On-demand dissolved hydrogel dressing and preparation method thereof

Abstract

The invention provides an on-demand dissolved hydrogel dressing and a preparation method thereof. The on-demand dissolved hydrogel dressing is prepared from a natural polymer solution with a side chain containing a phenylboronic acid group, a natural polymer or polyvinyl alcohol solution with a side chain containing a catechol group and polydopamine coating functional nanoparticles through doublecrosslinking at room temperature according to a certain proportion. The injectable performance is regulated and controlled by regulating the polymer concentration and the proportion of phenylboronic acid groups to catechol groups or m-hydroxy groups; the hydrogel dressing is endowed with an on-demand dissolving function through breakage of a phenylboronic acid ester bond responded by glucose; andthrough release of the element-doped nanoparticles and metal ions thereof, the hydrogel dressing is endowed with multiple biological functions such as antibiosis, anti-inflammation, healing promotion,imaging, oxidative stress regulation and control and the like. The hydrogel dressing is prepared by a one-step method, the process is simple, the reaction conditions are mild, and the preparation efficiency is high. Due to the fact that the hydrogel dressing has various biological functions, the dressing has great application potential in the aspects of adhesion and repair of various wound surfaces such as the skin and the oral cavity and the like, especially in the field of painless dressing change.

Description

technical field [0001] The invention relates to a medical dressing and belongs to the technical field of biological materials. Background technique [0002] Acute and chronic skin wounds that are common in life are often accompanied by bacterial infection, inflammation, etc., resulting in difficult wound healing, requiring frequent and short-term continuous dressing changes to achieve rapid wound healing. However, commonly used gauze or medical dressings will adhere to the wound, and the pain caused by tearing when changing the dressing is sometimes even greater than the pain of the wound itself, and tearing will cause damage to new tissue. Therefore, in view of the pain caused by multiple dressing changes in patients with skin trauma, a new type of rapidly degradable hydrogel that is suitable for wound repair and can avoid the pain of dressing changes is designed and developed, especially the development of rapid Degraded dressings are an effective way to solve the problem...

AI Technical Summary

Problems solved by technology

However, too long dissolution time still cannot meet people's needs for rapid dressing change

[0004] The soluble dressings reported in Chinese invention patents (CN107602432A; CN107583102A; CN107496978A; CN107625992A) are all prepared from small molecule olefin monomers, initiators, auxiliary agents, etc. through a series of chemical reactions, but some small molecule monomers or crosslinking agents are synthesized The process is complex and difficult to obtain

Moreover, the presence of unreacted small molecular compounds in this water-soluble dressing will cause potential cytotoxicity, so it is not suitable for in situ gelation of wounds

More importantly, most of the hydrogel dressings on the market are fixed in shape, and the wound is deep or shallow, so the fixed shape of the dressing cannot achieve a tight fit for complex shaped wounds