antibody molecules on the PEG-modified nano liposome. The Endoglin antibody coupled liposome can be used for preparing drugs for diagnosing and treating solid tumors.

The invention relates to a system for acute coronary syndrome case information collection. The system comprises a data collection side, a server side, a control side, a user side, a doctor inquiry side and a data cloud platform. The system is in butt joint with data information of a hospital information system, a clinical data center, a data warehouse and the user side and can comprehensively collect related information of the acute coronary syndrome; the doctor inquiry side is provided with identity authentication equipment, the examination information of a patient can be obtained in real time, information sharing of departments is achieved, and the diagnosis efficiency is improved. Information of doctors is opened to users, and convenience is brought to the users for independently choosing doctors and hospitals for seeking medical advices.

The invention discloses a branched gold-platinum dual-metal nanoparticle as well as a preparation method and application thereof. The gold-platinum dual-metal nanoparticle has photo-thermal / radio-sensitization combined treatment performance and structurally contains gold-platinum nanoparticles and polyethylene glycol, wherein the gold-platinum nanoparticles are used for photo-thermal / radio-sensitization combined treatment, and polyethylene glycol is used for the surface modification of a thioctic acid terminal of a hydrophilic polymer. The gold-platinum dual-metal nanoparticle can be applied to the photo-thermal / radio-sensitization combined treatment and has the advantages of simplicity in preparation, low cost and remarkable treatment effect.

The invention relates to copper selenide / mesoporous silica core-shell nanoparticles and a preparation method and application thereof. The copper selenide / mesoporous silica core-shell nanoparticles are Cu2<-x>Se / mSiO2-PEG core-shell nanoparticles, where x is 0-1, and m is mesoporous. The preparation method comprises the following steps: preparing a Cu2<-x>Se nanocrystalline, transferring the hydrophobic Cu2<-x>Se nanocrystalline into an aqueous phase through CTAB (Cetyltrimethyl Ammonium Bromide), and growing a mesoporous silica layer on the surface of the CTAB through a sol-gel method by taking the CTAB as a template; and finally, modifying and coupling polyethylene glycol to the surface, and obtaining the copper selenide / mesoporous silica core-shell nanoparticles. The invention also discloses application in preparation of diagnosis and treatment preparations. The obtained Cu2<-x>Se / mSiO2-PEG has extremely low cytotoxicity, so that cancer cells can be effectively killed through light and heat, and the anti-cancer drug DOX can be effectively transmitted into the cells and has pH and laser-sensitive drug sustained release performance, so that a synergistic effect between photothermal therapy and chemotherapy can be realized.

The invention relates to an intelligent acupuncture diagnosis and treatment system, which comprises an information acquisition module, a data center, a diagnosis module and a treatment module, whereinthe information acquisition module comprises a traditional Chinese medicine detection module and a Western medicine detection module, and the traditional Chinese medicine detection module comprises ameridian and acupoint information acquisition device; the data center comprises a database and a data mining module, the data mining module establishes a diagnosis mathematical model and a treatmentmathematical model; the data center receives and analyzes the detection information obtained by the information acquisition module to generate a detection report; the diagnosis module comprises a traditional Chinese medicine diagnosis evaluation module and a Western medicine diagnosis evaluation module; the diagnosis module generates diagnosis information according to the detection report and thediagnosis mathematical model; the treatment module comprises a traditional Chinese medicine treatment suggestion module and a Western medicine treatment suggestion module; and the treatment module generates treatment information according to the diagnosis information and the treatment mathematical model, and the treatment information comprises acupuncture treatment acupuncture point combinations.The system can improve the accuracy of acupoint positioning, diagnosis and treatment.

The present invention provides a new type balloon dilation catheter which includes ballon and medication material coated on stent. Said medication material comes from one or two and more than two mixtures of heparin sodium, fiber degrading enzyme, serine proteinase, batroxobin, aspirin, genistein, hirudin and its recombined product, colchicine, sirolimus, biolimus, zotarolimus, tracrolimus, pimecrolimus, simvastatin, atorvastatin, pravastatin, ciclosporin, Anti-CD34, dexamethasone, bleomycin, plicamycin, daunomycin, mitomycin C, actinomycin D, taxol, celastrol, methopterin, 5-fluorouracil, cytarabine and 6-purinethol. The balloon is made of macromolecule nylon material, and the stimulation to blood vessel is far lower than the stent with metal structure.

The invention discloses a tumor targeting metal complex, a synthetic method and application. The synthetic method comprises the steps of connecting a ligand with a substituent group and a targeting molecule, complexing the ligand and metal ions, and synthesizing to obtain the tumor targeting metal complex, wherein the ligand is one of a phenanthroline derivative, a dipyridyl derivative, a benzimidazole derivative, a phenyl-pyridine derivative and a thiophene-pyridine derivative; the targeting molecule is one of biotin, folic acid, integrin, transferrin, cell-penetrating peptide, octa-poly-L-arginine, MUC-1 attached membrane protein, galactosamine, neovascular targeting peptide and a granulocyte-macrophage colony-stimulating factor; the metal ions are ruthenium, osmium, rhodium or iridium ions. The complex obtained by the method provided by the invention can be selectively absorbed by tumor cells, and induces apoptosis of the tumor cells. In a nude mouse tumor-bearing model, the tumor targeting metal complex can image and treat tumors, and the toxicity of organs and tissues is reduced.

The invention provides an on-demand dissolved hydrogel dressing and a preparation method thereof. The on-demand dissolved hydrogel dressing is prepared from a natural polymer solution with a side chain containing a phenylboronic acid group, a natural polymer or polyvinyl alcohol solution with a side chain containing a catechol group and polydopamine coating functional nanoparticles through doublecrosslinking at room temperature according to a certain proportion. The injectable performance is regulated and controlled by regulating the polymer concentration and the proportion of phenylboronic acid groups to catechol groups or m-hydroxy groups; the hydrogel dressing is endowed with an on-demand dissolving function through breakage of a phenylboronic acid ester bond responded by glucose; andthrough release of the element-doped nanoparticles and metal ions thereof, the hydrogel dressing is endowed with multiple biological functions such as antibiosis, anti-inflammation, healing promotion,imaging, oxidative stress regulation and control and the like. The hydrogel dressing is prepared by a one-step method, the process is simple, the reaction conditions are mild, and the preparation efficiency is high. Due to the fact that the hydrogel dressing has various biological functions, the dressing has great application potential in the aspects of adhesion and repair of various wound surfaces such as the skin and the oral cavity and the like, especially in the field of painless dressing change.